Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006

Detalhes bibliográficos
Autor(a) principal: Macêdo, Olinda
Data de Publicação: 2012
Outros Autores: Ferreira, Luciana Macedo, Lopes, Carmen Andréa Freitas, Sousa, Rita Catarina Medeiros, Araújo, José Ricardo Mourão, Vasconcelos, Pedro Fernando da Costa
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: http://patua.iec.gov.br//handle/iec/2962
Resumo: The aim of this study was to determine the distribution of HIV-1 subtypes in patients undergoing highly active antiretroviral therapy (HAART) therapeutic failure in Amazonas and Pará, two States in northern Brazil, from 2002 to 2006. This study was performed using plasma collected from individuals with human immunodeficiency virus-1 (HIV-1) and/or acquired immunodeficiency syndrome (AIDS) who were selected from the National Genotyping Network (Rede Nacional de Genotipagem – RENAGENO). From 2002 to 2006, a total of 127 plasma samples from the States of Amazonas and Pará, in northern Brazil, were obtained from AIDS and/or HIV-positive patients and subjected to genotyping and resistance testing TM using the ViroSeq Genotyping System kit. Using the genetic information obtained from the HIV-1 protease and/or reverse transcriptase regions, HIV-1 subtype B was identified in 85% of the cases, followed by subtype F1 (4.6%) and the recombinant forms BF1 (4.6%) and CF1 (0.8%). The results of this study were similar to the results of other studies conducted in other regions of Brazil, with the exception of the detection of recombinant CF1, which was described for the first time in the Amazon Region.
id IEC-2_3e7203dd8c42d69a417b37a685ca4b3c
oai_identifier_str oai:patua.iec.gov.br:iec/2962
network_acronym_str IEC-2
network_name_str Repositório Digital do Instituto Evandro Chagas (Patuá)
repository_id_str
spelling Macêdo, OlindaFerreira, Luciana MacedoLopes, Carmen Andréa FreitasSousa, Rita Catarina MedeirosAraújo, José Ricardo MourãoVasconcelos, Pedro Fernando da Costa2018-02-19T13:29:41Z2018-02-19T13:29:41Z2012MACÊDO, Olinda et al.Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006. Revista Pan-Amazônica de Saúde, v. 3, n. 2, p. 11-16, jun. 2012. Disponível em: <http://scielo.iec.gov.br/pdf/rpas/v3n2/v3n2a02.pdf>. Acesso em: 26 fev. 2018.2176-6223http://patua.iec.gov.br//handle/iec/296210.5123/S2176-62232012000200002The aim of this study was to determine the distribution of HIV-1 subtypes in patients undergoing highly active antiretroviral therapy (HAART) therapeutic failure in Amazonas and Pará, two States in northern Brazil, from 2002 to 2006. This study was performed using plasma collected from individuals with human immunodeficiency virus-1 (HIV-1) and/or acquired immunodeficiency syndrome (AIDS) who were selected from the National Genotyping Network (Rede Nacional de Genotipagem – RENAGENO). From 2002 to 2006, a total of 127 plasma samples from the States of Amazonas and Pará, in northern Brazil, were obtained from AIDS and/or HIV-positive patients and subjected to genotyping and resistance testing TM using the ViroSeq Genotyping System kit. Using the genetic information obtained from the HIV-1 protease and/or reverse transcriptase regions, HIV-1 subtype B was identified in 85% of the cases, followed by subtype F1 (4.6%) and the recombinant forms BF1 (4.6%) and CF1 (0.8%). The results of this study were similar to the results of other studies conducted in other regions of Brazil, with the exception of the detection of recombinant CF1, which was described for the first time in the Amazon Region.O objetivo deste estudo foi determinar a distribuição dos subtipos de HIV-1 em pacientes com falha terapêutica à highly active antiretroviral therapy (HAART) nos Estados do Amazonas e Pará, Região Norte do Brasil, entre 2002 e 2006. Este estudo foi realizado utilizando-se soro coletado de indivíduos infectados com o vírus da imunodeficiência humana tipo 1 (HIV-1), e/ou portadores da síndrome da imunodeficiência adquirida (aids), selecionados a partir do banco de dados da Rede Nacional de Genotipagem (RENAGENO). Entre 2002 e 2006, foram obtidas 127 amostras sorológicas de pacientes portadores de aids e/ou HIV-positivos dos Estados do Amazonas e Pará, as quais foram submetidas a TM genotipagem e teste de resistência com o kit ViroSeq Genotyping System. Considerando as informações genéticas obtidas das regiões da protease e/ou transcriptase reversa do HIV-1, o subtipo B foi identificado em 85% dos casos, seguido do subtipo F1 (4,6%) e as formas recombinantes BF1 (4,6%) e CF1 (0,8%). Os resultados dessa pesquisa foram semelhantes aos encontrados em estudos realizados em outras regiões do Brasil, exceto pela detecção da forma recombinante CF1, que foi descrita pela primeira vez na Região Amazônica.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Universidade Federal do Pará. Hospital Universitário João de Barros Barreto. Belém, PA, Brasil.Universidade Federal do Pará. Núcleo de Medicina Tropical. Belém, PA, Brasil.Centro de Atenção em Doenças Infecciosas Adquiridas. Casa Dia. Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.porInstituto Evandro ChagasDistribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006Distribuição de subtipos de HIV-1 em pacientes com falha terapêutica à HAART nos Estados do Pará e Amazonas, Brasil, entre 2002 e 2006Distribución de subtipos de VIH-1 en pacientes con fallo terapéutico al HAART en los Estados de Pará y Amazonas, Brasil, entre 2002 y 2006info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHIV-1Terapia Antirretroviral de Alta Atividadeinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALDistribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006.pdfDistribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006.pdfapplication/pdf527225https://patua.iec.gov.br/bitstreams/76de4638-10a3-4bc1-99be-976e32bf6b53/downloaddf7e1b6df50b9cfccdb9e136e91ef72dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/df398c24-72f0-4db0-a8f3-ddd4125b33e4/download52f1732ea66fbd1123abe39f5373b797MD52TEXTDistribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006.pdf.txtDistribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006.pdf.txtExtracted texttext/plain28158https://patua.iec.gov.br/bitstreams/9a818907-a05a-4299-8f92-7efaa4d8d1a6/download2a5708d1a45469f5d70f08cc4864dc2fMD55THUMBNAILDistribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006.pdf.jpgDistribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006.pdf.jpgGenerated Thumbnailimage/jpeg5631https://patua.iec.gov.br/bitstreams/c072b1cb-2d83-4dac-b038-24488fc9fcbe/download9a23c741504b5566e1290530e366fcfdMD56iec/29622023-04-03 14:05:13.793oai:patua.iec.gov.br:iec/2962https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2023-04-03T14:05:13Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4=
dc.title.pt_BR.fl_str_mv Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006
dc.title.alternative.pt_BR.fl_str_mv Distribuição de subtipos de HIV-1 em pacientes com falha terapêutica à HAART nos Estados do Pará e Amazonas, Brasil, entre 2002 e 2006
Distribución de subtipos de VIH-1 en pacientes con fallo terapéutico al HAART en los Estados de Pará y Amazonas, Brasil, entre 2002 y 2006
title Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006
spellingShingle Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006
Macêdo, Olinda
HIV-1
Terapia Antirretroviral de Alta Atividade
title_short Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006
title_full Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006
title_fullStr Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006
title_full_unstemmed Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006
title_sort Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006
author Macêdo, Olinda
author_facet Macêdo, Olinda
Ferreira, Luciana Macedo
Lopes, Carmen Andréa Freitas
Sousa, Rita Catarina Medeiros
Araújo, José Ricardo Mourão
Vasconcelos, Pedro Fernando da Costa
author_role author
author2 Ferreira, Luciana Macedo
Lopes, Carmen Andréa Freitas
Sousa, Rita Catarina Medeiros
Araújo, José Ricardo Mourão
Vasconcelos, Pedro Fernando da Costa
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Macêdo, Olinda
Ferreira, Luciana Macedo
Lopes, Carmen Andréa Freitas
Sousa, Rita Catarina Medeiros
Araújo, José Ricardo Mourão
Vasconcelos, Pedro Fernando da Costa
dc.subject.decsPrimary.pt_BR.fl_str_mv HIV-1
Terapia Antirretroviral de Alta Atividade
topic HIV-1
Terapia Antirretroviral de Alta Atividade
description The aim of this study was to determine the distribution of HIV-1 subtypes in patients undergoing highly active antiretroviral therapy (HAART) therapeutic failure in Amazonas and Pará, two States in northern Brazil, from 2002 to 2006. This study was performed using plasma collected from individuals with human immunodeficiency virus-1 (HIV-1) and/or acquired immunodeficiency syndrome (AIDS) who were selected from the National Genotyping Network (Rede Nacional de Genotipagem – RENAGENO). From 2002 to 2006, a total of 127 plasma samples from the States of Amazonas and Pará, in northern Brazil, were obtained from AIDS and/or HIV-positive patients and subjected to genotyping and resistance testing TM using the ViroSeq Genotyping System kit. Using the genetic information obtained from the HIV-1 protease and/or reverse transcriptase regions, HIV-1 subtype B was identified in 85% of the cases, followed by subtype F1 (4.6%) and the recombinant forms BF1 (4.6%) and CF1 (0.8%). The results of this study were similar to the results of other studies conducted in other regions of Brazil, with the exception of the detection of recombinant CF1, which was described for the first time in the Amazon Region.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2018-02-19T13:29:41Z
dc.date.available.fl_str_mv 2018-02-19T13:29:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MACÊDO, Olinda et al.Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006. Revista Pan-Amazônica de Saúde, v. 3, n. 2, p. 11-16, jun. 2012. Disponível em: <http://scielo.iec.gov.br/pdf/rpas/v3n2/v3n2a02.pdf>. Acesso em: 26 fev. 2018.
dc.identifier.uri.fl_str_mv http://patua.iec.gov.br//handle/iec/2962
dc.identifier.issn.-.fl_str_mv 2176-6223
dc.identifier.doi.-.fl_str_mv 10.5123/S2176-62232012000200002
identifier_str_mv MACÊDO, Olinda et al.Distribution of HIV-1 subtypes in patients with HAART therapeutic failure in the States of Pará and Amazonas, Brazil: 2002 to 2006. Revista Pan-Amazônica de Saúde, v. 3, n. 2, p. 11-16, jun. 2012. Disponível em: <http://scielo.iec.gov.br/pdf/rpas/v3n2/v3n2a02.pdf>. Acesso em: 26 fev. 2018.
2176-6223
10.5123/S2176-62232012000200002
url http://patua.iec.gov.br//handle/iec/2962
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Instituto Evandro Chagas
publisher.none.fl_str_mv Instituto Evandro Chagas
dc.source.none.fl_str_mv reponame:Repositório Digital do Instituto Evandro Chagas (Patuá)
instname:Instituto Evandro Chagas (IEC)
instacron:IEC
instname_str Instituto Evandro Chagas (IEC)
instacron_str IEC
institution IEC
reponame_str Repositório Digital do Instituto Evandro Chagas (Patuá)
collection Repositório Digital do Instituto Evandro Chagas (Patuá)
bitstream.url.fl_str_mv https://patua.iec.gov.br/bitstreams/76de4638-10a3-4bc1-99be-976e32bf6b53/download
https://patua.iec.gov.br/bitstreams/df398c24-72f0-4db0-a8f3-ddd4125b33e4/download
https://patua.iec.gov.br/bitstreams/9a818907-a05a-4299-8f92-7efaa4d8d1a6/download
https://patua.iec.gov.br/bitstreams/c072b1cb-2d83-4dac-b038-24488fc9fcbe/download
bitstream.checksum.fl_str_mv df7e1b6df50b9cfccdb9e136e91ef72d
52f1732ea66fbd1123abe39f5373b797
2a5708d1a45469f5d70f08cc4864dc2f
9a23c741504b5566e1290530e366fcfd
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)
repository.mail.fl_str_mv clariceneta@iec.gov.br || Biblioteca@iec.gov.br
_version_ 1809190050984886272