PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus

Detalhes bibliográficos
Autor(a) principal: Bosco, Lidiane Dal
Data de Publicação: 2015
Outros Autores: Weber, Gisele Eva Bruch, Parfitt, Gustavo Morrone, Paese, Karina, Gonçalves, Carla Onara Ferreirra, Serodre, Tiago de Mattos, Furtado, Clascidia Aparecida, Santos, Adelina Pinheiro, Monserrat, José María, Barros, Daniela Marti
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FURG (RI FURG)
Texto Completo: http://repositorio.furg.br/handle/1/7361
http://dx.doi.org/10.1155/2015/104135
Resumo: Carbon nanotubes (CNT) are promising materials for biomedical applications, especially in the field of neuroscience; therefore, it is essential to evaluate the neurotoxicity of these nanomaterials. The present work assessed the effects of single-walled CNT functionalized with polyethylene glycol (SWCNT-PEG) on the consolidation and retrieval of contextual fear memory in rats and on oxidative stress parameters in the hippocampus. SWCNT-PEG were dispersed in water at concentrations of 0.5, 1.0, and 2.1 mg/mL and infused into the rat hippocampus. The infusion was completed immediately after training and 30 min before testing of a contextual fear conditioning task, resulting in exposure times of 24 h and 30 min, respectively. The results showed that a short exposure to SWCNT-PEG impaired fear memory retrieval and caused lipid peroxidation in the hippocampus. This response was transient and overcome by the mobilization of antioxidant defenses at 24 h. These effects occurred at low and intermediate but not high concentration of SWCNT-PEG, suggesting that the observed biological response may be related to the concentrationdependent increase in particle size in SWCNT-PEG dispersions.
id FURG_03c4b599ff6473fbfec2b939264669ca
oai_identifier_str oai:repositorio.furg.br:1/7361
network_acronym_str FURG
network_name_str Repositório Institucional da FURG (RI FURG)
repository_id_str
spelling PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat HippocampusCarbon nanotubes (CNT) are promising materials for biomedical applications, especially in the field of neuroscience; therefore, it is essential to evaluate the neurotoxicity of these nanomaterials. The present work assessed the effects of single-walled CNT functionalized with polyethylene glycol (SWCNT-PEG) on the consolidation and retrieval of contextual fear memory in rats and on oxidative stress parameters in the hippocampus. SWCNT-PEG were dispersed in water at concentrations of 0.5, 1.0, and 2.1 mg/mL and infused into the rat hippocampus. The infusion was completed immediately after training and 30 min before testing of a contextual fear conditioning task, resulting in exposure times of 24 h and 30 min, respectively. The results showed that a short exposure to SWCNT-PEG impaired fear memory retrieval and caused lipid peroxidation in the hippocampus. This response was transient and overcome by the mobilization of antioxidant defenses at 24 h. These effects occurred at low and intermediate but not high concentration of SWCNT-PEG, suggesting that the observed biological response may be related to the concentrationdependent increase in particle size in SWCNT-PEG dispersions.2017-07-18T17:35:40Z2017-07-18T17:35:40Z2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfBOSCO, Lidiane Dal et al. PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus. BioMed Research International, v. 2015 , p. 1-11, 2015. Disponível em:<https://www.hindawi.com/journals/bmri/2015/104135/>. Acesso em: 01 maio 2017.2314-6133http://repositorio.furg.br/handle/1/7361http://dx.doi.org/10.1155/2015/104135engBosco, Lidiane DalWeber, Gisele Eva BruchParfitt, Gustavo MorronePaese, KarinaGonçalves, Carla Onara FerreirraSerodre, Tiago de MattosFurtado, Clascidia AparecidaSantos, Adelina PinheiroMonserrat, José MaríaBarros, Daniela Martiinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURG2019-11-22T13:43:08Zoai:repositorio.furg.br:1/7361Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2019-11-22T13:43:08Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false
dc.title.none.fl_str_mv PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus
title PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus
spellingShingle PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus
Bosco, Lidiane Dal
title_short PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus
title_full PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus
title_fullStr PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus
title_full_unstemmed PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus
title_sort PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus
author Bosco, Lidiane Dal
author_facet Bosco, Lidiane Dal
Weber, Gisele Eva Bruch
Parfitt, Gustavo Morrone
Paese, Karina
Gonçalves, Carla Onara Ferreirra
Serodre, Tiago de Mattos
Furtado, Clascidia Aparecida
Santos, Adelina Pinheiro
Monserrat, José María
Barros, Daniela Marti
author_role author
author2 Weber, Gisele Eva Bruch
Parfitt, Gustavo Morrone
Paese, Karina
Gonçalves, Carla Onara Ferreirra
Serodre, Tiago de Mattos
Furtado, Clascidia Aparecida
Santos, Adelina Pinheiro
Monserrat, José María
Barros, Daniela Marti
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bosco, Lidiane Dal
Weber, Gisele Eva Bruch
Parfitt, Gustavo Morrone
Paese, Karina
Gonçalves, Carla Onara Ferreirra
Serodre, Tiago de Mattos
Furtado, Clascidia Aparecida
Santos, Adelina Pinheiro
Monserrat, José María
Barros, Daniela Marti
description Carbon nanotubes (CNT) are promising materials for biomedical applications, especially in the field of neuroscience; therefore, it is essential to evaluate the neurotoxicity of these nanomaterials. The present work assessed the effects of single-walled CNT functionalized with polyethylene glycol (SWCNT-PEG) on the consolidation and retrieval of contextual fear memory in rats and on oxidative stress parameters in the hippocampus. SWCNT-PEG were dispersed in water at concentrations of 0.5, 1.0, and 2.1 mg/mL and infused into the rat hippocampus. The infusion was completed immediately after training and 30 min before testing of a contextual fear conditioning task, resulting in exposure times of 24 h and 30 min, respectively. The results showed that a short exposure to SWCNT-PEG impaired fear memory retrieval and caused lipid peroxidation in the hippocampus. This response was transient and overcome by the mobilization of antioxidant defenses at 24 h. These effects occurred at low and intermediate but not high concentration of SWCNT-PEG, suggesting that the observed biological response may be related to the concentrationdependent increase in particle size in SWCNT-PEG dispersions.
publishDate 2015
dc.date.none.fl_str_mv 2015
2017-07-18T17:35:40Z
2017-07-18T17:35:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv BOSCO, Lidiane Dal et al. PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus. BioMed Research International, v. 2015 , p. 1-11, 2015. Disponível em:<https://www.hindawi.com/journals/bmri/2015/104135/>. Acesso em: 01 maio 2017.
2314-6133
http://repositorio.furg.br/handle/1/7361
http://dx.doi.org/10.1155/2015/104135
identifier_str_mv BOSCO, Lidiane Dal et al. PEGylated Carbon Nanotubes Impair Retrieval of Contextual Fear Memory and Alter Oxidative Stress Parameters in the Rat Hippocampus. BioMed Research International, v. 2015 , p. 1-11, 2015. Disponível em:<https://www.hindawi.com/journals/bmri/2015/104135/>. Acesso em: 01 maio 2017.
2314-6133
url http://repositorio.furg.br/handle/1/7361
http://dx.doi.org/10.1155/2015/104135
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da FURG (RI FURG)
instname:Universidade Federal do Rio Grande (FURG)
instacron:FURG
instname_str Universidade Federal do Rio Grande (FURG)
instacron_str FURG
institution FURG
reponame_str Repositório Institucional da FURG (RI FURG)
collection Repositório Institucional da FURG (RI FURG)
repository.name.fl_str_mv Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)
repository.mail.fl_str_mv
_version_ 1813187263082790912