Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats

Detalhes bibliográficos
Autor(a) principal: Hädrich, Gabriela
Data de Publicação: 2015
Outros Autores: Vaz, Gustavo Richter, Maidana, Michelle, Kratz, Jadel Müller, Neckel, Gecioni Loch, Favarin, Daniely Cornélio, Rogerio, Alexandre de Paula, Silva Júnior, Flávio Manoel Rodrigues da, Baisch, Ana Luiza Muccillo, Dora, Cristiana Lima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FURG (RI FURG)
Texto Completo: http://repositorio.furg.br/handle/1/7341
Resumo: Purpose This study evaluates the advantage of the quercetin encapsulation in nanosized emulsion (QU-NE) administered orally in rats in order to demonstrate its anti-oedematous and antioxidant effects as well as its toxicity. Methods The nanocarriers were prepared using the hot solvent diffusion with the phase inversion temperature methods. The nanocarriers physicochemical properties were then investigated. The anti-edematous activity was tested using paw edema in rats. In addition, NF-kB expression in subcutaneous tissue of the paws was accessed by immunohistochemistry while the lipid peroxidation was analyzed in the liver by malondialdehyde reaction with thiobarbituric acid. Hematological, renal and hepatic toxicity as well as the genetic damage were also evaluated. Results The results demonstrated that QU-NE exhibited pronounced anti-oedematous property comparable to drug diclofenac. This effect was associated with NF-κB pathway inhibition. The lipid peroxidation was also only reduced in rats treated with QU-NE. Besides this, no genetic damage, hematological, renal or hepatic toxicities were observed after administration of QU-NE. Conclusions These results suggest that quercetin nanosized emulsion exhibits anti-oedematous and antioxidant properties and does not demonstrate toxic effects. This indicates that it has a potential application in the treatment of inflammatory diseases.
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spelling Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in RatsAnti-oedematous activityAntioxidantInflammationLipid nanocarriersQuercetinToxicityPurpose This study evaluates the advantage of the quercetin encapsulation in nanosized emulsion (QU-NE) administered orally in rats in order to demonstrate its anti-oedematous and antioxidant effects as well as its toxicity. Methods The nanocarriers were prepared using the hot solvent diffusion with the phase inversion temperature methods. The nanocarriers physicochemical properties were then investigated. The anti-edematous activity was tested using paw edema in rats. In addition, NF-kB expression in subcutaneous tissue of the paws was accessed by immunohistochemistry while the lipid peroxidation was analyzed in the liver by malondialdehyde reaction with thiobarbituric acid. Hematological, renal and hepatic toxicity as well as the genetic damage were also evaluated. Results The results demonstrated that QU-NE exhibited pronounced anti-oedematous property comparable to drug diclofenac. This effect was associated with NF-κB pathway inhibition. The lipid peroxidation was also only reduced in rats treated with QU-NE. Besides this, no genetic damage, hematological, renal or hepatic toxicities were observed after administration of QU-NE. Conclusions These results suggest that quercetin nanosized emulsion exhibits anti-oedematous and antioxidant properties and does not demonstrate toxic effects. This indicates that it has a potential application in the treatment of inflammatory diseases.2017-07-17T21:26:53Z2017-07-17T21:26:53Z2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfHÄDRICH, Gabriela et al. Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats. Pharmaceutical Research, v. 33, n. 4, p. 983-993, 2016. Disponível em:< https://www.researchgate.net/publication/287640894_Anti-inflammatory_Effect_and_Toxicology_Analysis_of_Oral_Delivery_Quercetin_Nanosized_Emulsion_in_Rats>. Acesso em: 31 mar. 2017.0724-8741http://repositorio.furg.br/handle/1/734110.1007/s11095-015-1844-6engHädrich, GabrielaVaz, Gustavo RichterMaidana, MichelleKratz, Jadel MüllerNeckel, Gecioni LochFavarin, Daniely CornélioRogerio, Alexandre de PaulaSilva Júnior, Flávio Manoel Rodrigues daBaisch, Ana Luiza MuccilloDora, Cristiana Limainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURG2023-11-14T12:43:58Zoai:repositorio.furg.br:1/7341Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2023-11-14T12:43:58Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false
dc.title.none.fl_str_mv Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats
title Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats
spellingShingle Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats
Hädrich, Gabriela
Anti-oedematous activity
Antioxidant
Inflammation
Lipid nanocarriers
Quercetin
Toxicity
title_short Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats
title_full Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats
title_fullStr Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats
title_full_unstemmed Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats
title_sort Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats
author Hädrich, Gabriela
author_facet Hädrich, Gabriela
Vaz, Gustavo Richter
Maidana, Michelle
Kratz, Jadel Müller
Neckel, Gecioni Loch
Favarin, Daniely Cornélio
Rogerio, Alexandre de Paula
Silva Júnior, Flávio Manoel Rodrigues da
Baisch, Ana Luiza Muccillo
Dora, Cristiana Lima
author_role author
author2 Vaz, Gustavo Richter
Maidana, Michelle
Kratz, Jadel Müller
Neckel, Gecioni Loch
Favarin, Daniely Cornélio
Rogerio, Alexandre de Paula
Silva Júnior, Flávio Manoel Rodrigues da
Baisch, Ana Luiza Muccillo
Dora, Cristiana Lima
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Hädrich, Gabriela
Vaz, Gustavo Richter
Maidana, Michelle
Kratz, Jadel Müller
Neckel, Gecioni Loch
Favarin, Daniely Cornélio
Rogerio, Alexandre de Paula
Silva Júnior, Flávio Manoel Rodrigues da
Baisch, Ana Luiza Muccillo
Dora, Cristiana Lima
dc.subject.por.fl_str_mv Anti-oedematous activity
Antioxidant
Inflammation
Lipid nanocarriers
Quercetin
Toxicity
topic Anti-oedematous activity
Antioxidant
Inflammation
Lipid nanocarriers
Quercetin
Toxicity
description Purpose This study evaluates the advantage of the quercetin encapsulation in nanosized emulsion (QU-NE) administered orally in rats in order to demonstrate its anti-oedematous and antioxidant effects as well as its toxicity. Methods The nanocarriers were prepared using the hot solvent diffusion with the phase inversion temperature methods. The nanocarriers physicochemical properties were then investigated. The anti-edematous activity was tested using paw edema in rats. In addition, NF-kB expression in subcutaneous tissue of the paws was accessed by immunohistochemistry while the lipid peroxidation was analyzed in the liver by malondialdehyde reaction with thiobarbituric acid. Hematological, renal and hepatic toxicity as well as the genetic damage were also evaluated. Results The results demonstrated that QU-NE exhibited pronounced anti-oedematous property comparable to drug diclofenac. This effect was associated with NF-κB pathway inhibition. The lipid peroxidation was also only reduced in rats treated with QU-NE. Besides this, no genetic damage, hematological, renal or hepatic toxicities were observed after administration of QU-NE. Conclusions These results suggest that quercetin nanosized emulsion exhibits anti-oedematous and antioxidant properties and does not demonstrate toxic effects. This indicates that it has a potential application in the treatment of inflammatory diseases.
publishDate 2015
dc.date.none.fl_str_mv 2015
2017-07-17T21:26:53Z
2017-07-17T21:26:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv HÄDRICH, Gabriela et al. Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats. Pharmaceutical Research, v. 33, n. 4, p. 983-993, 2016. Disponível em:< https://www.researchgate.net/publication/287640894_Anti-inflammatory_Effect_and_Toxicology_Analysis_of_Oral_Delivery_Quercetin_Nanosized_Emulsion_in_Rats>. Acesso em: 31 mar. 2017.
0724-8741
http://repositorio.furg.br/handle/1/7341
10.1007/s11095-015-1844-6
identifier_str_mv HÄDRICH, Gabriela et al. Anti-inflammatory Effect and Toxicology Analysis of Oral Delivery Quercetin Nanosized Emulsion in Rats. Pharmaceutical Research, v. 33, n. 4, p. 983-993, 2016. Disponível em:< https://www.researchgate.net/publication/287640894_Anti-inflammatory_Effect_and_Toxicology_Analysis_of_Oral_Delivery_Quercetin_Nanosized_Emulsion_in_Rats>. Acesso em: 31 mar. 2017.
0724-8741
10.1007/s11095-015-1844-6
url http://repositorio.furg.br/handle/1/7341
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da FURG (RI FURG)
instname:Universidade Federal do Rio Grande (FURG)
instacron:FURG
instname_str Universidade Federal do Rio Grande (FURG)
instacron_str FURG
institution FURG
reponame_str Repositório Institucional da FURG (RI FURG)
collection Repositório Institucional da FURG (RI FURG)
repository.name.fl_str_mv Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)
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