On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FURG (RI FURG) |
| Texto Completo: | http://repositorio.furg.br/handle/1/7149 http://dx.doi.org/10.5935/0103-5053.20150067 |
Resumo: | Fifteen naphthoquinones, sixteen phenazines and fifteen aryl triazoles were synthesized and evaluated against Mycobacterium tuberculosis. Twenty five substances are reported here for the first time and, among all of the compounds evaluated, six presented MIC (minimal inhibitory concentration) values ≤ 6.25 μg mL-1. These substances are promising antimycobacterial prototypes. |
| id |
FURG_ab76616e1a4bd742608b0cec181ed234 |
|---|---|
| oai_identifier_str |
oai:repositorio.furg.br:1/7149 |
| network_acronym_str |
FURG |
| network_name_str |
Repositório Institucional da FURG (RI FURG) |
| repository_id_str |
|
| spelling |
On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosisLapacholPhenazinesMycobacterium tuberculosisAntitubercularTriazolesFifteen naphthoquinones, sixteen phenazines and fifteen aryl triazoles were synthesized and evaluated against Mycobacterium tuberculosis. Twenty five substances are reported here for the first time and, among all of the compounds evaluated, six presented MIC (minimal inhibitory concentration) values ≤ 6.25 μg mL-1. These substances are promising antimycobacterial prototypes.2017-04-27T22:06:09Z2017-04-27T22:06:09Z2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfJARDIM, Guilherme Augusto de Melo et al. On the search for potential antimycobacterial drugs: Synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis. Journal of the Brazilian Chemical Society, v. 26, n. 5, p. 1-15, 2015. Disponível em: < http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000501013&lng=en&nrm=iso&tlng=en#c01>. Acesso em: 08 abr. 2017.0103-5053http://repositorio.furg.br/handle/1/7149http://dx.doi.org/10.5935/0103-5053.20150067engJardim, Guilherme Augusto de MeloCruz, Eduardo Henrique Guimarães daValença, WagnerResende, Jarbas MagalhãesRodrigues, Bernardo LagesSoares, Daniela Fernandes RamosOliveira, RonaldoSilva, Pedro Eduardo Almeida daSilva Júnior, Eufrânio Nunes dainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURG2019-12-03T20:26:07Zoai:repositorio.furg.br:1/7149Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2019-12-03T20:26:07Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false |
| dc.title.none.fl_str_mv |
On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis |
| title |
On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis |
| spellingShingle |
On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis Jardim, Guilherme Augusto de Melo Lapachol Phenazines Mycobacterium tuberculosis Antitubercular Triazoles |
| title_short |
On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis |
| title_full |
On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis |
| title_fullStr |
On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis |
| title_full_unstemmed |
On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis |
| title_sort |
On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis |
| author |
Jardim, Guilherme Augusto de Melo |
| author_facet |
Jardim, Guilherme Augusto de Melo Cruz, Eduardo Henrique Guimarães da Valença, Wagner Resende, Jarbas Magalhães Rodrigues, Bernardo Lages Soares, Daniela Fernandes Ramos Oliveira, Ronaldo Silva, Pedro Eduardo Almeida da Silva Júnior, Eufrânio Nunes da |
| author_role |
author |
| author2 |
Cruz, Eduardo Henrique Guimarães da Valença, Wagner Resende, Jarbas Magalhães Rodrigues, Bernardo Lages Soares, Daniela Fernandes Ramos Oliveira, Ronaldo Silva, Pedro Eduardo Almeida da Silva Júnior, Eufrânio Nunes da |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Jardim, Guilherme Augusto de Melo Cruz, Eduardo Henrique Guimarães da Valença, Wagner Resende, Jarbas Magalhães Rodrigues, Bernardo Lages Soares, Daniela Fernandes Ramos Oliveira, Ronaldo Silva, Pedro Eduardo Almeida da Silva Júnior, Eufrânio Nunes da |
| dc.subject.por.fl_str_mv |
Lapachol Phenazines Mycobacterium tuberculosis Antitubercular Triazoles |
| topic |
Lapachol Phenazines Mycobacterium tuberculosis Antitubercular Triazoles |
| description |
Fifteen naphthoquinones, sixteen phenazines and fifteen aryl triazoles were synthesized and evaluated against Mycobacterium tuberculosis. Twenty five substances are reported here for the first time and, among all of the compounds evaluated, six presented MIC (minimal inhibitory concentration) values ≤ 6.25 μg mL-1. These substances are promising antimycobacterial prototypes. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015 2017-04-27T22:06:09Z 2017-04-27T22:06:09Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
JARDIM, Guilherme Augusto de Melo et al. On the search for potential antimycobacterial drugs: Synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis. Journal of the Brazilian Chemical Society, v. 26, n. 5, p. 1-15, 2015. Disponível em: < http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000501013&lng=en&nrm=iso&tlng=en#c01>. Acesso em: 08 abr. 2017. 0103-5053 http://repositorio.furg.br/handle/1/7149 http://dx.doi.org/10.5935/0103-5053.20150067 |
| identifier_str_mv |
JARDIM, Guilherme Augusto de Melo et al. On the search for potential antimycobacterial drugs: Synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against Mycobacterium tuberculosis. Journal of the Brazilian Chemical Society, v. 26, n. 5, p. 1-15, 2015. Disponível em: < http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000501013&lng=en&nrm=iso&tlng=en#c01>. Acesso em: 08 abr. 2017. 0103-5053 |
| url |
http://repositorio.furg.br/handle/1/7149 http://dx.doi.org/10.5935/0103-5053.20150067 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FURG (RI FURG) instname:Universidade Federal do Rio Grande (FURG) instacron:FURG |
| instname_str |
Universidade Federal do Rio Grande (FURG) |
| instacron_str |
FURG |
| institution |
FURG |
| reponame_str |
Repositório Institucional da FURG (RI FURG) |
| collection |
Repositório Institucional da FURG (RI FURG) |
| repository.name.fl_str_mv |
Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG) |
| repository.mail.fl_str_mv |
|
| _version_ |
1813187278877491200 |