Molecular epidemiology of dengue type 3 virus in Brazil and Paraguay, 2002-2004

• Autor(a) principal: Aquino, Victor Hugo
• Data de Publicação: 2006
• Outros Autores: Anatriello, Elen, Gonçalves, Paula F, Silva, Eliana Vieira Pinto da, Vasconcelos, Pedro Fernando da Costa, Vieira, Deusylene S, Batista, Weber V, Bobadilla, Maria L, Vazquez, Cynthia, Moran, Mirian, Figueiredo, Luiz T. M
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/1002
• topic: Vírus da Dengue / isolamento & purificação; Epidemiologia Molecular / métodos; Vírus da Dengue / classificação; Brasil (BR); Paraguai (PY)

We studied the molecular epidemiology of dengue virus type 3 (DENV-3) in Brazil and Paraguay by analyzing the 5' and 3' untranslated regions (5' and 3' UTRs) and the E protein gene of viruses isolated between 2002 and 2004. Both 5' and 3' UTRs were highly conserved. However, the 3' UTR of two isolates from Brazil contained eight nucleotide deletions compared with the remaining 26 viruses. Phylogenetic analyses suggested that DENV-3 was introduced into Brazil from the Caribbean Islands at least twice and into Paraguay from Brazil at least three times.