Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FURG (RI FURG) |
Texto Completo: | http://repositorio.furg.br/handle/1/7341 |
Resumo: | Purpose This study evaluates the advantage of the quercetin encapsulation in nanosized emulsion (QU-NE) administered orally in rats in order to demonstrate its anti-oedematous and antioxidant effects as well as its toxicity. Methods The nanocarriers were prepared using the hot solvent diffusion with the phase inversion temperature methods. The nanocarriers physicochemical properties were then investigated. The anti-edematous activity was tested using paw edema in rats. In addition, NF-kB expression in subcutaneous tissue of the paws was accessed by immunohistochemistry while the lipid peroxidation was analyzed in the liver by malondialdehyde reaction with thiobarbituric acid. Hematological, renal and hepatic toxicity as well as the genetic damage were also evaluated. Results The results demonstrated that QU-NE exhibited pronounced anti-oedematous property comparable to drug diclofenac. This effect was associated with NF-κB pathway inhibition. The lipid peroxidation was also only reduced in rats treated with QU-NE. Besides this, no genetic damage, hematological, renal or hepatic toxicities were observed after administration of QU-NE. Conclusions These results suggest that quercetin nanosized emulsion exhibits anti-oedematous and antioxidant properties and does not demonstrate toxic effects. This indicates that it has a potential application in the treatment of inflammatory diseases. |
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Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in RatsAnti-oedematous activityAntioxidantInflammationLipid nanocarriersQuercetinToxicityPurpose This study evaluates the advantage of the quercetin encapsulation in nanosized emulsion (QU-NE) administered orally in rats in order to demonstrate its anti-oedematous and antioxidant effects as well as its toxicity. Methods The nanocarriers were prepared using the hot solvent diffusion with the phase inversion temperature methods. The nanocarriers physicochemical properties were then investigated. The anti-edematous activity was tested using paw edema in rats. In addition, NF-kB expression in subcutaneous tissue of the paws was accessed by immunohistochemistry while the lipid peroxidation was analyzed in the liver by malondialdehyde reaction with thiobarbituric acid. Hematological, renal and hepatic toxicity as well as the genetic damage were also evaluated. Results The results demonstrated that QU-NE exhibited pronounced anti-oedematous property comparable to drug diclofenac. This effect was associated with NF-κB pathway inhibition. The lipid peroxidation was also only reduced in rats treated with QU-NE. Besides this, no genetic damage, hematological, renal or hepatic toxicities were observed after administration of QU-NE. Conclusions These results suggest that quercetin nanosized emulsion exhibits anti-oedematous and antioxidant properties and does not demonstrate toxic effects. This indicates that it has a potential application in the treatment of inflammatory diseases.2017-07-17T21:26:53Z2017-07-17T21:26:53Z2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfHÄDRICH, Gabriela et al. Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats. Pharmaceutical Research, v. 33, n. 4, p. 983-993, 2016. Disponível em:< https://www.researchgate.net/publication/287640894_Anti-inflammatory_Effect_and_Toxicology_Analysis_of_Oral_Delivery_Quercetin_Nanosized_Emulsion_in_Rats>. Acesso em: 31 mar. 2017.0724-8741http://repositorio.furg.br/handle/1/734110.1007/s11095-015-1844-6engHädrich, GabrielaVaz, Gustavo RichterMaidana, MichelleKratz, Jadel MüllerNeckel, Gecioni LochFavarin, Daniely CornélioRogerio, Alexandre de PaulaSilva Júnior, Flávio Manoel Rodrigues daBaisch, Ana Luiza MuccilloDora, Cristiana Limainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURG2023-11-14T12:43:58Zoai:repositorio.furg.br:1/7341Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2023-11-14T12:43:58Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false |
dc.title.none.fl_str_mv |
Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats |
title |
Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats |
spellingShingle |
Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats Hädrich, Gabriela Anti-oedematous activity Antioxidant Inflammation Lipid nanocarriers Quercetin Toxicity |
title_short |
Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats |
title_full |
Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats |
title_fullStr |
Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats |
title_full_unstemmed |
Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats |
title_sort |
Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats |
author |
Hädrich, Gabriela |
author_facet |
Hädrich, Gabriela Vaz, Gustavo Richter Maidana, Michelle Kratz, Jadel Müller Neckel, Gecioni Loch Favarin, Daniely Cornélio Rogerio, Alexandre de Paula Silva Júnior, Flávio Manoel Rodrigues da Baisch, Ana Luiza Muccillo Dora, Cristiana Lima |
author_role |
author |
author2 |
Vaz, Gustavo Richter Maidana, Michelle Kratz, Jadel Müller Neckel, Gecioni Loch Favarin, Daniely Cornélio Rogerio, Alexandre de Paula Silva Júnior, Flávio Manoel Rodrigues da Baisch, Ana Luiza Muccillo Dora, Cristiana Lima |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Hädrich, Gabriela Vaz, Gustavo Richter Maidana, Michelle Kratz, Jadel Müller Neckel, Gecioni Loch Favarin, Daniely Cornélio Rogerio, Alexandre de Paula Silva Júnior, Flávio Manoel Rodrigues da Baisch, Ana Luiza Muccillo Dora, Cristiana Lima |
dc.subject.por.fl_str_mv |
Anti-oedematous activity Antioxidant Inflammation Lipid nanocarriers Quercetin Toxicity |
topic |
Anti-oedematous activity Antioxidant Inflammation Lipid nanocarriers Quercetin Toxicity |
description |
Purpose This study evaluates the advantage of the quercetin encapsulation in nanosized emulsion (QU-NE) administered orally in rats in order to demonstrate its anti-oedematous and antioxidant effects as well as its toxicity. Methods The nanocarriers were prepared using the hot solvent diffusion with the phase inversion temperature methods. The nanocarriers physicochemical properties were then investigated. The anti-edematous activity was tested using paw edema in rats. In addition, NF-kB expression in subcutaneous tissue of the paws was accessed by immunohistochemistry while the lipid peroxidation was analyzed in the liver by malondialdehyde reaction with thiobarbituric acid. Hematological, renal and hepatic toxicity as well as the genetic damage were also evaluated. Results The results demonstrated that QU-NE exhibited pronounced anti-oedematous property comparable to drug diclofenac. This effect was associated with NF-κB pathway inhibition. The lipid peroxidation was also only reduced in rats treated with QU-NE. Besides this, no genetic damage, hematological, renal or hepatic toxicities were observed after administration of QU-NE. Conclusions These results suggest that quercetin nanosized emulsion exhibits anti-oedematous and antioxidant properties and does not demonstrate toxic effects. This indicates that it has a potential application in the treatment of inflammatory diseases. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2017-07-17T21:26:53Z 2017-07-17T21:26:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
HÄDRICH, Gabriela et al. Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats. Pharmaceutical Research, v. 33, n. 4, p. 983-993, 2016. Disponível em:< https://www.researchgate.net/publication/287640894_Anti-inflammatory_Effect_and_Toxicology_Analysis_of_Oral_Delivery_Quercetin_Nanosized_Emulsion_in_Rats>. Acesso em: 31 mar. 2017. 0724-8741 http://repositorio.furg.br/handle/1/7341 10.1007/s11095-015-1844-6 |
identifier_str_mv |
HÄDRICH, Gabriela et al. Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats. Pharmaceutical Research, v. 33, n. 4, p. 983-993, 2016. Disponível em:< https://www.researchgate.net/publication/287640894_Anti-inflammatory_Effect_and_Toxicology_Analysis_of_Oral_Delivery_Quercetin_Nanosized_Emulsion_in_Rats>. Acesso em: 31 mar. 2017. 0724-8741 10.1007/s11095-015-1844-6 |
url |
http://repositorio.furg.br/handle/1/7341 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FURG (RI FURG) instname:Universidade Federal do Rio Grande (FURG) instacron:FURG |
instname_str |
Universidade Federal do Rio Grande (FURG) |
instacron_str |
FURG |
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FURG |
reponame_str |
Repositório Institucional da FURG (RI FURG) |
collection |
Repositório Institucional da FURG (RI FURG) |
repository.name.fl_str_mv |
Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG) |
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