Phenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2001 |
Outros Autores: | , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/4358 |
Resumo: | The yellow fever (YF) 17D virus is one of the most successful vaccines developed to data. Its use has been estimated to be over 400 million doses with an excellent record of safety. In the past 3 years, yellow fever vaccination was intensified in Brazil in response to higher risk of urban outbreaks of the disease. Two fatal adverse events temporally associated with YF vaccination were reported. Both cases had features similar to yellow fever disease, including hepatitis and multiorgan failure. Two different lots of YF 17DD virus vaccine were administered to the affected patients and also to hundreds of thousands of other individuals without any other reported serious adverse events. The lots were prepared from the secondary seed, which has been in continuous use since 1984. Nucleotide sequencing revealed minor variations at some nucleotide positions between the secondary seed lot virus and the virus isolates from patients; these differences were not consistent across the isolates, represented differences in the relative amount of each nucleotide in a heterogeneous position, and did not result in amino acid substitutions. Inoculation of rhesus monkeys with the viruses isolated from the two patients by the intracerebral (ic) or intrahepatic (ih) route caused minimal viremia and no clinical signs of infection or alterations in laboratory markers. Central nervous system histological scores of rhesus monkeys inoculated ic were within the expected range, and there were no histopathological lesions in animals inoculated ih. Altogether, these results demonstrated the genetic stability and attenuated phenotype of the viruses that caused fatal illness in the two patients. Therefore, the fatal adverse events experienced by the vaccinees are related to individual, genetically determined host factors that regulate cellular susceptibility to yellow fever virus. Such increased susceptibility, resulting in clinically overt disease expression, appears to be extremely rare. |
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Galler, RPugachev, K. VSantos, C. L. SOcran, S. WJabor, A. VRodrigues, Sueli GuerreiroMarchevsky, R. SFreire, M. SAlmeida, L. F. CCruz, Ana Cecília RibeiroYamamura, A. M. YRocco, I. MRosa, Elizabeth Salbé Travassos daSouza, L. T. MVasconcelos, Pedro Fernando da CostaGuirakhoo, FMonath, T. P2021-07-16T12:51:14Z2021-07-16T12:51:14Z2001GALLER, R et al. Phenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazil. Virology, v. 290, n. 2, p. 309-3019, Nov. 2001.0042-6822https://patua.iec.gov.br/handle/iec/435810.1006/viro.2001.1168The yellow fever (YF) 17D virus is one of the most successful vaccines developed to data. Its use has been estimated to be over 400 million doses with an excellent record of safety. In the past 3 years, yellow fever vaccination was intensified in Brazil in response to higher risk of urban outbreaks of the disease. Two fatal adverse events temporally associated with YF vaccination were reported. Both cases had features similar to yellow fever disease, including hepatitis and multiorgan failure. Two different lots of YF 17DD virus vaccine were administered to the affected patients and also to hundreds of thousands of other individuals without any other reported serious adverse events. The lots were prepared from the secondary seed, which has been in continuous use since 1984. Nucleotide sequencing revealed minor variations at some nucleotide positions between the secondary seed lot virus and the virus isolates from patients; these differences were not consistent across the isolates, represented differences in the relative amount of each nucleotide in a heterogeneous position, and did not result in amino acid substitutions. Inoculation of rhesus monkeys with the viruses isolated from the two patients by the intracerebral (ic) or intrahepatic (ih) route caused minimal viremia and no clinical signs of infection or alterations in laboratory markers. Central nervous system histological scores of rhesus monkeys inoculated ic were within the expected range, and there were no histopathological lesions in animals inoculated ih. Altogether, these results demonstrated the genetic stability and attenuated phenotype of the viruses that caused fatal illness in the two patients. Therefore, the fatal adverse events experienced by the vaccinees are related to individual, genetically determined host factors that regulate cellular susceptibility to yellow fever virus. Such increased susceptibility, resulting in clinically overt disease expression, appears to be extremely rare.Pan American Health Organization, Fundação Nacional de Saúde (Ministry of Health, Brazil), and CNPq (Brazil)Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brazil.Acambis. Cambridge, Massachusetts.Instituto Adolpho Lutz. São Paulo, SP, Brazil.Acambis. Cambridge, Massachusetts.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brazil.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brazil.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brazil.Instituto Adolpho Lutz. São Paulo, SP, Brazil.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Instituto Adolpho Lutz. São Paulo, SP, Brazil.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Acambis. Cambridge, Massachusetts.Acambis. Cambridge, Massachusetts.engElsevierPhenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFebre Amarela / virologiaVacina contra Febre Amarela / efeitos adversosVacina contra Febre Amarela / administração & dosagemVacinaçãoinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALPhenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazil.pdfPhenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazil.pdfapplication/pdf115489https://patua.iec.gov.br/bitstreams/da6f7364-3fcc-43a1-a69c-516aa7ffb343/download3a85835b156a4f2080d0ad62f65afe25MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/64434639-4426-4a95-b043-37451e781bea/download11832eea31b16df8613079d742d61793MD52TEXTPhenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazil.pdf.txtPhenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazil.pdf.txtExtracted texttext/plain56825https://patua.iec.gov.br/bitstreams/8814fdb4-f244-43b0-ab7f-bb3da248738b/downloadb0b6c33e370fbb7f10058e95dd420de9MD55THUMBNAILPhenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazil.pdf.jpgPhenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazil.pdf.jpgGenerated Thumbnailimage/jpeg5692https://patua.iec.gov.br/bitstreams/32a0ebbf-5c1f-4ab2-80d2-157361c42855/downloadf63d1aa765ed631fd781ca4dcae799c5MD56iec/43582022-10-20 21:17:40.568oai:patua.iec.gov.br:iec/4358https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T21:17:40Repositório Digital do Instituto Evandro Chagas (Patuá) - 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dc.title.pt_BR.fl_str_mv |
Phenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazil |
title |
Phenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazil |
spellingShingle |
Phenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazil Galler, R Febre Amarela / virologia Vacina contra Febre Amarela / efeitos adversos Vacina contra Febre Amarela / administração & dosagem Vacinação |
title_short |
Phenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazil |
title_full |
Phenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazil |
title_fullStr |
Phenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazil |
title_full_unstemmed |
Phenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazil |
title_sort |
Phenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazil |
author |
Galler, R |
author_facet |
Galler, R Pugachev, K. V Santos, C. L. S Ocran, S. W Jabor, A. V Rodrigues, Sueli Guerreiro Marchevsky, R. S Freire, M. S Almeida, L. F. C Cruz, Ana Cecília Ribeiro Yamamura, A. M. Y Rocco, I. M Rosa, Elizabeth Salbé Travassos da Souza, L. T. M Vasconcelos, Pedro Fernando da Costa Guirakhoo, F Monath, T. P |
author_role |
author |
author2 |
Pugachev, K. V Santos, C. L. S Ocran, S. W Jabor, A. V Rodrigues, Sueli Guerreiro Marchevsky, R. S Freire, M. S Almeida, L. F. C Cruz, Ana Cecília Ribeiro Yamamura, A. M. Y Rocco, I. M Rosa, Elizabeth Salbé Travassos da Souza, L. T. M Vasconcelos, Pedro Fernando da Costa Guirakhoo, F Monath, T. P |
author2_role |
author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Galler, R Pugachev, K. V Santos, C. L. S Ocran, S. W Jabor, A. V Rodrigues, Sueli Guerreiro Marchevsky, R. S Freire, M. S Almeida, L. F. C Cruz, Ana Cecília Ribeiro Yamamura, A. M. Y Rocco, I. M Rosa, Elizabeth Salbé Travassos da Souza, L. T. M Vasconcelos, Pedro Fernando da Costa Guirakhoo, F Monath, T. P |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Febre Amarela / virologia Vacina contra Febre Amarela / efeitos adversos Vacina contra Febre Amarela / administração & dosagem Vacinação |
topic |
Febre Amarela / virologia Vacina contra Febre Amarela / efeitos adversos Vacina contra Febre Amarela / administração & dosagem Vacinação |
description |
The yellow fever (YF) 17D virus is one of the most successful vaccines developed to data. Its use has been estimated to be over 400 million doses with an excellent record of safety. In the past 3 years, yellow fever vaccination was intensified in Brazil in response to higher risk of urban outbreaks of the disease. Two fatal adverse events temporally associated with YF vaccination were reported. Both cases had features similar to yellow fever disease, including hepatitis and multiorgan failure. Two different lots of YF 17DD virus vaccine were administered to the affected patients and also to hundreds of thousands of other individuals without any other reported serious adverse events. The lots were prepared from the secondary seed, which has been in continuous use since 1984. Nucleotide sequencing revealed minor variations at some nucleotide positions between the secondary seed lot virus and the virus isolates from patients; these differences were not consistent across the isolates, represented differences in the relative amount of each nucleotide in a heterogeneous position, and did not result in amino acid substitutions. Inoculation of rhesus monkeys with the viruses isolated from the two patients by the intracerebral (ic) or intrahepatic (ih) route caused minimal viremia and no clinical signs of infection or alterations in laboratory markers. Central nervous system histological scores of rhesus monkeys inoculated ic were within the expected range, and there were no histopathological lesions in animals inoculated ih. Altogether, these results demonstrated the genetic stability and attenuated phenotype of the viruses that caused fatal illness in the two patients. Therefore, the fatal adverse events experienced by the vaccinees are related to individual, genetically determined host factors that regulate cellular susceptibility to yellow fever virus. Such increased susceptibility, resulting in clinically overt disease expression, appears to be extremely rare. |
publishDate |
2001 |
dc.date.issued.fl_str_mv |
2001 |
dc.date.accessioned.fl_str_mv |
2021-07-16T12:51:14Z |
dc.date.available.fl_str_mv |
2021-07-16T12:51:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GALLER, R et al. Phenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazil. Virology, v. 290, n. 2, p. 309-3019, Nov. 2001. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/4358 |
dc.identifier.issn.-.fl_str_mv |
0042-6822 |
dc.identifier.doi.-.fl_str_mv |
10.1006/viro.2001.1168 |
identifier_str_mv |
GALLER, R et al. Phenotypic and molecular analyses of yellow fever 17DD vaccine viruses associated with serious adverse events in Brazil. Virology, v. 290, n. 2, p. 309-3019, Nov. 2001. 0042-6822 10.1006/viro.2001.1168 |
url |
https://patua.iec.gov.br/handle/iec/4358 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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