Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FURG (RI FURG) |
Texto Completo: | http://repositorio.furg.br/handle/1/7088 https://doi.org/10.5588/ijtld.15.0126 |
Resumo: | SETTING: Tuberculosis (TB) in prisons is a challenge for the public health system. Active and passive case screening are important tools for TB case detection. OBJECTIVE: To characterise TB in a southern Brazil prison in terms of epidemiological variables, diagnostic approaches and clinical isolate genotypes. DESIGN: Inmates of a southern Brazilian prison were assessed using active and passive TB case screening. Sputum microscopy, culture, drug susceptibility testing and genotyping were performed. Data were analysed using descriptive statistics and multivariable logistic regression. RESULTS: TB prevalence was 4712 per 100 000 inmates, and was associated with low educational level, time incarcerated, productive cough, previous TB history, smoking and human immunodeficiency virus (HIV) infection. Overall, 27.8% of TB cases were detected by culture only; the prevalence of drug-resistant strains was 7.8%; 58.3% of clinical isolates had an identical genotypic profile. CONCLUSION: The study showed extensive circulation of Mycobacterium tuberculosis strains in a highly endemic prison. It is recommended that priority be given to the evaluation of prison inmates with longer jail times, those who are HIV-positive, those with symptoms and those with a previous history of tuberculosis. We observed that active case finding induced passive case detection. |
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Prevalence of tuberculosis in prisons: risk factors and molecular epidemiologyMycobacterium tuberculosisDiagnosisGenotypingMultidrug resistancePrisonsSETTING: Tuberculosis (TB) in prisons is a challenge for the public health system. Active and passive case screening are important tools for TB case detection. OBJECTIVE: To characterise TB in a southern Brazil prison in terms of epidemiological variables, diagnostic approaches and clinical isolate genotypes. DESIGN: Inmates of a southern Brazilian prison were assessed using active and passive TB case screening. Sputum microscopy, culture, drug susceptibility testing and genotyping were performed. Data were analysed using descriptive statistics and multivariable logistic regression. RESULTS: TB prevalence was 4712 per 100 000 inmates, and was associated with low educational level, time incarcerated, productive cough, previous TB history, smoking and human immunodeficiency virus (HIV) infection. Overall, 27.8% of TB cases were detected by culture only; the prevalence of drug-resistant strains was 7.8%; 58.3% of clinical isolates had an identical genotypic profile. CONCLUSION: The study showed extensive circulation of Mycobacterium tuberculosis strains in a highly endemic prison. It is recommended that priority be given to the evaluation of prison inmates with longer jail times, those who are HIV-positive, those with symptoms and those with a previous history of tuberculosis. We observed that active case finding induced passive case detection.2017-03-06T13:08:35Z2017-03-06T13:08:35Z2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfVALENÇA, Mariana Soares; et al. Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology. The International Journal of Tuberculosis and Lung Disease. v. 19, n. 10, p. 1182-1187, 2015. Disponível em: <http://www.ingentaconnect.com/content/iuatld/ijtld/2015/00000019/00000010/art00010 >. Acesso em: 13 jan. 2017.http://repositorio.furg.br/handle/1/7088https://doi.org/10.5588/ijtld.15.0126engValença, Mariana SoaresScaini, João Luis RheingantzAbilleira, Fernanda de SouzaGonçalves, Carla VitolaGroll, Andrea VonSilva, Pedro Eduardo Almeida dainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURG2017-03-06T13:08:35Zoai:repositorio.furg.br:1/7088Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2017-03-06T13:08:35Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false |
dc.title.none.fl_str_mv |
Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology |
title |
Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology |
spellingShingle |
Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology Valença, Mariana Soares Mycobacterium tuberculosis Diagnosis Genotyping Multidrug resistance Prisons |
title_short |
Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology |
title_full |
Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology |
title_fullStr |
Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology |
title_full_unstemmed |
Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology |
title_sort |
Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology |
author |
Valença, Mariana Soares |
author_facet |
Valença, Mariana Soares Scaini, João Luis Rheingantz Abilleira, Fernanda de Souza Gonçalves, Carla Vitola Groll, Andrea Von Silva, Pedro Eduardo Almeida da |
author_role |
author |
author2 |
Scaini, João Luis Rheingantz Abilleira, Fernanda de Souza Gonçalves, Carla Vitola Groll, Andrea Von Silva, Pedro Eduardo Almeida da |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Valença, Mariana Soares Scaini, João Luis Rheingantz Abilleira, Fernanda de Souza Gonçalves, Carla Vitola Groll, Andrea Von Silva, Pedro Eduardo Almeida da |
dc.subject.por.fl_str_mv |
Mycobacterium tuberculosis Diagnosis Genotyping Multidrug resistance Prisons |
topic |
Mycobacterium tuberculosis Diagnosis Genotyping Multidrug resistance Prisons |
description |
SETTING: Tuberculosis (TB) in prisons is a challenge for the public health system. Active and passive case screening are important tools for TB case detection. OBJECTIVE: To characterise TB in a southern Brazil prison in terms of epidemiological variables, diagnostic approaches and clinical isolate genotypes. DESIGN: Inmates of a southern Brazilian prison were assessed using active and passive TB case screening. Sputum microscopy, culture, drug susceptibility testing and genotyping were performed. Data were analysed using descriptive statistics and multivariable logistic regression. RESULTS: TB prevalence was 4712 per 100 000 inmates, and was associated with low educational level, time incarcerated, productive cough, previous TB history, smoking and human immunodeficiency virus (HIV) infection. Overall, 27.8% of TB cases were detected by culture only; the prevalence of drug-resistant strains was 7.8%; 58.3% of clinical isolates had an identical genotypic profile. CONCLUSION: The study showed extensive circulation of Mycobacterium tuberculosis strains in a highly endemic prison. It is recommended that priority be given to the evaluation of prison inmates with longer jail times, those who are HIV-positive, those with symptoms and those with a previous history of tuberculosis. We observed that active case finding induced passive case detection. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2017-03-06T13:08:35Z 2017-03-06T13:08:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
VALENÇA, Mariana Soares; et al. Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology. The International Journal of Tuberculosis and Lung Disease. v. 19, n. 10, p. 1182-1187, 2015. Disponível em: <http://www.ingentaconnect.com/content/iuatld/ijtld/2015/00000019/00000010/art00010 >. Acesso em: 13 jan. 2017. http://repositorio.furg.br/handle/1/7088 https://doi.org/10.5588/ijtld.15.0126 |
identifier_str_mv |
VALENÇA, Mariana Soares; et al. Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology. The International Journal of Tuberculosis and Lung Disease. v. 19, n. 10, p. 1182-1187, 2015. Disponível em: <http://www.ingentaconnect.com/content/iuatld/ijtld/2015/00000019/00000010/art00010 >. Acesso em: 13 jan. 2017. |
url |
http://repositorio.furg.br/handle/1/7088 https://doi.org/10.5588/ijtld.15.0126 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
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reponame:Repositório Institucional da FURG (RI FURG) instname:Universidade Federal do Rio Grande (FURG) instacron:FURG |
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Universidade Federal do Rio Grande (FURG) |
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FURG |
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FURG |
reponame_str |
Repositório Institucional da FURG (RI FURG) |
collection |
Repositório Institucional da FURG (RI FURG) |
repository.name.fl_str_mv |
Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG) |
repository.mail.fl_str_mv |
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1807384411871641600 |