Effects of cannabidiol on the signs and comorbidities of autistic spectrum disorder
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/18607 |
Resumo: | Autism is considered a neuropsychiatric disorder, with development in early childhood, with losses in the following domains: social interaction, communication, restricted interests and stereotyped patterns of behavior. There is no established definitive treatment for autism, and the objective of pharmacological ones is the relief of specific signs. In general, traditionally used medications (atypical antipsychotics, selective serotonin reuptake inhibitors, stimulants and anticonvulsants) have several side effects, reflecting treatment discontinuation. Cannabidiol (CBD), a component of the Cannabis Sativa plant, is free from lysergic effects and has been used as an alternative to the treatment of Autistic Spectrum Disorder (ASD). The endocaninoid system acts in several physiological functions, accessing the therapeutic potential of CBD in the regulation of hyper or hypostimulated functions. Thus, a systematic review of clinical studies that used CBD in the treatment of signs and comorbidity of ASD was prepared. The databases used were PubMed and Medline, considering the following descriptors in each database: “autismo” and “treatment” and “cannabis”; and “autismo” and “treatment” and “canabidiol”, in the title and abstract. Manuscripts must be published in national and international journals, in English and Portuguese, and free full text. The selected manuscripts were read in full and relevant data extracted for analysis and interpretation. The results presented that overall, clinical trial participants have been shown to have improvements in all signs associated with the ASD considered in each study. |
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Effects of cannabidiol on the signs and comorbidities of autistic spectrum disorderEfectos del cannabidiol sobre los signos y las comorbilidades del trastorno del espectro autistaEfeitos do canabidiol nos sinais e comorbidades do transtorno do espectro autistaTranstorno do Espectro AutistaTratamentoCanabidiolCannabis.Autistic Spectrum DisorderTreatmentCanabidiolCannabis.Trastorno del Espectro AutistaTratamentoCanabidiolCannabis.Autism is considered a neuropsychiatric disorder, with development in early childhood, with losses in the following domains: social interaction, communication, restricted interests and stereotyped patterns of behavior. There is no established definitive treatment for autism, and the objective of pharmacological ones is the relief of specific signs. In general, traditionally used medications (atypical antipsychotics, selective serotonin reuptake inhibitors, stimulants and anticonvulsants) have several side effects, reflecting treatment discontinuation. Cannabidiol (CBD), a component of the Cannabis Sativa plant, is free from lysergic effects and has been used as an alternative to the treatment of Autistic Spectrum Disorder (ASD). The endocaninoid system acts in several physiological functions, accessing the therapeutic potential of CBD in the regulation of hyper or hypostimulated functions. Thus, a systematic review of clinical studies that used CBD in the treatment of signs and comorbidity of ASD was prepared. The databases used were PubMed and Medline, considering the following descriptors in each database: “autismo” and “treatment” and “cannabis”; and “autismo” and “treatment” and “canabidiol”, in the title and abstract. Manuscripts must be published in national and international journals, in English and Portuguese, and free full text. The selected manuscripts were read in full and relevant data extracted for analysis and interpretation. The results presented that overall, clinical trial participants have been shown to have improvements in all signs associated with the ASD considered in each study.El autismo es considerado un trastorno neuropsiquiátrico, con desarrollo en la primera infancia, con pérdidas en los siguientes dominios: interacción social, comunicación, intereses restringidos y patrones de comportamiento estereotipados. No existe un tratamiento definitivo establecido para el autismo, siendo el objetivo de las intervenciones farmacológicas el alivio de signos específicos. En general, los medicamentos de uso tradicional (antipsicóticos atípicos, inhibidores selectivos de la recaptación de serotonina, estimulantes y anticonvulsivos) tienen varios efectos secundarios que reflejan la interrupción del tratamiento. El cannabidiol (CBD), un componente de la planta Cannabis Sativa, no tiene efectos lisérgicos y se ha utilizado como alternativa al tratamiento del trastorno del espectro autista (TEA). El sistema endocaninoide actúa en varias funciones fisiológicas, siendo el potencial terapéutico del CBD en la regulación de funciones hiper o hipoestimuladas. Por lo tanto, se elaboró una revisión sistemática de los estudios clínicos que utilizaron CBD en el tratamiento de los signos y la comorbilidad del TEA. Las bases de datos utilizadas fueron PubMed y Medline, considerándose en cada base de datos los siguientes descriptores: “autismo” y “tratamento” y “cannabis”; y “autismo” y “tratamento” y “canabidiol”, en el título y resumen. Se incluyeron investigaciones publicadas en revistas nacionales e internacionales, en inglés y portugués, de libre acceso y distribuidas íntegramente. Los artículos seleccionados se leyeron en su totalidad y se extrajeron los datos relevantes para su análisis e interpretación. Los resultados muestran que, en general, los participantes de los ensayos clínicos mostraron una mejoría en todos los signos asociados con el TEA considerados en cada estudio.O autismo é considerado um transtorno neuropsiquiátrico, com desenvolvimento na infância precoce, havendo prejuízos nos seguintes domínios: interação social, comunicação, interesses restritos e padrões estereotipados do comportamento. Não há tratamento definitivo estabelecido para o autismo, sendo o objetivo das intervenções farmacológicas o alívio de sinais específicos. Em geral, os medicamentos tradicionalmente utilizados (antipsicóticos atípicos, inibidores seletivos de recaptação de serotonina, estimulantes e anticonvulsivantes) apresentam diversos efeitos colaterais, refletindo em descontinuidade do tratamento. O canabidiol (CBD), componente da planta Cannabis Sativa, é livre dos efeitos lisérgicos e tem sido utilizado como uma alternativa ao tratamento do Transtorno do Espectro Autista (TEA). O sistema endocaninóide atua em diversas funções fisiológicas, estando o potencial terapêutico do CBD na regulação das funções hiper ou hipoestimuladas. Desta forma, foi elaborada uma revisão sistemática dos estudos clínicos que utilizaram o CBD no tratamento dos sinais e comorbidade do TEA. As bases de dados utilizadas foram PubMed e Medline, sendo considerados os seguintes descritores em cada base: autism and treatment and cannabis e autism and treatment and cannabidiol, no título e resumo. Foram incluídas pesquisas publicadas em periódicos nacionais e internacionais, nos idiomas inglês e português, com livre acesso e distribuídos na integra. Os artigos selecionados foram lidos na íntegra e extraídos dados relevantes para análise e interpretação. Os resultados mostram que de forma geral, os participantes dos ensaios-clínicos mostraram ter melhoras de todos os sinais associados ao TEA considerados em cada estudo.Research, Society and Development2021-08-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1860710.33448/rsd-v10i10.18607Research, Society and Development; Vol. 10 No. 10; e64101018607Research, Society and Development; Vol. 10 Núm. 10; e64101018607Research, Society and Development; v. 10 n. 10; e641010186072525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/18607/16592Copyright (c) 2021 Flávia Cristina Osaku Minella; Vagner Fagnani Linartevichihttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMinella, Flávia Cristina OsakuLinartevichi, Vagner Fagnani 2021-10-02T21:49:16Zoai:ojs.pkp.sfu.ca:article/18607Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:38:42.592812Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Effects of cannabidiol on the signs and comorbidities of autistic spectrum disorder Efectos del cannabidiol sobre los signos y las comorbilidades del trastorno del espectro autista Efeitos do canabidiol nos sinais e comorbidades do transtorno do espectro autista |
title |
Effects of cannabidiol on the signs and comorbidities of autistic spectrum disorder |
spellingShingle |
Effects of cannabidiol on the signs and comorbidities of autistic spectrum disorder Minella, Flávia Cristina Osaku Transtorno do Espectro Autista Tratamento Canabidiol Cannabis. Autistic Spectrum Disorder Treatment Canabidiol Cannabis. Trastorno del Espectro Autista Tratamento Canabidiol Cannabis. |
title_short |
Effects of cannabidiol on the signs and comorbidities of autistic spectrum disorder |
title_full |
Effects of cannabidiol on the signs and comorbidities of autistic spectrum disorder |
title_fullStr |
Effects of cannabidiol on the signs and comorbidities of autistic spectrum disorder |
title_full_unstemmed |
Effects of cannabidiol on the signs and comorbidities of autistic spectrum disorder |
title_sort |
Effects of cannabidiol on the signs and comorbidities of autistic spectrum disorder |
author |
Minella, Flávia Cristina Osaku |
author_facet |
Minella, Flávia Cristina Osaku Linartevichi, Vagner Fagnani |
author_role |
author |
author2 |
Linartevichi, Vagner Fagnani |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Minella, Flávia Cristina Osaku Linartevichi, Vagner Fagnani |
dc.subject.por.fl_str_mv |
Transtorno do Espectro Autista Tratamento Canabidiol Cannabis. Autistic Spectrum Disorder Treatment Canabidiol Cannabis. Trastorno del Espectro Autista Tratamento Canabidiol Cannabis. |
topic |
Transtorno do Espectro Autista Tratamento Canabidiol Cannabis. Autistic Spectrum Disorder Treatment Canabidiol Cannabis. Trastorno del Espectro Autista Tratamento Canabidiol Cannabis. |
description |
Autism is considered a neuropsychiatric disorder, with development in early childhood, with losses in the following domains: social interaction, communication, restricted interests and stereotyped patterns of behavior. There is no established definitive treatment for autism, and the objective of pharmacological ones is the relief of specific signs. In general, traditionally used medications (atypical antipsychotics, selective serotonin reuptake inhibitors, stimulants and anticonvulsants) have several side effects, reflecting treatment discontinuation. Cannabidiol (CBD), a component of the Cannabis Sativa plant, is free from lysergic effects and has been used as an alternative to the treatment of Autistic Spectrum Disorder (ASD). The endocaninoid system acts in several physiological functions, accessing the therapeutic potential of CBD in the regulation of hyper or hypostimulated functions. Thus, a systematic review of clinical studies that used CBD in the treatment of signs and comorbidity of ASD was prepared. The databases used were PubMed and Medline, considering the following descriptors in each database: “autismo” and “treatment” and “cannabis”; and “autismo” and “treatment” and “canabidiol”, in the title and abstract. Manuscripts must be published in national and international journals, in English and Portuguese, and free full text. The selected manuscripts were read in full and relevant data extracted for analysis and interpretation. The results presented that overall, clinical trial participants have been shown to have improvements in all signs associated with the ASD considered in each study. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-05 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/18607 10.33448/rsd-v10i10.18607 |
url |
https://rsdjournal.org/index.php/rsd/article/view/18607 |
identifier_str_mv |
10.33448/rsd-v10i10.18607 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/18607/16592 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Flávia Cristina Osaku Minella; Vagner Fagnani Linartevichi https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Flávia Cristina Osaku Minella; Vagner Fagnani Linartevichi https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 10; e64101018607 Research, Society and Development; Vol. 10 Núm. 10; e64101018607 Research, Society and Development; v. 10 n. 10; e64101018607 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052685322551296 |