Early and late neuropathological features of meningoencephalitis associated with Maraba virus infection
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/4085 |
Resumo: | Maraba virus is a member of the genus Vesiculovirus of the Rhabdoviridae family that was isolated in 1983 from sandflies captured in the municipality of Maraba, state of Pará, Amazônia, Brazil. Despite 30 years having passed since its isolation, little is known about the neuropathology induced by the Maraba virus. Accordingly, in this study the histopathological features, inflammatory glial changes, cytokine concentrations, and nitric oxide activity in the encephalon of adult mice subjected to Maraba virus nostril infection were evaluated. The results showed that 6 days after intranasal inoculation, severe neuropathological-associated disease signs appeared, including edema, necrosis and pyknosis of neurons, generalized congestion of encephalic vessels, and intra- and perivascular meningeal lymphocytic infiltrates in several brain regions. Immunolabeling of viral antigens was observed in almost all central nervous system (CNS) areas and this was associated with intense microglial activation and astrogliosis. Compared to control animals, infected mice showed significant increases in interleukin (IL)-6, tumor necrosis factor (TNF)-a, interferon (INF)-g, MCP-1, nitric oxide, and encephalic cytokine levels. We suggest that an exacerbated inflammatory response in several regions of the CNS of adult BALB/c mice might be responsible for their deaths. |
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Farias, Alexandre Maia deLima, Camila Mendes deFreitas, Priscilla dos Santos LieuthierDiniz, Daniel GuerreiroRodrigues, Ana Paula DrummondQuaresma, Juarez Antônio SimõesDiniz, Cristovam Wanderley PicançoDiniz Junior, José Antonio Picanço2020-04-29T01:05:26Z2020-04-29T01:05:26Z2020FARIAS, Alexandre Maia de et al. Early and late neuropathological features of meningoencephalitis associated with Maraba virus infection. Brazilian Journal of Medical and Biological Research, v. 53, n. 4, e8604, 2020.1414-431Xhttps://patua.iec.gov.br/handle/iec/408510.1590/1414-431X20208604Maraba virus is a member of the genus Vesiculovirus of the Rhabdoviridae family that was isolated in 1983 from sandflies captured in the municipality of Maraba, state of Pará, Amazônia, Brazil. Despite 30 years having passed since its isolation, little is known about the neuropathology induced by the Maraba virus. Accordingly, in this study the histopathological features, inflammatory glial changes, cytokine concentrations, and nitric oxide activity in the encephalon of adult mice subjected to Maraba virus nostril infection were evaluated. The results showed that 6 days after intranasal inoculation, severe neuropathological-associated disease signs appeared, including edema, necrosis and pyknosis of neurons, generalized congestion of encephalic vessels, and intra- and perivascular meningeal lymphocytic infiltrates in several brain regions. Immunolabeling of viral antigens was observed in almost all central nervous system (CNS) areas and this was associated with intense microglial activation and astrogliosis. Compared to control animals, infected mice showed significant increases in interleukin (IL)-6, tumor necrosis factor (TNF)-a, interferon (INF)-g, MCP-1, nitric oxide, and encephalic cytokine levels. We suggest that an exacerbated inflammatory response in several regions of the CNS of adult BALB/c mice might be responsible for their deaths.Universidade Estadual do Pará, Instituto Evandro Chagas, and Universidade Federal do Pará.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Microscopia Eletrônica. Ananindeua, PA, Brasil.Universidade Federal do Pará. Hospital Universitário João Barros Barreto. Instituto de Ciências Biológicas. Laboratório de Neurodegeneração e Infecção. Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Microscopia Eletrônica. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Microscopia Eletrônica. Ananindeua, PA, Brasil / Universidade Federal do Pará. Hospital Universitário João Barros Barreto. Instituto de Ciências Biológicas. Laboratório de Neurodegeneração e Infecção. Belém, PA, Brasil.Universidade Federal do Pará. Núcleo de Medicina Tropical. Belém, PA, Brasil.Universidade Federal do Pará. Hospital Universitário João Barros Barreto. Instituto de Ciências Biológicas. Laboratório de Neurodegeneração e Infecção. Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Microscopia Eletrônica. Ananindeua, PA, Brasil / Universidade Federal do Pará. Hospital Universitário João Barros Barreto. Instituto de Ciências Biológicas. Laboratório de Neurodegeneração e Infecção. Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Microscopia Eletrônica. Ananindeua, PA, Brasil.engAssociação Brasileira de Divulgação CientíficaEarly and late neuropathological features of meningoencephalitis associated with Maraba virus infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleRhabdoviridae / patogenicidadeInfecções por Rhabdoviridae / virologiaSistema Nervoso Central / virologiaMeningoencefalite / virologiaMicrogliaVirus Marabáinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALEarly and late neuropathological features of meningoencephalitis associated with Maraba virus infection.pdfEarly and late neuropathological features of meningoencephalitis associated with Maraba virus infection.pdfapplication/pdf3343672https://patua.iec.gov.br/bitstreams/a69a4535-a8d3-489b-8de9-cc23aa54f2df/download95bc6e45cd09f44d2e6c225f99ab73c3MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/ce1fc7f9-9c61-4f8b-b614-46e8aa726095/download11832eea31b16df8613079d742d61793MD52TEXTEarly and late neuropathological features of meningoencephalitis associated with Maraba virus infection.pdf.txtEarly and late neuropathological features of meningoencephalitis associated with Maraba virus infection.pdf.txtExtracted texttext/plain41819https://patua.iec.gov.br/bitstreams/3e49ecb7-f46f-406f-9f0c-e66902ff8c47/download2606150ceb1b6115897fafa6c2f838e8MD55THUMBNAILEarly and late neuropathological features of meningoencephalitis associated with Maraba virus infection.pdf.jpgEarly and late neuropathological features of meningoencephalitis associated with Maraba virus infection.pdf.jpgGenerated Thumbnailimage/jpeg5932https://patua.iec.gov.br/bitstreams/07180a98-1464-4b7c-9453-b96230942e1b/download1b304929092a92af6891d1355e711a19MD56iec/40852023-03-20 12:34:47.219oai:patua.iec.gov.br:iec/4085https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2023-03-20T12:34:47Repositório Digital do Instituto Evandro Chagas (Patuá) - 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dc.title.pt_BR.fl_str_mv |
Early and late neuropathological features of meningoencephalitis associated with Maraba virus infection |
title |
Early and late neuropathological features of meningoencephalitis associated with Maraba virus infection |
spellingShingle |
Early and late neuropathological features of meningoencephalitis associated with Maraba virus infection Farias, Alexandre Maia de Rhabdoviridae / patogenicidade Infecções por Rhabdoviridae / virologia Sistema Nervoso Central / virologia Meningoencefalite / virologia Microglia Virus Marabá |
title_short |
Early and late neuropathological features of meningoencephalitis associated with Maraba virus infection |
title_full |
Early and late neuropathological features of meningoencephalitis associated with Maraba virus infection |
title_fullStr |
Early and late neuropathological features of meningoencephalitis associated with Maraba virus infection |
title_full_unstemmed |
Early and late neuropathological features of meningoencephalitis associated with Maraba virus infection |
title_sort |
Early and late neuropathological features of meningoencephalitis associated with Maraba virus infection |
author |
Farias, Alexandre Maia de |
author_facet |
Farias, Alexandre Maia de Lima, Camila Mendes de Freitas, Priscilla dos Santos Lieuthier Diniz, Daniel Guerreiro Rodrigues, Ana Paula Drummond Quaresma, Juarez Antônio Simões Diniz, Cristovam Wanderley Picanço Diniz Junior, José Antonio Picanço |
author_role |
author |
author2 |
Lima, Camila Mendes de Freitas, Priscilla dos Santos Lieuthier Diniz, Daniel Guerreiro Rodrigues, Ana Paula Drummond Quaresma, Juarez Antônio Simões Diniz, Cristovam Wanderley Picanço Diniz Junior, José Antonio Picanço |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Farias, Alexandre Maia de Lima, Camila Mendes de Freitas, Priscilla dos Santos Lieuthier Diniz, Daniel Guerreiro Rodrigues, Ana Paula Drummond Quaresma, Juarez Antônio Simões Diniz, Cristovam Wanderley Picanço Diniz Junior, José Antonio Picanço |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Rhabdoviridae / patogenicidade Infecções por Rhabdoviridae / virologia Sistema Nervoso Central / virologia |
topic |
Rhabdoviridae / patogenicidade Infecções por Rhabdoviridae / virologia Sistema Nervoso Central / virologia Meningoencefalite / virologia Microglia Virus Marabá |
dc.subject.decsPrimary.pt-BR.fl_str_mv |
Meningoencefalite / virologia Microglia Virus Marabá |
description |
Maraba virus is a member of the genus Vesiculovirus of the Rhabdoviridae family that was isolated in 1983 from sandflies captured in the municipality of Maraba, state of Pará, Amazônia, Brazil. Despite 30 years having passed since its isolation, little is known about the neuropathology induced by the Maraba virus. Accordingly, in this study the histopathological features, inflammatory glial changes, cytokine concentrations, and nitric oxide activity in the encephalon of adult mice subjected to Maraba virus nostril infection were evaluated. The results showed that 6 days after intranasal inoculation, severe neuropathological-associated disease signs appeared, including edema, necrosis and pyknosis of neurons, generalized congestion of encephalic vessels, and intra- and perivascular meningeal lymphocytic infiltrates in several brain regions. Immunolabeling of viral antigens was observed in almost all central nervous system (CNS) areas and this was associated with intense microglial activation and astrogliosis. Compared to control animals, infected mice showed significant increases in interleukin (IL)-6, tumor necrosis factor (TNF)-a, interferon (INF)-g, MCP-1, nitric oxide, and encephalic cytokine levels. We suggest that an exacerbated inflammatory response in several regions of the CNS of adult BALB/c mice might be responsible for their deaths. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-04-29T01:05:26Z |
dc.date.available.fl_str_mv |
2020-04-29T01:05:26Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FARIAS, Alexandre Maia de et al. Early and late neuropathological features of meningoencephalitis associated with Maraba virus infection. Brazilian Journal of Medical and Biological Research, v. 53, n. 4, e8604, 2020. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/4085 |
dc.identifier.issn.-.fl_str_mv |
1414-431X |
dc.identifier.doi.-.fl_str_mv |
10.1590/1414-431X20208604 |
identifier_str_mv |
FARIAS, Alexandre Maia de et al. Early and late neuropathological features of meningoencephalitis associated with Maraba virus infection. Brazilian Journal of Medical and Biological Research, v. 53, n. 4, e8604, 2020. 1414-431X 10.1590/1414-431X20208604 |
url |
https://patua.iec.gov.br/handle/iec/4085 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
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reponame:Repositório Digital do Instituto Evandro Chagas (Patuá) instname:Instituto Evandro Chagas (IEC) instacron:IEC |
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Instituto Evandro Chagas (IEC) |
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IEC |
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IEC |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
collection |
Repositório Digital do Instituto Evandro Chagas (Patuá) |
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