Genetic divergence and dispersal of Yellow Fever Virus, Brazil

Detalhes bibliográficos
Autor(a) principal: Vasconcelos, Pedro Fernando da Costa
Data de Publicação: 2004
Outros Autores: Bryant, Juliet E, Rosa, Amélia Paes de Andrade Travassos da, Tesh, Robert B, Rodrigues, Sueli Guerreiro, Barrett, Alan D. T
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/3958
Resumo: An analysis of 79 yellow fever virus(YFV) isolates collected from 1935 to 2001 in Brazil showed a single genotype (South America) circulating in the country, with the exception of a single strain from Rôndonia, wich represented South America genotype II. Brazilian YFV strains have diverged into two clades; an older clade appears to have become extinct and another has become the dominant lineage in recent years. Pairwise nucleotide diversity between strains ranged from 0 per cent to 7.4 per cent, while amino acid divergence ranged from 0 per cent to 4.6 per cent. Phylogenetic analysis indicated traffic of virus variants through large geographic areas and suggested that migration of infected people may be an important mechanism of virus dispersal. Isolation of vaccine virus from a patient with a fatal case suggests that vaccine-related illness may have been misdiagnosed in the past.
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spelling Vasconcelos, Pedro Fernando da CostaBryant, Juliet ERosa, Amélia Paes de Andrade Travassos daTesh, Robert BRodrigues, Sueli GuerreiroBarrett, Alan D. T2019-10-09T11:27:11Z2019-10-09T11:27:11Z2004VASCONCELOS, Pedro Fernando da Costa et al. Genetic divergence and dispersal of Yellow Fever Virus, Brazil. Emerging Infectious Disease, v. 10, n. 9, p. 1578-1584, Sept. 2004.1080-6040https://patua.iec.gov.br/handle/iec/3958An analysis of 79 yellow fever virus(YFV) isolates collected from 1935 to 2001 in Brazil showed a single genotype (South America) circulating in the country, with the exception of a single strain from Rôndonia, wich represented South America genotype II. Brazilian YFV strains have diverged into two clades; an older clade appears to have become extinct and another has become the dominant lineage in recent years. Pairwise nucleotide diversity between strains ranged from 0 per cent to 7.4 per cent, while amino acid divergence ranged from 0 per cent to 4.6 per cent. Phylogenetic analysis indicated traffic of virus variants through large geographic areas and suggested that migration of infected people may be an important mechanism of virus dispersal. Isolation of vaccine virus from a patient with a fatal case suggests that vaccine-related illness may have been misdiagnosed in the past.CNPq (Brazilian Agency for Scientific and Technologic Development, process 302770/02-0) and the National Institutes of Health (grant AI 50175)Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. World Health Organization Collaborating Center for Arbovirus Reference and Research. Belém, PA, Brasil.University of Texas Medical Branch. Galveston, TX, USA.University of Texas Medical Branch. Galveston, TX, USA.University of Texas Medical Branch. Galveston, TX, USA.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. World Health Organization Collaborating Center for Arbovirus Reference and Research. Belém, PA, Brasil.University of Texas Medical Branch. Galveston, TX, USA.engCenters for Disease Control and PreventionGenetic divergence and dispersal of Yellow Fever Virus, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFebre Amarela / epidemiologiaFebre Amarela / genéticaFebre Amarela / fisiopatologiaVacina contra Febre Amarela / análiseinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALGenetic divergence and dispersal of Yellow Fever Virus, Brazil.pdfGenetic divergence and dispersal of Yellow Fever Virus, Brazil.pdfapplication/pdf357276https://patua.iec.gov.br/bitstreams/972a030f-d3fc-4ceb-b8ca-bc5f10ab68ac/downloadef1c3da819fa3f02ea45e4876c01a157MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/9632ddcc-1dea-4a56-b72c-875c61cae100/download11832eea31b16df8613079d742d61793MD52TEXTGenetic divergence and dispersal of Yellow Fever Virus, Brazil.pdf.txtGenetic divergence and dispersal of Yellow Fever Virus, Brazil.pdf.txtExtracted texttext/plain34302https://patua.iec.gov.br/bitstreams/cb8e8990-406f-4389-ab76-49009c15fbc7/download7cd982adb178ebd318ec406a2045139fMD55THUMBNAILGenetic divergence and dispersal of Yellow Fever Virus, Brazil.pdf.jpgGenetic divergence and dispersal of Yellow Fever Virus, Brazil.pdf.jpgGenerated Thumbnailimage/jpeg6159https://patua.iec.gov.br/bitstreams/4ccc43a8-a687-40fa-967c-609148b3865f/download233770fd01c3995293be0399b2137542MD56iec/39582022-10-20 21:06:56.143oai:patua.iec.gov.br:iec/3958https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T21:06:56Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)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
dc.title.pt_BR.fl_str_mv Genetic divergence and dispersal of Yellow Fever Virus, Brazil
title Genetic divergence and dispersal of Yellow Fever Virus, Brazil
spellingShingle Genetic divergence and dispersal of Yellow Fever Virus, Brazil
Vasconcelos, Pedro Fernando da Costa
Febre Amarela / epidemiologia
Febre Amarela / genética
Febre Amarela / fisiopatologia
Vacina contra Febre Amarela / análise
title_short Genetic divergence and dispersal of Yellow Fever Virus, Brazil
title_full Genetic divergence and dispersal of Yellow Fever Virus, Brazil
title_fullStr Genetic divergence and dispersal of Yellow Fever Virus, Brazil
title_full_unstemmed Genetic divergence and dispersal of Yellow Fever Virus, Brazil
title_sort Genetic divergence and dispersal of Yellow Fever Virus, Brazil
author Vasconcelos, Pedro Fernando da Costa
author_facet Vasconcelos, Pedro Fernando da Costa
Bryant, Juliet E
Rosa, Amélia Paes de Andrade Travassos da
Tesh, Robert B
Rodrigues, Sueli Guerreiro
Barrett, Alan D. T
author_role author
author2 Bryant, Juliet E
Rosa, Amélia Paes de Andrade Travassos da
Tesh, Robert B
Rodrigues, Sueli Guerreiro
Barrett, Alan D. T
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Vasconcelos, Pedro Fernando da Costa
Bryant, Juliet E
Rosa, Amélia Paes de Andrade Travassos da
Tesh, Robert B
Rodrigues, Sueli Guerreiro
Barrett, Alan D. T
dc.subject.decsPrimary.pt_BR.fl_str_mv Febre Amarela / epidemiologia
Febre Amarela / genética
Febre Amarela / fisiopatologia
Vacina contra Febre Amarela / análise
topic Febre Amarela / epidemiologia
Febre Amarela / genética
Febre Amarela / fisiopatologia
Vacina contra Febre Amarela / análise
description An analysis of 79 yellow fever virus(YFV) isolates collected from 1935 to 2001 in Brazil showed a single genotype (South America) circulating in the country, with the exception of a single strain from Rôndonia, wich represented South America genotype II. Brazilian YFV strains have diverged into two clades; an older clade appears to have become extinct and another has become the dominant lineage in recent years. Pairwise nucleotide diversity between strains ranged from 0 per cent to 7.4 per cent, while amino acid divergence ranged from 0 per cent to 4.6 per cent. Phylogenetic analysis indicated traffic of virus variants through large geographic areas and suggested that migration of infected people may be an important mechanism of virus dispersal. Isolation of vaccine virus from a patient with a fatal case suggests that vaccine-related illness may have been misdiagnosed in the past.
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2019-10-09T11:27:11Z
dc.date.available.fl_str_mv 2019-10-09T11:27:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VASCONCELOS, Pedro Fernando da Costa et al. Genetic divergence and dispersal of Yellow Fever Virus, Brazil. Emerging Infectious Disease, v. 10, n. 9, p. 1578-1584, Sept. 2004.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/3958
dc.identifier.issn.-.fl_str_mv 1080-6040
identifier_str_mv VASCONCELOS, Pedro Fernando da Costa et al. Genetic divergence and dispersal of Yellow Fever Virus, Brazil. Emerging Infectious Disease, v. 10, n. 9, p. 1578-1584, Sept. 2004.
1080-6040
url https://patua.iec.gov.br/handle/iec/3958
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Centers for Disease Control and Prevention
publisher.none.fl_str_mv Centers for Disease Control and Prevention
dc.source.none.fl_str_mv reponame:Repositório Digital do Instituto Evandro Chagas (Patuá)
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