Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology

Detalhes bibliográficos
Autor(a) principal: Valença, Mariana Soares
Data de Publicação: 2015
Outros Autores: Scaini, João Luis Rheingantz, Abilleira, Fernanda de Souza, Gonçalves, Carla Vitola, Von Groll, Andrea, Silva, Pedro Eduardo Almeida da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FURG (RI FURG)
Texto Completo: http://repositorio.furg.br/handle/1/7063
http://dx.doi.org/10.5588/ijtld.15.0126
Resumo: SETTING: Tuberculosis (TB) in prisons is a challenge for the public health system. Active and passive case screening are important tools for TB case detection. OBJECTIVE: To characterise TB in a southern Brazil prison in terms of epidemiological variables, diagnostic approaches and clinical isolate genotypes. DESIGN: Inmates of a southern Brazilian prison were assessed using active and passive TB case screening. Sputum microscopy, culture, drug susceptibility testing and genotyping were performed. Data were analysed using descriptive statistics and multivariable logistic regression. RESULTS: TB prevalence was 4712 per 100 000 inmates, and was associated with low educational level, time incarcerated, productive cough, previous TB history, smoking and human immunodeficiency virus (HIV) infection. Overall, 27.8% of TB cases were detected by culture only; the prevalence of drug-resistant strains was 7.8%; 58.3% of clinical isolates had an identical genotypic profile. CONCLUSION: The study showed extensive circulation of Mycobacterium tuberculosis strains in a highly endemic prison. It is recommended that priority be given to the evaluation of prison inmates with longer jail times, those who are HIV-positive, those with symptoms and those with a previous history of tuberculosis. We observed that active case finding induced passive case detection.
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spelling Valença, Mariana SoaresScaini, João Luis RheingantzAbilleira, Fernanda de SouzaGonçalves, Carla VitolaVon Groll, AndreaSilva, Pedro Eduardo Almeida da2017-02-09T00:38:28Z2017-02-09T00:38:28Z2015VALENÇA, Mariana Soares et al. Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology. The International Journal of Tuberculosis and Lung Disease, v. 19, n.10, p. 1182-1187, 2015. Disponível em: <http://www.ingentaconnect.com/content/iuatld/ijtld/2015/00000019/00000010/art00010#aff_2>. Acesso em: 08 fev. 2017.1027-3719http://repositorio.furg.br/handle/1/7063http://dx.doi.org/10.5588/ijtld.15.0126SETTING: Tuberculosis (TB) in prisons is a challenge for the public health system. Active and passive case screening are important tools for TB case detection. OBJECTIVE: To characterise TB in a southern Brazil prison in terms of epidemiological variables, diagnostic approaches and clinical isolate genotypes. DESIGN: Inmates of a southern Brazilian prison were assessed using active and passive TB case screening. Sputum microscopy, culture, drug susceptibility testing and genotyping were performed. Data were analysed using descriptive statistics and multivariable logistic regression. RESULTS: TB prevalence was 4712 per 100 000 inmates, and was associated with low educational level, time incarcerated, productive cough, previous TB history, smoking and human immunodeficiency virus (HIV) infection. Overall, 27.8% of TB cases were detected by culture only; the prevalence of drug-resistant strains was 7.8%; 58.3% of clinical isolates had an identical genotypic profile. CONCLUSION: The study showed extensive circulation of Mycobacterium tuberculosis strains in a highly endemic prison. It is recommended that priority be given to the evaluation of prison inmates with longer jail times, those who are HIV-positive, those with symptoms and those with a previous history of tuberculosis. We observed that active case finding induced passive case detection.CONTEXTE : La tuberculose (TB) en prison constitue un d´efi majeur pour le syst`eme de sant´e publique. Le d´epistage actif et passif des cas est un outil important pour la d´etection des cas de TB. OBJECTIF : Caract´eriser la TB dans une prison du sud du Br´esil en termes de variables ´epid´emiologiques, d’approches diagnostiques et de g´enotypes des isolats cliniques. SCHE´ MA : Cette ´etude a ´et´e r´ealis´ee dans une prison du sud du Br´esil. Les d´etenus ont ´et´e ´evalu´es grˆace aux approches de d´epistage actif et passif des cas. On a r´ealis´e une microscopie de crachats, une culture, un test de pharmacosensibilit´e et un g´enotypage. Les donn´ees ont ´et´e analys´ees grˆace `a des statistiques descriptives et `a une r´egression logistique multivari´ee. R E´ SULTATS : La pr´evalence de la TB a ´et´e de 4712 pour 100 000 d´etenus et a ´et´e associ´ee `a un faible niveau d’instruction, `a la dur´ee de la d´etention, `a une toux productive, `a des ant´ec´edents de TB, `a l’usage du tabac et au virus de l’immunod´eficience humaine (VIH). Dans l’ensemble, 27,8% des cas de TB ont ´et´e d´etect´es par culture seule et la pr´evalence de souches de TB r´esistantes a ´et´e de 7,8%. De plus, 58,3% des isolats cliniques avaient un profil g´enotypique identique. CONCLUSIONS : Cette ´etude a mis en ´evidence une circulation extensive de Mycobacterium tuberculosis dans une prison hautement end´emique. On sugg`ere de donner la priorit´e `a l’´evaluation des d´etenus anciens, ceux qui sont VIH positifs, ceux qui ont des symptˆomes et ceux qui ont d´ej`a eu la TB dans le pass´e. De plus, nous avons constat´e que le d´epistage actif des cas induisait une d´etection passive des cas.M A R C O D E R E F E R E N C I A: La tuberculosis (TB) en las prisiones representa un gran problema del sistema de salud pública. La detección activa y pasiva de casos es un instrumento importante en la detección de los casos de TB. O B J E T I V O: Caracterizar la TB en una prisión del sur del Brasil mediante el análisis de las variables epidemiológicas, los enfoques diagnósticos y los genotipos de los aislados clínicos. M E´ T O D O S: El estudio se llevó a cabo en una prisión del sur del Brasil. La investigación de los reclusos siguío estrategias de búsqueda activa y pasiva de casos. Se practicaron la baciloscopia del esputo, el cultivo, las pruebas de sensibilidad a los medicamentos y la genotipificación. Los datos se analizaron mediante estadısticas descriptivas y análisis de regresión logística multifactorial. R E S U LTA D O S: Se observó una prevalencia de TB de 4712 por 100 000 reclusos y la enfermedad se asoció con un bajo nivel educativo, el tiempo de permanencia en prisión, la tos productiva, el antecedente de TB, el tabaquismo y la situación frente al virus de la inmunodeficiencia humana (VIH). En general, el 27,8% de los casos de TB se detecto solo mediante el cultivo y la prevalencia de cepas farmacorresistentes fue 7,8%. Además, el 58,3% de los aislados clínicos presentó un perfil genotípico identico. CONCLUSIÓN: El estudio puso de manifiesto una extensa circulacion de Mycobacterium tuberculosis en una prision con alta endemia. Se recomienda dar prioridad a la evaluacion de los prisioneros con un tiempo más prolongado de encarcelamiento, los que presentan una serología positiva frente al VIH, los que refieren sıntomas y los que presentan un antecedente de infección tuberculosa. Además, el estudio indico que la búsqueda activa de casos favorece la detección pasiva.engMycobacterium tuberculosisDiagnosisGenotypingMultidrug resistancePrisonsPrevalence of tuberculosis in prisons: risk factors and molecular epidemiologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGORIGINALs10.pdfs10.pdfapplication/pdf164069https://repositorio.furg.br/bitstream/1/7063/1/s10.pdf42e73cd8664b8b13545b19bab610645bMD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.furg.br/bitstream/1/7063/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52open access1/70632017-02-08 22:38:28.557open accessoai:repositorio.furg.br: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Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2017-02-09T00:38:28Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false
dc.title.pt_BR.fl_str_mv Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology
title Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology
spellingShingle Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology
Valença, Mariana Soares
Mycobacterium tuberculosis
Diagnosis
Genotyping
Multidrug resistance
Prisons
title_short Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology
title_full Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology
title_fullStr Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology
title_full_unstemmed Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology
title_sort Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology
author Valença, Mariana Soares
author_facet Valença, Mariana Soares
Scaini, João Luis Rheingantz
Abilleira, Fernanda de Souza
Gonçalves, Carla Vitola
Von Groll, Andrea
Silva, Pedro Eduardo Almeida da
author_role author
author2 Scaini, João Luis Rheingantz
Abilleira, Fernanda de Souza
Gonçalves, Carla Vitola
Von Groll, Andrea
Silva, Pedro Eduardo Almeida da
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Valença, Mariana Soares
Scaini, João Luis Rheingantz
Abilleira, Fernanda de Souza
Gonçalves, Carla Vitola
Von Groll, Andrea
Silva, Pedro Eduardo Almeida da
dc.subject.por.fl_str_mv Mycobacterium tuberculosis
Diagnosis
Genotyping
Multidrug resistance
Prisons
topic Mycobacterium tuberculosis
Diagnosis
Genotyping
Multidrug resistance
Prisons
description SETTING: Tuberculosis (TB) in prisons is a challenge for the public health system. Active and passive case screening are important tools for TB case detection. OBJECTIVE: To characterise TB in a southern Brazil prison in terms of epidemiological variables, diagnostic approaches and clinical isolate genotypes. DESIGN: Inmates of a southern Brazilian prison were assessed using active and passive TB case screening. Sputum microscopy, culture, drug susceptibility testing and genotyping were performed. Data were analysed using descriptive statistics and multivariable logistic regression. RESULTS: TB prevalence was 4712 per 100 000 inmates, and was associated with low educational level, time incarcerated, productive cough, previous TB history, smoking and human immunodeficiency virus (HIV) infection. Overall, 27.8% of TB cases were detected by culture only; the prevalence of drug-resistant strains was 7.8%; 58.3% of clinical isolates had an identical genotypic profile. CONCLUSION: The study showed extensive circulation of Mycobacterium tuberculosis strains in a highly endemic prison. It is recommended that priority be given to the evaluation of prison inmates with longer jail times, those who are HIV-positive, those with symptoms and those with a previous history of tuberculosis. We observed that active case finding induced passive case detection.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2017-02-09T00:38:28Z
dc.date.available.fl_str_mv 2017-02-09T00:38:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VALENÇA, Mariana Soares et al. Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology. The International Journal of Tuberculosis and Lung Disease, v. 19, n.10, p. 1182-1187, 2015. Disponível em: <http://www.ingentaconnect.com/content/iuatld/ijtld/2015/00000019/00000010/art00010#aff_2>. Acesso em: 08 fev. 2017.
dc.identifier.uri.fl_str_mv http://repositorio.furg.br/handle/1/7063
dc.identifier.issn.none.fl_str_mv 1027-3719
dc.identifier.doi.pt_BR.fl_str_mv http://dx.doi.org/10.5588/ijtld.15.0126
identifier_str_mv VALENÇA, Mariana Soares et al. Prevalence of tuberculosis in prisons: risk factors and molecular epidemiology. The International Journal of Tuberculosis and Lung Disease, v. 19, n.10, p. 1182-1187, 2015. Disponível em: <http://www.ingentaconnect.com/content/iuatld/ijtld/2015/00000019/00000010/art00010#aff_2>. Acesso em: 08 fev. 2017.
1027-3719
url http://repositorio.furg.br/handle/1/7063
http://dx.doi.org/10.5588/ijtld.15.0126
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