Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion

Detalhes bibliográficos
Autor(a) principal: Ferreira, Luan Oliveira
Data de Publicação: 2021
Outros Autores: Mattos, Bruna Gerrits, Mello, Vanessa Jóia de, Martins Filho, Arnaldo Jorge, Costa, Edmar Tavares da, Yamada, Elizabeth Sumi, Hamoy, Moisés, Lopes, Dielly Catrina Favacho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/4295
Resumo: The present study describes the electroencephalographic changes that occur during cerebral ischemia and reperfusion in animals submitted to transient focal cerebral ischemia by middle cerebral artery occlusion (MCAO) for 30 min. For this, male Wistar rats were divided into two groups (n = 6 animals/group): (1) sham (control) group, and (2) ischemic/reperfusion group. The quantitative electroencephalography (qEEG) was recorded during the ischemic and immediate reperfusion (acute) phases, and then once a day for 7 days after the MCAO (subacute phase). The acute phase was characterized by a marked increase in the relative delta wave band power (p < 0.001), with a smaller, but significant increase in the relative alpha wave bandpower in the ischemic stroke phase, in comparison with the control group (p = 0.0054). In the immediate reperfusion phase, however, there was an increase in the theta, alpha, and beta waves bandpower (p < 0.001), but no alteration in the delta waves (p = 0.9984), in comparison with the control group. We also observed high values in the delta/theta ratio (DTR), the delta/alpha ratio (DAR), and the (delta+theta)/(alpha+beta) ratio (DTABR) indices during the ischemia (p < 0.05), with a major reduction in the reperfusion phase. In the subacute phase, the activity of all the waves was lower than that of the control group (p < 0.05), although the DTR, DAR, and DTABR indices remained relatively high. In conclusion, early and accurate identification of decreased delta wave bandpower, DTR, DAR, and DTABR indices, and an increase in the activity of other waves in the immediate reperfusion phase may represent an important advance for the recognition of the effectiveness of reperfusion therapy.
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spelling Ferreira, Luan OliveiraMattos, Bruna GerritsMello, Vanessa Jóia deMartins Filho, Arnaldo JorgeCosta, Edmar Tavares daYamada, Elizabeth SumiHamoy, MoisésLopes, Dielly Catrina Favacho2021-04-20T11:30:34Z2021-04-20T11:30:34Z2021FERREIRA, Luan Oliveira et al. Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion. Frontiers in Neurology, v. 12, n. 645138, Apr. 2021.1664-2295https://patua.iec.gov.br/handle/iec/429510.3389/fneur.2021.645138The present study describes the electroencephalographic changes that occur during cerebral ischemia and reperfusion in animals submitted to transient focal cerebral ischemia by middle cerebral artery occlusion (MCAO) for 30 min. For this, male Wistar rats were divided into two groups (n = 6 animals/group): (1) sham (control) group, and (2) ischemic/reperfusion group. The quantitative electroencephalography (qEEG) was recorded during the ischemic and immediate reperfusion (acute) phases, and then once a day for 7 days after the MCAO (subacute phase). The acute phase was characterized by a marked increase in the relative delta wave band power (p < 0.001), with a smaller, but significant increase in the relative alpha wave bandpower in the ischemic stroke phase, in comparison with the control group (p = 0.0054). In the immediate reperfusion phase, however, there was an increase in the theta, alpha, and beta waves bandpower (p < 0.001), but no alteration in the delta waves (p = 0.9984), in comparison with the control group. We also observed high values in the delta/theta ratio (DTR), the delta/alpha ratio (DAR), and the (delta+theta)/(alpha+beta) ratio (DTABR) indices during the ischemia (p < 0.05), with a major reduction in the reperfusion phase. In the subacute phase, the activity of all the waves was lower than that of the control group (p < 0.05), although the DTR, DAR, and DTABR indices remained relatively high. In conclusion, early and accurate identification of decreased delta wave bandpower, DTR, DAR, and DTABR indices, and an increase in the activity of other waves in the immediate reperfusion phase may represent an important advance for the recognition of the effectiveness of reperfusion therapy.This work was funded in part by PROPESP-UFPA.Federal University of Pará. João de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.Federal University of Pará. João de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.Federal University of Pará. Institute Biological Science. Laboratory of Pharmacology and Toxicology of Natural Products. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Federal University of Pará. João de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.Federal University of Pará. João de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.Federal University of Pará. Institute Biological Science. Laboratory of Pharmacology and Toxicology of Natural Products. Belém, PA, Brazil.Federal University of Pará. João de Barros Barreto University Hospital. Laboratory of Experimental Neuropathology. Belém, PA, Brazil.engFrontiers MediaIncreased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleIsquemia Encefálica / veterináriaAcidente Vascular CerebralInfarto da Artéria Cerebral MédiaReperfusãoLesões EncefálicasEletroencefalografia / métodosinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALIncreased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion.pdfIncreased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion.pdfapplication/pdf1695791https://patua.iec.gov.br/bitstreams/708ed6a7-1b49-4280-91e8-4dbfa1f3df0e/downloadd89868eebf78e697eb64a8e0293101deMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/94ca85df-3ff6-4b7d-bb2d-c63e66d56b82/download11832eea31b16df8613079d742d61793MD52TEXTIncreased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion.pdf.txtIncreased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion.pdf.txtExtracted texttext/plain57947https://patua.iec.gov.br/bitstreams/1b5085d1-c79f-4c30-90ae-b9d491a4f15e/download344a327dc44a6f37381d79cf6fdc4bf2MD55THUMBNAILIncreased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion.pdf.jpgIncreased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion.pdf.jpgGenerated Thumbnailimage/jpeg5867https://patua.iec.gov.br/bitstreams/9c1d4881-a249-48b3-95b0-d7801fc86511/downloadd0a3a2a17d81adaa61c13da476c915a8MD56iec/42952022-10-20 21:08:21.941oai:patua.iec.gov.br:iec/4295https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T21:08:21Repositório Digital do Instituto Evandro Chagas (Patuá) - 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dc.title.pt_BR.fl_str_mv Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion
title Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion
spellingShingle Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion
Ferreira, Luan Oliveira
Isquemia Encefálica / veterinária
Acidente Vascular Cerebral
Infarto da Artéria Cerebral Média
Reperfusão
Lesões Encefálicas
Eletroencefalografia / métodos
title_short Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion
title_full Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion
title_fullStr Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion
title_full_unstemmed Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion
title_sort Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion
author Ferreira, Luan Oliveira
author_facet Ferreira, Luan Oliveira
Mattos, Bruna Gerrits
Mello, Vanessa Jóia de
Martins Filho, Arnaldo Jorge
Costa, Edmar Tavares da
Yamada, Elizabeth Sumi
Hamoy, Moisés
Lopes, Dielly Catrina Favacho
author_role author
author2 Mattos, Bruna Gerrits
Mello, Vanessa Jóia de
Martins Filho, Arnaldo Jorge
Costa, Edmar Tavares da
Yamada, Elizabeth Sumi
Hamoy, Moisés
Lopes, Dielly Catrina Favacho
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, Luan Oliveira
Mattos, Bruna Gerrits
Mello, Vanessa Jóia de
Martins Filho, Arnaldo Jorge
Costa, Edmar Tavares da
Yamada, Elizabeth Sumi
Hamoy, Moisés
Lopes, Dielly Catrina Favacho
dc.subject.decsPrimary.pt_BR.fl_str_mv Isquemia Encefálica / veterinária
Acidente Vascular Cerebral
Infarto da Artéria Cerebral Média
Reperfusão
Lesões Encefálicas
Eletroencefalografia / métodos
topic Isquemia Encefálica / veterinária
Acidente Vascular Cerebral
Infarto da Artéria Cerebral Média
Reperfusão
Lesões Encefálicas
Eletroencefalografia / métodos
description The present study describes the electroencephalographic changes that occur during cerebral ischemia and reperfusion in animals submitted to transient focal cerebral ischemia by middle cerebral artery occlusion (MCAO) for 30 min. For this, male Wistar rats were divided into two groups (n = 6 animals/group): (1) sham (control) group, and (2) ischemic/reperfusion group. The quantitative electroencephalography (qEEG) was recorded during the ischemic and immediate reperfusion (acute) phases, and then once a day for 7 days after the MCAO (subacute phase). The acute phase was characterized by a marked increase in the relative delta wave band power (p < 0.001), with a smaller, but significant increase in the relative alpha wave bandpower in the ischemic stroke phase, in comparison with the control group (p = 0.0054). In the immediate reperfusion phase, however, there was an increase in the theta, alpha, and beta waves bandpower (p < 0.001), but no alteration in the delta waves (p = 0.9984), in comparison with the control group. We also observed high values in the delta/theta ratio (DTR), the delta/alpha ratio (DAR), and the (delta+theta)/(alpha+beta) ratio (DTABR) indices during the ischemia (p < 0.05), with a major reduction in the reperfusion phase. In the subacute phase, the activity of all the waves was lower than that of the control group (p < 0.05), although the DTR, DAR, and DTABR indices remained relatively high. In conclusion, early and accurate identification of decreased delta wave bandpower, DTR, DAR, and DTABR indices, and an increase in the activity of other waves in the immediate reperfusion phase may represent an important advance for the recognition of the effectiveness of reperfusion therapy.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-04-20T11:30:34Z
dc.date.available.fl_str_mv 2021-04-20T11:30:34Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERREIRA, Luan Oliveira et al. Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion. Frontiers in Neurology, v. 12, n. 645138, Apr. 2021.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/4295
dc.identifier.issn.-.fl_str_mv 1664-2295
dc.identifier.doi.-.fl_str_mv 10.3389/fneur.2021.645138
identifier_str_mv FERREIRA, Luan Oliveira et al. Increased relative delta bandpower and delta indices revealed by continuous qEEG monitoring in a rat model of ischemia-reperfusion. Frontiers in Neurology, v. 12, n. 645138, Apr. 2021.
1664-2295
10.3389/fneur.2021.645138
url https://patua.iec.gov.br/handle/iec/4295
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