Effect of therapeutic ultrasound in pulse mode on the release, retention and permeation of ascorbic acid in a vertical diffusion system
Autor(a) principal: | |
---|---|
Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Implantology and Health Sciences |
Texto Completo: | https://bjihs.emnuvens.com.br/bjihs/article/view/571 |
Resumo: | Transdermal drug delivery offers many advantages over other routes of administration, such as potential for superior efficacy and minimal side effects. However, ways are sought new to increase the permeation of these active ingredients in the skin. A commonly used resource for this purpose is the phonophoresis; however, the real effectiveness of phonophoresis in numerous topical substances, such as ascorbic acid, is still unknown. In this sense, this study compares the effect of 5% ascorbic acid release, retention and permeation associated with ultrasound from studies in vitro. The release analysis was performed at 5, 10, 15 and 20 minutes, and the retention and permeation analysis was used in pig skin at 20 minutes, 1 and 2 hours. It was observed that in the release assays the ultrasound had the ability to increase the release of the active in the times of 5 and 10 minutes. In relation to the retention tests, the ultrasound was effective when compared to the control group in a time of 1 hour for stratum corneum and epidermis, given the remainder of the analyzed times it was not possible to analyze the difference among the analyzed groups. |
id |
GOE-1_28212caceee297159fb5d0fd3db02bd5 |
---|---|
oai_identifier_str |
oai:ojs.bjihs.emnuvens.com.br:article/571 |
network_acronym_str |
GOE-1 |
network_name_str |
Brazilian Journal of Implantology and Health Sciences |
repository_id_str |
|
spelling |
Effect of therapeutic ultrasound in pulse mode on the release, retention and permeation of ascorbic acid in a vertical diffusion systemEFEITO DO ULTRASSOM TERAPÊUTICO NO MODO PULSADO NA LIBERAÇÃO, RETENÇÃO E PERMEAÇÃO DO ÁCIDO ASCÓRBICO EM SISTEMA DE DIFUSÃO VERTICALFisioterapia, Ultrassom, Fonoforese.Physiotherapy, Ultrasound, Phonophoresis.Transdermal drug delivery offers many advantages over other routes of administration, such as potential for superior efficacy and minimal side effects. However, ways are sought new to increase the permeation of these active ingredients in the skin. A commonly used resource for this purpose is the phonophoresis; however, the real effectiveness of phonophoresis in numerous topical substances, such as ascorbic acid, is still unknown. In this sense, this study compares the effect of 5% ascorbic acid release, retention and permeation associated with ultrasound from studies in vitro. The release analysis was performed at 5, 10, 15 and 20 minutes, and the retention and permeation analysis was used in pig skin at 20 minutes, 1 and 2 hours. It was observed that in the release assays the ultrasound had the ability to increase the release of the active in the times of 5 and 10 minutes. In relation to the retention tests, the ultrasound was effective when compared to the control group in a time of 1 hour for stratum corneum and epidermis, given the remainder of the analyzed times it was not possible to analyze the difference among the analyzed groups.Administração transdérmica de fármacos oferece muitas vantagens sobre as outras vias de administração como potencial de eficácia superior e efeitos colaterais mínimos. Entretanto, buscam-se novas formas de ampliar a permeação desses fármacos na pele. Um recurso utilizado para essa finalidade é a fonoforese, que através do Ultrassom (US), gera uma onda acústica, também chamada de cavitação, sendo capaz de aumentar a permeação de princípios ativos sobre a pele. O estudo compara o efeito da liberação, retenção e permeação do ácido ascórbico (AA) 5% associada ao US. Em análise de liberação utilizou-se ácido ascórbico com US nos tempos de 5, 10, 15 e 20 minutos. Em análise da retenção e permeação utilizou-se pele de suíno nos tempos de 20 minutos, 1 e 2 horas. Observou-se diferença na liberação da substância, porém, quando comparado com os tempos utilizando o US houve diferença nos tempos de 5 e 10 min. Os resultados apontam que existe diferença em termos de retenção do ativo no estrato córneo e na epiderme quando aplicada a técnica de fonoforese no tempo de 1 hora; na derme e na permeação não existe diferença ao ser associada a fonoforese, quando comparado com o grupo controle em todos os tempos analisados.Specialized Dentistry Group2023-09-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://bjihs.emnuvens.com.br/bjihs/article/view/57110.36557/2674-8169.2023v5n4p2542-2555Brazilian Journal of Implantology and Health Sciences ; Vol. 5 No. 4 (2023): BJIHS QUALIS B3; 2542-2555Brazilian Journal of Implantology and Health Sciences ; Vol. 5 Núm. 4 (2023): BJIHS QUALIS B3; 2542-2555Brazilian Journal of Implantology and Health Sciences ; v. 5 n. 4 (2023): BJIHS QUALIS B3; 2542-25552674-8169reponame:Brazilian Journal of Implantology and Health Sciencesinstname:Grupo de Odontologia Especializada (GOE)instacron:GOEporhttps://bjihs.emnuvens.com.br/bjihs/article/view/571/690Copyright (c) 2023 Aline Martinazzi , João Alberto Fioravante Tassinary , Giovana Sinigaglia , Magali Quevedo Grave , Lydia Koetz Jaeger https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMartinazzi , AlineTassinary , João Alberto FioravanteSinigaglia , GiovanaGrave , Magali QuevedoJaeger , Lydia Koetz2023-09-26T08:28:30Zoai:ojs.bjihs.emnuvens.com.br:article/571Revistahttps://bjihs.emnuvens.com.br/bjihsONGhttps://bjihs.emnuvens.com.br/bjihs/oaijournal.bjihs@periodicosbrasil.com.br2674-81692674-8169opendoar:2023-09-26T08:28:30Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE)false |
dc.title.none.fl_str_mv |
Effect of therapeutic ultrasound in pulse mode on the release, retention and permeation of ascorbic acid in a vertical diffusion system EFEITO DO ULTRASSOM TERAPÊUTICO NO MODO PULSADO NA LIBERAÇÃO, RETENÇÃO E PERMEAÇÃO DO ÁCIDO ASCÓRBICO EM SISTEMA DE DIFUSÃO VERTICAL |
title |
Effect of therapeutic ultrasound in pulse mode on the release, retention and permeation of ascorbic acid in a vertical diffusion system |
spellingShingle |
Effect of therapeutic ultrasound in pulse mode on the release, retention and permeation of ascorbic acid in a vertical diffusion system Martinazzi , Aline Fisioterapia, Ultrassom, Fonoforese. Physiotherapy, Ultrasound, Phonophoresis. |
title_short |
Effect of therapeutic ultrasound in pulse mode on the release, retention and permeation of ascorbic acid in a vertical diffusion system |
title_full |
Effect of therapeutic ultrasound in pulse mode on the release, retention and permeation of ascorbic acid in a vertical diffusion system |
title_fullStr |
Effect of therapeutic ultrasound in pulse mode on the release, retention and permeation of ascorbic acid in a vertical diffusion system |
title_full_unstemmed |
Effect of therapeutic ultrasound in pulse mode on the release, retention and permeation of ascorbic acid in a vertical diffusion system |
title_sort |
Effect of therapeutic ultrasound in pulse mode on the release, retention and permeation of ascorbic acid in a vertical diffusion system |
author |
Martinazzi , Aline |
author_facet |
Martinazzi , Aline Tassinary , João Alberto Fioravante Sinigaglia , Giovana Grave , Magali Quevedo Jaeger , Lydia Koetz |
author_role |
author |
author2 |
Tassinary , João Alberto Fioravante Sinigaglia , Giovana Grave , Magali Quevedo Jaeger , Lydia Koetz |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Martinazzi , Aline Tassinary , João Alberto Fioravante Sinigaglia , Giovana Grave , Magali Quevedo Jaeger , Lydia Koetz |
dc.subject.por.fl_str_mv |
Fisioterapia, Ultrassom, Fonoforese. Physiotherapy, Ultrasound, Phonophoresis. |
topic |
Fisioterapia, Ultrassom, Fonoforese. Physiotherapy, Ultrasound, Phonophoresis. |
description |
Transdermal drug delivery offers many advantages over other routes of administration, such as potential for superior efficacy and minimal side effects. However, ways are sought new to increase the permeation of these active ingredients in the skin. A commonly used resource for this purpose is the phonophoresis; however, the real effectiveness of phonophoresis in numerous topical substances, such as ascorbic acid, is still unknown. In this sense, this study compares the effect of 5% ascorbic acid release, retention and permeation associated with ultrasound from studies in vitro. The release analysis was performed at 5, 10, 15 and 20 minutes, and the retention and permeation analysis was used in pig skin at 20 minutes, 1 and 2 hours. It was observed that in the release assays the ultrasound had the ability to increase the release of the active in the times of 5 and 10 minutes. In relation to the retention tests, the ultrasound was effective when compared to the control group in a time of 1 hour for stratum corneum and epidermis, given the remainder of the analyzed times it was not possible to analyze the difference among the analyzed groups. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-09-25 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/571 10.36557/2674-8169.2023v5n4p2542-2555 |
url |
https://bjihs.emnuvens.com.br/bjihs/article/view/571 |
identifier_str_mv |
10.36557/2674-8169.2023v5n4p2542-2555 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/571/690 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Specialized Dentistry Group |
publisher.none.fl_str_mv |
Specialized Dentistry Group |
dc.source.none.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences ; Vol. 5 No. 4 (2023): BJIHS QUALIS B3; 2542-2555 Brazilian Journal of Implantology and Health Sciences ; Vol. 5 Núm. 4 (2023): BJIHS QUALIS B3; 2542-2555 Brazilian Journal of Implantology and Health Sciences ; v. 5 n. 4 (2023): BJIHS QUALIS B3; 2542-2555 2674-8169 reponame:Brazilian Journal of Implantology and Health Sciences instname:Grupo de Odontologia Especializada (GOE) instacron:GOE |
instname_str |
Grupo de Odontologia Especializada (GOE) |
instacron_str |
GOE |
institution |
GOE |
reponame_str |
Brazilian Journal of Implantology and Health Sciences |
collection |
Brazilian Journal of Implantology and Health Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE) |
repository.mail.fl_str_mv |
journal.bjihs@periodicosbrasil.com.br |
_version_ |
1796798439507361792 |