Pharmacological Therapies for the Treatment of Neuropathic Pain: An Integrative Analysis

• Autor(a) principal: Simões Montefuscolo, Bheatriz
• Data de Publicação: 2023
• Outros Autores: Leão França , Débora, Cavaco Gonçalves Pereira, Isabella, Polachini da Silva, Amanda Augusta, Barrancos Barbosa Mello , José Victor
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Brazilian Journal of Implantology and Health Sciences
• Texto Completo: https://bjihs.emnuvens.com.br/bjihs/article/view/860
• topic: Dor neuropática; Abordagem farmacológica; Qualidade de vida.; Neuropathic pain; Pharmacological approach; Quality of life.

Neuropathic pain poses a significant challenge in clinical practice due to its complexity and impact on patients' quality of life. In this context, various pharmacological therapies have been explored as strategies to alleviate symptoms associated with this condition. The present integrative analysis aims to examine and consolidate the available scientific evidence on pharmacological therapies used in the treatment of neuropathic pain, providing a comprehensive overview of the current therapeutic landscape. Among the pharmacological approaches, research on histone deacetylase inhibitors (HDACs) and bromodomain 4 inhibitors (BRD4) stands out, highlighting their promising efficacy in relieving neuropathic pain by modulating the inflammatory response in microglial cells. Additionally, the analysis also encompasses recent advances in the use of agents that interfere with the renin-angiotensin system to prevent chemotherapy-induced peripheral neuropathy, underscoring the importance of these innovative interventions in managing neuropathic pain associated with oncological treatments. A deeper understanding of pharmacological strategies for neuropathic pain, spanning from molecular mechanisms to clinical outcomes, provides valuable insights for healthcare professionals in choosing personalized therapeutic approaches. This integrative analysis seeks to contribute to the development of more effective and comprehensive approaches to address this challenging condition, emphasizing the crucial role of pharmacological therapies in managing neuropathic pain and their potential positive impacts on patients' quality of life.