Clinical and immunopathological spectrum of american cutaneous leishmaniasis with special reference to the disease in amazonian Brazil - a review
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/3555 |
Resumo: | The wide variety of Leishmania species responsible for human American cutaneous leishmaniasis combined with the immune mechanisms of the host results in a large spectrum of clinical, histopathological, and immunopathological manifestations. At the middle of this spectrum are the most frequent cases of localized cutaneous leishmaniasis (LCL) caused by members of the subgenera Leishmania and Viannia, which respond well to conventional therapy. The two pathogenicity extremes of the spectrum generally recognized are represented at the hypersensitivity pole by mucocutaneous leishmaniasis (MCL) and at the hyposensitivity pole by anergic diffuse cutaneous leishmaniasis (ADCL). Following the present study on the clinical, histopathological and immunopathological features of cutaneous leishmaniasis in Amazonian Brazil, we propose the use of the term “borderline disseminated cutaneous leishmaniasis” for the disseminated form of the disease, due to parasites of the subgenera Leishmania and Viannia, which might be regarded as intermediate between LCL and the extreme pathogenicity poles MCL and ADCL. |
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Silveira, Fernando TobiasLainson, RalphCorbett, Carlos Eduardo Pereira2019-01-15T13:05:08Z2019-01-15T13:05:08Z2004SILVEIRA, Fernando Tobias; LAINSON, Ralph; CORBETT, Carlos E. P. Clinical and immunopathological spectrum of american cutaneous leishmaniasis with special reference to the disease in amazonian Brazil - a review. Memórias do Instituto Oswaldo Cruz, v. 99, n. 3, p. 239-251, 2004.0074-0276https://patua.iec.gov.br/handle/iec/355510.1590/S0074-02762004000300001The wide variety of Leishmania species responsible for human American cutaneous leishmaniasis combined with the immune mechanisms of the host results in a large spectrum of clinical, histopathological, and immunopathological manifestations. At the middle of this spectrum are the most frequent cases of localized cutaneous leishmaniasis (LCL) caused by members of the subgenera Leishmania and Viannia, which respond well to conventional therapy. The two pathogenicity extremes of the spectrum generally recognized are represented at the hypersensitivity pole by mucocutaneous leishmaniasis (MCL) and at the hyposensitivity pole by anergic diffuse cutaneous leishmaniasis (ADCL). Following the present study on the clinical, histopathological and immunopathological features of cutaneous leishmaniasis in Amazonian Brazil, we propose the use of the term “borderline disseminated cutaneous leishmaniasis” for the disseminated form of the disease, due to parasites of the subgenera Leishmania and Viannia, which might be regarded as intermediate between LCL and the extreme pathogenicity poles MCL and ADCL.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia. São Paulo, SP, Brasil.engInstituto Oswaldo CruzClinical and immunopathological spectrum of american cutaneous leishmaniasis with special reference to the disease in amazonian Brazil - a reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLeishmaniose Cutânea / diagnósticoLeishmaniose Cutânea / imunologiainfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALClinical and immunopathological spectrum of american cutaneous leishmaniasis with special reference to the disease in amazonian Brazil - a review.pdfClinical and immunopathological spectrum of american cutaneous leishmaniasis with special reference to the disease in amazonian Brazil - a review.pdfapplication/pdf195819https://patua.iec.gov.br/bitstreams/bfc7a65a-7fe5-4a13-9154-92a71f501159/downloaddff2139f3c4469423204c211a9766c55MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/2065f0a1-3e91-4bdf-9dfd-2e134440d096/download11832eea31b16df8613079d742d61793MD52TEXTClinical and immunopathological spectrum of american cutaneous leishmaniasis with special reference to the disease in amazonian Brazil - 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dc.title.pt_BR.fl_str_mv |
Clinical and immunopathological spectrum of american cutaneous leishmaniasis with special reference to the disease in amazonian Brazil - a review |
title |
Clinical and immunopathological spectrum of american cutaneous leishmaniasis with special reference to the disease in amazonian Brazil - a review |
spellingShingle |
Clinical and immunopathological spectrum of american cutaneous leishmaniasis with special reference to the disease in amazonian Brazil - a review Silveira, Fernando Tobias Leishmaniose Cutânea / diagnóstico Leishmaniose Cutânea / imunologia |
title_short |
Clinical and immunopathological spectrum of american cutaneous leishmaniasis with special reference to the disease in amazonian Brazil - a review |
title_full |
Clinical and immunopathological spectrum of american cutaneous leishmaniasis with special reference to the disease in amazonian Brazil - a review |
title_fullStr |
Clinical and immunopathological spectrum of american cutaneous leishmaniasis with special reference to the disease in amazonian Brazil - a review |
title_full_unstemmed |
Clinical and immunopathological spectrum of american cutaneous leishmaniasis with special reference to the disease in amazonian Brazil - a review |
title_sort |
Clinical and immunopathological spectrum of american cutaneous leishmaniasis with special reference to the disease in amazonian Brazil - a review |
author |
Silveira, Fernando Tobias |
author_facet |
Silveira, Fernando Tobias Lainson, Ralph Corbett, Carlos Eduardo Pereira |
author_role |
author |
author2 |
Lainson, Ralph Corbett, Carlos Eduardo Pereira |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Silveira, Fernando Tobias Lainson, Ralph Corbett, Carlos Eduardo Pereira |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Leishmaniose Cutânea / diagnóstico Leishmaniose Cutânea / imunologia |
topic |
Leishmaniose Cutânea / diagnóstico Leishmaniose Cutânea / imunologia |
description |
The wide variety of Leishmania species responsible for human American cutaneous leishmaniasis combined with the immune mechanisms of the host results in a large spectrum of clinical, histopathological, and immunopathological manifestations. At the middle of this spectrum are the most frequent cases of localized cutaneous leishmaniasis (LCL) caused by members of the subgenera Leishmania and Viannia, which respond well to conventional therapy. The two pathogenicity extremes of the spectrum generally recognized are represented at the hypersensitivity pole by mucocutaneous leishmaniasis (MCL) and at the hyposensitivity pole by anergic diffuse cutaneous leishmaniasis (ADCL). Following the present study on the clinical, histopathological and immunopathological features of cutaneous leishmaniasis in Amazonian Brazil, we propose the use of the term “borderline disseminated cutaneous leishmaniasis” for the disseminated form of the disease, due to parasites of the subgenera Leishmania and Viannia, which might be regarded as intermediate between LCL and the extreme pathogenicity poles MCL and ADCL. |
publishDate |
2004 |
dc.date.issued.fl_str_mv |
2004 |
dc.date.accessioned.fl_str_mv |
2019-01-15T13:05:08Z |
dc.date.available.fl_str_mv |
2019-01-15T13:05:08Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVEIRA, Fernando Tobias; LAINSON, Ralph; CORBETT, Carlos E. P. Clinical and immunopathological spectrum of american cutaneous leishmaniasis with special reference to the disease in amazonian Brazil - a review. Memórias do Instituto Oswaldo Cruz, v. 99, n. 3, p. 239-251, 2004. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/3555 |
dc.identifier.issn.-.fl_str_mv |
0074-0276 |
dc.identifier.doi.-.fl_str_mv |
10.1590/S0074-02762004000300001 |
identifier_str_mv |
SILVEIRA, Fernando Tobias; LAINSON, Ralph; CORBETT, Carlos E. P. Clinical and immunopathological spectrum of american cutaneous leishmaniasis with special reference to the disease in amazonian Brazil - a review. Memórias do Instituto Oswaldo Cruz, v. 99, n. 3, p. 239-251, 2004. 0074-0276 10.1590/S0074-02762004000300001 |
url |
https://patua.iec.gov.br/handle/iec/3555 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz |
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reponame:Repositório Digital do Instituto Evandro Chagas (Patuá) instname:Instituto Evandro Chagas (IEC) instacron:IEC |
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Instituto Evandro Chagas (IEC) |
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IEC |
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IEC |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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