Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy

• Autor(a) principal: Alecrim, Maria das Graças Costa
• Data de Publicação: 2021
• Outros Autores: Amorim, Melania Maria Ramos de, Araújo, Thalia Velho Barreto de, Brasil, Patrícia, Brickley, Elizabeth B, Castilho, Marcia da Costa, Coelho, Bernadete Perez, Cunha, Antônio José Ledo Alves da, Duarte, Geraldo, Estofolete, Cássia Fernanda, Gurgel, Ricardo Queiroz, Herrero-Silva, Juliana, Hofer, Cristina Barroso, Lopes, Aline Siqueira Alves, Martelli, Celina Maria Turchi, Melo, Adriana Suely de Oliveira, Miranda Filho, Demócrito de Barros, Montarroyos, Ulisses Ramos, Moreira, Maria Elisabeth, Mussi-Pinhata, Marisa Marcia, Oliveira, Consuelo Silva de, Passos, Saulo Duarte, Prata-Barbosa, Arnaldo, Santos, Darci Neves dos, Schuler-Faccini, Lavínia, Silva, Antônio Augusto Moura da, Siqueira, Isadora Cristina de, Sousa, Patrícia da Silva, Turchi, Marília Dalva, Ximenes, Ricardo Arraes de Alencar, Zara, Ana Laura de Sene Amâncio
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/4310
• topic: Zika virus / patogenicidade; Infecção por Zika virus / genética; Microcefalia; Gestantes; Exantema; Metanálise em Rede; Estudos de Coortes

Despite great advances in our knowledge of the consequences of Zika virus to human health, many questions remain unanswered, and results are often inconsistent. The small sample size of individual studies has limited inference about the spectrum of congenital Zika manifestations and the prognosis of affected children. The Brazilian Zika Cohorts Consortium addresses these limitations by bringing together and harmonizing epidemiological data from a series of prospective cohort studies of pregnant women with rash and of children with microcephaly and/or other manifestations of congenital Zika. The objective is to estimate the absolute risk of congenital Zika manifestations and to characterize the full spectrum and natural history of the manifestations of congenital Zika in children with and without microcephaly. This protocol describes the assembly of the Consortium and protocol for the Individual Participant Data Meta-analyses (IPD Meta-analyses). The findings will address knowledge gaps and inform public policies related to Zika virus. The large harmonized dataset and joint analyses will facilitate more precise estimates of the absolute risk of congenital Zika manifestations among Zika virus-infected pregnancies and more complete descriptions of its full spectrum, including rare manifestations. It will enable sensitivity analyses using different definitions of exposure and outcomes, and the investigation of the sources of heterogeneity between studies and regions.