Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | http://patua.iec.gov.br//handle/iec/2962 |
Resumo: | The aim of this study was to determine the distribution of HIV-1 subtypes in patients undergoing highly active antiretroviral therapy (HAART) therapeutic failure in Amazonas and Pará, two States in northern Brazil, from 2002 to 2006. This study was performed using plasma collected from individuals with human immunodeficiency virus-1 (HIV-1) and/or acquired immunodeficiency syndrome (AIDS) who were selected from the National Genotyping Network (Rede Nacional de Genotipagem – RENAGENO). From 2002 to 2006, a total of 127 plasma samples from the States of Amazonas and Pará, in northern Brazil, were obtained from AIDS and/or HIV-positive patients and subjected to genotyping and resistance testing TM using the ViroSeq Genotyping System kit. Using the genetic information obtained from the HIV-1 protease and/or reverse transcriptase regions, HIV-1 subtype B was identified in 85% of the cases, followed by subtype F1 (4.6%) and the recombinant forms BF1 (4.6%) and CF1 (0.8%). The results of this study were similar to the results of other studies conducted in other regions of Brazil, with the exception of the detection of recombinant CF1, which was described for the first time in the Amazon Region. |
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Macêdo, OlindaFerreira, Luciana MacedoLopes, Carmen Andréa FreitasSousa, Rita Catarina MedeirosAraújo, José Ricardo MourãoVasconcelos, Pedro Fernando da Costa2018-02-19T13:29:41Z2018-02-19T13:29:41Z2012MACÊDO, Olinda et al.Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006. Revista Pan-Amazônica de Saúde, v. 3, n. 2, p. 11-16, jun. 2012. Disponível em: <http://scielo.iec.gov.br/pdf/rpas/v3n2/v3n2a02.pdf>. Acesso em: 26 fev. 2018.2176-6223http://patua.iec.gov.br//handle/iec/296210.5123/S2176-62232012000200002The aim of this study was to determine the distribution of HIV-1 subtypes in patients undergoing highly active antiretroviral therapy (HAART) therapeutic failure in Amazonas and Pará, two States in northern Brazil, from 2002 to 2006. This study was performed using plasma collected from individuals with human immunodeficiency virus-1 (HIV-1) and/or acquired immunodeficiency syndrome (AIDS) who were selected from the National Genotyping Network (Rede Nacional de Genotipagem – RENAGENO). From 2002 to 2006, a total of 127 plasma samples from the States of Amazonas and Pará, in northern Brazil, were obtained from AIDS and/or HIV-positive patients and subjected to genotyping and resistance testing TM using the ViroSeq Genotyping System kit. Using the genetic information obtained from the HIV-1 protease and/or reverse transcriptase regions, HIV-1 subtype B was identified in 85% of the cases, followed by subtype F1 (4.6%) and the recombinant forms BF1 (4.6%) and CF1 (0.8%). The results of this study were similar to the results of other studies conducted in other regions of Brazil, with the exception of the detection of recombinant CF1, which was described for the first time in the Amazon Region.O objetivo deste estudo foi determinar a distribuição dos subtipos de HIV-1 em pacientes com falha terapêutica à highly active antiretroviral therapy (HAART) nos Estados do Amazonas e Pará, Região Norte do Brasil, entre 2002 e 2006. Este estudo foi realizado utilizando-se soro coletado de indivíduos infectados com o vírus da imunodeficiência humana tipo 1 (HIV-1), e/ou portadores da síndrome da imunodeficiência adquirida (aids), selecionados a partir do banco de dados da Rede Nacional de Genotipagem (RENAGENO). Entre 2002 e 2006, foram obtidas 127 amostras sorológicas de pacientes portadores de aids e/ou HIV-positivos dos Estados do Amazonas e Pará, as quais foram submetidas a TM genotipagem e teste de resistência com o kit ViroSeq Genotyping System. Considerando as informações genéticas obtidas das regiões da protease e/ou transcriptase reversa do HIV-1, o subtipo B foi identificado em 85% dos casos, seguido do subtipo F1 (4,6%) e as formas recombinantes BF1 (4,6%) e CF1 (0,8%). Os resultados dessa pesquisa foram semelhantes aos encontrados em estudos realizados em outras regiões do Brasil, exceto pela detecção da forma recombinante CF1, que foi descrita pela primeira vez na Região Amazônica.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Universidade Federal do Pará. Hospital Universitário João de Barros Barreto. Belém, PA, Brasil.Universidade Federal do Pará. Núcleo de Medicina Tropical. Belém, PA, Brasil.Centro de Atenção em Doenças Infecciosas Adquiridas. Casa Dia. Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.porInstituto Evandro ChagasDistribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006Distribuição de subtipos de HIV-1 em pacientes com falha terapêutica à HAART nos Estados do Pará e Amazonas, Brasil, entre 2002 e 2006Distribución de subtipos de VIH-1 en pacientes con fallo terapéutico al HAART en los Estados de Pará y Amazonas, Brasil, entre 2002 y 2006info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHIV-1Terapia Antirretroviral de Alta Atividadeinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALDistribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006.pdfDistribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006.pdfapplication/pdf527225https://patua.iec.gov.br/bitstreams/76de4638-10a3-4bc1-99be-976e32bf6b53/downloaddf7e1b6df50b9cfccdb9e136e91ef72dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/df398c24-72f0-4db0-a8f3-ddd4125b33e4/download52f1732ea66fbd1123abe39f5373b797MD52TEXTDistribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006.pdf.txtDistribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006.pdf.txtExtracted texttext/plain28158https://patua.iec.gov.br/bitstreams/9a818907-a05a-4299-8f92-7efaa4d8d1a6/download2a5708d1a45469f5d70f08cc4864dc2fMD55THUMBNAILDistribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006.pdf.jpgDistribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006.pdf.jpgGenerated Thumbnailimage/jpeg5631https://patua.iec.gov.br/bitstreams/c072b1cb-2d83-4dac-b038-24488fc9fcbe/download9a23c741504b5566e1290530e366fcfdMD56iec/29622023-04-03 14:05:13.793oai:patua.iec.gov.br:iec/2962https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2023-04-03T14:05:13Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4= |
dc.title.pt_BR.fl_str_mv |
Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006 |
dc.title.alternative.pt_BR.fl_str_mv |
Distribuição de subtipos de HIV-1 em pacientes com falha terapêutica à HAART nos Estados do Pará e Amazonas, Brasil, entre 2002 e 2006 Distribución de subtipos de VIH-1 en pacientes con fallo terapéutico al HAART en los Estados de Pará y Amazonas, Brasil, entre 2002 y 2006 |
title |
Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006 |
spellingShingle |
Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006 Macêdo, Olinda HIV-1 Terapia Antirretroviral de Alta Atividade |
title_short |
Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006 |
title_full |
Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006 |
title_fullStr |
Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006 |
title_full_unstemmed |
Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006 |
title_sort |
Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006 |
author |
Macêdo, Olinda |
author_facet |
Macêdo, Olinda Ferreira, Luciana Macedo Lopes, Carmen Andréa Freitas Sousa, Rita Catarina Medeiros Araújo, José Ricardo Mourão Vasconcelos, Pedro Fernando da Costa |
author_role |
author |
author2 |
Ferreira, Luciana Macedo Lopes, Carmen Andréa Freitas Sousa, Rita Catarina Medeiros Araújo, José Ricardo Mourão Vasconcelos, Pedro Fernando da Costa |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Macêdo, Olinda Ferreira, Luciana Macedo Lopes, Carmen Andréa Freitas Sousa, Rita Catarina Medeiros Araújo, José Ricardo Mourão Vasconcelos, Pedro Fernando da Costa |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
HIV-1 Terapia Antirretroviral de Alta Atividade |
topic |
HIV-1 Terapia Antirretroviral de Alta Atividade |
description |
The aim of this study was to determine the distribution of HIV-1 subtypes in patients undergoing highly active antiretroviral therapy (HAART) therapeutic failure in Amazonas and Pará, two States in northern Brazil, from 2002 to 2006. This study was performed using plasma collected from individuals with human immunodeficiency virus-1 (HIV-1) and/or acquired immunodeficiency syndrome (AIDS) who were selected from the National Genotyping Network (Rede Nacional de Genotipagem – RENAGENO). From 2002 to 2006, a total of 127 plasma samples from the States of Amazonas and Pará, in northern Brazil, were obtained from AIDS and/or HIV-positive patients and subjected to genotyping and resistance testing TM using the ViroSeq Genotyping System kit. Using the genetic information obtained from the HIV-1 protease and/or reverse transcriptase regions, HIV-1 subtype B was identified in 85% of the cases, followed by subtype F1 (4.6%) and the recombinant forms BF1 (4.6%) and CF1 (0.8%). The results of this study were similar to the results of other studies conducted in other regions of Brazil, with the exception of the detection of recombinant CF1, which was described for the first time in the Amazon Region. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2018-02-19T13:29:41Z |
dc.date.available.fl_str_mv |
2018-02-19T13:29:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MACÊDO, Olinda et al.Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006. Revista Pan-Amazônica de Saúde, v. 3, n. 2, p. 11-16, jun. 2012. Disponível em: <http://scielo.iec.gov.br/pdf/rpas/v3n2/v3n2a02.pdf>. Acesso em: 26 fev. 2018. |
dc.identifier.uri.fl_str_mv |
http://patua.iec.gov.br//handle/iec/2962 |
dc.identifier.issn.-.fl_str_mv |
2176-6223 |
dc.identifier.doi.-.fl_str_mv |
10.5123/S2176-62232012000200002 |
identifier_str_mv |
MACÊDO, Olinda et al.Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006. Revista Pan-Amazônica de Saúde, v. 3, n. 2, p. 11-16, jun. 2012. Disponível em: <http://scielo.iec.gov.br/pdf/rpas/v3n2/v3n2a02.pdf>. Acesso em: 26 fev. 2018. 2176-6223 10.5123/S2176-62232012000200002 |
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http://patua.iec.gov.br//handle/iec/2962 |
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por |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Instituto Evandro Chagas |
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Instituto Evandro Chagas |
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