Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/4295 |
Resumo: | The present study describes the electroencephalographic changes that occur during cerebral ischemia and reperfusion in animals submitted to transient focal cerebral ischemia by middle cerebral artery occlusion (MCAO) for 30 min. For this, male Wistar rats were divided into two groups (n = 6 animals/group): (1) sham (control) group, and (2) ischemic/reperfusion group. The quantitative electroencephalography (qEEG) was recorded during the ischemic and immediate reperfusion (acute) phases, and then once a day for 7 days after the MCAO (subacute phase). The acute phase was characterized by a marked increase in the relative delta wave band power (p < 0.001), with a smaller, but significant increase in the relative alpha wave bandpower in the ischemic stroke phase, in comparison with the control group (p = 0.0054). In the immediate reperfusion phase, however, there was an increase in the theta, alpha, and beta waves bandpower (p < 0.001), but no alteration in the delta waves (p = 0.9984), in comparison with the control group. We also observed high values in the delta/theta ratio (DTR), the delta/alpha ratio (DAR), and the (delta+theta)/(alpha+beta) ratio (DTABR) indices during the ischemia (p < 0.05), with a major reduction in the reperfusion phase. In the subacute phase, the activity of all the waves was lower than that of the control group (p < 0.05), although the DTR, DAR, and DTABR indices remained relatively high. In conclusion, early and accurate identification of decreased delta wave bandpower, DTR, DAR, and DTABR indices, and an increase in the activity of other waves in the immediate reperfusion phase may represent an important advance for the recognition of the effectiveness of reperfusion therapy. |
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Ferreira, Luan OliveiraMattos, Bruna GerritsMello, Vanessa Jóia deMartins Filho, Arnaldo JorgeCosta, Edmar Tavares daYamada, Elizabeth SumiHamoy, MoisésLopes, Dielly Catrina Favacho2021-04-20T11:30:34Z2021-04-20T11:30:34Z2021FERREIRA, Luan Oliveira et al. Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion. Frontiers in Neurology, v. 12, n. 645138, Apr. 2021.1664-2295https://patua.iec.gov.br/handle/iec/429510.3389/fneur.2021.645138The present study describes the electroencephalographic changes that occur during cerebral ischemia and reperfusion in animals submitted to transient focal cerebral ischemia by middle cerebral artery occlusion (MCAO) for 30 min. For this, male Wistar rats were divided into two groups (n = 6 animals/group): (1) sham (control) group, and (2) ischemic/reperfusion group. The quantitative electroencephalography (qEEG) was recorded during the ischemic and immediate reperfusion (acute) phases, and then once a day for 7 days after the MCAO (subacute phase). The acute phase was characterized by a marked increase in the relative delta wave band power (p < 0.001), with a smaller, but significant increase in the relative alpha wave bandpower in the ischemic stroke phase, in comparison with the control group (p = 0.0054). In the immediate reperfusion phase, however, there was an increase in the theta, alpha, and beta waves bandpower (p < 0.001), but no alteration in the delta waves (p = 0.9984), in comparison with the control group. We also observed high values in the delta/theta ratio (DTR), the delta/alpha ratio (DAR), and the (delta+theta)/(alpha+beta) ratio (DTABR) indices during the ischemia (p < 0.05), with a major reduction in the reperfusion phase. In the subacute phase, the activity of all the waves was lower than that of the control group (p < 0.05), although the DTR, DAR, and DTABR indices remained relatively high. In conclusion, early and accurate identification of decreased delta wave bandpower, DTR, DAR, and DTABR indices, and an increase in the activity of other waves in the immediate reperfusion phase may represent an important advance for the recognition of the effectiveness of reperfusion therapy.This work was funded in part by PROPESP-UFPA.Federal University of Pará. João de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.Federal University of Pará. João de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.Federal University of Pará. Institute Biological Science. Laboratory of Pharmacology and Toxicology of Natural Products. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Federal University of Pará. João de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.Federal University of Pará. João de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.Federal University of Pará. Institute Biological Science. Laboratory of Pharmacology and Toxicology of Natural Products. Belém, PA, Brazil.Federal University of Pará. João de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.engFrontiers MediaIncreased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleIsquemia Encefálica / veterináriaAcidente Vascular CerebralInfarto da Artéria Cerebral MédiaReperfusãoLesões EncefálicasEletroencefalografia / métodosinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALIncreased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion.pdfIncreased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion.pdfapplication/pdf1695791https://patua.iec.gov.br/bitstreams/708ed6a7-1b49-4280-91e8-4dbfa1f3df0e/downloadd89868eebf78e697eb64a8e0293101deMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/94ca85df-3ff6-4b7d-bb2d-c63e66d56b82/download11832eea31b16df8613079d742d61793MD52TEXTIncreased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion.pdf.txtIncreased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion.pdf.txtExtracted texttext/plain57947https://patua.iec.gov.br/bitstreams/1b5085d1-c79f-4c30-90ae-b9d491a4f15e/download344a327dc44a6f37381d79cf6fdc4bf2MD55THUMBNAILIncreased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion.pdf.jpgIncreased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion.pdf.jpgGenerated Thumbnailimage/jpeg5867https://patua.iec.gov.br/bitstreams/9c1d4881-a249-48b3-95b0-d7801fc86511/downloadd0a3a2a17d81adaa61c13da476c915a8MD56iec/42952022-10-20 21:08:21.941oai:patua.iec.gov.br:iec/4295https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T21:08:21Repositório Digital do Instituto Evandro Chagas (Patuá) - 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dc.title.pt_BR.fl_str_mv |
Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion |
title |
Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion |
spellingShingle |
Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion Ferreira, Luan Oliveira Isquemia Encefálica / veterinária Acidente Vascular Cerebral Infarto da Artéria Cerebral Média Reperfusão Lesões Encefálicas Eletroencefalografia / métodos |
title_short |
Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion |
title_full |
Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion |
title_fullStr |
Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion |
title_full_unstemmed |
Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion |
title_sort |
Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion |
author |
Ferreira, Luan Oliveira |
author_facet |
Ferreira, Luan Oliveira Mattos, Bruna Gerrits Mello, Vanessa Jóia de Martins Filho, Arnaldo Jorge Costa, Edmar Tavares da Yamada, Elizabeth Sumi Hamoy, Moisés Lopes, Dielly Catrina Favacho |
author_role |
author |
author2 |
Mattos, Bruna Gerrits Mello, Vanessa Jóia de Martins Filho, Arnaldo Jorge Costa, Edmar Tavares da Yamada, Elizabeth Sumi Hamoy, Moisés Lopes, Dielly Catrina Favacho |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Ferreira, Luan Oliveira Mattos, Bruna Gerrits Mello, Vanessa Jóia de Martins Filho, Arnaldo Jorge Costa, Edmar Tavares da Yamada, Elizabeth Sumi Hamoy, Moisés Lopes, Dielly Catrina Favacho |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Isquemia Encefálica / veterinária Acidente Vascular Cerebral Infarto da Artéria Cerebral Média Reperfusão Lesões Encefálicas Eletroencefalografia / métodos |
topic |
Isquemia Encefálica / veterinária Acidente Vascular Cerebral Infarto da Artéria Cerebral Média Reperfusão Lesões Encefálicas Eletroencefalografia / métodos |
description |
The present study describes the electroencephalographic changes that occur during cerebral ischemia and reperfusion in animals submitted to transient focal cerebral ischemia by middle cerebral artery occlusion (MCAO) for 30 min. For this, male Wistar rats were divided into two groups (n = 6 animals/group): (1) sham (control) group, and (2) ischemic/reperfusion group. The quantitative electroencephalography (qEEG) was recorded during the ischemic and immediate reperfusion (acute) phases, and then once a day for 7 days after the MCAO (subacute phase). The acute phase was characterized by a marked increase in the relative delta wave band power (p < 0.001), with a smaller, but significant increase in the relative alpha wave bandpower in the ischemic stroke phase, in comparison with the control group (p = 0.0054). In the immediate reperfusion phase, however, there was an increase in the theta, alpha, and beta waves bandpower (p < 0.001), but no alteration in the delta waves (p = 0.9984), in comparison with the control group. We also observed high values in the delta/theta ratio (DTR), the delta/alpha ratio (DAR), and the (delta+theta)/(alpha+beta) ratio (DTABR) indices during the ischemia (p < 0.05), with a major reduction in the reperfusion phase. In the subacute phase, the activity of all the waves was lower than that of the control group (p < 0.05), although the DTR, DAR, and DTABR indices remained relatively high. In conclusion, early and accurate identification of decreased delta wave bandpower, DTR, DAR, and DTABR indices, and an increase in the activity of other waves in the immediate reperfusion phase may represent an important advance for the recognition of the effectiveness of reperfusion therapy. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-04-20T11:30:34Z |
dc.date.available.fl_str_mv |
2021-04-20T11:30:34Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FERREIRA, Luan Oliveira et al. Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion. Frontiers in Neurology, v. 12, n. 645138, Apr. 2021. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/4295 |
dc.identifier.issn.-.fl_str_mv |
1664-2295 |
dc.identifier.doi.-.fl_str_mv |
10.3389/fneur.2021.645138 |
identifier_str_mv |
FERREIRA, Luan Oliveira et al. Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion. Frontiers in Neurology, v. 12, n. 645138, Apr. 2021. 1664-2295 10.3389/fneur.2021.645138 |
url |
https://patua.iec.gov.br/handle/iec/4295 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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