Fluoroquinolone resistance in mycobacterium tuberculosis and mutations in gyra and gyrb

Detalhes bibliográficos
Autor(a) principal: Groll, Andrea Von
Data de Publicação: 2009
Outros Autores: Martin, Anandi, Jureen, Pontus, Hoffner, Sven, Vandamme, Peter, Portaels, Françoise, Palomino, Juan Carlos, Silva, Pedro Eduardo Almeida da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FURG (RI FURG)
Texto Completo: http://repositorio.furg.br/handle/1/2593
Resumo: This study evaluated cross-resistance of Mycobacterium tuberculosis strains to ofloxacin, moxifloxacin, and gatifloxacin and investigated the presence of mutations in gyrA and gyrB. Fluoroquinolone susceptibilities were determined for 41 M. tuberculosis strains by the proportion method on 7H11, and MICs were determined by the resazurin microtiter assay. Forty strains shared the same resistance results for the three fluoroquinolones. However, one strain, with an Asn-533 3 Thr mutation in gyrB, was susceptible to ofloxacin but resistant to moxifloxacin and gatifloxacin.
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spelling Fluoroquinolone resistance in mycobacterium tuberculosis and mutations in gyra and gyrbThis study evaluated cross-resistance of Mycobacterium tuberculosis strains to ofloxacin, moxifloxacin, and gatifloxacin and investigated the presence of mutations in gyrA and gyrB. Fluoroquinolone susceptibilities were determined for 41 M. tuberculosis strains by the proportion method on 7H11, and MICs were determined by the resazurin microtiter assay. Forty strains shared the same resistance results for the three fluoroquinolones. However, one strain, with an Asn-533 3 Thr mutation in gyrB, was susceptible to ofloxacin but resistant to moxifloxacin and gatifloxacin.2012-09-26T23:32:37Z2012-09-26T23:32:37Z2009info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfGROLL, Andrea Von et al. Fluoroquinolone resistance in mycobacterium tuberculosis and mutations in gyra and gyrb. Antimicrobial Agents and Chemotherapy, v. 53, n. 10, p. 4498-4500, 2009. Disponível em: <http://aac.asm.org/content/53/10/4498.full.pdf+html>. Acesso em: 18 set. 2012.http://repositorio.furg.br/handle/1/259310.1128/AAC.00287-09engGroll, Andrea VonMartin, AnandiJureen, PontusHoffner, SvenVandamme, PeterPortaels, FrançoisePalomino, Juan CarlosSilva, Pedro Eduardo Almeida dainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURG2012-09-26T23:32:37Zoai:repositorio.furg.br:1/2593Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2012-09-26T23:32:37Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false
dc.title.none.fl_str_mv Fluoroquinolone resistance in mycobacterium tuberculosis and mutations in gyra and gyrb
title Fluoroquinolone resistance in mycobacterium tuberculosis and mutations in gyra and gyrb
spellingShingle Fluoroquinolone resistance in mycobacterium tuberculosis and mutations in gyra and gyrb
Groll, Andrea Von
title_short Fluoroquinolone resistance in mycobacterium tuberculosis and mutations in gyra and gyrb
title_full Fluoroquinolone resistance in mycobacterium tuberculosis and mutations in gyra and gyrb
title_fullStr Fluoroquinolone resistance in mycobacterium tuberculosis and mutations in gyra and gyrb
title_full_unstemmed Fluoroquinolone resistance in mycobacterium tuberculosis and mutations in gyra and gyrb
title_sort Fluoroquinolone resistance in mycobacterium tuberculosis and mutations in gyra and gyrb
author Groll, Andrea Von
author_facet Groll, Andrea Von
Martin, Anandi
Jureen, Pontus
Hoffner, Sven
Vandamme, Peter
Portaels, Françoise
Palomino, Juan Carlos
Silva, Pedro Eduardo Almeida da
author_role author
author2 Martin, Anandi
Jureen, Pontus
Hoffner, Sven
Vandamme, Peter
Portaels, Françoise
Palomino, Juan Carlos
Silva, Pedro Eduardo Almeida da
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Groll, Andrea Von
Martin, Anandi
Jureen, Pontus
Hoffner, Sven
Vandamme, Peter
Portaels, Françoise
Palomino, Juan Carlos
Silva, Pedro Eduardo Almeida da
description This study evaluated cross-resistance of Mycobacterium tuberculosis strains to ofloxacin, moxifloxacin, and gatifloxacin and investigated the presence of mutations in gyrA and gyrB. Fluoroquinolone susceptibilities were determined for 41 M. tuberculosis strains by the proportion method on 7H11, and MICs were determined by the resazurin microtiter assay. Forty strains shared the same resistance results for the three fluoroquinolones. However, one strain, with an Asn-533 3 Thr mutation in gyrB, was susceptible to ofloxacin but resistant to moxifloxacin and gatifloxacin.
publishDate 2009
dc.date.none.fl_str_mv 2009
2012-09-26T23:32:37Z
2012-09-26T23:32:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv GROLL, Andrea Von et al. Fluoroquinolone resistance in mycobacterium tuberculosis and mutations in gyra and gyrb. Antimicrobial Agents and Chemotherapy, v. 53, n. 10, p. 4498-4500, 2009. Disponível em: <http://aac.asm.org/content/53/10/4498.full.pdf+html>. Acesso em: 18 set. 2012.
http://repositorio.furg.br/handle/1/2593
10.1128/AAC.00287-09
identifier_str_mv GROLL, Andrea Von et al. Fluoroquinolone resistance in mycobacterium tuberculosis and mutations in gyra and gyrb. Antimicrobial Agents and Chemotherapy, v. 53, n. 10, p. 4498-4500, 2009. Disponível em: <http://aac.asm.org/content/53/10/4498.full.pdf+html>. Acesso em: 18 set. 2012.
10.1128/AAC.00287-09
url http://repositorio.furg.br/handle/1/2593
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da FURG (RI FURG)
instname:Universidade Federal do Rio Grande (FURG)
instacron:FURG
instname_str Universidade Federal do Rio Grande (FURG)
instacron_str FURG
institution FURG
reponame_str Repositório Institucional da FURG (RI FURG)
collection Repositório Institucional da FURG (RI FURG)
repository.name.fl_str_mv Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)
repository.mail.fl_str_mv
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