Bone marrow hypoplasia: atypical manifestation of hyperthyroidism

Detalhes bibliográficos
Autor(a) principal: Lucia, Carolina Vitória de
Data de Publicação: 2021
Outros Autores: Santana, Nina Maia, Khouri, Nadia de Andrade
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Baiana de Saúde Pública (Online)
Texto Completo: https://rbsp.sesab.ba.gov.br/index.php/rbsp/article/view/3554
Resumo: Hematological changes such as anemia or pancytopenia can occur as atypical manifestations of hyperthyroidism. Although most cases of pancytopenia in Graves’ disease are due to the use of antithyroid drugs (thionamides), it can also be associated with untreated hyperthyroidism, thus manifesting as a serious complication. This study aims to report the case of a 39-year-old hyperthyroid female patient who developed pancytopenia during hospitalization. Data were collected by means of the medical record, an interview conducted with the patient, and literature review. The patient was admitted to a hospital in Salvador presenting lower extremity edema that progressively evolved to anasarca within 45 days prior to the interview. She also presented weight loss, paroxysmal nocturnal dyspnea, tachycardia, sweating, chills, and laboratory test results for pancytopenia. The case reported here demonstrates an atypical and rare manifestation of hyperthyroidism that improved after the beginning of the treatment, reaching the euthyroid state.
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spelling Bone marrow hypoplasia: atypical manifestation of hyperthyroidismHipoplasia de la médula ósea: manifestación atípica del hipertiroidismoHipoplasia de medula óssea: manifestação atípica do hipertireoidismoHipertireoidismoPancitopeniaTireotoxicoseHipertireoidismoPancitopeniaTireotoxicoseHyperthyroidismPancytopeniaThyrotoxicosisHematological changes such as anemia or pancytopenia can occur as atypical manifestations of hyperthyroidism. Although most cases of pancytopenia in Graves’ disease are due to the use of antithyroid drugs (thionamides), it can also be associated with untreated hyperthyroidism, thus manifesting as a serious complication. This study aims to report the case of a 39-year-old hyperthyroid female patient who developed pancytopenia during hospitalization. Data were collected by means of the medical record, an interview conducted with the patient, and literature review. The patient was admitted to a hospital in Salvador presenting lower extremity edema that progressively evolved to anasarca within 45 days prior to the interview. She also presented weight loss, paroxysmal nocturnal dyspnea, tachycardia, sweating, chills, and laboratory test results for pancytopenia. The case reported here demonstrates an atypical and rare manifestation of hyperthyroidism that improved after the beginning of the treatment, reaching the euthyroid state.Los cambios hematológicos como anemia o pancitopenia pueden ocurrir como manifestaciones atípicas de hipertiroidismo. Aunque la mayoría de los casos de pancitopenia en la enfermedad de Graves se deben al uso de fármacos antitiroideos (tionamidas), también se puede asociar a um hipertiroidismo no tratado y, por tanto, puede manifestarse como una complicación grave. Este estudio tiene como objetivo reportar el caso de una paciente con hipertiroidismo que desarrolló durante la hospitalización pancitopenia secundaria a la enfermedad primaria. La información se obtuvo revisando la historia clínica, entrevistando a la paciente y revisando la literatura. Se trata de una paciente de 39 años ingresada en un hospital de Salvador por presentar edema en miembros inferiores, evolucionando progresivamente a anasarca durante 45 días. Asociado a la afección, presentaba pérdida de peso, disnea paroxística nocturna, taquicardia, sudoración, escalofríos y análisis de laboratorio que mostraban pancitopenia. El caso aquí reportado demuestra una manifestación atípica y rara de hipertiroidismo, que evolucionó luego del inicio del tratamiento y del estado de eutiroidismo.Alterações hematológicas, como anemia ou pancitopenia, podem ser manifestações atípicas do hipertireoidismo. Embora a maioria dos casos de pancitopenia na doença de Graves seja decorrente do uso de drogas antitireoidianas – tionamidas –, ela também pode estar associada ao quadro de hipertireoidismo não tratado e, assim, se manifestar como uma complicação grave. Este estudo tem como objetivo relatar o caso de uma paciente portadora de hipertireoidismo que evoluiu durante o internamento por pancitopenia secundária à doença primária. As informações foram obtidas por meio da revisão do prontuário, entrevista com a paciente e revisão da literatura. Trata-se de uma paciente do sexo feminino, de 39 anos, internada em um hospital de Salvador por apresentar um quadro de edema em membros inferiores que evoluiu progressivamente para anasarca por 45 dias. Associados ao quadro, a paciente apresentava perda ponderal, dispneia paroxística noturna, taquicardia, sudorese e calafrios, além dos exames laboratoriais terem apresentado pancitopenia. O caso relatado demonstra uma manifestação atípica e rara do hipertireoidismo, que melhorou após o início do tratamento e do estado de eutireoidismo.SESAB2021-12-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rbsp.sesab.ba.gov.br/index.php/rbsp/article/view/355410.22278/2318-2660.2021.v45.nSupl_2.a3554Revista Baiana de Saúde Pública; v. 45 n. supl. 2 (2021); 89-972318-26600100-023310.22278/2318-2660.2021.v45.NSupl_2reponame:Revista Baiana de Saúde Pública (Online)instname:Secretaria da Saúde do Estado da Bahia (Sesab)instacron:IBICTporhttps://rbsp.sesab.ba.gov.br/index.php/rbsp/article/view/3554/2890Copyright (c) 2021 Revista Baiana de Saúde Públicainfo:eu-repo/semantics/openAccessLucia, Carolina Vitória de Santana, Nina Maia Khouri, Nadia de Andrade 2023-02-13T17:00:34Zoai:ojs.pkp.sfu.ca:article/3554Revistahttps://rbsp.sesab.ba.gov.br/index.php/rbspPUBhttps://rbsp.sesab.ba.gov.br/index.php/rbsp/oai||saude.revista@saude.ba.gov.br|| rbsp.saude@saude.ba.gov.br2318-26600100-0233opendoar:2024-03-06T12:58:21.768090Revista Baiana de Saúde Pública (Online) - Secretaria da Saúde do Estado da Bahia (Sesab)false
dc.title.none.fl_str_mv Bone marrow hypoplasia: atypical manifestation of hyperthyroidism
Hipoplasia de la médula ósea: manifestación atípica del hipertiroidismo
Hipoplasia de medula óssea: manifestação atípica do hipertireoidismo
title Bone marrow hypoplasia: atypical manifestation of hyperthyroidism
spellingShingle Bone marrow hypoplasia: atypical manifestation of hyperthyroidism
Lucia, Carolina Vitória de
Hipertireoidismo
Pancitopenia
Tireotoxicose
Hipertireoidismo
Pancitopenia
Tireotoxicose
Hyperthyroidism
Pancytopenia
Thyrotoxicosis
title_short Bone marrow hypoplasia: atypical manifestation of hyperthyroidism
title_full Bone marrow hypoplasia: atypical manifestation of hyperthyroidism
title_fullStr Bone marrow hypoplasia: atypical manifestation of hyperthyroidism
title_full_unstemmed Bone marrow hypoplasia: atypical manifestation of hyperthyroidism
title_sort Bone marrow hypoplasia: atypical manifestation of hyperthyroidism
author Lucia, Carolina Vitória de
author_facet Lucia, Carolina Vitória de
Santana, Nina Maia
Khouri, Nadia de Andrade
author_role author
author2 Santana, Nina Maia
Khouri, Nadia de Andrade
author2_role author
author
dc.contributor.author.fl_str_mv Lucia, Carolina Vitória de
Santana, Nina Maia
Khouri, Nadia de Andrade
dc.subject.por.fl_str_mv Hipertireoidismo
Pancitopenia
Tireotoxicose
Hipertireoidismo
Pancitopenia
Tireotoxicose
Hyperthyroidism
Pancytopenia
Thyrotoxicosis
topic Hipertireoidismo
Pancitopenia
Tireotoxicose
Hipertireoidismo
Pancitopenia
Tireotoxicose
Hyperthyroidism
Pancytopenia
Thyrotoxicosis
description Hematological changes such as anemia or pancytopenia can occur as atypical manifestations of hyperthyroidism. Although most cases of pancytopenia in Graves’ disease are due to the use of antithyroid drugs (thionamides), it can also be associated with untreated hyperthyroidism, thus manifesting as a serious complication. This study aims to report the case of a 39-year-old hyperthyroid female patient who developed pancytopenia during hospitalization. Data were collected by means of the medical record, an interview conducted with the patient, and literature review. The patient was admitted to a hospital in Salvador presenting lower extremity edema that progressively evolved to anasarca within 45 days prior to the interview. She also presented weight loss, paroxysmal nocturnal dyspnea, tachycardia, sweating, chills, and laboratory test results for pancytopenia. The case reported here demonstrates an atypical and rare manifestation of hyperthyroidism that improved after the beginning of the treatment, reaching the euthyroid state.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-28
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbsp.sesab.ba.gov.br/index.php/rbsp/article/view/3554
10.22278/2318-2660.2021.v45.nSupl_2.a3554
url https://rbsp.sesab.ba.gov.br/index.php/rbsp/article/view/3554
identifier_str_mv 10.22278/2318-2660.2021.v45.nSupl_2.a3554
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbsp.sesab.ba.gov.br/index.php/rbsp/article/view/3554/2890
dc.rights.driver.fl_str_mv Copyright (c) 2021 Revista Baiana de Saúde Pública
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Revista Baiana de Saúde Pública
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SESAB
publisher.none.fl_str_mv SESAB
dc.source.none.fl_str_mv Revista Baiana de Saúde Pública; v. 45 n. supl. 2 (2021); 89-97
2318-2660
0100-0233
10.22278/2318-2660.2021.v45.NSupl_2
reponame:Revista Baiana de Saúde Pública (Online)
instname:Secretaria da Saúde do Estado da Bahia (Sesab)
instacron:IBICT
instname_str Secretaria da Saúde do Estado da Bahia (Sesab)
instacron_str IBICT
institution IBICT
reponame_str Revista Baiana de Saúde Pública (Online)
collection Revista Baiana de Saúde Pública (Online)
repository.name.fl_str_mv Revista Baiana de Saúde Pública (Online) - Secretaria da Saúde do Estado da Bahia (Sesab)
repository.mail.fl_str_mv ||saude.revista@saude.ba.gov.br|| rbsp.saude@saude.ba.gov.br
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