Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy

Detalhes bibliográficos
Autor(a) principal: Alecrim, Maria das Graças Costa
Data de Publicação: 2021
Outros Autores: Ximenes, Ricardo Arraes de Alencar, Faccini, Lavinia Schuler, Zara, Ana Laura de Sene Amâncio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/267016
Resumo: Despite great advances in our knowledge of the consequences of Zika virus to human health, many questions remain unanswered, and results are often inconsistent. The small sample size of individual studies has limited inference about the spectrum of congenital Zika manifestations and the prognosis of affected children. The Brazilian Zika Cohorts Consortium addresses these limitations by bringing together and harmonizing epidemiological data from a series of prospective cohort studies of pregnant women with rash and of children with microcephaly and/or other manifestations of congenital Zika. The objective is to estimate the absolute risk of congenital Zika manifestations and to characterize the full spectrum and natural history of the manifestations of congenital Zika in children with and without microcephaly. This protocol describes the assembly of the Consortium and protocol for the Individual Participant Data Meta-analyses (IPD Meta-analyses). The findings will address knowledge gaps and inform public policies related to Zika virus. The large harmonized dataset and joint analyses will facilitate more precise estimates of the absolute risk of congenital Zika manifestations among Zika virus-infected pregnancies and more complete descriptions of its full spectrum, including rare manifestations. It will enable sensitivity analyses using different definitions of exposure and outcomes, and the investigation of the sources of heterogeneity between studies and regions.
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spelling Alecrim, Maria das Graças CostaXimenes, Ricardo Arraes de AlencarFaccini, Lavinia SchulerZara, Ana Laura de Sene Amâncio2023-11-11T03:25:04Z20211999-4915http://hdl.handle.net/10183/267016001153914Despite great advances in our knowledge of the consequences of Zika virus to human health, many questions remain unanswered, and results are often inconsistent. The small sample size of individual studies has limited inference about the spectrum of congenital Zika manifestations and the prognosis of affected children. The Brazilian Zika Cohorts Consortium addresses these limitations by bringing together and harmonizing epidemiological data from a series of prospective cohort studies of pregnant women with rash and of children with microcephaly and/or other manifestations of congenital Zika. The objective is to estimate the absolute risk of congenital Zika manifestations and to characterize the full spectrum and natural history of the manifestations of congenital Zika in children with and without microcephaly. This protocol describes the assembly of the Consortium and protocol for the Individual Participant Data Meta-analyses (IPD Meta-analyses). The findings will address knowledge gaps and inform public policies related to Zika virus. The large harmonized dataset and joint analyses will facilitate more precise estimates of the absolute risk of congenital Zika manifestations among Zika virus-infected pregnancies and more complete descriptions of its full spectrum, including rare manifestations. It will enable sensitivity analyses using different definitions of exposure and outcomes, and the investigation of the sources of heterogeneity between studies and regions.application/pdfengViruses. Basel. Vol. 13, no. 4 (2021), e687, 13 p.Zika virusExposição maternaMicrocefaliaAnomalias congênitasIPD meta-analysisZika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001153914.pdf.txt001153914.pdf.txtExtracted Texttext/plain54822http://www.lume.ufrgs.br/bitstream/10183/267016/2/001153914.pdf.txt1992f6456c86e22662a5170e2515bfe3MD52ORIGINAL001153914.pdfTexto completo (inglês)application/pdf499764http://www.lume.ufrgs.br/bitstream/10183/267016/1/001153914.pdf0c2aaa1f8138dc6ddca211e8e57665e1MD5110183/2670162023-11-12 04:24:07.434443oai:www.lume.ufrgs.br:10183/267016Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-11-12T06:24:07Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy
title Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy
spellingShingle Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy
Alecrim, Maria das Graças Costa
Zika virus
Exposição materna
Microcefalia
Anomalias congênitas
IPD meta-analysis
title_short Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy
title_full Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy
title_fullStr Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy
title_full_unstemmed Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy
title_sort Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy
author Alecrim, Maria das Graças Costa
author_facet Alecrim, Maria das Graças Costa
Ximenes, Ricardo Arraes de Alencar
Faccini, Lavinia Schuler
Zara, Ana Laura de Sene Amâncio
author_role author
author2 Ximenes, Ricardo Arraes de Alencar
Faccini, Lavinia Schuler
Zara, Ana Laura de Sene Amâncio
author2_role author
author
author
dc.contributor.author.fl_str_mv Alecrim, Maria das Graças Costa
Ximenes, Ricardo Arraes de Alencar
Faccini, Lavinia Schuler
Zara, Ana Laura de Sene Amâncio
dc.subject.por.fl_str_mv Zika virus
Exposição materna
Microcefalia
Anomalias congênitas
topic Zika virus
Exposição materna
Microcefalia
Anomalias congênitas
IPD meta-analysis
dc.subject.eng.fl_str_mv IPD meta-analysis
description Despite great advances in our knowledge of the consequences of Zika virus to human health, many questions remain unanswered, and results are often inconsistent. The small sample size of individual studies has limited inference about the spectrum of congenital Zika manifestations and the prognosis of affected children. The Brazilian Zika Cohorts Consortium addresses these limitations by bringing together and harmonizing epidemiological data from a series of prospective cohort studies of pregnant women with rash and of children with microcephaly and/or other manifestations of congenital Zika. The objective is to estimate the absolute risk of congenital Zika manifestations and to characterize the full spectrum and natural history of the manifestations of congenital Zika in children with and without microcephaly. This protocol describes the assembly of the Consortium and protocol for the Individual Participant Data Meta-analyses (IPD Meta-analyses). The findings will address knowledge gaps and inform public policies related to Zika virus. The large harmonized dataset and joint analyses will facilitate more precise estimates of the absolute risk of congenital Zika manifestations among Zika virus-infected pregnancies and more complete descriptions of its full spectrum, including rare manifestations. It will enable sensitivity analyses using different definitions of exposure and outcomes, and the investigation of the sources of heterogeneity between studies and regions.
publishDate 2021
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dc.date.accessioned.fl_str_mv 2023-11-11T03:25:04Z
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dc.identifier.issn.pt_BR.fl_str_mv 1999-4915
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dc.relation.ispartof.pt_BR.fl_str_mv Viruses. Basel. Vol. 13, no. 4 (2021), e687, 13 p.
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