The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke

Detalhes bibliográficos
Autor(a) principal: Ferreira, Luan Oliveira
Data de Publicação: 2023
Outros Autores: Souza, Rafael Dias de, Teixeira, Leonan Lima, Pinto, Laine Celestino, Rodrigues, João Cleiton Martins, Martins Filho, Arnaldo Jorge, Costa, Edmar Tavares da, Hamoy, Moisés, Lopes, Dielly Catrina Favacho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/6895
Resumo: Stroke is one of the principal cerebrovascular diseases in human populations and contributes to a majority of the functional impairments in the elderly. Recent discoveries have led to the inclusion of electroencephalography (EEG) in the complementary prognostic evaluation of patients. The present study describes the EEG, behavioral, and histological changes that occur following cerebral ischemia associated with treatment by G1, a potent and selective G protein-coupled estrogen receptor 1 (GPER1) agonist in a rat model. Treatment with G1 attenuated the neurological deficits induced by ischemic stroke from the second day onward, and reduced areas of infarction. Treatment with G1 also improved the total brainwave power, as well as the theta and alpha wave activity, specifically, and restored the delta band power to levels similar to those observed in the controls. Treatment with G1 also attenuated the peaks of harmful activity observed in the EEG indices. These improvements in brainwave activity indicate that GPER1 plays a fundamental role in the mediation of cerebral injury and in the behavioral outcome of ischemic brain injuries, which points to treatment with G1 as a potential pharmacological strategy for the therapy of stroke.
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spelling Ferreira, Luan OliveiraSouza, Rafael Dias deTeixeira, Leonan LimaPinto, Laine CelestinoRodrigues, João Cleiton MartinsMartins Filho, Arnaldo JorgeCosta, Edmar Tavares daHamoy, MoisésLopes, Dielly Catrina Favacho2023-08-21T17:46:25Z2023-08-21T17:46:25Z2023FERREIRA, Luan Oliveira et al. The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke. Journal of Neuropathology & Experimental Neurology, v. 82, n. 9, p. 787-797, Sept. 2023. DOI: https://doi.org/10.1093/jnen/nlad061.1554-6578https://patua.iec.gov.br/handle/iec/689510.1093/jnen/nlad061Stroke is one of the principal cerebrovascular diseases in human populations and contributes to a majority of the functional impairments in the elderly. Recent discoveries have led to the inclusion of electroencephalography (EEG) in the complementary prognostic evaluation of patients. The present study describes the EEG, behavioral, and histological changes that occur following cerebral ischemia associated with treatment by G1, a potent and selective G protein-coupled estrogen receptor 1 (GPER1) agonist in a rat model. Treatment with G1 attenuated the neurological deficits induced by ischemic stroke from the second day onward, and reduced areas of infarction. Treatment with G1 also improved the total brainwave power, as well as the theta and alpha wave activity, specifically, and restored the delta band power to levels similar to those observed in the controls. Treatment with G1 also attenuated the peaks of harmful activity observed in the EEG indices. These improvements in brainwave activity indicate that GPER1 plays a fundamental role in the mediation of cerebral injury and in the behavioral outcome of ischemic brain injuries, which points to treatment with G1 as a potential pharmacological strategy for the therapy of stroke.PROPESP-UFPAFederal University of Pará. Joao de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.Federal University of Pará. Joao de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.Federal University of Pará. Joao de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.Federal University of Pará. Joao de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.Federal University of Pará. Joao de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Federal University of Pará. Joao de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.Federal University of Pará. Biological Sciences Institute. Laboratory of Pharmacology and Toxicology of Natural Products. Belém, PA, Brazil.Federal University of Pará. Joao de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. 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dc.title.pt_BR.fl_str_mv The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke
title The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke
spellingShingle The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke
Ferreira, Luan Oliveira
Sistema Nervoso Central
Acidente Vascular Cerebral / tratamento farmacológico
Isquemia Encefálica
Eletroencefalografia / métodos
Neurofarmacologia / métodos
title_short The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke
title_full The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke
title_fullStr The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke
title_full_unstemmed The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke
title_sort The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke
author Ferreira, Luan Oliveira
author_facet Ferreira, Luan Oliveira
Souza, Rafael Dias de
Teixeira, Leonan Lima
Pinto, Laine Celestino
Rodrigues, João Cleiton Martins
Martins Filho, Arnaldo Jorge
Costa, Edmar Tavares da
Hamoy, Moisés
Lopes, Dielly Catrina Favacho
author_role author
author2 Souza, Rafael Dias de
Teixeira, Leonan Lima
Pinto, Laine Celestino
Rodrigues, João Cleiton Martins
Martins Filho, Arnaldo Jorge
Costa, Edmar Tavares da
Hamoy, Moisés
Lopes, Dielly Catrina Favacho
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, Luan Oliveira
Souza, Rafael Dias de
Teixeira, Leonan Lima
Pinto, Laine Celestino
Rodrigues, João Cleiton Martins
Martins Filho, Arnaldo Jorge
Costa, Edmar Tavares da
Hamoy, Moisés
Lopes, Dielly Catrina Favacho
dc.subject.decsPrimary.pt_BR.fl_str_mv Sistema Nervoso Central
Acidente Vascular Cerebral / tratamento farmacológico
Isquemia Encefálica
Eletroencefalografia / métodos
Neurofarmacologia / métodos
topic Sistema Nervoso Central
Acidente Vascular Cerebral / tratamento farmacológico
Isquemia Encefálica
Eletroencefalografia / métodos
Neurofarmacologia / métodos
description Stroke is one of the principal cerebrovascular diseases in human populations and contributes to a majority of the functional impairments in the elderly. Recent discoveries have led to the inclusion of electroencephalography (EEG) in the complementary prognostic evaluation of patients. The present study describes the EEG, behavioral, and histological changes that occur following cerebral ischemia associated with treatment by G1, a potent and selective G protein-coupled estrogen receptor 1 (GPER1) agonist in a rat model. Treatment with G1 attenuated the neurological deficits induced by ischemic stroke from the second day onward, and reduced areas of infarction. Treatment with G1 also improved the total brainwave power, as well as the theta and alpha wave activity, specifically, and restored the delta band power to levels similar to those observed in the controls. Treatment with G1 also attenuated the peaks of harmful activity observed in the EEG indices. These improvements in brainwave activity indicate that GPER1 plays a fundamental role in the mediation of cerebral injury and in the behavioral outcome of ischemic brain injuries, which points to treatment with G1 as a potential pharmacological strategy for the therapy of stroke.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-08-21T17:46:25Z
dc.date.available.fl_str_mv 2023-08-21T17:46:25Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv FERREIRA, Luan Oliveira et al. The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke. Journal of Neuropathology & Experimental Neurology, v. 82, n. 9, p. 787-797, Sept. 2023. DOI: https://doi.org/10.1093/jnen/nlad061.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/6895
dc.identifier.issn.-.fl_str_mv 1554-6578
dc.identifier.doi.pt_BR.fl_str_mv 10.1093/jnen/nlad061
identifier_str_mv FERREIRA, Luan Oliveira et al. The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke. Journal of Neuropathology & Experimental Neurology, v. 82, n. 9, p. 787-797, Sept. 2023. DOI: https://doi.org/10.1093/jnen/nlad061.
1554-6578
10.1093/jnen/nlad061
url https://patua.iec.gov.br/handle/iec/6895
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