Diabetic foot ulcer: pathogenic and therapeutic aspects
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Implantology and Health Sciences |
Texto Completo: | https://bjihs.emnuvens.com.br/bjihs/article/view/1826 |
Resumo: | Introduction: Diabetic foot ulcer (DUP) is a chronic and debilitating complication associated with diabetes mellitus. It is characterized by ulcerative lesions that can progress to deep infections and even amputations. Objective: To evaluate the pathogenesis and management of diabetic foot ulcers. Methodology: This is a bibliographic review that included original articles and systematic reviews in English and Portuguese, which addressed the pathogenic and therapeutic factors associated with UPD, published between 2012 and 2024, selected from the PubMed, Scopus and SciELO databases. After careful selection, 16 articles were chosen to compose this bibliographic review. Results: A comprehensive understanding of the pathogenesis of UPD reveals that sensory and structural changes in the feet, resulting from diabetic peripheral neuropathy, make the lesions less noticeable and susceptible to damage and can lead to foot deformities, exacerbating the development or worsening of UPD. Autonomic neuropathy compromises sweating and blood circulation, increasing the risk of skin infections. Furthermore, peripheral arterial disease promotes vascular changes that increase the risk of micro and macrovascular complications. Management of UPD involves debridement, appropriate dressings, antibiotic therapy and load-relieving strategies, and arterial revascularization to promote healing and reduce the risk of amputation. Considerations: The complexity and breadth of the pathogenesis of UPD stands out, which can be characterized by three fundamental pillars: peripheral neuropathy, peripheral arterial disease and infection. Managing the condition requires comprehensive care and specialized assessment to ensure effective results. Expert assessment is essential to determine the severity of the condition, identify possible complications such as infections, and develop a personalized treatment plan for each patient. |
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Brazilian Journal of Implantology and Health Sciences |
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Diabetic foot ulcer: pathogenic and therapeutic aspectsÚlcera do pé diabético: aspectos patogênicos e terapêuticosúlcera do pé diabéticopatogênesefisiopatologiatratamentodiabetic foot ulcerpathogenesispathophysiologytreatmentIntroduction: Diabetic foot ulcer (DUP) is a chronic and debilitating complication associated with diabetes mellitus. It is characterized by ulcerative lesions that can progress to deep infections and even amputations. Objective: To evaluate the pathogenesis and management of diabetic foot ulcers. Methodology: This is a bibliographic review that included original articles and systematic reviews in English and Portuguese, which addressed the pathogenic and therapeutic factors associated with UPD, published between 2012 and 2024, selected from the PubMed, Scopus and SciELO databases. After careful selection, 16 articles were chosen to compose this bibliographic review. Results: A comprehensive understanding of the pathogenesis of UPD reveals that sensory and structural changes in the feet, resulting from diabetic peripheral neuropathy, make the lesions less noticeable and susceptible to damage and can lead to foot deformities, exacerbating the development or worsening of UPD. Autonomic neuropathy compromises sweating and blood circulation, increasing the risk of skin infections. Furthermore, peripheral arterial disease promotes vascular changes that increase the risk of micro and macrovascular complications. Management of UPD involves debridement, appropriate dressings, antibiotic therapy and load-relieving strategies, and arterial revascularization to promote healing and reduce the risk of amputation. Considerations: The complexity and breadth of the pathogenesis of UPD stands out, which can be characterized by three fundamental pillars: peripheral neuropathy, peripheral arterial disease and infection. Managing the condition requires comprehensive care and specialized assessment to ensure effective results. Expert assessment is essential to determine the severity of the condition, identify possible complications such as infections, and develop a personalized treatment plan for each patient.Introdução: A úlcera do pé diabético (UPD) é uma complicação crônica e debilitanteassociada ao diabetes mellitus. Caracteriza-se por lesões ulcerativas que podem progredir para infecções profundas e até mesmo amputações. Objetivo: Avaliar a patogênese e o manejo da úlcera do pé diabético. Metodologia: Trata-se de uma revisão bibliográfica que incluiu artigos originais e revisões sistemáticas em inglês e português, que abordaram os fatores patogênicos e terapêuticos associados à UPD, publicados entre 2012 e 2024, selecionados nas bases de dados PubMed, Scopus e SciELO. Após a seleção criteriosa, foram escolhidos 16 artigos para compor esta revisão bibliográfica. Resultados: O entendimento abrangente da patogênese da UPD revela que alterações sensoriais e estruturais nos pés, advindas da neuropatia periférica diabética, torna as lesões menos perceptíveis e suscetíveis a danos e pode levar a deformidades nos pés, exacerbando o desenvolvimento ou agravamento da UPD. A neuropatia autonômica compromete a transpiração e a circulação sanguínea, aumentando o risco de infecções cutâneas. Ademais, a doença arterial periférica promove alterações vasculares que aumentam o risco de complicações micro e macrovasculares. O manejo da UPD envolve desbridamento, curativos adequados, antibioticoterapia e estratégias de alívio de carga e revascularização arterial para promover a cicatrização e reduzir o risco de amputação. Considerações: Destaca-se a complexidade e a amplitude da patogênese da UPD, que pode ser caracterizada por três pilares fundamentais: neuropatia periférica, doença arterial periférica e infecção. O manejo do quadro requer um cuidado abrangente e uma avaliação especializada para garantir resultados eficazes. A avaliação especializada é essencial para determinar a gravidade da condição, identificar possíveis complicações, como infecções, e desenvolver um plano de tratamento personalizado para cada paciente.Specialized Dentistry Group2024-04-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://bjihs.emnuvens.com.br/bjihs/article/view/182610.36557/2674-8169.2024v6n4p474-483Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 4 (2024): BJIHS QUALIS B3 - IMPACT FACTOR SJIF 5.807; 474-483Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 4 (2024): BJIHS QUALIS B3 - FATOR DE IMPACTO SJIF 5.807; 474-483Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 4 (2024): BJIHS QUALIS B3 - FATOR DE IMPACTO SJIF 5.807; 474-4832674-8169reponame:Brazilian Journal of Implantology and Health Sciencesinstname:Grupo de Odontologia Especializada (GOE)instacron:GOEporhttps://bjihs.emnuvens.com.br/bjihs/article/view/1826/2058Copyright (c) 2024 Paulo Vytor Cardoso Nobre, Ane Valéria Cardoso Nobre, Vinicius Cerqueira de Barros Silveira, Wendell Santos Santana , Paulo Victor Santos Brito, Bettyjany de Araújo Melo Granja, Ruane Clemente Costa d’Oliveira , José César De Oliveira Cerqueira , Josivaldo de Araújo Alves Júnior , Gustavo José Araújo Bezerra, Igor Macedo Ferreira, Amanda Virgínia Oliveira Leite https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessVytor Cardoso Nobre, PauloValéria Cardoso Nobre, AneCerqueira de Barros Silveira, ViniciusSantos Santana , WendellVictor Santos Brito, Paulode Araújo Melo Granja, BettyjanyClemente Costa d’Oliveira , RuaneCésar De Oliveira Cerqueira , Joséde Araújo Alves Júnior , JosivaldoJosé Araújo Bezerra, GustavoMacedo Ferreira, IgorVirgínia Oliveira Leite , Amanda2024-04-09T11:05:05Zoai:ojs.bjihs.emnuvens.com.br:article/1826Revistahttps://bjihs.emnuvens.com.br/bjihsONGhttps://bjihs.emnuvens.com.br/bjihs/oaijournal.bjihs@periodicosbrasil.com.br2674-81692674-8169opendoar:2024-04-09T11:05:05Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE)false |
dc.title.none.fl_str_mv |
Diabetic foot ulcer: pathogenic and therapeutic aspects Úlcera do pé diabético: aspectos patogênicos e terapêuticos |
title |
Diabetic foot ulcer: pathogenic and therapeutic aspects |
spellingShingle |
Diabetic foot ulcer: pathogenic and therapeutic aspects Vytor Cardoso Nobre, Paulo úlcera do pé diabético patogênese fisiopatologia tratamento diabetic foot ulcer pathogenesis pathophysiology treatment |
title_short |
Diabetic foot ulcer: pathogenic and therapeutic aspects |
title_full |
Diabetic foot ulcer: pathogenic and therapeutic aspects |
title_fullStr |
Diabetic foot ulcer: pathogenic and therapeutic aspects |
title_full_unstemmed |
Diabetic foot ulcer: pathogenic and therapeutic aspects |
title_sort |
Diabetic foot ulcer: pathogenic and therapeutic aspects |
author |
Vytor Cardoso Nobre, Paulo |
author_facet |
Vytor Cardoso Nobre, Paulo Valéria Cardoso Nobre, Ane Cerqueira de Barros Silveira, Vinicius Santos Santana , Wendell Victor Santos Brito, Paulo de Araújo Melo Granja, Bettyjany Clemente Costa d’Oliveira , Ruane César De Oliveira Cerqueira , José de Araújo Alves Júnior , Josivaldo José Araújo Bezerra, Gustavo Macedo Ferreira, Igor Virgínia Oliveira Leite , Amanda |
author_role |
author |
author2 |
Valéria Cardoso Nobre, Ane Cerqueira de Barros Silveira, Vinicius Santos Santana , Wendell Victor Santos Brito, Paulo de Araújo Melo Granja, Bettyjany Clemente Costa d’Oliveira , Ruane César De Oliveira Cerqueira , José de Araújo Alves Júnior , Josivaldo José Araújo Bezerra, Gustavo Macedo Ferreira, Igor Virgínia Oliveira Leite , Amanda |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Vytor Cardoso Nobre, Paulo Valéria Cardoso Nobre, Ane Cerqueira de Barros Silveira, Vinicius Santos Santana , Wendell Victor Santos Brito, Paulo de Araújo Melo Granja, Bettyjany Clemente Costa d’Oliveira , Ruane César De Oliveira Cerqueira , José de Araújo Alves Júnior , Josivaldo José Araújo Bezerra, Gustavo Macedo Ferreira, Igor Virgínia Oliveira Leite , Amanda |
dc.subject.por.fl_str_mv |
úlcera do pé diabético patogênese fisiopatologia tratamento diabetic foot ulcer pathogenesis pathophysiology treatment |
topic |
úlcera do pé diabético patogênese fisiopatologia tratamento diabetic foot ulcer pathogenesis pathophysiology treatment |
description |
Introduction: Diabetic foot ulcer (DUP) is a chronic and debilitating complication associated with diabetes mellitus. It is characterized by ulcerative lesions that can progress to deep infections and even amputations. Objective: To evaluate the pathogenesis and management of diabetic foot ulcers. Methodology: This is a bibliographic review that included original articles and systematic reviews in English and Portuguese, which addressed the pathogenic and therapeutic factors associated with UPD, published between 2012 and 2024, selected from the PubMed, Scopus and SciELO databases. After careful selection, 16 articles were chosen to compose this bibliographic review. Results: A comprehensive understanding of the pathogenesis of UPD reveals that sensory and structural changes in the feet, resulting from diabetic peripheral neuropathy, make the lesions less noticeable and susceptible to damage and can lead to foot deformities, exacerbating the development or worsening of UPD. Autonomic neuropathy compromises sweating and blood circulation, increasing the risk of skin infections. Furthermore, peripheral arterial disease promotes vascular changes that increase the risk of micro and macrovascular complications. Management of UPD involves debridement, appropriate dressings, antibiotic therapy and load-relieving strategies, and arterial revascularization to promote healing and reduce the risk of amputation. Considerations: The complexity and breadth of the pathogenesis of UPD stands out, which can be characterized by three fundamental pillars: peripheral neuropathy, peripheral arterial disease and infection. Managing the condition requires comprehensive care and specialized assessment to ensure effective results. Expert assessment is essential to determine the severity of the condition, identify possible complications such as infections, and develop a personalized treatment plan for each patient. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-04-04 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/1826 10.36557/2674-8169.2024v6n4p474-483 |
url |
https://bjihs.emnuvens.com.br/bjihs/article/view/1826 |
identifier_str_mv |
10.36557/2674-8169.2024v6n4p474-483 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/1826/2058 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Specialized Dentistry Group |
publisher.none.fl_str_mv |
Specialized Dentistry Group |
dc.source.none.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 4 (2024): BJIHS QUALIS B3 - IMPACT FACTOR SJIF 5.807; 474-483 Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 4 (2024): BJIHS QUALIS B3 - FATOR DE IMPACTO SJIF 5.807; 474-483 Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 4 (2024): BJIHS QUALIS B3 - FATOR DE IMPACTO SJIF 5.807; 474-483 2674-8169 reponame:Brazilian Journal of Implantology and Health Sciences instname:Grupo de Odontologia Especializada (GOE) instacron:GOE |
instname_str |
Grupo de Odontologia Especializada (GOE) |
instacron_str |
GOE |
institution |
GOE |
reponame_str |
Brazilian Journal of Implantology and Health Sciences |
collection |
Brazilian Journal of Implantology and Health Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE) |
repository.mail.fl_str_mv |
journal.bjihs@periodicosbrasil.com.br |
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