Differential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-Cell response during Leishmania (Viannia) braziliensis or Leishmania (Leishmania) amazonensis infection
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/2483 |
Resumo: | Leishmania (L.) amazonensis (La) and L. (V.) braziliensis (Lb) are responsible for a large clinical and immunopathological spectrum in human disease; while La may be responsible for anergic disease, Lb infection leads to cellular hypersensitivity. To better understand the dichotomy in the immune response caused by these Leishmania species, we evaluated subsets of dendritic cells (DCs) and T lymphocyte in draining lymph nodes during the course of La and Lb infection in BALB/c mice. Our results demonstrated a high involvement of DCs in La infection, which was characterized by the greater accumulation of Langerhans cells (LCs); conversely, Lb infection led to an increase in dermal DCs (dDCs) throughout the infection. Considering the T lymphocyte response, an increase of effector, activated, and memory CD4+ T-cells was observed in Lb infection. Interleukin- (IL-) 4- and IL-10-producing CD4+ and CD8+ T-cells were present in both La and Lb infection; however, interferon- (IFN-) γ-producing CD4+ and CD8+ T-cells were detected only in Lb infection. The results suggest that during Lb infection, the dDCs were the predominant subset of DCs that in turn was associated with the development of Th1 immune response; in contrast La infection was associated with a preferential accumulation of LCs and total blockage of the development of Th1 immune response. |
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Carvalho, Ana KelyCarvalho, Karina IPassero, L. Felipe DSousa, M. G. TMatta, Vania L. R. daGomes, Claúdia M. CCorbett, Carlos Eduardo PereiraKallas, G. EsperSilveira, Fernando TobiasLaurent, Marcia Dalastra2017-02-07T14:31:51Z2017-02-07T14:31:51Z2016CARVALHO, Ana Kely et al. Differential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-Cell response during Leishmania (Viannia) braziliensis or Leishmania (Leishmania) amazonensis infection. Mediators of Inflammation, v. 2016, n. ID 706828, p. 1-12, 2016. DOI: https://doi.org/10.1155/2016/7068287. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814687/pdf/MI2016-7068287.pdf1466-1861https://patua.iec.gov.br/handle/iec/248310.1155/2016/7068287Leishmania (L.) amazonensis (La) and L. (V.) braziliensis (Lb) are responsible for a large clinical and immunopathological spectrum in human disease; while La may be responsible for anergic disease, Lb infection leads to cellular hypersensitivity. To better understand the dichotomy in the immune response caused by these Leishmania species, we evaluated subsets of dendritic cells (DCs) and T lymphocyte in draining lymph nodes during the course of La and Lb infection in BALB/c mice. Our results demonstrated a high involvement of DCs in La infection, which was characterized by the greater accumulation of Langerhans cells (LCs); conversely, Lb infection led to an increase in dermal DCs (dDCs) throughout the infection. Considering the T lymphocyte response, an increase of effector, activated, and memory CD4+ T-cells was observed in Lb infection. Interleukin- (IL-) 4- and IL-10-producing CD4+ and CD8+ T-cells were present in both La and Lb infection; however, interferon- (IFN-) γ-producing CD4+ and CD8+ T-cells were detected only in Lb infection. The results suggest that during Lb infection, the dDCs were the predominant subset of DCs that in turn was associated with the development of Th1 immune response; in contrast La infection was associated with a preferential accumulation of LCs and total blockage of the development of Th1 immune response.University of São Paulo. Medical School. Laboratory of Pathology of Infectious Diseases. São Paulo, SP, Brazil.University of São Paulo. Medical School. Laboratory of Pathology of Infectious Diseases. São Paulo, SP, Brazil.University of São Paulo. Medical School. Laboratory of Pathology of Infectious Diseases. São Paulo, SP, Brazil.University of São Paulo. Medical School. Laboratory of Pathology of Infectious Diseases. São Paulo, SP, Brazil.University of São Paulo. Medical School. Laboratory of Pathology of Infectious Diseases. São Paulo, SP, Brazil.University of São Paulo. Medical School. Laboratory of Pathology of Infectious Diseases. São Paulo, SP, Brazil.University of São Paulo. Medical School. Laboratory of Pathology of Infectious Diseases. São Paulo, SP, Brazil.University of São Paulo. Medical School. Laboratory of Immunology. São Paulo, SP, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brazil / Federal University of Para. Tropical Medicine Nucleus. Belem, PA, Brazil.University of São Paulo. Medical School. Laboratory of Pathology of Infectious Diseases. São Paulo, SP, Brazil.engHindawi Publishing CorporationDifferential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-Cell response during Leishmania (Viannia) braziliensis or Leishmania (Leishmania) amazonensis infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLeishmaniaLeishmania braziliensisCélulas DendríticasLinfonodosLinfócitos TLeishmaniose Cutâneainfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECTHUMBNAILDifferential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-Cell response during Leishmania (Viannia) braziliensis or Leishmania (Leishmania) amazonensis infection.pdf.jpgDifferential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-Cell response during Leishmania (Viannia) braziliensis or Leishmania (Leishmania) amazonensis infection.pdf.jpgGenerated Thumbnailimage/jpeg5589https://patua.iec.gov.br/bitstreams/9419ccfb-0082-4b9f-b11e-95c7971e433a/download37b3aaaf8a2c27345b251e5545c8e8ffMD57ORIGINALDifferential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-Cell response during Leishmania (Viannia) braziliensis or Leishmania (Leishmania) amazonensis infection.pdfDifferential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-Cell response during Leishmania (Viannia) braziliensis or Leishmania (Leishmania) amazonensis infection.pdfapplication/pdf2335383https://patua.iec.gov.br/bitstreams/7f868eda-7a7c-45bd-b30e-32a85a6632b6/download25ab351ab2228bfcb9c1a4e1976bd5d0MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/37ade857-3f10-4383-aba0-2e8f56a179d9/download52f1732ea66fbd1123abe39f5373b797MD52TEXTDifferential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-cell response during Leishmania (Viannia) Braziliensis or Leishmania (Leishmania) Amazonensis Infection.pdf.txtDifferential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-cell response during Leishmania (Viannia) Braziliensis or Leishmania (Leishmania) Amazonensis Infection.pdf.txtExtracted texttext/plain50958https://patua.iec.gov.br/bitstreams/c6d6aabc-f73e-48ba-85e4-74506e5dec7d/downloada3db324781a73674c8181c76c521e618MD53Differential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-Cell response during Leishmania (Viannia) braziliensis or Leishmania (Leishmania) amazonensis infection.pdf.txtDifferential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-Cell response during Leishmania (Viannia) braziliensis or Leishmania (Leishmania) amazonensis infection.pdf.txtExtracted texttext/plain51584https://patua.iec.gov.br/bitstreams/9ad0bb54-cb0a-4c34-835e-5142f79fb837/download0bbb8f3cc7ef700504cfb64199e12ba2MD56iec/24832023-05-10 12:19:21.237oai:patua.iec.gov.br:iec/2483https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2023-05-10T12:19:21Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4= |
dc.title.pt_BR.fl_str_mv |
Differential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-Cell response during Leishmania (Viannia) braziliensis or Leishmania (Leishmania) amazonensis infection |
title |
Differential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-Cell response during Leishmania (Viannia) braziliensis or Leishmania (Leishmania) amazonensis infection |
spellingShingle |
Differential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-Cell response during Leishmania (Viannia) braziliensis or Leishmania (Leishmania) amazonensis infection Carvalho, Ana Kely Leishmania Leishmania braziliensis Células Dendríticas Linfonodos Linfócitos T Leishmaniose Cutânea |
title_short |
Differential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-Cell response during Leishmania (Viannia) braziliensis or Leishmania (Leishmania) amazonensis infection |
title_full |
Differential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-Cell response during Leishmania (Viannia) braziliensis or Leishmania (Leishmania) amazonensis infection |
title_fullStr |
Differential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-Cell response during Leishmania (Viannia) braziliensis or Leishmania (Leishmania) amazonensis infection |
title_full_unstemmed |
Differential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-Cell response during Leishmania (Viannia) braziliensis or Leishmania (Leishmania) amazonensis infection |
title_sort |
Differential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-Cell response during Leishmania (Viannia) braziliensis or Leishmania (Leishmania) amazonensis infection |
author |
Carvalho, Ana Kely |
author_facet |
Carvalho, Ana Kely Carvalho, Karina I Passero, L. Felipe D Sousa, M. G. T Matta, Vania L. R. da Gomes, Claúdia M. C Corbett, Carlos Eduardo Pereira Kallas, G. Esper Silveira, Fernando Tobias Laurent, Marcia Dalastra |
author_role |
author |
author2 |
Carvalho, Karina I Passero, L. Felipe D Sousa, M. G. T Matta, Vania L. R. da Gomes, Claúdia M. C Corbett, Carlos Eduardo Pereira Kallas, G. Esper Silveira, Fernando Tobias Laurent, Marcia Dalastra |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Carvalho, Ana Kely Carvalho, Karina I Passero, L. Felipe D Sousa, M. G. T Matta, Vania L. R. da Gomes, Claúdia M. C Corbett, Carlos Eduardo Pereira Kallas, G. Esper Silveira, Fernando Tobias Laurent, Marcia Dalastra |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Leishmania Leishmania braziliensis Células Dendríticas Linfonodos Linfócitos T Leishmaniose Cutânea |
topic |
Leishmania Leishmania braziliensis Células Dendríticas Linfonodos Linfócitos T Leishmaniose Cutânea |
description |
Leishmania (L.) amazonensis (La) and L. (V.) braziliensis (Lb) are responsible for a large clinical and immunopathological spectrum in human disease; while La may be responsible for anergic disease, Lb infection leads to cellular hypersensitivity. To better understand the dichotomy in the immune response caused by these Leishmania species, we evaluated subsets of dendritic cells (DCs) and T lymphocyte in draining lymph nodes during the course of La and Lb infection in BALB/c mice. Our results demonstrated a high involvement of DCs in La infection, which was characterized by the greater accumulation of Langerhans cells (LCs); conversely, Lb infection led to an increase in dermal DCs (dDCs) throughout the infection. Considering the T lymphocyte response, an increase of effector, activated, and memory CD4+ T-cells was observed in Lb infection. Interleukin- (IL-) 4- and IL-10-producing CD4+ and CD8+ T-cells were present in both La and Lb infection; however, interferon- (IFN-) γ-producing CD4+ and CD8+ T-cells were detected only in Lb infection. The results suggest that during Lb infection, the dDCs were the predominant subset of DCs that in turn was associated with the development of Th1 immune response; in contrast La infection was associated with a preferential accumulation of LCs and total blockage of the development of Th1 immune response. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-02-07T14:31:51Z |
dc.date.available.fl_str_mv |
2017-02-07T14:31:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CARVALHO, Ana Kely et al. Differential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-Cell response during Leishmania (Viannia) braziliensis or Leishmania (Leishmania) amazonensis infection. Mediators of Inflammation, v. 2016, n. ID 706828, p. 1-12, 2016. DOI: https://doi.org/10.1155/2016/7068287. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814687/pdf/MI2016-7068287.pdf |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/2483 |
dc.identifier.issn.-.fl_str_mv |
1466-1861 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1155/2016/7068287 |
identifier_str_mv |
CARVALHO, Ana Kely et al. Differential recruitment of dendritic cells subsets to lymph nodes correlates with a protective or permissive T-Cell response during Leishmania (Viannia) braziliensis or Leishmania (Leishmania) amazonensis infection. Mediators of Inflammation, v. 2016, n. ID 706828, p. 1-12, 2016. DOI: https://doi.org/10.1155/2016/7068287. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814687/pdf/MI2016-7068287.pdf 1466-1861 10.1155/2016/7068287 |
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https://patua.iec.gov.br/handle/iec/2483 |
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Hindawi Publishing Corporation |
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Hindawi Publishing Corporation |
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