CARDIOVASCULAR EFFECTS OF FREE OR COMPLEXED LINALOOL WITH Β-CYCLODEXTRIN: A FOCUS FOR ANTIHYPERTENSIVE ACTION
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Implantology and Health Sciences |
Texto Completo: | https://bjihs.emnuvens.com.br/bjihs/article/view/1404 |
Resumo: | Investigating the cardiovascular effects of natural compounds, such as linalool, has aroused interest due to the potential impact on cardiovascular health. Linalool, a component present in several essential oils, has demonstrated promising pharmacological properties, including antihypertensive activity. However, its bioavailability and efficacy can be influenced by complexation with β-cyclodextrin, a strategy frequently used to improve the solubility and stability of bioactive substances. This study aimed to carry out a systematic review of the literature, exploring the cardiovascular effects of free linalool and linalool complexed with β-cyclodextrin. Objective: To investigate the cardiovascular effects of free linalool and linalool complexed with β-cyclodextrin, with emphasis on the antihypertensive action, through a systematic review of the literature. Methodology: The review was conducted according to PRISMA guidelines. The PubMed, Scielo and Web of Science databases were consulted, using the descriptors "linalool", "β-cyclodextrin", "cardiovascular effects", "antihypertensive" and "complexation". The inclusion criteria covered studies published in the last 10 years, focusing on in vivo experiments, clinical trials and systematic reviews. Articles unrelated to the topic, duplicate studies and those without peer review were excluded. Results: They revealed that linalool, when complexed with β-cyclodextrin, presented greater bioavailability and stability, enhancing its antihypertensive action. In vivo studies have demonstrated a significant reduction in blood pressure in hypertensive animal models. Furthermore, the complexation positively influenced the gastrointestinal absorption of linalool. These findings suggest that the complexed formulation may represent an effective approach to improving the cardiovascular effects of linalool. Conclusion: The systematic review highlights the relevance of complexing linalool to β-cyclodextrin as a strategy to enhance its antihypertensive effects. Understanding these mechanisms can contribute to the development of more effective pharmaceutical formulations in the management of hypertension, promoting advances in cardiovascular therapy. |
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CARDIOVASCULAR EFFECTS OF FREE OR COMPLEXED LINALOOL WITH Β-CYCLODEXTRIN: A FOCUS FOR ANTIHYPERTENSIVE ACTIONCARDIOVASCULAR EFFECTS OF FREE OR COMPLEXED LINALOOL WITH Β-CYCLODEXTRIN: A FOCUS FOR ANTIHYPERTENSIVE ACTIONInvestigating the cardiovascular effects of natural compounds, such as linalool, has aroused interest due to the potential impact on cardiovascular health. Linalool, a component present in several essential oils, has demonstrated promising pharmacological properties, including antihypertensive activity. However, its bioavailability and efficacy can be influenced by complexation with β-cyclodextrin, a strategy frequently used to improve the solubility and stability of bioactive substances. This study aimed to carry out a systematic review of the literature, exploring the cardiovascular effects of free linalool and linalool complexed with β-cyclodextrin. Objective: To investigate the cardiovascular effects of free linalool and linalool complexed with β-cyclodextrin, with emphasis on the antihypertensive action, through a systematic review of the literature. Methodology: The review was conducted according to PRISMA guidelines. The PubMed, Scielo and Web of Science databases were consulted, using the descriptors "linalool", "β-cyclodextrin", "cardiovascular effects", "antihypertensive" and "complexation". The inclusion criteria covered studies published in the last 10 years, focusing on in vivo experiments, clinical trials and systematic reviews. Articles unrelated to the topic, duplicate studies and those without peer review were excluded. Results: They revealed that linalool, when complexed with β-cyclodextrin, presented greater bioavailability and stability, enhancing its antihypertensive action. In vivo studies have demonstrated a significant reduction in blood pressure in hypertensive animal models. Furthermore, the complexation positively influenced the gastrointestinal absorption of linalool. These findings suggest that the complexed formulation may represent an effective approach to improving the cardiovascular effects of linalool. Conclusion: The systematic review highlights the relevance of complexing linalool to β-cyclodextrin as a strategy to enhance its antihypertensive effects. Understanding these mechanisms can contribute to the development of more effective pharmaceutical formulations in the management of hypertension, promoting advances in cardiovascular therapy.Investigating the cardiovascular effects of natural compounds, such as linalool, has aroused interest due to the potential impact on cardiovascular health. Linalool, a component present in several essential oils, has demonstrated promising pharmacological properties, including antihypertensive activity. However, its bioavailability and efficacy can be influenced by complexation with β-cyclodextrin, a strategy frequently used to improve the solubility and stability of bioactive substances. This study aimed to carry out a systematic review of the literature, exploring the cardiovascular effects of free linalool and linalool complexed with β-cyclodextrin. Objective: To investigate the cardiovascular effects of free linalool and linalool complexed with β-cyclodextrin, with emphasis on the antihypertensive action, through a systematic review of the literature. Methodology: The review was conducted according to PRISMA guidelines. The PubMed, Scielo and Web of Science databases were consulted, using the descriptors "linalool", "β-cyclodextrin", "cardiovascular effects", "antihypertensive" and "complexation". The inclusion criteria covered studies published in the last 10 years, focusing on in vivo experiments, clinical trials and systematic reviews. Articles unrelated to the topic, duplicate studies and those without peer review were excluded. Results: They revealed that linalool, when complexed with β-cyclodextrin, presented greater bioavailability and stability, enhancing its antihypertensive action. In vivo studies have demonstrated a significant reduction in blood pressure in hypertensive animal models. Furthermore, the complexation positively influenced the gastrointestinal absorption of linalool. These findings suggest that the complexed formulation may represent an effective approach to improving the cardiovascular effects of linalool. Conclusion: The systematic review highlights the relevance of complexing linalool to β-cyclodextrin as a strategy to enhance its antihypertensive effects. Understanding these mechanisms can contribute to the development of more effective pharmaceutical formulations in the management of hypertension, promoting advances in cardiovascular therapy.Specialized Dentistry Group2024-02-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://bjihs.emnuvens.com.br/bjihs/article/view/140410.36557/2674-8169.2024v6n2p335-347Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 2 (2024): BJIHS QUALIS B3; 335-347Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 2 (2024): BJIHS QUALIS B3; 335-347Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 2 (2024): BJIHS QUALIS B3; 335-3472674-8169reponame:Brazilian Journal of Implantology and Health Sciencesinstname:Grupo de Odontologia Especializada (GOE)instacron:GOEporhttps://bjihs.emnuvens.com.br/bjihs/article/view/1404/1582Copyright (c) 2024 Jordana Clara Gomes Pedreira, Edward Rodrigues de Oliveira Filho, Héllida Patrícia Oliveira Camilo Pereira, Anderson Felipe Caixêta Martins, , Felipe Dayrell Schoepfer, Rafaella Ribeiro Gomes Nogueira, Jim Davis de Oliveira, Herik Jansen de Souza Pimentel, Josiely Anelise Mendonça, Paulo Otávio Magalhães Costa, Nara Márcia Amaro Domingos Guimarães , Vinícius Guimarãeshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPedreira, Jordana Clara GomesFilho, Edward Rodrigues de OliveiraPereira, Héllida Patrícia Oliveira CamiloMartins, Anderson Felipe Caixêta Schoepfer, Felipe Dayrell Nogueira, Rafaella Ribeiro GomesOliveira, Jim Davis dePimentel, Herik Jansen de SouzaMendonça, Josiely AneliseCosta, Paulo Otávio MagalhãesGuimarães , Nara Márcia Amaro DomingosGuimarães, Vinícius2024-02-04T12:40:22Zoai:ojs.bjihs.emnuvens.com.br:article/1404Revistahttps://bjihs.emnuvens.com.br/bjihsONGhttps://bjihs.emnuvens.com.br/bjihs/oaijournal.bjihs@periodicosbrasil.com.br2674-81692674-8169opendoar:2024-02-04T12:40:22Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE)false |
dc.title.none.fl_str_mv |
CARDIOVASCULAR EFFECTS OF FREE OR COMPLEXED LINALOOL WITH Β-CYCLODEXTRIN: A FOCUS FOR ANTIHYPERTENSIVE ACTION CARDIOVASCULAR EFFECTS OF FREE OR COMPLEXED LINALOOL WITH Β-CYCLODEXTRIN: A FOCUS FOR ANTIHYPERTENSIVE ACTION |
title |
CARDIOVASCULAR EFFECTS OF FREE OR COMPLEXED LINALOOL WITH Β-CYCLODEXTRIN: A FOCUS FOR ANTIHYPERTENSIVE ACTION |
spellingShingle |
CARDIOVASCULAR EFFECTS OF FREE OR COMPLEXED LINALOOL WITH Β-CYCLODEXTRIN: A FOCUS FOR ANTIHYPERTENSIVE ACTION Pedreira, Jordana Clara Gomes |
title_short |
CARDIOVASCULAR EFFECTS OF FREE OR COMPLEXED LINALOOL WITH Β-CYCLODEXTRIN: A FOCUS FOR ANTIHYPERTENSIVE ACTION |
title_full |
CARDIOVASCULAR EFFECTS OF FREE OR COMPLEXED LINALOOL WITH Β-CYCLODEXTRIN: A FOCUS FOR ANTIHYPERTENSIVE ACTION |
title_fullStr |
CARDIOVASCULAR EFFECTS OF FREE OR COMPLEXED LINALOOL WITH Β-CYCLODEXTRIN: A FOCUS FOR ANTIHYPERTENSIVE ACTION |
title_full_unstemmed |
CARDIOVASCULAR EFFECTS OF FREE OR COMPLEXED LINALOOL WITH Β-CYCLODEXTRIN: A FOCUS FOR ANTIHYPERTENSIVE ACTION |
title_sort |
CARDIOVASCULAR EFFECTS OF FREE OR COMPLEXED LINALOOL WITH Β-CYCLODEXTRIN: A FOCUS FOR ANTIHYPERTENSIVE ACTION |
author |
Pedreira, Jordana Clara Gomes |
author_facet |
Pedreira, Jordana Clara Gomes Filho, Edward Rodrigues de Oliveira Pereira, Héllida Patrícia Oliveira Camilo Martins, Anderson Felipe Caixêta Schoepfer, Felipe Dayrell Nogueira, Rafaella Ribeiro Gomes Oliveira, Jim Davis de Pimentel, Herik Jansen de Souza Mendonça, Josiely Anelise Costa, Paulo Otávio Magalhães Guimarães , Nara Márcia Amaro Domingos Guimarães, Vinícius |
author_role |
author |
author2 |
Filho, Edward Rodrigues de Oliveira Pereira, Héllida Patrícia Oliveira Camilo Martins, Anderson Felipe Caixêta Schoepfer, Felipe Dayrell Nogueira, Rafaella Ribeiro Gomes Oliveira, Jim Davis de Pimentel, Herik Jansen de Souza Mendonça, Josiely Anelise Costa, Paulo Otávio Magalhães Guimarães , Nara Márcia Amaro Domingos Guimarães, Vinícius |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pedreira, Jordana Clara Gomes Filho, Edward Rodrigues de Oliveira Pereira, Héllida Patrícia Oliveira Camilo Martins, Anderson Felipe Caixêta Schoepfer, Felipe Dayrell Nogueira, Rafaella Ribeiro Gomes Oliveira, Jim Davis de Pimentel, Herik Jansen de Souza Mendonça, Josiely Anelise Costa, Paulo Otávio Magalhães Guimarães , Nara Márcia Amaro Domingos Guimarães, Vinícius |
description |
Investigating the cardiovascular effects of natural compounds, such as linalool, has aroused interest due to the potential impact on cardiovascular health. Linalool, a component present in several essential oils, has demonstrated promising pharmacological properties, including antihypertensive activity. However, its bioavailability and efficacy can be influenced by complexation with β-cyclodextrin, a strategy frequently used to improve the solubility and stability of bioactive substances. This study aimed to carry out a systematic review of the literature, exploring the cardiovascular effects of free linalool and linalool complexed with β-cyclodextrin. Objective: To investigate the cardiovascular effects of free linalool and linalool complexed with β-cyclodextrin, with emphasis on the antihypertensive action, through a systematic review of the literature. Methodology: The review was conducted according to PRISMA guidelines. The PubMed, Scielo and Web of Science databases were consulted, using the descriptors "linalool", "β-cyclodextrin", "cardiovascular effects", "antihypertensive" and "complexation". The inclusion criteria covered studies published in the last 10 years, focusing on in vivo experiments, clinical trials and systematic reviews. Articles unrelated to the topic, duplicate studies and those without peer review were excluded. Results: They revealed that linalool, when complexed with β-cyclodextrin, presented greater bioavailability and stability, enhancing its antihypertensive action. In vivo studies have demonstrated a significant reduction in blood pressure in hypertensive animal models. Furthermore, the complexation positively influenced the gastrointestinal absorption of linalool. These findings suggest that the complexed formulation may represent an effective approach to improving the cardiovascular effects of linalool. Conclusion: The systematic review highlights the relevance of complexing linalool to β-cyclodextrin as a strategy to enhance its antihypertensive effects. Understanding these mechanisms can contribute to the development of more effective pharmaceutical formulations in the management of hypertension, promoting advances in cardiovascular therapy. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-02-04 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/1404 10.36557/2674-8169.2024v6n2p335-347 |
url |
https://bjihs.emnuvens.com.br/bjihs/article/view/1404 |
identifier_str_mv |
10.36557/2674-8169.2024v6n2p335-347 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/1404/1582 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Specialized Dentistry Group |
publisher.none.fl_str_mv |
Specialized Dentistry Group |
dc.source.none.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 2 (2024): BJIHS QUALIS B3; 335-347 Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 2 (2024): BJIHS QUALIS B3; 335-347 Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 2 (2024): BJIHS QUALIS B3; 335-347 2674-8169 reponame:Brazilian Journal of Implantology and Health Sciences instname:Grupo de Odontologia Especializada (GOE) instacron:GOE |
instname_str |
Grupo de Odontologia Especializada (GOE) |
instacron_str |
GOE |
institution |
GOE |
reponame_str |
Brazilian Journal of Implantology and Health Sciences |
collection |
Brazilian Journal of Implantology and Health Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE) |
repository.mail.fl_str_mv |
journal.bjihs@periodicosbrasil.com.br |
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1796798444320325632 |