Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da FURG (RI FURG) |
Texto Completo: | http://repositorio.furg.br/handle/1/7013 http://dx.doi.org/10.1016/j.ram.2015.08.004 |
Resumo: | Asymptomatic meningococcus carriers in hospitals is a risk factor for acquiring meningococcal disease. Meningococcal carrier (MC) frequency was investigated in oropharyngeal swab samples collected from 200 staff members at a teaching hospital from Brazil. MC prevalence was 9 % (95 % CI 5---13 %). Risk factors associated with MC were: mean age of 26.5 years, male gender, bar attendance frequency and number of persons/house. Of 18 isolated meningococcal strains, 14 were non-groupable (NG), 3 corrresponded to serogroup B and 1 to serogroup 29E. The frequency of serotypes and serosubtypes was heterogenous, with a slight predominance of serotypes 4 and 7 and serosubtypes P1.7 and P1.5. Most strains (n = 13) were susceptible to the antimicrobials tested. The ctrA gene (PCR) was identified in 9 (64.3 %) of the 14 NG strains, suggesting virulence in most of the NG isolated strains. Therefore, a constant surveillance of these asymptomatic carriers is required. |
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Gióia, Carolina Alicia CochLemos, Ana Paula Silva deGorla, Maria Cecilia OuteiroMendoza-Sassi, Raul AndrésBallester, TeresaGroll, Andrea VonWedig, Bruna LaísEthur, Nathalia de VargasBragança, LetíciaMilagres, Lucimar GonçalvesSilva, Pedro Eduardo Almeida da2017-01-15T19:28:51Z2017-01-15T19:28:51Z2015GIOIA, Carolina Alicia Coch et al. Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil. Revista Argentina de Microbiologia, v. 47, n. 4, p. 322-327, 2015. Disponível em: < http://www.scielo.org.ar/pdf/ram/v47n4/v47n4a07.pdf>. Acesso em: 09 jan. 2017.1851-7617http://repositorio.furg.br/handle/1/7013http://dx.doi.org/10.1016/j.ram.2015.08.004Asymptomatic meningococcus carriers in hospitals is a risk factor for acquiring meningococcal disease. Meningococcal carrier (MC) frequency was investigated in oropharyngeal swab samples collected from 200 staff members at a teaching hospital from Brazil. MC prevalence was 9 % (95 % CI 5---13 %). Risk factors associated with MC were: mean age of 26.5 years, male gender, bar attendance frequency and number of persons/house. Of 18 isolated meningococcal strains, 14 were non-groupable (NG), 3 corrresponded to serogroup B and 1 to serogroup 29E. The frequency of serotypes and serosubtypes was heterogenous, with a slight predominance of serotypes 4 and 7 and serosubtypes P1.7 and P1.5. Most strains (n = 13) were susceptible to the antimicrobials tested. The ctrA gene (PCR) was identified in 9 (64.3 %) of the 14 NG strains, suggesting virulence in most of the NG isolated strains. Therefore, a constant surveillance of these asymptomatic carriers is required.Los portadores asintomáticos de meningococos en hospitales son un factor de riesgo (FR) para adquirir la enfermedad meningocócica. La frecuencia de portadores de meningococos fue determinada a través de colecta orofaríngea en personal de un hospital de Brasil (n = 200). La prevalencia de portadores fue del 9 % (IC del 95 %, 5-13 %). Los FR asociados al estado de portador fueron los siguientes: edad promedio 26,5 anos, ˜ sexo masculino, hábito de frecuentar bares y número de personas/casa. Entre las 18 cepas de meningococos aisladas, 14 eran no agrupables (NG), 3 correspondieron al serogrupo B y una al 29E. La frecuencia de los serotipos y serosubtipos fue heterogénea, con un ligero predominio de los serotipos 4 y 7 y de los serosubtipos P1.7 y P1.5. La mayoría de las cepas (n = 13) fueron sensibles a los antimicrobianos estudiados. El gen ctrA fue identificado por PCR en 9 (64,3 %) de las 14 cepas NG, lo que sugiere virulencia en la mayoría de las cepas NG aisladas. Por lo tanto, se requiere una vigilancia constante de estos portadores asintomáticos.porNeisseria meningitidisAsymptomatic carriersPrevalenceHospitalAntimicrobialsPCR ctrAPortadores asintomáticosPrevalenciaAntimicrobianosDetection of Neisseria meningitidis in asymptomatic carriers in a university hospital from BrazilDetección de Neisseria meningitidis en portadores asintomáticos en un hospital universitario de Brasilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGORIGINALv47n4a07.pdfv47n4a07.pdfapplication/pdf347662https://repositorio.furg.br/bitstream/1/7013/1/v47n4a07.pdfc904b61fb61ec1c6f963a17734d6a040MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.furg.br/bitstream/1/7013/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52open access1/70132019-11-13 22:48:31.132open accessoai:repositorio.furg.br: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Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2019-11-14T01:48:31Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false |
dc.title.pt_BR.fl_str_mv |
Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil |
dc.title.alternative.pt_BR.fl_str_mv |
Detección de Neisseria meningitidis en portadores asintomáticos en un hospital universitario de Brasil |
title |
Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil |
spellingShingle |
Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil Gióia, Carolina Alicia Coch Neisseria meningitidis Asymptomatic carriers Prevalence Hospital Antimicrobials PCR ctrA Portadores asintomáticos Prevalencia Antimicrobianos |
title_short |
Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil |
title_full |
Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil |
title_fullStr |
Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil |
title_full_unstemmed |
Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil |
title_sort |
Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil |
author |
Gióia, Carolina Alicia Coch |
author_facet |
Gióia, Carolina Alicia Coch Lemos, Ana Paula Silva de Gorla, Maria Cecilia Outeiro Mendoza-Sassi, Raul Andrés Ballester, Teresa Groll, Andrea Von Wedig, Bruna Laís Ethur, Nathalia de Vargas Bragança, Letícia Milagres, Lucimar Gonçalves Silva, Pedro Eduardo Almeida da |
author_role |
author |
author2 |
Lemos, Ana Paula Silva de Gorla, Maria Cecilia Outeiro Mendoza-Sassi, Raul Andrés Ballester, Teresa Groll, Andrea Von Wedig, Bruna Laís Ethur, Nathalia de Vargas Bragança, Letícia Milagres, Lucimar Gonçalves Silva, Pedro Eduardo Almeida da |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Gióia, Carolina Alicia Coch Lemos, Ana Paula Silva de Gorla, Maria Cecilia Outeiro Mendoza-Sassi, Raul Andrés Ballester, Teresa Groll, Andrea Von Wedig, Bruna Laís Ethur, Nathalia de Vargas Bragança, Letícia Milagres, Lucimar Gonçalves Silva, Pedro Eduardo Almeida da |
dc.subject.por.fl_str_mv |
Neisseria meningitidis Asymptomatic carriers Prevalence Hospital Antimicrobials PCR ctrA Portadores asintomáticos Prevalencia Antimicrobianos |
topic |
Neisseria meningitidis Asymptomatic carriers Prevalence Hospital Antimicrobials PCR ctrA Portadores asintomáticos Prevalencia Antimicrobianos |
description |
Asymptomatic meningococcus carriers in hospitals is a risk factor for acquiring meningococcal disease. Meningococcal carrier (MC) frequency was investigated in oropharyngeal swab samples collected from 200 staff members at a teaching hospital from Brazil. MC prevalence was 9 % (95 % CI 5---13 %). Risk factors associated with MC were: mean age of 26.5 years, male gender, bar attendance frequency and number of persons/house. Of 18 isolated meningococcal strains, 14 were non-groupable (NG), 3 corrresponded to serogroup B and 1 to serogroup 29E. The frequency of serotypes and serosubtypes was heterogenous, with a slight predominance of serotypes 4 and 7 and serosubtypes P1.7 and P1.5. Most strains (n = 13) were susceptible to the antimicrobials tested. The ctrA gene (PCR) was identified in 9 (64.3 %) of the 14 NG strains, suggesting virulence in most of the NG isolated strains. Therefore, a constant surveillance of these asymptomatic carriers is required. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2017-01-15T19:28:51Z |
dc.date.available.fl_str_mv |
2017-01-15T19:28:51Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
GIOIA, Carolina Alicia Coch et al. Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil. Revista Argentina de Microbiologia, v. 47, n. 4, p. 322-327, 2015. Disponível em: < http://www.scielo.org.ar/pdf/ram/v47n4/v47n4a07.pdf>. Acesso em: 09 jan. 2017. |
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http://repositorio.furg.br/handle/1/7013 |
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1851-7617 |
dc.identifier.doi.pt_BR.fl_str_mv |
http://dx.doi.org/10.1016/j.ram.2015.08.004 |
identifier_str_mv |
GIOIA, Carolina Alicia Coch et al. Detection of Neisseria meningitidis in asymptomatic carriers in a university hospital from Brazil. Revista Argentina de Microbiologia, v. 47, n. 4, p. 322-327, 2015. Disponível em: < http://www.scielo.org.ar/pdf/ram/v47n4/v47n4a07.pdf>. Acesso em: 09 jan. 2017. 1851-7617 |
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http://repositorio.furg.br/handle/1/7013 http://dx.doi.org/10.1016/j.ram.2015.08.004 |
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