Neuroplasticity and stimulation of the Vagus Nerve: Integrative review of advances in the treatment of epilepsy.
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Implantology and Health Sciences |
Texto Completo: | https://bjihs.emnuvens.com.br/bjihs/article/view/796 |
Resumo: | Introduction: Refractory epilepsy represents a challenge in neurology, affecting the quality of life of patients who do not respond to conventional pharmacological therapies. Vagus Nerve Stimulation (VNS) emerges as a promising approach. Methodology: This integrative review was based on 29 studies on VNS in the treatment of refractory epilepsy. The PICO strategy was used to construct the research question and articles were selected from databases such as MEDLINE/PubMed, Science Direct and LILACS. Results: VNS proved to be effective in reducing the frequency of epileptic seizures, with around 8% of patients achieving freedom from seizures. Side effects, such as headache and skin irritation, were mild and well tolerated. The therapy was especially beneficial for patients with specific epilepsy syndromes. However, the high cost of VNS can be a barrier for many patients. Conclusion: VNS is a safe and effective approach for the treatment of refractory epilepsy. Early intervention may be particularly beneficial, especially in pediatric patients. Future technological innovations could make ENV more accessible and effective. |
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Brazilian Journal of Implantology and Health Sciences |
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Neuroplasticity and stimulation of the Vagus Nerve: Integrative review of advances in the treatment of epilepsy.Neuroplasticidade e estimulação do Nervo Vago: Revisão Integrativa dos avanços no tratamento da Epilepsia. refratária, Estimulação do Nervo Vago, terapia farmacológica, efeitos colaterais, tratamento multidisciplinar, inovação tecnológica.refractory epilepsy, Vagus Nerve Stimulation, pharmacological therapy, side effects, multidisciplinary treatment, technological innovation.Introduction: Refractory epilepsy represents a challenge in neurology, affecting the quality of life of patients who do not respond to conventional pharmacological therapies. Vagus Nerve Stimulation (VNS) emerges as a promising approach. Methodology: This integrative review was based on 29 studies on VNS in the treatment of refractory epilepsy. The PICO strategy was used to construct the research question and articles were selected from databases such as MEDLINE/PubMed, Science Direct and LILACS. Results: VNS proved to be effective in reducing the frequency of epileptic seizures, with around 8% of patients achieving freedom from seizures. Side effects, such as headache and skin irritation, were mild and well tolerated. The therapy was especially beneficial for patients with specific epilepsy syndromes. However, the high cost of VNS can be a barrier for many patients. Conclusion: VNS is a safe and effective approach for the treatment of refractory epilepsy. Early intervention may be particularly beneficial, especially in pediatric patients. Future technological innovations could make ENV more accessible and effective.Introdução: A epilepsia refratária representa um desafio na neurologia, afetando a qualidade de vida dos pacientes que não respondem às terapias farmacológicas convencionais. A Estimulação do Nervo Vago (ENV) surge como uma abordagem promissora. Metodologia: Esta revisão integrativa foi baseada em 29 estudos sobre a ENV no tratamento da epilepsia refratária. Utilizou-se a estratégia PICO para a construção da pergunta de pesquisa e os artigos foram selecionados de bases de dados como MEDLINE/PubMed, Science Direct e LILACS. Resultados: A ENV mostrou-se eficaz na redução da frequência das crises epilépticas, com cerca de 8% dos pacientes alcançando liberdade de convulsões. Efeitos colaterais, como cefaleia e irritação da pele, foram leves e bem tolerados. A terapia foi especialmente benéfica para pacientes com síndromes epilépticas específicas. No entanto, o alto custo da ENV pode ser uma barreira para muitos pacientes. Conclusão: A ENV é uma abordagem segura e eficaz para o tratamento da epilepsia refratária. A intervenção precoce pode ser particularmente benéfica, especialmente em pacientes pediátricos. Futuras inovações tecnológicas podem tornar a ENV mais acessível e eficaz. Specialized Dentistry Group2023-11-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://bjihs.emnuvens.com.br/bjihs/article/view/79610.36557/2674-8169.2023v5n5p2355-2374Brazilian Journal of Implantology and Health Sciences ; Vol. 5 No. 5 (2023): BJIHS QUALIS B3; 2355-2374Brazilian Journal of Implantology and Health Sciences ; Vol. 5 Núm. 5 (2023): BJIHS QUALIS B3; 2355-2374Brazilian Journal of Implantology and Health Sciences ; v. 5 n. 5 (2023): BJIHS QUALIS B3; 2355-23742674-8169reponame:Brazilian Journal of Implantology and Health Sciencesinstname:Grupo de Odontologia Especializada (GOE)instacron:GOEporhttps://bjihs.emnuvens.com.br/bjihs/article/view/796/935Copyright (c) 2023 Gustavo Fernandes do Vale, Leticia De Queiroz Cunha, Maria Clara Cardoso Felipe , Luiz Felipe De Azevedo Assunção, Maria Oitava Rosado Cantídio , Fernando Marinho Filho, Keren Suely Rocha Bezerra, Maria Beatriz Leandro Bezerra, Edson Jovino de Oliveira, Ana Larissa Fernandes de Holandahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFernandes do Vale, GustavoDe Queiroz Cunha, LeticiaCardoso Felipe , Maria ClaraDe Azevedo Assunção, Luiz FelipeRosado Cantídio , Maria OitavaMarinho Filho, FernandoRocha Bezerra, Keren SuelyLeandro Bezerra, Maria BeatrizJovino de Oliveira, EdsonFernandes de Holanda, Ana Larissa2023-11-08T09:31:17Zoai:ojs.bjihs.emnuvens.com.br:article/796Revistahttps://bjihs.emnuvens.com.br/bjihsONGhttps://bjihs.emnuvens.com.br/bjihs/oaijournal.bjihs@periodicosbrasil.com.br2674-81692674-8169opendoar:2023-11-08T09:31:17Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE)false |
dc.title.none.fl_str_mv |
Neuroplasticity and stimulation of the Vagus Nerve: Integrative review of advances in the treatment of epilepsy. Neuroplasticidade e estimulação do Nervo Vago: Revisão Integrativa dos avanços no tratamento da Epilepsia. |
title |
Neuroplasticity and stimulation of the Vagus Nerve: Integrative review of advances in the treatment of epilepsy. |
spellingShingle |
Neuroplasticity and stimulation of the Vagus Nerve: Integrative review of advances in the treatment of epilepsy. Fernandes do Vale, Gustavo refratária, Estimulação do Nervo Vago, terapia farmacológica, efeitos colaterais, tratamento multidisciplinar, inovação tecnológica. refractory epilepsy, Vagus Nerve Stimulation, pharmacological therapy, side effects, multidisciplinary treatment, technological innovation. |
title_short |
Neuroplasticity and stimulation of the Vagus Nerve: Integrative review of advances in the treatment of epilepsy. |
title_full |
Neuroplasticity and stimulation of the Vagus Nerve: Integrative review of advances in the treatment of epilepsy. |
title_fullStr |
Neuroplasticity and stimulation of the Vagus Nerve: Integrative review of advances in the treatment of epilepsy. |
title_full_unstemmed |
Neuroplasticity and stimulation of the Vagus Nerve: Integrative review of advances in the treatment of epilepsy. |
title_sort |
Neuroplasticity and stimulation of the Vagus Nerve: Integrative review of advances in the treatment of epilepsy. |
author |
Fernandes do Vale, Gustavo |
author_facet |
Fernandes do Vale, Gustavo De Queiroz Cunha, Leticia Cardoso Felipe , Maria Clara De Azevedo Assunção, Luiz Felipe Rosado Cantídio , Maria Oitava Marinho Filho, Fernando Rocha Bezerra, Keren Suely Leandro Bezerra, Maria Beatriz Jovino de Oliveira, Edson Fernandes de Holanda, Ana Larissa |
author_role |
author |
author2 |
De Queiroz Cunha, Leticia Cardoso Felipe , Maria Clara De Azevedo Assunção, Luiz Felipe Rosado Cantídio , Maria Oitava Marinho Filho, Fernando Rocha Bezerra, Keren Suely Leandro Bezerra, Maria Beatriz Jovino de Oliveira, Edson Fernandes de Holanda, Ana Larissa |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Fernandes do Vale, Gustavo De Queiroz Cunha, Leticia Cardoso Felipe , Maria Clara De Azevedo Assunção, Luiz Felipe Rosado Cantídio , Maria Oitava Marinho Filho, Fernando Rocha Bezerra, Keren Suely Leandro Bezerra, Maria Beatriz Jovino de Oliveira, Edson Fernandes de Holanda, Ana Larissa |
dc.subject.por.fl_str_mv |
refratária, Estimulação do Nervo Vago, terapia farmacológica, efeitos colaterais, tratamento multidisciplinar, inovação tecnológica. refractory epilepsy, Vagus Nerve Stimulation, pharmacological therapy, side effects, multidisciplinary treatment, technological innovation. |
topic |
refratária, Estimulação do Nervo Vago, terapia farmacológica, efeitos colaterais, tratamento multidisciplinar, inovação tecnológica. refractory epilepsy, Vagus Nerve Stimulation, pharmacological therapy, side effects, multidisciplinary treatment, technological innovation. |
description |
Introduction: Refractory epilepsy represents a challenge in neurology, affecting the quality of life of patients who do not respond to conventional pharmacological therapies. Vagus Nerve Stimulation (VNS) emerges as a promising approach. Methodology: This integrative review was based on 29 studies on VNS in the treatment of refractory epilepsy. The PICO strategy was used to construct the research question and articles were selected from databases such as MEDLINE/PubMed, Science Direct and LILACS. Results: VNS proved to be effective in reducing the frequency of epileptic seizures, with around 8% of patients achieving freedom from seizures. Side effects, such as headache and skin irritation, were mild and well tolerated. The therapy was especially beneficial for patients with specific epilepsy syndromes. However, the high cost of VNS can be a barrier for many patients. Conclusion: VNS is a safe and effective approach for the treatment of refractory epilepsy. Early intervention may be particularly beneficial, especially in pediatric patients. Future technological innovations could make ENV more accessible and effective. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-11-07 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/796 10.36557/2674-8169.2023v5n5p2355-2374 |
url |
https://bjihs.emnuvens.com.br/bjihs/article/view/796 |
identifier_str_mv |
10.36557/2674-8169.2023v5n5p2355-2374 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/796/935 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Specialized Dentistry Group |
publisher.none.fl_str_mv |
Specialized Dentistry Group |
dc.source.none.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences ; Vol. 5 No. 5 (2023): BJIHS QUALIS B3; 2355-2374 Brazilian Journal of Implantology and Health Sciences ; Vol. 5 Núm. 5 (2023): BJIHS QUALIS B3; 2355-2374 Brazilian Journal of Implantology and Health Sciences ; v. 5 n. 5 (2023): BJIHS QUALIS B3; 2355-2374 2674-8169 reponame:Brazilian Journal of Implantology and Health Sciences instname:Grupo de Odontologia Especializada (GOE) instacron:GOE |
instname_str |
Grupo de Odontologia Especializada (GOE) |
instacron_str |
GOE |
institution |
GOE |
reponame_str |
Brazilian Journal of Implantology and Health Sciences |
collection |
Brazilian Journal of Implantology and Health Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE) |
repository.mail.fl_str_mv |
journal.bjihs@periodicosbrasil.com.br |
_version_ |
1796798440949153792 |