Evidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil

Detalhes bibliográficos
Autor(a) principal: Freitas, Ronaldo Barros de
Data de Publicação: 2003
Outros Autores: Freitas, Maria Rute Castro de, Linhares, Alexandre da Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/1912
Resumo: Trabalho apresentado no Encontro Nacional de Virologia, 14., 2003, Florianópolis.
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spelling Freitas, Ronaldo Barros deFreitas, Maria Rute Castro deLinhares, Alexandre da Costa2016-01-26T13:41:29Z2016-01-26T13:41:29Z2003FREITAS, Ronaldo Barros de; FREITAS, Maria Rute Castro de; LINHARES, Alexandre da Costa. Evidence of active of active herpesvirus 6 (variant-A) infection in patienets with lyphadenopathy in Belém, Brazil. Revista do Instituto de Medicina Tropical de São PauloI, v. 45, n. 5, p. 283-288, Sept.-Oct. 2003.https://patua.iec.gov.br/handle/iec/1912Trabalho apresentado no Encontro Nacional de Virologia, 14., 2003, Florianópolis.A total of 323 patients with lymphadenopathy were selected in Belém, Brazil, between January 1996 and December 2001, and screened for the presence of human herpesvirus-6 (HHV-6) IgM- and- IgG antibodies by enzyme-linked immunosorbent assay (ELISA). When seroprevalence is analyzed by gender, similar rates are found for female (60.6 percent) and male (55.7 percent) individuals. Seventy-seven (23.8 percent) patients were HHV-6-IgM-and- IgG-positive (IgM+ subgroup), with positivity rates of 29.7 percent and 17.7 percent (p = 0.0007) for female- and male individuals, respectively. Sera from a subgroup (n = 120) of these subjects, with high HHV-6 antibody levels (either IgM+ or IgG+ reactivities), were subsequently processed for the presence of HHV-6 DNA by polymerase chain reaction (PCR)/nested PCR. Active infections (IgM+ and/or IgG+ high levels specific antibodies plus detection of viral DNA) were diagnosed in 20/77 (20.0 percent) and 8/43 (18.6 percent); subgroup of the 120 individuals suspected of having HHV-6 suggestive recent infection. All (n = 28) cases of active infection were found to be associated with HHV-6 variant-A (HHV-6A), as detectable by PCR/nested PCR, using variant-specific primer that amplify regions of 195 base pairs (bp) (HHV-6A) and 423 bp (HHV-6B). Rates of HHV-6 DNA detection between female and male patients were similar (p 0.05) in the IgM+ and IgG+ groups: 20.4 percent versus 35.7 percent and 25.0 percent versus 13.0 percent, respectively. HHV-6 DNA was detected across 5 through 41-50-year age-groups for patients whose serum samples were IgM+, with rates ranging from 7.7 percent (female subjects aged 5 years) to 80.0 percent (male, 11-20 years). Among patients whose serological status was IgG+, HHV-6 DNA was detected in 5, 6-10, 21-30 and 50 age-groups at rates that ranged from 15.4 percent (male, 5 years of age) to 100.0 percent (female aged 11-20 years). Swelling cervical lymph nodes were the most common sign, accounting for 9 (32.0 percent) cases in each gender group. Among patients (n = 28) with active infection by HHV-6A variant, duration of symptoms lasted 1-5 days in 35.7 percent of subjects, whereas in 64.3 percent of them the disease lasted 6-20 days. Our data suggest that it is worth seeking for HHV-6 infection whenever a patient (infant or adult) presents with lymphadenopathy as a prominent symptom in the course of an acute febrile illness.Um total de 323 pacientes apresentando linfadenopatia foi selecionado em Belém, Pará, Brasil, entre janeiro de 1996 a dezembro de 2001 e, posteriormente, examinado quanto à presença de anticorpos IgM e IgG para o herpesvírus 6 (HHV-6), utilizando-se a técnica imunoenzimática (ELISA). Taxas similares são encontradas quando a soroprevalência é analisada nos indivíduos do sexo feminino (60,6%) e masculino (55,7%). Setenta e sete (23,8%) pacientes apresentaram anticorpos IgM e IgG para o HHV-6 (subgrupo IgM+), com taxas de positividade de 29,7% e 17,7% (p = 0,0007) para indivíduos dos sexos feminino e masculino, respectivamente. Soros de um subgrupo (n = 120) desses indivíduos, com altos níveis de anticorpos IgM+ ou IgG+, foram subseqüentemente processados para detecção do DNA viral do HHV-6, através da reação em cadeia da polimerase (PCR) e do "nested" PCR. Infecções ativas (detecção de altos níveis de anticorpos IgM+ e/ou IgG+ específicos mais a presença de DNA viral) foram diagnosticadas em 20/77 (26,0%) e 8/43 (18,6%); subgrupo de 120 indivíduos com quadro sugestivo de infecção recente por HHV-6. Todos (n = 28) os casos de infecção ativa foram associados com variante A do HHV-6 (HHV-6A), detectada pela técnica de PCR/"nested" PCR, utilizando-se "primers" específicos que amplificam regiões de 195 pares de bases (pb) (HHV-6A) e 423 pb (HHV-6B).Taxas de detecção do DNA do HHV-6 foram similares (p 0,05) em pacientes dos sexos feminino e masculino, no grupo IgM+ e IgG+ com: 20,4% versus 35,7% e 25,0% versus 13,0%, respectivamente. A detecção do DNA viral do HHV-6 ocorreu no grupo etário 5 até o de 41-50 anos, nos pacientes cujas amostras de soro apresentaram presença de IgM+, com taxas variando de 7,7% (mulheres do grupo 5 anos) a 80,0% (homens, 11-20 anos). Acerca dos pacientes cujo "status" sorológico foi IgG+, o DNA do HHV-6 foi detectado nos grupos de 5, 6-10, 21-30 e 50 anos, com taxas que variaram de 15,4% (homens, 5 anos) a 100,0% (mulheres, 11-20 anos). O aumento dos linfonodos cervicais foi registrado como mais freqüente, ocorrendo em número de 9 (32,0%) casos, tanto entre indivíduos do sexo masculino como naqueles do feminino. Entre os pacientes (n = 28) com infecção ativa pela variante A do HHV-6, a duração dos sintomas em 35,7% deles foi de 1-5 dias, enquanto em 64,3% durou de 6-20 dias. Nossos dados sugerem ser importante investigar a infecção pelo HHV-6 entre os pacientes (crianças e adultos) portadores de linfadenopatia como manifestação clínica proeminente no curso das doenças agudas febris.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas, Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas, Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas, Belém, PA, Brasil.application/pdfengUniversidade de São PauloEvidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, BrazilEvidência de infecção ativa por herpesvírus 6 (variante- A) em pacientes com linfadenopatia em Belém, Pará, Brasilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHerpesvirus Humano 6Belém (PA)info:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALEvidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil.pdfEvidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil.pdfapplication/pdf153006https://patua.iec.gov.br/bitstreams/e6d78290-9233-444c-aa43-03762819e651/downloadd594a7730c88deb02066fc07a91e80edMD58Evidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil [Pôster] .pdfapplication/pdf1845742https://patua.iec.gov.br/bitstreams/bd716f39-2969-492b-9faa-46bda3c67837/downloadb2b245a5c983f98c2eb61cd995103a08MD51TEXTEvidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil .pdf.txtEvidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil .pdf.txtExtracted texttext/plain7919https://patua.iec.gov.br/bitstreams/f1c4587d-7be1-49c2-947a-028867a5f076/download149f063d791efbe0d693e1617ace1fa2MD54file_1.pdf.txtfile_1.pdf.txtExtracted texttext/plain7919https://patua.iec.gov.br/bitstreams/61e1537a-e0b4-477d-8ef0-32ea17b8e55a/download149f063d791efbe0d693e1617ace1fa2MD52Evidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil.pdf.txtEvidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil.pdf.txtExtracted texttext/plain36143https://patua.iec.gov.br/bitstreams/336e2828-c51a-41ad-b800-198822a6bcd2/download81f3063ece87c28a87c40fa31538c1dfMD512Evidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil [Pôster] .pdf.txtEvidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil [Pôster] .pdf.txtExtracted texttext/plain8016https://patua.iec.gov.br/bitstreams/1383dc51-4542-4bfc-8236-ce540d18ab6e/download87756984c97c95e8cd168bb0e0e9df1cMD514THUMBNAILEvidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil .pdf.jpgEvidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil .pdf.jpgIM Thumbnailimage/jpeg5428https://patua.iec.gov.br/bitstreams/036ed722-a53f-4a22-a026-c504070c7c2a/download2c889e51f5898c7f8268c35a5b75f4abMD55file_1.pdf.jpgfile_1.pdf.jpgIM Thumbnailimage/jpeg5428https://patua.iec.gov.br/bitstreams/2518f372-8a8b-4962-a5ac-90c8c50f2041/download2c889e51f5898c7f8268c35a5b75f4abMD53Evidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil.pdf.jpgEvidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil.pdf.jpgGenerated Thumbnailimage/jpeg5446https://patua.iec.gov.br/bitstreams/dfeae9cc-e434-49ee-895e-ad4a7f232f79/downloadb1bd1bca716b07fe325f86b892abcb7cMD513Evidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil [Pôster] .pdf.jpgEvidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil [Pôster] .pdf.jpgGenerated Thumbnailimage/jpeg7870https://patua.iec.gov.br/bitstreams/2a06b9fb-4a11-4045-8df1-1630d8b6af00/downloadda12f41eb4533f6b56c1019cec32c65fMD515LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Evidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil
dc.title.alternative.pt_BR.fl_str_mv Evidência de infecção ativa por herpesvírus 6 (variante- A) em pacientes com linfadenopatia em Belém, Pará, Brasil
title Evidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil
spellingShingle Evidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil
Freitas, Ronaldo Barros de
Herpesvirus Humano 6
Belém (PA)
title_short Evidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil
title_full Evidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil
title_fullStr Evidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil
title_full_unstemmed Evidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil
title_sort Evidence of active of active herpesvirus 6 (variant-A) infection in patients with lyphadenopathy in Belém, Brazil
author Freitas, Ronaldo Barros de
author_facet Freitas, Ronaldo Barros de
Freitas, Maria Rute Castro de
Linhares, Alexandre da Costa
author_role author
author2 Freitas, Maria Rute Castro de
Linhares, Alexandre da Costa
author2_role author
author
dc.contributor.author.fl_str_mv Freitas, Ronaldo Barros de
Freitas, Maria Rute Castro de
Linhares, Alexandre da Costa
dc.subject.decsPrimary.pt_BR.fl_str_mv Herpesvirus Humano 6
Belém (PA)
topic Herpesvirus Humano 6
Belém (PA)
description Trabalho apresentado no Encontro Nacional de Virologia, 14., 2003, Florianópolis.
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2016-01-26T13:41:29Z
dc.date.available.fl_str_mv 2016-01-26T13:41:29Z
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dc.identifier.citation.fl_str_mv FREITAS, Ronaldo Barros de; FREITAS, Maria Rute Castro de; LINHARES, Alexandre da Costa. Evidence of active of active herpesvirus 6 (variant-A) infection in patienets with lyphadenopathy in Belém, Brazil. Revista do Instituto de Medicina Tropical de São PauloI, v. 45, n. 5, p. 283-288, Sept.-Oct. 2003.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/1912
identifier_str_mv FREITAS, Ronaldo Barros de; FREITAS, Maria Rute Castro de; LINHARES, Alexandre da Costa. Evidence of active of active herpesvirus 6 (variant-A) infection in patienets with lyphadenopathy in Belém, Brazil. Revista do Instituto de Medicina Tropical de São PauloI, v. 45, n. 5, p. 283-288, Sept.-Oct. 2003.
url https://patua.iec.gov.br/handle/iec/1912
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dc.publisher.none.fl_str_mv Universidade de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo
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