The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/6895 |
Resumo: | Stroke is one of the principal cerebrovascular diseases in human populations and contributes to a majority of the functional impairments in the elderly. Recent discoveries have led to the inclusion of electroencephalography (EEG) in the complementary prognostic evaluation of patients. The present study describes the EEG, behavioral, and histological changes that occur following cerebral ischemia associated with treatment by G1, a potent and selective G protein-coupled estrogen receptor 1 (GPER1) agonist in a rat model. Treatment with G1 attenuated the neurological deficits induced by ischemic stroke from the second day onward, and reduced areas of infarction. Treatment with G1 also improved the total brainwave power, as well as the theta and alpha wave activity, specifically, and restored the delta band power to levels similar to those observed in the controls. Treatment with G1 also attenuated the peaks of harmful activity observed in the EEG indices. These improvements in brainwave activity indicate that GPER1 plays a fundamental role in the mediation of cerebral injury and in the behavioral outcome of ischemic brain injuries, which points to treatment with G1 as a potential pharmacological strategy for the therapy of stroke. |
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Ferreira, Luan OliveiraSouza, Rafael Dias deTeixeira, Leonan LimaPinto, Laine CelestinoRodrigues, João Cleiton MartinsMartins Filho, Arnaldo JorgeCosta, Edmar Tavares daHamoy, MoisésLopes, Dielly Catrina Favacho2023-08-21T17:46:25Z2023-08-21T17:46:25Z2023FERREIRA, Luan Oliveira et al. The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke. Journal of Neuropathology & Experimental Neurology, v. 82, n. 9, p. 787-797, Sept. 2023. DOI: https://doi.org/10.1093/jnen/nlad061.1554-6578https://patua.iec.gov.br/handle/iec/689510.1093/jnen/nlad061Stroke is one of the principal cerebrovascular diseases in human populations and contributes to a majority of the functional impairments in the elderly. Recent discoveries have led to the inclusion of electroencephalography (EEG) in the complementary prognostic evaluation of patients. The present study describes the EEG, behavioral, and histological changes that occur following cerebral ischemia associated with treatment by G1, a potent and selective G protein-coupled estrogen receptor 1 (GPER1) agonist in a rat model. Treatment with G1 attenuated the neurological deficits induced by ischemic stroke from the second day onward, and reduced areas of infarction. Treatment with G1 also improved the total brainwave power, as well as the theta and alpha wave activity, specifically, and restored the delta band power to levels similar to those observed in the controls. Treatment with G1 also attenuated the peaks of harmful activity observed in the EEG indices. These improvements in brainwave activity indicate that GPER1 plays a fundamental role in the mediation of cerebral injury and in the behavioral outcome of ischemic brain injuries, which points to treatment with G1 as a potential pharmacological strategy for the therapy of stroke.PROPESP-UFPAFederal University of Pará. Joao de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.Federal University of Pará. Joao de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.Federal University of Pará. Joao de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.Federal University of Pará. Joao de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.Federal University of Pará. Joao de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Federal University of Pará. Joao de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.Federal University of Pará. Biological Sciences Institute. Laboratory of Pharmacology and Toxicology of Natural Products. Belém, PA, Brazil.Federal University of Pará. Joao de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.engOxford Academic PressThe GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic strokeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSistema Nervoso CentralAcidente Vascular Cerebral / tratamento farmacológicoIsquemia EncefálicaEletroencefalografia / métodosNeurofarmacologia / métodosinfo:eu-repo/semantics/embargoedAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALAcesso Embargado.pdfAcesso Embargado.pdfapplication/pdf551083https://patua.iec.gov.br/bitstreams/0932c3b5-e1c6-4950-88fd-c2d53a2c0b24/downloadc9a9c128e29cac82a5d7fdf3f4e6da73MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/5e189aa1-17ab-4500-a3cd-136b31ad5733/download11832eea31b16df8613079d742d61793MD52TEXTAcesso Embargado.pdf.txtAcesso Embargado.pdf.txtExtracted texttext/plain2https://patua.iec.gov.br/bitstreams/7fb920be-3545-43bd-85a3-96153df0f443/downloade1c06d85ae7b8b032bef47e42e4c08f9MD53THUMBNAILAcesso Embargado.pdf.jpgAcesso Embargado.pdf.jpgGenerated Thumbnailimage/jpeg3095https://patua.iec.gov.br/bitstreams/e53c93bf-89e3-43cf-ac9b-f30ea190eeed/download71859d578212107f7f8c49a4ce09d9eeMD54iec/68952023-08-21 18:05:20.208oai:patua.iec.gov.br:iec/6895https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2023-08-21T18:05:20Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)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 |
dc.title.pt_BR.fl_str_mv |
The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke |
title |
The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke |
spellingShingle |
The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke Ferreira, Luan Oliveira Sistema Nervoso Central Acidente Vascular Cerebral / tratamento farmacológico Isquemia Encefálica Eletroencefalografia / métodos Neurofarmacologia / métodos |
title_short |
The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke |
title_full |
The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke |
title_fullStr |
The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke |
title_full_unstemmed |
The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke |
title_sort |
The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke |
author |
Ferreira, Luan Oliveira |
author_facet |
Ferreira, Luan Oliveira Souza, Rafael Dias de Teixeira, Leonan Lima Pinto, Laine Celestino Rodrigues, João Cleiton Martins Martins Filho, Arnaldo Jorge Costa, Edmar Tavares da Hamoy, Moisés Lopes, Dielly Catrina Favacho |
author_role |
author |
author2 |
Souza, Rafael Dias de Teixeira, Leonan Lima Pinto, Laine Celestino Rodrigues, João Cleiton Martins Martins Filho, Arnaldo Jorge Costa, Edmar Tavares da Hamoy, Moisés Lopes, Dielly Catrina Favacho |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Ferreira, Luan Oliveira Souza, Rafael Dias de Teixeira, Leonan Lima Pinto, Laine Celestino Rodrigues, João Cleiton Martins Martins Filho, Arnaldo Jorge Costa, Edmar Tavares da Hamoy, Moisés Lopes, Dielly Catrina Favacho |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Sistema Nervoso Central Acidente Vascular Cerebral / tratamento farmacológico Isquemia Encefálica Eletroencefalografia / métodos Neurofarmacologia / métodos |
topic |
Sistema Nervoso Central Acidente Vascular Cerebral / tratamento farmacológico Isquemia Encefálica Eletroencefalografia / métodos Neurofarmacologia / métodos |
description |
Stroke is one of the principal cerebrovascular diseases in human populations and contributes to a majority of the functional impairments in the elderly. Recent discoveries have led to the inclusion of electroencephalography (EEG) in the complementary prognostic evaluation of patients. The present study describes the EEG, behavioral, and histological changes that occur following cerebral ischemia associated with treatment by G1, a potent and selective G protein-coupled estrogen receptor 1 (GPER1) agonist in a rat model. Treatment with G1 attenuated the neurological deficits induced by ischemic stroke from the second day onward, and reduced areas of infarction. Treatment with G1 also improved the total brainwave power, as well as the theta and alpha wave activity, specifically, and restored the delta band power to levels similar to those observed in the controls. Treatment with G1 also attenuated the peaks of harmful activity observed in the EEG indices. These improvements in brainwave activity indicate that GPER1 plays a fundamental role in the mediation of cerebral injury and in the behavioral outcome of ischemic brain injuries, which points to treatment with G1 as a potential pharmacological strategy for the therapy of stroke. |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-08-21T17:46:25Z |
dc.date.available.fl_str_mv |
2023-08-21T17:46:25Z |
dc.date.issued.fl_str_mv |
2023 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FERREIRA, Luan Oliveira et al. The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke. Journal of Neuropathology & Experimental Neurology, v. 82, n. 9, p. 787-797, Sept. 2023. DOI: https://doi.org/10.1093/jnen/nlad061. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/6895 |
dc.identifier.issn.-.fl_str_mv |
1554-6578 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1093/jnen/nlad061 |
identifier_str_mv |
FERREIRA, Luan Oliveira et al. The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke. Journal of Neuropathology & Experimental Neurology, v. 82, n. 9, p. 787-797, Sept. 2023. DOI: https://doi.org/10.1093/jnen/nlad061. 1554-6578 10.1093/jnen/nlad061 |
url |
https://patua.iec.gov.br/handle/iec/6895 |
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eng |
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eng |
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dc.publisher.none.fl_str_mv |
Oxford Academic Press |
publisher.none.fl_str_mv |
Oxford Academic Press |
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