PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FURG (RI FURG) |
Texto Completo: | http://repositorio.furg.br/handle/1/7361 http://dx.doi.org/10.1155/2015/104135 |
Resumo: | Carbon nanotubes (CNT) are promising materials for biomedical applications, especially in the field of neuroscience; therefore, it is essential to evaluate the neurotoxicity of these nanomaterials. The present work assessed the effects of single-walled CNT functionalized with polyethylene glycol (SWCNT-PEG) on the consolidation and retrieval of contextual fear memory in rats and on oxidative stress parameters in the hippocampus. SWCNT-PEG were dispersed in water at concentrations of 0.5, 1.0, and 2.1 mg/mL and infused into the rat hippocampus. The infusion was completed immediately after training and 30 min before testing of a contextual fear conditioning task, resulting in exposure times of 24 h and 30 min, respectively. The results showed that a short exposure to SWCNT-PEG impaired fear memory retrieval and caused lipid peroxidation in the hippocampus. This response was transient and overcome by the mobilization of antioxidant defenses at 24 h. These effects occurred at low and intermediate but not high concentration of SWCNT-PEG, suggesting that the observed biological response may be related to the concentrationdependent increase in particle size in SWCNT-PEG dispersions. |
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PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat HippocampusCarbon nanotubes (CNT) are promising materials for biomedical applications, especially in the field of neuroscience; therefore, it is essential to evaluate the neurotoxicity of these nanomaterials. The present work assessed the effects of single-walled CNT functionalized with polyethylene glycol (SWCNT-PEG) on the consolidation and retrieval of contextual fear memory in rats and on oxidative stress parameters in the hippocampus. SWCNT-PEG were dispersed in water at concentrations of 0.5, 1.0, and 2.1 mg/mL and infused into the rat hippocampus. The infusion was completed immediately after training and 30 min before testing of a contextual fear conditioning task, resulting in exposure times of 24 h and 30 min, respectively. The results showed that a short exposure to SWCNT-PEG impaired fear memory retrieval and caused lipid peroxidation in the hippocampus. This response was transient and overcome by the mobilization of antioxidant defenses at 24 h. These effects occurred at low and intermediate but not high concentration of SWCNT-PEG, suggesting that the observed biological response may be related to the concentrationdependent increase in particle size in SWCNT-PEG dispersions.2017-07-18T17:35:40Z2017-07-18T17:35:40Z2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfBOSCO, Lidiane Dal et al. PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus. BioMed Research International, v. 2015 , p. 1-11, 2015. Disponível em:<https://www.hindawi.com/journals/bmri/2015/104135/>. Acesso em: 01 maio 2017.2314-6133http://repositorio.furg.br/handle/1/7361http://dx.doi.org/10.1155/2015/104135engBosco, Lidiane DalWeber, Gisele Eva BruchParfitt, Gustavo MorronePaese, KarinaGonçalves, Carla Onara FerreirraSerodre, Tiago de MattosFurtado, Clascidia AparecidaSantos, Adelina PinheiroMonserrat, José MaríaBarros, Daniela Martiinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURG2019-11-22T13:43:08Zoai:repositorio.furg.br:1/7361Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2019-11-22T13:43:08Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false |
dc.title.none.fl_str_mv |
PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus |
title |
PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus |
spellingShingle |
PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus Bosco, Lidiane Dal |
title_short |
PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus |
title_full |
PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus |
title_fullStr |
PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus |
title_full_unstemmed |
PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus |
title_sort |
PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus |
author |
Bosco, Lidiane Dal |
author_facet |
Bosco, Lidiane Dal Weber, Gisele Eva Bruch Parfitt, Gustavo Morrone Paese, Karina Gonçalves, Carla Onara Ferreirra Serodre, Tiago de Mattos Furtado, Clascidia Aparecida Santos, Adelina Pinheiro Monserrat, José María Barros, Daniela Marti |
author_role |
author |
author2 |
Weber, Gisele Eva Bruch Parfitt, Gustavo Morrone Paese, Karina Gonçalves, Carla Onara Ferreirra Serodre, Tiago de Mattos Furtado, Clascidia Aparecida Santos, Adelina Pinheiro Monserrat, José María Barros, Daniela Marti |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Bosco, Lidiane Dal Weber, Gisele Eva Bruch Parfitt, Gustavo Morrone Paese, Karina Gonçalves, Carla Onara Ferreirra Serodre, Tiago de Mattos Furtado, Clascidia Aparecida Santos, Adelina Pinheiro Monserrat, José María Barros, Daniela Marti |
description |
Carbon nanotubes (CNT) are promising materials for biomedical applications, especially in the field of neuroscience; therefore, it is essential to evaluate the neurotoxicity of these nanomaterials. The present work assessed the effects of single-walled CNT functionalized with polyethylene glycol (SWCNT-PEG) on the consolidation and retrieval of contextual fear memory in rats and on oxidative stress parameters in the hippocampus. SWCNT-PEG were dispersed in water at concentrations of 0.5, 1.0, and 2.1 mg/mL and infused into the rat hippocampus. The infusion was completed immediately after training and 30 min before testing of a contextual fear conditioning task, resulting in exposure times of 24 h and 30 min, respectively. The results showed that a short exposure to SWCNT-PEG impaired fear memory retrieval and caused lipid peroxidation in the hippocampus. This response was transient and overcome by the mobilization of antioxidant defenses at 24 h. These effects occurred at low and intermediate but not high concentration of SWCNT-PEG, suggesting that the observed biological response may be related to the concentrationdependent increase in particle size in SWCNT-PEG dispersions. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2017-07-18T17:35:40Z 2017-07-18T17:35:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
BOSCO, Lidiane Dal et al. PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus. BioMed Research International, v. 2015 , p. 1-11, 2015. Disponível em:<https://www.hindawi.com/journals/bmri/2015/104135/>. Acesso em: 01 maio 2017. 2314-6133 http://repositorio.furg.br/handle/1/7361 http://dx.doi.org/10.1155/2015/104135 |
identifier_str_mv |
BOSCO, Lidiane Dal et al. PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus. BioMed Research International, v. 2015 , p. 1-11, 2015. Disponível em:<https://www.hindawi.com/journals/bmri/2015/104135/>. Acesso em: 01 maio 2017. 2314-6133 |
url |
http://repositorio.furg.br/handle/1/7361 http://dx.doi.org/10.1155/2015/104135 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FURG (RI FURG) instname:Universidade Federal do Rio Grande (FURG) instacron:FURG |
instname_str |
Universidade Federal do Rio Grande (FURG) |
instacron_str |
FURG |
institution |
FURG |
reponame_str |
Repositório Institucional da FURG (RI FURG) |
collection |
Repositório Institucional da FURG (RI FURG) |
repository.name.fl_str_mv |
Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG) |
repository.mail.fl_str_mv |
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