Atividade inibitória do óleo essencial de orégano em fungos de importância médica e veterinária

• Autor(a) principal: Cleff, Marlete Brum
• Data de Publicação: 2010
• Outros Autores: Meinerz, Ana Raquel Mano, Faria, Renata Osório de, Xavier, Melissa Orzechowski, Santin, Rosema, Nascente, Patrícia da Silva, Rodrigues, Maria Regina Alves, Meireles, Mario Carlos Araujo
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da FURG (RI FURG)
• Texto Completo: http://repositorio.furg.br/handle/1/2655; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000500040&lng=pt&nrm=iso&tlng=pt
• topic: Fungos; Óleo essencial; Orégano; Fungal; Essential oil; Origanum

The in vitro activity of Origanum vulgare essential oil against fungal isolates was evaluated. A total of 27 clinical isolates were used, including: C. albicans, S. schenckii, M. pachydermatis, Aspergillus flavus, and A. fumigatus. Microdilution in broth technique (NCCLS M27-A2 and M-38) was used and susceptibility was expressed as Minimum Inhibitory Concentration (MIC). Essential oil was obtained by hydrodistillation in Clevenger and analyzed by gas chromatography, showing the presence of 4-terpineol, alpha-terpineol, 4-terpinene, thymol and carvacrol, as the main compounds. Origanum oil MIC for C. albicans varied from 125 to 500μL/mL; for S. schenckii, from 250 to 500μL/mL; for M. pachydermatis, from 15 to 30μL/mL; and for Aspergillus, from 30 to 60L/mL. Isolates sensitivity showed to the origanum oil stimulates the accomplishment of new studies, including in vivo tests, contributing to the search of alternative treatments to mycosis.