Comparative cytotoxic and anti-tuberculosis activity of Aplysina caissara marine sponge crude extracts.
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FURG (RI FURG) |
Texto Completo: | http://repositorio.furg.br/handle/1/412 |
Resumo: | Three crude extracts of Aplysina caissara, a marine sponge endemic to Brazil, were tested against a hepatoma cell line and Mycobacterium tuberculosis. The results demonstrate that all extracts are toxic and capable of inhibiting cellular growth. Additionally, the extracts produced morphological aberrations and inhibited cell attachment to culture substrates. These effects were dose/time dependent. Our results also suggest that reactive oxygen species (ROS) production is not involved in the cytotoxic processes levied by the extracts employed in this study and that active metabolites are likely to be present in the polar fractions of the crude extracts. Finally, our results indicate that all three extracts exhibit a moderate anti-tuberculosis capacity, and that the removal of an extract's lipid fraction appears to diminish this activity. |
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Comparative cytotoxic and anti-tuberculosis activity of Aplysina caissara marine sponge crude extracts.Aplysina caissara marine spongeAnti-tuberculosis assayCytotoxic assayThree crude extracts of Aplysina caissara, a marine sponge endemic to Brazil, were tested against a hepatoma cell line and Mycobacterium tuberculosis. The results demonstrate that all extracts are toxic and capable of inhibiting cellular growth. Additionally, the extracts produced morphological aberrations and inhibited cell attachment to culture substrates. These effects were dose/time dependent. Our results also suggest that reactive oxygen species (ROS) production is not involved in the cytotoxic processes levied by the extracts employed in this study and that active metabolites are likely to be present in the polar fractions of the crude extracts. Finally, our results indicate that all three extracts exhibit a moderate anti-tuberculosis capacity, and that the removal of an extract's lipid fraction appears to diminish this activity.2011-03-22T00:43:20Z2011-03-22T00:43:20Z2008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAZEVEDO, Luciana Guterres de et al. Comparative cytotoxic and anti-tuberculosis activity of Aplysina caissara marine sponge crude extracts. Comparative Biochemistry and Physiology, Part C, v. 147, n. 1, p. 36–42, 2008. Disponível em: <http://www.icmbio.gov.br/brasil/SC/reserva-biologica-marinha-do-arvoredo/downloads/trabalhos-cientificos/Azevedo,%20G.%20L.%20et%20al.%202008.%20Comparative%20cytotoxic%20and%20anti-tuberculosis%20activity%20of%20Aplysina%20caissara%20marine%20sponge%20crude%20extracts.pdf> Acesso em: 21 mar. 2011.1095-6433http://repositorio.furg.br/handle/1/412engAzevedo, Luciana Gutterres deBaisch, Ana Luiza MuccilloFilgueira, Daza de Moraes Vaz BatistaBoyle, Robert TewSoares, Daniela Fernandes RamosSoares, Andréa DalbenLerner, Cléa BeatrizSilva, Pedro Eduardo Almeida daTrindade, Gilma Santosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURG2019-12-03T20:21:54Zoai:repositorio.furg.br:1/412Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2019-12-03T20:21:54Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false |
dc.title.none.fl_str_mv |
Comparative cytotoxic and anti-tuberculosis activity of Aplysina caissara marine sponge crude extracts. |
title |
Comparative cytotoxic and anti-tuberculosis activity of Aplysina caissara marine sponge crude extracts. |
spellingShingle |
Comparative cytotoxic and anti-tuberculosis activity of Aplysina caissara marine sponge crude extracts. Azevedo, Luciana Gutterres de Aplysina caissara marine sponge Anti-tuberculosis assay Cytotoxic assay |
title_short |
Comparative cytotoxic and anti-tuberculosis activity of Aplysina caissara marine sponge crude extracts. |
title_full |
Comparative cytotoxic and anti-tuberculosis activity of Aplysina caissara marine sponge crude extracts. |
title_fullStr |
Comparative cytotoxic and anti-tuberculosis activity of Aplysina caissara marine sponge crude extracts. |
title_full_unstemmed |
Comparative cytotoxic and anti-tuberculosis activity of Aplysina caissara marine sponge crude extracts. |
title_sort |
Comparative cytotoxic and anti-tuberculosis activity of Aplysina caissara marine sponge crude extracts. |
author |
Azevedo, Luciana Gutterres de |
author_facet |
Azevedo, Luciana Gutterres de Baisch, Ana Luiza Muccillo Filgueira, Daza de Moraes Vaz Batista Boyle, Robert Tew Soares, Daniela Fernandes Ramos Soares, Andréa Dalben Lerner, Cléa Beatriz Silva, Pedro Eduardo Almeida da Trindade, Gilma Santos |
author_role |
author |
author2 |
Baisch, Ana Luiza Muccillo Filgueira, Daza de Moraes Vaz Batista Boyle, Robert Tew Soares, Daniela Fernandes Ramos Soares, Andréa Dalben Lerner, Cléa Beatriz Silva, Pedro Eduardo Almeida da Trindade, Gilma Santos |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Azevedo, Luciana Gutterres de Baisch, Ana Luiza Muccillo Filgueira, Daza de Moraes Vaz Batista Boyle, Robert Tew Soares, Daniela Fernandes Ramos Soares, Andréa Dalben Lerner, Cléa Beatriz Silva, Pedro Eduardo Almeida da Trindade, Gilma Santos |
dc.subject.por.fl_str_mv |
Aplysina caissara marine sponge Anti-tuberculosis assay Cytotoxic assay |
topic |
Aplysina caissara marine sponge Anti-tuberculosis assay Cytotoxic assay |
description |
Three crude extracts of Aplysina caissara, a marine sponge endemic to Brazil, were tested against a hepatoma cell line and Mycobacterium tuberculosis. The results demonstrate that all extracts are toxic and capable of inhibiting cellular growth. Additionally, the extracts produced morphological aberrations and inhibited cell attachment to culture substrates. These effects were dose/time dependent. Our results also suggest that reactive oxygen species (ROS) production is not involved in the cytotoxic processes levied by the extracts employed in this study and that active metabolites are likely to be present in the polar fractions of the crude extracts. Finally, our results indicate that all three extracts exhibit a moderate anti-tuberculosis capacity, and that the removal of an extract's lipid fraction appears to diminish this activity. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008 2011-03-22T00:43:20Z 2011-03-22T00:43:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
AZEVEDO, Luciana Guterres de et al. Comparative cytotoxic and anti-tuberculosis activity of Aplysina caissara marine sponge crude extracts. Comparative Biochemistry and Physiology, Part C, v. 147, n. 1, p. 36–42, 2008. Disponível em: <http://www.icmbio.gov.br/brasil/SC/reserva-biologica-marinha-do-arvoredo/downloads/trabalhos-cientificos/Azevedo,%20G.%20L.%20et%20al.%202008.%20Comparative%20cytotoxic%20and%20anti-tuberculosis%20activity%20of%20Aplysina%20caissara%20marine%20sponge%20crude%20extracts.pdf> Acesso em: 21 mar. 2011. 1095-6433 http://repositorio.furg.br/handle/1/412 |
identifier_str_mv |
AZEVEDO, Luciana Guterres de et al. Comparative cytotoxic and anti-tuberculosis activity of Aplysina caissara marine sponge crude extracts. Comparative Biochemistry and Physiology, Part C, v. 147, n. 1, p. 36–42, 2008. Disponível em: <http://www.icmbio.gov.br/brasil/SC/reserva-biologica-marinha-do-arvoredo/downloads/trabalhos-cientificos/Azevedo,%20G.%20L.%20et%20al.%202008.%20Comparative%20cytotoxic%20and%20anti-tuberculosis%20activity%20of%20Aplysina%20caissara%20marine%20sponge%20crude%20extracts.pdf> Acesso em: 21 mar. 2011. 1095-6433 |
url |
http://repositorio.furg.br/handle/1/412 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FURG (RI FURG) instname:Universidade Federal do Rio Grande (FURG) instacron:FURG |
instname_str |
Universidade Federal do Rio Grande (FURG) |
instacron_str |
FURG |
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FURG |
reponame_str |
Repositório Institucional da FURG (RI FURG) |
collection |
Repositório Institucional da FURG (RI FURG) |
repository.name.fl_str_mv |
Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG) |
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