Comparison between endoscopic brush cytology performed before and after biliary stricture dilation for cancer detection

Detalhes bibliográficos
Autor(a) principal: Ornellas,Laura Cotta
Data de Publicação: 2006
Outros Autores: Santos,Gilda da Cunha, Nakao,Frank Shigueo, Ferrari,Angelo Paulo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de gastroenterologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032006000100007
Resumo: BACKGROUND: Confirmation of malignancy within biliary strictures is endoscopically challenging. Dilation of strictures has been reported to enhance cytological diagnosis. AIM: To compare brush cytology results before and after biliary stricture dilation. PATIENTS AND METHODS: Patients with extra-hepatic biliary stricture at endoscopic retrograde cholangiopancreatography were included in the study. Brushing was performed before and immediately after dilation using a 10 Fr dilating catheter. Cytology samples were classified as: negative for malignancy, presence of atypical cells, insufficient material, suspicious for malignancy or positive for malignancy. Final diagnosis was established by surgery, biopsy or follow-up. RESULTS: Biliary brush cytology was performed in 50 patients, with an overall sensitivity of 40% and 27.5%, before and after dilation, respectively. The combination of results increased cancer detection rate to 45%. There were 5/50 (10%) minor complications and one death related to the procedure. CONCLUSIONS: Brush cytology performed before biliary stricture dilation has a similar cancer detection rate to that following dilation, although the combination of results enhances sensitivity.
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spelling Comparison between endoscopic brush cytology performed before and after biliary stricture dilation for cancer detectionCytological techniquesBalloon dilatationCholangiopancreatography, endoscopic retrogradeBile duct neoplasmsPancreatic ductsBACKGROUND: Confirmation of malignancy within biliary strictures is endoscopically challenging. Dilation of strictures has been reported to enhance cytological diagnosis. AIM: To compare brush cytology results before and after biliary stricture dilation. PATIENTS AND METHODS: Patients with extra-hepatic biliary stricture at endoscopic retrograde cholangiopancreatography were included in the study. Brushing was performed before and immediately after dilation using a 10 Fr dilating catheter. Cytology samples were classified as: negative for malignancy, presence of atypical cells, insufficient material, suspicious for malignancy or positive for malignancy. Final diagnosis was established by surgery, biopsy or follow-up. RESULTS: Biliary brush cytology was performed in 50 patients, with an overall sensitivity of 40% and 27.5%, before and after dilation, respectively. The combination of results increased cancer detection rate to 45%. There were 5/50 (10%) minor complications and one death related to the procedure. CONCLUSIONS: Brush cytology performed before biliary stricture dilation has a similar cancer detection rate to that following dilation, although the combination of results enhances sensitivity.Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE. 2006-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032006000100007Arquivos de Gastroenterologia v.43 n.1 2006reponame:Arquivos de gastroenterologia (Online)instname:Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologiainstacron:IBEPEGE10.1590/S0004-28032006000100007info:eu-repo/semantics/openAccessOrnellas,Laura CottaSantos,Gilda da CunhaNakao,Frank ShigueoFerrari,Angelo Pauloeng2006-05-08T00:00:00Zoai:scielo:S0004-28032006000100007Revistahttp://www.scielo.br/aghttps://old.scielo.br/oai/scielo-oai.php||secretariaarqgastr@hospitaligesp.com.br1678-42190004-2803opendoar:2006-05-08T00:00Arquivos de gastroenterologia (Online) - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologiafalse
dc.title.none.fl_str_mv Comparison between endoscopic brush cytology performed before and after biliary stricture dilation for cancer detection
title Comparison between endoscopic brush cytology performed before and after biliary stricture dilation for cancer detection
spellingShingle Comparison between endoscopic brush cytology performed before and after biliary stricture dilation for cancer detection
Ornellas,Laura Cotta
Cytological techniques
Balloon dilatation
Cholangiopancreatography, endoscopic retrograde
Bile duct neoplasms
Pancreatic ducts
title_short Comparison between endoscopic brush cytology performed before and after biliary stricture dilation for cancer detection
title_full Comparison between endoscopic brush cytology performed before and after biliary stricture dilation for cancer detection
title_fullStr Comparison between endoscopic brush cytology performed before and after biliary stricture dilation for cancer detection
title_full_unstemmed Comparison between endoscopic brush cytology performed before and after biliary stricture dilation for cancer detection
title_sort Comparison between endoscopic brush cytology performed before and after biliary stricture dilation for cancer detection
author Ornellas,Laura Cotta
author_facet Ornellas,Laura Cotta
Santos,Gilda da Cunha
Nakao,Frank Shigueo
Ferrari,Angelo Paulo
author_role author
author2 Santos,Gilda da Cunha
Nakao,Frank Shigueo
Ferrari,Angelo Paulo
author2_role author
author
author
dc.contributor.author.fl_str_mv Ornellas,Laura Cotta
Santos,Gilda da Cunha
Nakao,Frank Shigueo
Ferrari,Angelo Paulo
dc.subject.por.fl_str_mv Cytological techniques
Balloon dilatation
Cholangiopancreatography, endoscopic retrograde
Bile duct neoplasms
Pancreatic ducts
topic Cytological techniques
Balloon dilatation
Cholangiopancreatography, endoscopic retrograde
Bile duct neoplasms
Pancreatic ducts
description BACKGROUND: Confirmation of malignancy within biliary strictures is endoscopically challenging. Dilation of strictures has been reported to enhance cytological diagnosis. AIM: To compare brush cytology results before and after biliary stricture dilation. PATIENTS AND METHODS: Patients with extra-hepatic biliary stricture at endoscopic retrograde cholangiopancreatography were included in the study. Brushing was performed before and immediately after dilation using a 10 Fr dilating catheter. Cytology samples were classified as: negative for malignancy, presence of atypical cells, insufficient material, suspicious for malignancy or positive for malignancy. Final diagnosis was established by surgery, biopsy or follow-up. RESULTS: Biliary brush cytology was performed in 50 patients, with an overall sensitivity of 40% and 27.5%, before and after dilation, respectively. The combination of results increased cancer detection rate to 45%. There were 5/50 (10%) minor complications and one death related to the procedure. CONCLUSIONS: Brush cytology performed before biliary stricture dilation has a similar cancer detection rate to that following dilation, although the combination of results enhances sensitivity.
publishDate 2006
dc.date.none.fl_str_mv 2006-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032006000100007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032006000100007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-28032006000100007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE.
publisher.none.fl_str_mv Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades - IBEPEGE.
dc.source.none.fl_str_mv Arquivos de Gastroenterologia v.43 n.1 2006
reponame:Arquivos de gastroenterologia (Online)
instname:Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia
instacron:IBEPEGE
instname_str Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia
instacron_str IBEPEGE
institution IBEPEGE
reponame_str Arquivos de gastroenterologia (Online)
collection Arquivos de gastroenterologia (Online)
repository.name.fl_str_mv Arquivos de gastroenterologia (Online) - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia
repository.mail.fl_str_mv ||secretariaarqgastr@hospitaligesp.com.br
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