EFFICACY ANALYSIS OF CANNABIDIOL IN AUTISM SPECTRUM DISORDER: integrative review

• Autor(a) principal: Silva, Paloma Lara Ferreira
• Data de Publicação: 2023
• Outros Autores: Amâncio, Natália de Fátima Gonçalves, Pereira Tolentino, Vanessa
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Brazilian Journal of Implantology and Health Sciences
• Texto Completo: https://bjihs.emnuvens.com.br/bjihs/article/view/1066
• topic: Transtorno do Espectro Autista; Canabidiol (CBD); terapia complementar

Introduction: Autism Spectrum Disorder (ASD) is characterized as a neurological condition with complex causes, potentially affecting social interactions and manifesting repetitive behaviors. Cannabidiol (CBD), a non-intoxicating component of the cannabis plant, shows therapeutic potential for relieving these symptoms safely and with minimal side effects, thereby improving the quality of life and daily functioning in individuals with ASD. Objective: This systematic review aims, through controlled studies, case reports, and reviews, to understand and describe the benefits and drawbacks of the relationship between individuals with ASD and the therapeutic use of CBD. Methodology: In this literature review, descriptors in Portuguese, English, and Spanish were used for bibliographic searches on databases such as Google Scholar, SciELO, PubMed, and BVS in September 2023. Inclusion criteria restricted articles to the last 5 years, published in Portuguese or English. Out of the initially identified 277 articles, 20 were selected. Results: The findings highlight improvements in social interaction, behavioral symptoms, and sleep quality with the use of CBD. However, there are reports of adverse effects such as drowsiness and decreased appetite, yet the majority of studies deem CBD to be safe. Conclusion: The research emphasizes the lack of a specific pharmacological treatment for ASD but underscores the importance of CBD as a complementary therapy, given the notable benefits and mild complications observed with the use of this substance. It further highlights the need for more medical and scientific research to better understand the effectiveness and potential adverse effects of CBD therapy in ASD.