On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against mycobacterium tuberculosis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
| Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000501013 |
Resumo: | Fifteen naphthoquinones, sixteen phenazines and fifteen aryl triazoles were synthesized and evaluated against Mycobacterium tuberculosis. Twenty five substances are reported here for the first time and, among all of the compounds evaluated, six presented MIC (minimal inhibitory concentration) values < 6.25 µg mL-1. These substances are promising antimycobacterial prototypes. |
| id |
SBQ-2_e033d94f47bf2727f732b80baafcaa72 |
|---|---|
| oai_identifier_str |
oai:scielo:S0103-50532015000501013 |
| network_acronym_str |
SBQ-2 |
| network_name_str |
Journal of the Brazilian Chemical Society (Online) |
| repository_id_str |
|
| spelling |
On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against mycobacterium tuberculosislapacholphenazinesMycobacterium tuberculosistriazolesFifteen naphthoquinones, sixteen phenazines and fifteen aryl triazoles were synthesized and evaluated against Mycobacterium tuberculosis. Twenty five substances are reported here for the first time and, among all of the compounds evaluated, six presented MIC (minimal inhibitory concentration) values < 6.25 µg mL-1. These substances are promising antimycobacterial prototypes.Sociedade Brasileira de Química2015-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000501013Journal of the Brazilian Chemical Society v.26 n.5 2015reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20150067info:eu-repo/semantics/openAccessJardim,Guilherme A. M.Cruz,Eduardo H. G.Valença,Wagner O.Resende,Jarbas M.Rodrigues,Bernardo L.Ramos,Daniela F.Oliveira,Ronaldo N.Silva,Pedro E. A.Silva Júnior,Eufrânio N. daeng2015-10-26T00:00:00Zoai:scielo:S0103-50532015000501013Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2015-10-26T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
| dc.title.none.fl_str_mv |
On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against mycobacterium tuberculosis |
| title |
On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against mycobacterium tuberculosis |
| spellingShingle |
On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against mycobacterium tuberculosis Jardim,Guilherme A. M. lapachol phenazines Mycobacterium tuberculosis triazoles |
| title_short |
On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against mycobacterium tuberculosis |
| title_full |
On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against mycobacterium tuberculosis |
| title_fullStr |
On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against mycobacterium tuberculosis |
| title_full_unstemmed |
On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against mycobacterium tuberculosis |
| title_sort |
On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against mycobacterium tuberculosis |
| author |
Jardim,Guilherme A. M. |
| author_facet |
Jardim,Guilherme A. M. Cruz,Eduardo H. G. Valença,Wagner O. Resende,Jarbas M. Rodrigues,Bernardo L. Ramos,Daniela F. Oliveira,Ronaldo N. Silva,Pedro E. A. Silva Júnior,Eufrânio N. da |
| author_role |
author |
| author2 |
Cruz,Eduardo H. G. Valença,Wagner O. Resende,Jarbas M. Rodrigues,Bernardo L. Ramos,Daniela F. Oliveira,Ronaldo N. Silva,Pedro E. A. Silva Júnior,Eufrânio N. da |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Jardim,Guilherme A. M. Cruz,Eduardo H. G. Valença,Wagner O. Resende,Jarbas M. Rodrigues,Bernardo L. Ramos,Daniela F. Oliveira,Ronaldo N. Silva,Pedro E. A. Silva Júnior,Eufrânio N. da |
| dc.subject.por.fl_str_mv |
lapachol phenazines Mycobacterium tuberculosis triazoles |
| topic |
lapachol phenazines Mycobacterium tuberculosis triazoles |
| description |
Fifteen naphthoquinones, sixteen phenazines and fifteen aryl triazoles were synthesized and evaluated against Mycobacterium tuberculosis. Twenty five substances are reported here for the first time and, among all of the compounds evaluated, six presented MIC (minimal inhibitory concentration) values < 6.25 µg mL-1. These substances are promising antimycobacterial prototypes. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015-05-01 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000501013 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000501013 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
10.5935/0103-5053.20150067 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
text/html |
| dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
| publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
| dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.26 n.5 2015 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
| instname_str |
Sociedade Brasileira de Química (SBQ) |
| instacron_str |
SBQ |
| institution |
SBQ |
| reponame_str |
Journal of the Brazilian Chemical Society (Online) |
| collection |
Journal of the Brazilian Chemical Society (Online) |
| repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
| repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
| _version_ |
1750318177088176128 |