In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus

• Autor(a) principal: Azevedo, Raimunda do Socorro da Silva
• Data de Publicação: 2018
• Outros Autores: Sousa, Jorge Rodrigues de, Araújo, Marialva Tereza Ferreira de, Martins Filho, Arnaldo Jorge, Alcantara, Bianca Nascimento de, Araújo, Fernanda Montenegro de Carvalho, Queiroz, Maria Goretti Lins de, Cruz, Ana Cecília Ribeiro, Vasconcelos, Beatriz Helena Baldez, Chiang, Jannifer Oliveira, Martins, Lívia Caricio, Casseb, Lívia Medeiros Neves, Silva, Eliana Vieira Pinto da, Carvalho, Valéria Lima, Vasconcelos, Barbara Cristina Baldez, Rodrigues, Sueli Guerreiro, Oliveira, Consuelo Silva de, Quaresma, Juarez Antônio Simões, Vasconcelos, Pedro Fernando da Costa
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: http://patua.iec.gov.br/handle/iec/3058
• topic: Microcefalia / complicações; Microcefalia / fisiopatologia; Infecção pelo Zika virus / complicações; Infecção pelo Zika virus / epidemiologia; Zika virus / patogenicidade; Meninges / anormalidades; Sistema Nervoso Central / patologia; Sistema Nervoso Central / anormalidades; Encefalopatias / congênito; Morte Perinatal; Imuno-Histoquímica; Brasil / epidemiologia

Zika virus (ZIKV) has recently caused a pandemic disease, and many cases of ZIKV infection in pregnant women resulted in abortion, stillbirth, deaths and congenital defects including microcephaly, which now has been proposed as ZIKV congenital syndrome. This study aimed to investigate the in situ immune response profle and mechanisms of neuronal cell damage in fatal Zika microcephaly cases. Brain tissue samples were collected from 15 cases, including 10 microcephalic ZIKV-positive neonates with fatal outcome and fve neonatal control favivirus-negative neonates that died due to other causes, but with preserved central nervous system (CNS) architecture. In microcephaly cases, the histopathological features of the tissue samples were characterized in three CNS areas (meninges, perivascular space, and parenchyma). The changes found were mainly calcification, necrosis, neuronophagy, gliosis, microglial nodules, and infammatory infltration of mononuclear cells. The in situ immune response against ZIKV in the CNS of newborns is complex. Despite the predominant expression of Th2 cytokines, other cytokines such as Th1, Th17, Treg, Th9, and Th22 are involved to a lesser extent, but are still likely to participate in the immunopathogenic mechanisms of neural disease in fatal cases of microcephaly caused by ZIKV.