A influência do HPV como fator de risco para o carcinoma epidermoide bucal
Autor(a) principal: | |
---|---|
Data de Publicação: | 2024 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Implantology and Health Sciences |
Texto Completo: | https://bjihs.emnuvens.com.br/bjihs/article/view/1528 |
Resumo: | Introduction: Oral squamous cell carcinoma (SCB) is a type of malignant neoplasm, considered one of the tumors with the highest incidence rate in the Brazilian population, corresponding to 90% to 95% of cancer cases affecting the oral cavity and oropharynx. The Human Papillomavirus (HPV) is a virus that has an affinity for epithelial tissue, comprises several subtypes and is often associated with the formation of benign and malignant neoplasms. Objective: Therefore, the present research aims to address the correlation between CEB and HPV. Methodology: The study consists of a literature review, based on scientific articles searched in the Scielo, PubMed/Medline and LILACS databases, using the descriptors: "Human Papillomavirus"; "Oral Neoplasms" and "Dentistry". Original articles, literature reviews, and case reports in Portuguese, English, and Spanish were included, without taking into account the periods of publication. Results: HPV has some virus subtypes that are related to benign lesions and others with carcinogenic potential. The latter is directly linked to the protein encoded by the E2 gene, which inhibits the expression of the E6 and E7 genes, which are active in cell immortalization. The absence of these genes results in excessive and unregulated cellular degradation, which favors the accumulation of mutations and the occurrence of chromosomal aberrations. Conclusion: There is a need for more specific studies to understand the role of HPV as a carcinogen. Despite the diversity of factors seen in the literature, there are still no conclusive studies relating HPV as a risk factor for oral carcinoma. Keywords: Human Papillomavirus; Oral Neoplasms; Dentistry. |
id |
GOE-1_43625b7c711e37e121598b9355b5c60a |
---|---|
oai_identifier_str |
oai:ojs.bjihs.emnuvens.com.br:article/1528 |
network_acronym_str |
GOE-1 |
network_name_str |
Brazilian Journal of Implantology and Health Sciences |
repository_id_str |
|
spelling |
A influência do HPV como fator de risco para o carcinoma epidermoide bucal Papilomavírus HumanoNeoplasias BucaisOdontologiaHuman PapillomavirusOral NeoplasmsDentistryIntroduction: Oral squamous cell carcinoma (SCB) is a type of malignant neoplasm, considered one of the tumors with the highest incidence rate in the Brazilian population, corresponding to 90% to 95% of cancer cases affecting the oral cavity and oropharynx. The Human Papillomavirus (HPV) is a virus that has an affinity for epithelial tissue, comprises several subtypes and is often associated with the formation of benign and malignant neoplasms. Objective: Therefore, the present research aims to address the correlation between CEB and HPV. Methodology: The study consists of a literature review, based on scientific articles searched in the Scielo, PubMed/Medline and LILACS databases, using the descriptors: "Human Papillomavirus"; "Oral Neoplasms" and "Dentistry". Original articles, literature reviews, and case reports in Portuguese, English, and Spanish were included, without taking into account the periods of publication. Results: HPV has some virus subtypes that are related to benign lesions and others with carcinogenic potential. The latter is directly linked to the protein encoded by the E2 gene, which inhibits the expression of the E6 and E7 genes, which are active in cell immortalization. The absence of these genes results in excessive and unregulated cellular degradation, which favors the accumulation of mutations and the occurrence of chromosomal aberrations. Conclusion: There is a need for more specific studies to understand the role of HPV as a carcinogen. Despite the diversity of factors seen in the literature, there are still no conclusive studies relating HPV as a risk factor for oral carcinoma. Keywords: Human Papillomavirus; Oral Neoplasms; Dentistry.Introdução: O carcinoma epidermoide bucal (CEB) é um tipo de neoplasia maligna, considerada um dos tumores com maior taxa de incidência na população brasileira, correspondendo de 90% a 95% dos casos de câncer que acometem a cavidade oral e orofaringe. O Papilomavírus Humano (HPV) é um vírus que possui afinidade pelo tecido epitelial, compreende diversos subtipos e frequentemente é associado à formação de neoplasias benignas e malignas. Objetivo: Diante disso, a presente pesquisa tem como objetivo abordar a correlação entre o CEB e o HPV. Metodologia: O estudo constitui-se de uma revisão de literatura, baseada em artigos científicos pesquisados nos bancos de dados Scielo, PubMed/Medline e LILACS, através dos descritores: “Papilomavírus Humano”; “Neoplasias Bucais” e “Odontologia”. Foram incluídos artigos originais, revisões de literatura e relatos de caso em português, inglês e espanhol, sem levar em consideração os períodos de publicação. Resultado: O HPV possui alguns subtipos de vírus que se relacionam com lesões benignas e outros com potencial carcinogênico. Esse último está diretamente ligado à proteína codificada pelo gene E2 que inibe a expressão dos genes E6 e E7, atuantes na imortalização celular. A inexistência desses genes resulta em uma uma degradação celular excessiva e desregulada, que favorece o acúmulo de mutações e a ocorrência de aberrações cromossômicas. Conclusão: É preciso que haja mais estudos específicos que permitam a compreensão da atuação do HPV como agente carcinogênico. Apesar da diversidade de fatores vistos na literatura, ainda não há estudos conclusivos relacionando o HPV como fator de risco para o carcinoma oral.Specialized Dentistry Group2024-02-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://bjihs.emnuvens.com.br/bjihs/article/view/152810.36557/2674-8169.2024v6n2p453-470Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 2 (2024): BJIHS QUALIS B3; 453-470Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 2 (2024): BJIHS QUALIS B3; 453-470Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 2 (2024): BJIHS QUALIS B3; 453-4702674-8169reponame:Brazilian Journal of Implantology and Health Sciencesinstname:Grupo de Odontologia Especializada (GOE)instacron:GOEporhttps://bjihs.emnuvens.com.br/bjihs/article/view/1528/1721Copyright (c) 2024 Maria Gabriela de Souza Andrade Brandão, Louise Bárbara Azevedo da Silva, Joab Gabriel do Nascimento Santos, Brenda Camila Santos da Silva, Ana Luísa Gomes Lourenço, Jemima Hanã de Oliveira Batista dos Santos, Anna Beatriz Arruda Barroso de Moraes, Maurício Alves Martins, Glauciele Souza de Santana, Ilídia Carol dos Santos Pereira, Edith Maria Feitosa El-Deir, Anna Luiza Brilhante Ribeiro Silveira, Bárbara Guedes Alcoforado, Ítalo Alencar Barros Araújohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessde Souza Andrade Brandão, Maria GabrielaAzevedo da Silva, Louise Bárbarado Nascimento Santos, Joab GabrielSantos da Silva, Brenda CamilaGomes Lourenço, Ana Luísade Oliveira Batista dos Santos, Jemima HanãArruda Barroso de Moraes, Anna Beatriz Alves Martins, MaurícioSouza de Santana, Glaucieledos Santos Pereira, Ilídia CarolFeitosa El-Deir, Edith MariaBrilhante Ribeiro Silveira, Anna LuizaGuedes Alcoforado, BárbaraAlencar Barros Araújo, Ítalo2024-02-23T19:46:44Zoai:ojs.bjihs.emnuvens.com.br:article/1528Revistahttps://bjihs.emnuvens.com.br/bjihsONGhttps://bjihs.emnuvens.com.br/bjihs/oaijournal.bjihs@periodicosbrasil.com.br2674-81692674-8169opendoar:2024-02-23T19:46:44Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE)false |
dc.title.none.fl_str_mv |
A influência do HPV como fator de risco para o carcinoma epidermoide bucal |
title |
A influência do HPV como fator de risco para o carcinoma epidermoide bucal |
spellingShingle |
A influência do HPV como fator de risco para o carcinoma epidermoide bucal de Souza Andrade Brandão, Maria Gabriela Papilomavírus Humano Neoplasias Bucais Odontologia Human Papillomavirus Oral Neoplasms Dentistry |
title_short |
A influência do HPV como fator de risco para o carcinoma epidermoide bucal |
title_full |
A influência do HPV como fator de risco para o carcinoma epidermoide bucal |
title_fullStr |
A influência do HPV como fator de risco para o carcinoma epidermoide bucal |
title_full_unstemmed |
A influência do HPV como fator de risco para o carcinoma epidermoide bucal |
title_sort |
A influência do HPV como fator de risco para o carcinoma epidermoide bucal |
author |
de Souza Andrade Brandão, Maria Gabriela |
author_facet |
de Souza Andrade Brandão, Maria Gabriela Azevedo da Silva, Louise Bárbara do Nascimento Santos, Joab Gabriel Santos da Silva, Brenda Camila Gomes Lourenço, Ana Luísa de Oliveira Batista dos Santos, Jemima Hanã Arruda Barroso de Moraes, Anna Beatriz Alves Martins, Maurício Souza de Santana, Glauciele dos Santos Pereira, Ilídia Carol Feitosa El-Deir, Edith Maria Brilhante Ribeiro Silveira, Anna Luiza Guedes Alcoforado, Bárbara Alencar Barros Araújo, Ítalo |
author_role |
author |
author2 |
Azevedo da Silva, Louise Bárbara do Nascimento Santos, Joab Gabriel Santos da Silva, Brenda Camila Gomes Lourenço, Ana Luísa de Oliveira Batista dos Santos, Jemima Hanã Arruda Barroso de Moraes, Anna Beatriz Alves Martins, Maurício Souza de Santana, Glauciele dos Santos Pereira, Ilídia Carol Feitosa El-Deir, Edith Maria Brilhante Ribeiro Silveira, Anna Luiza Guedes Alcoforado, Bárbara Alencar Barros Araújo, Ítalo |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
de Souza Andrade Brandão, Maria Gabriela Azevedo da Silva, Louise Bárbara do Nascimento Santos, Joab Gabriel Santos da Silva, Brenda Camila Gomes Lourenço, Ana Luísa de Oliveira Batista dos Santos, Jemima Hanã Arruda Barroso de Moraes, Anna Beatriz Alves Martins, Maurício Souza de Santana, Glauciele dos Santos Pereira, Ilídia Carol Feitosa El-Deir, Edith Maria Brilhante Ribeiro Silveira, Anna Luiza Guedes Alcoforado, Bárbara Alencar Barros Araújo, Ítalo |
dc.subject.por.fl_str_mv |
Papilomavírus Humano Neoplasias Bucais Odontologia Human Papillomavirus Oral Neoplasms Dentistry |
topic |
Papilomavírus Humano Neoplasias Bucais Odontologia Human Papillomavirus Oral Neoplasms Dentistry |
description |
Introduction: Oral squamous cell carcinoma (SCB) is a type of malignant neoplasm, considered one of the tumors with the highest incidence rate in the Brazilian population, corresponding to 90% to 95% of cancer cases affecting the oral cavity and oropharynx. The Human Papillomavirus (HPV) is a virus that has an affinity for epithelial tissue, comprises several subtypes and is often associated with the formation of benign and malignant neoplasms. Objective: Therefore, the present research aims to address the correlation between CEB and HPV. Methodology: The study consists of a literature review, based on scientific articles searched in the Scielo, PubMed/Medline and LILACS databases, using the descriptors: "Human Papillomavirus"; "Oral Neoplasms" and "Dentistry". Original articles, literature reviews, and case reports in Portuguese, English, and Spanish were included, without taking into account the periods of publication. Results: HPV has some virus subtypes that are related to benign lesions and others with carcinogenic potential. The latter is directly linked to the protein encoded by the E2 gene, which inhibits the expression of the E6 and E7 genes, which are active in cell immortalization. The absence of these genes results in excessive and unregulated cellular degradation, which favors the accumulation of mutations and the occurrence of chromosomal aberrations. Conclusion: There is a need for more specific studies to understand the role of HPV as a carcinogen. Despite the diversity of factors seen in the literature, there are still no conclusive studies relating HPV as a risk factor for oral carcinoma. Keywords: Human Papillomavirus; Oral Neoplasms; Dentistry. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-02-23 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/1528 10.36557/2674-8169.2024v6n2p453-470 |
url |
https://bjihs.emnuvens.com.br/bjihs/article/view/1528 |
identifier_str_mv |
10.36557/2674-8169.2024v6n2p453-470 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/1528/1721 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Specialized Dentistry Group |
publisher.none.fl_str_mv |
Specialized Dentistry Group |
dc.source.none.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 2 (2024): BJIHS QUALIS B3; 453-470 Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 2 (2024): BJIHS QUALIS B3; 453-470 Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 2 (2024): BJIHS QUALIS B3; 453-470 2674-8169 reponame:Brazilian Journal of Implantology and Health Sciences instname:Grupo de Odontologia Especializada (GOE) instacron:GOE |
instname_str |
Grupo de Odontologia Especializada (GOE) |
instacron_str |
GOE |
institution |
GOE |
reponame_str |
Brazilian Journal of Implantology and Health Sciences |
collection |
Brazilian Journal of Implantology and Health Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE) |
repository.mail.fl_str_mv |
journal.bjihs@periodicosbrasil.com.br |
_version_ |
1796798445152894976 |