Metabólitos secundários das esponjas Aplysina fistularis e Dysidea sp. e atividade antituberculose da 11-cetofistularina-3
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/3766 |
Resumo: | p. 1853-1858. |
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Gandolfi, Renata C.Medina, Marina B.Berlinck, Roberto Gomes de SouzaLira, Simone Possedente deGaletti, Fabio Cícero de SáSilva, Célio L.Veloso, KatyuscyaFerreira, Antonio G.Hajdu, EduardoPeixinho, SolangeGandolfi, Renata C.Medina, Marina B.Berlinck, Roberto Gomes de SouzaLira, Simone Possedente deGaletti, Fabio Cícero de SáSilva, Célio L.Veloso, KatyuscyaFerreira, Antonio G.Hajdu, EduardoPeixinho, Solange2011-11-18T12:22:31Z2011-11-18T12:22:31Z20100100-4042http://www.repositorio.ufba.br/ri/handle/ri/3766v. 33, n. 9.p. 1853-1858.The present investigation reports the isolation of aeroplysinin-2, 2-(3,5-dibromo-4-methoxyphenyl)-N,N,N-trimethyletanamonium, 7,9-dibromo-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,6,8-trien-3-carboxylic acid and its methyl ester, 11-oxoaerothionin, aerothionin, 11-keto-12-hydroxyaerothionin, 11-ketofistularin-3 and fistularin-3 from Aplysina fistularis, as well as of furodysinin lactone and 9α,11α-epoxicholest-7-en-3β,5α,6α,10-tetrol-6-acetate from Dysidea sp. Although the extracts of both sponges displayed antituberculosis activity, only 11-ketofistularin-3 isolated from A. fistularis displayed antimycobacterial activity against Mycobacterium tuberculosis H34Rv, with MIC at 16 μg/mL and SI of 40, a result that reinforce that fistularin-3 derivatives are interesting leads for the development of antituberculosis drugs.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2011-11-18T12:22:31Z No. of bitstreams: 1 06.pdf: 1854741 bytes, checksum: a887ee97822cbc5314b54184045f8496 (MD5)Made available in DSpace on 2011-11-18T12:22:31Z (GMT). No. of bitstreams: 1 06.pdf: 1854741 bytes, checksum: a887ee97822cbc5314b54184045f8496 (MD5) Previous issue date: 2010São Paulomarine spongeAplysina fistularisDysidea spMetabólitos secundários das esponjas Aplysina fistularis e Dysidea sp. e atividade antituberculose da 11-cetofistularina-3Química Novainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleporreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINAL06.pdf06.pdfapplication/pdf1854741https://repositorio.ufba.br/bitstream/ri/3766/1/06.pdfa887ee97822cbc5314b54184045f8496MD51LICENSElicense.txtlicense.txttext/plain1906https://repositorio.ufba.br/bitstream/ri/3766/2/license.txt7150257806295d206c46fc38ff5165e4MD52TEXT06.pdf.txt06.pdf.txtExtracted texttext/plain37959https://repositorio.ufba.br/bitstream/ri/3766/3/06.pdf.txt6918dd80166dc0b7e8cc20467f5cc475MD53ri/37662022-07-05 14:03:18.303oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:18Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Metabólitos secundários das esponjas Aplysina fistularis e Dysidea sp. e atividade antituberculose da 11-cetofistularina-3 |
| dc.title.alternative.pt_BR.fl_str_mv |
Química Nova |
| title |
Metabólitos secundários das esponjas Aplysina fistularis e Dysidea sp. e atividade antituberculose da 11-cetofistularina-3 |
| spellingShingle |
Metabólitos secundários das esponjas Aplysina fistularis e Dysidea sp. e atividade antituberculose da 11-cetofistularina-3 Gandolfi, Renata C. marine sponge Aplysina fistularis Dysidea sp |
| title_short |
Metabólitos secundários das esponjas Aplysina fistularis e Dysidea sp. e atividade antituberculose da 11-cetofistularina-3 |
| title_full |
Metabólitos secundários das esponjas Aplysina fistularis e Dysidea sp. e atividade antituberculose da 11-cetofistularina-3 |
| title_fullStr |
Metabólitos secundários das esponjas Aplysina fistularis e Dysidea sp. e atividade antituberculose da 11-cetofistularina-3 |
| title_full_unstemmed |
Metabólitos secundários das esponjas Aplysina fistularis e Dysidea sp. e atividade antituberculose da 11-cetofistularina-3 |
| title_sort |
Metabólitos secundários das esponjas Aplysina fistularis e Dysidea sp. e atividade antituberculose da 11-cetofistularina-3 |
| author |
Gandolfi, Renata C. |
| author_facet |
Gandolfi, Renata C. Medina, Marina B. Berlinck, Roberto Gomes de Souza Lira, Simone Possedente de Galetti, Fabio Cícero de Sá Silva, Célio L. Veloso, Katyuscya Ferreira, Antonio G. Hajdu, Eduardo Peixinho, Solange |
| author_role |
author |
| author2 |
Medina, Marina B. Berlinck, Roberto Gomes de Souza Lira, Simone Possedente de Galetti, Fabio Cícero de Sá Silva, Célio L. Veloso, Katyuscya Ferreira, Antonio G. Hajdu, Eduardo Peixinho, Solange |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gandolfi, Renata C. Medina, Marina B. Berlinck, Roberto Gomes de Souza Lira, Simone Possedente de Galetti, Fabio Cícero de Sá Silva, Célio L. Veloso, Katyuscya Ferreira, Antonio G. Hajdu, Eduardo Peixinho, Solange Gandolfi, Renata C. Medina, Marina B. Berlinck, Roberto Gomes de Souza Lira, Simone Possedente de Galetti, Fabio Cícero de Sá Silva, Célio L. Veloso, Katyuscya Ferreira, Antonio G. Hajdu, Eduardo Peixinho, Solange |
| dc.subject.por.fl_str_mv |
marine sponge Aplysina fistularis Dysidea sp |
| topic |
marine sponge Aplysina fistularis Dysidea sp |
| description |
p. 1853-1858. |
| publishDate |
2010 |
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2010 |
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2011-11-18T12:22:31Z |
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2011-11-18T12:22:31Z |
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0100-4042 |
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v. 33, n. 9. |
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0100-4042 v. 33, n. 9. |
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http://www.repositorio.ufba.br/ri/handle/ri/3766 |
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