Increase in the antioxidant and anti-inflammatory activity of Euterpe oleracea Martius oil complexed into β-cyclodextrin and HP-β-cyclodextrin

Detalhes bibliográficos
Autor(a) principal: Macedo, Pollyana Cristina de Oliveira
Data de Publicação: 2021
Tipo de documento: Trabalho de conclusão de curso
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/handle/123456789/35701
Resumo: CAPES, CNPq.
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spelling Macedo, Pollyana Cristina de OliveiraThalita Sévia Soares de Almeida MagalhãesMoura, Túlio Flavio Accioly de Lima eSilva, Marcelo de Sousa daLima, Ádley Antonini Neves de2021-05-13T12:50:41Z2021-09-20T17:49:21Z2021-05-13T12:50:41Z2021-09-20T17:49:21Z2021-04-0820150118774MACEDO, Pollyana Cristina de Oliveira. Increase in the antioxidant and anti-inflammatory activity of Euterpe oleracea Martius oil complexed into β-cyclodextrin and HP-β-cyclodextrin. 2021. 26f. Trabalho de conclusão de curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2021.https://repositorio.ufrn.br/handle/123456789/35701CAPES, CNPq.Reactive oxygen species (ROS) are aerobic products generated during cellular respiration, but in case of oxidative stress, they become key factors in the development of inflammatory processes and chronic diseases, such as diabetes and rheumatoid arthritis. In this work, Euterpe oleracea oil (EOO), as well as the complexes produced by slurry and kneading, were analyzed for antioxidant capacity in vitro, meanwhile the EOO-β-CD (M) complex was selected for anti-inflammatory assays in vivo. In the scavenging activity of OH., EOO-HP-β-CD (M) exhibited an activity 437% better than pure oil. In the paw edema assay, EOO-β-CD (M) reduced edema by 200% and myeloperoxidase (MPO) activity by 112%. In an air pouch model, this treatment showed a reduction in leukocyte, MPO and Interleukin-1β (IL-1β) levels, meanwhile glutathione and IL-10 were increased, demonstrating to potentiate the anti-inflammatory effect of EOO.Universidade Federal do Rio Grande do NorteUFRNBrasilFarmácia4.03.00.00-5 FarmáciaEuterpe oleraceaInclusion complexesAntioxidantAnti-inflammatoryIncrease in the antioxidant and anti-inflammatory activity of Euterpe oleracea Martius oil complexed into β-cyclodextrin and HP-β-cyclodextrininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessORIGINALIncreaseInTheAntioxidantAndAntiinflammatory_Macedo_2021Texto Completoapplication/pdf979181https://repositorio.ufrn.br/bitstream/123456789/35701/1/IncreaseInTheAntioxidantAndAntiinflammatory_Macedo_2021301730910e3df9f5cd7e33f60c4d7d8cMD51CC-LICENSElicense_rdfapplication/octet-stream701https://repositorio.ufrn.br/bitstream/123456789/35701/2/license_rdf42fd4ad1e89814f5e4a476b409eb708cMD52LICENSElicense.txttext/plain714https://repositorio.ufrn.br/bitstream/123456789/35701/3/license.txt7278bab9c5c886812fa7d225dc807888MD53123456789/357012023-03-01 13:29:47.046oai:https://repositorio.ufrn.br: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ório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-03-01T16:29:47Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Increase in the antioxidant and anti-inflammatory activity of Euterpe oleracea Martius oil complexed into β-cyclodextrin and HP-β-cyclodextrin
title Increase in the antioxidant and anti-inflammatory activity of Euterpe oleracea Martius oil complexed into β-cyclodextrin and HP-β-cyclodextrin
spellingShingle Increase in the antioxidant and anti-inflammatory activity of Euterpe oleracea Martius oil complexed into β-cyclodextrin and HP-β-cyclodextrin
Macedo, Pollyana Cristina de Oliveira
4.03.00.00-5 Farmácia
Euterpe oleracea
Inclusion complexes
Antioxidant
Anti-inflammatory
title_short Increase in the antioxidant and anti-inflammatory activity of Euterpe oleracea Martius oil complexed into β-cyclodextrin and HP-β-cyclodextrin
title_full Increase in the antioxidant and anti-inflammatory activity of Euterpe oleracea Martius oil complexed into β-cyclodextrin and HP-β-cyclodextrin
title_fullStr Increase in the antioxidant and anti-inflammatory activity of Euterpe oleracea Martius oil complexed into β-cyclodextrin and HP-β-cyclodextrin
title_full_unstemmed Increase in the antioxidant and anti-inflammatory activity of Euterpe oleracea Martius oil complexed into β-cyclodextrin and HP-β-cyclodextrin
title_sort Increase in the antioxidant and anti-inflammatory activity of Euterpe oleracea Martius oil complexed into β-cyclodextrin and HP-β-cyclodextrin
author Macedo, Pollyana Cristina de Oliveira
author_facet Macedo, Pollyana Cristina de Oliveira
author_role author
dc.contributor.referees1.none.fl_str_mv Moura, Túlio Flavio Accioly de Lima e
dc.contributor.referees2.none.fl_str_mv Silva, Marcelo de Sousa da
dc.contributor.author.fl_str_mv Macedo, Pollyana Cristina de Oliveira
dc.contributor.advisor-co1.fl_str_mv Thalita Sévia Soares de Almeida Magalhães
dc.contributor.advisor1.fl_str_mv Lima, Ádley Antonini Neves de
contributor_str_mv Thalita Sévia Soares de Almeida Magalhães
Lima, Ádley Antonini Neves de
dc.subject.cnpq.fl_str_mv 4.03.00.00-5 Farmácia
topic 4.03.00.00-5 Farmácia
Euterpe oleracea
Inclusion complexes
Antioxidant
Anti-inflammatory
dc.subject.por.fl_str_mv Euterpe oleracea
Inclusion complexes
Antioxidant
Anti-inflammatory
description CAPES, CNPq.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-05-13T12:50:41Z
2021-09-20T17:49:21Z
dc.date.available.fl_str_mv 2021-05-13T12:50:41Z
2021-09-20T17:49:21Z
dc.date.issued.fl_str_mv 2021-04-08
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bachelorThesis
format bachelorThesis
status_str publishedVersion
dc.identifier.pt_BR.fl_str_mv 20150118774
dc.identifier.citation.fl_str_mv MACEDO, Pollyana Cristina de Oliveira. Increase in the antioxidant and anti-inflammatory activity of Euterpe oleracea Martius oil complexed into β-cyclodextrin and HP-β-cyclodextrin. 2021. 26f. Trabalho de conclusão de curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2021.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/handle/123456789/35701
identifier_str_mv 20150118774
MACEDO, Pollyana Cristina de Oliveira. Increase in the antioxidant and anti-inflammatory activity of Euterpe oleracea Martius oil complexed into β-cyclodextrin and HP-β-cyclodextrin. 2021. 26f. Trabalho de conclusão de curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2021.
url https://repositorio.ufrn.br/handle/123456789/35701
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal do Rio Grande do Norte
dc.publisher.initials.fl_str_mv UFRN
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Farmácia
publisher.none.fl_str_mv Universidade Federal do Rio Grande do Norte
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRN
instname:Universidade Federal do Rio Grande do Norte (UFRN)
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instname_str Universidade Federal do Rio Grande do Norte (UFRN)
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