Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/267016 |
Resumo: | Despite great advances in our knowledge of the consequences of Zika virus to human health, many questions remain unanswered, and results are often inconsistent. The small sample size of individual studies has limited inference about the spectrum of congenital Zika manifestations and the prognosis of affected children. The Brazilian Zika Cohorts Consortium addresses these limitations by bringing together and harmonizing epidemiological data from a series of prospective cohort studies of pregnant women with rash and of children with microcephaly and/or other manifestations of congenital Zika. The objective is to estimate the absolute risk of congenital Zika manifestations and to characterize the full spectrum and natural history of the manifestations of congenital Zika in children with and without microcephaly. This protocol describes the assembly of the Consortium and protocol for the Individual Participant Data Meta-analyses (IPD Meta-analyses). The findings will address knowledge gaps and inform public policies related to Zika virus. The large harmonized dataset and joint analyses will facilitate more precise estimates of the absolute risk of congenital Zika manifestations among Zika virus-infected pregnancies and more complete descriptions of its full spectrum, including rare manifestations. It will enable sensitivity analyses using different definitions of exposure and outcomes, and the investigation of the sources of heterogeneity between studies and regions. |
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Alecrim, Maria das Graças CostaXimenes, Ricardo Arraes de AlencarFaccini, Lavinia SchulerZara, Ana Laura de Sene Amâncio2023-11-11T03:25:04Z20211999-4915http://hdl.handle.net/10183/267016001153914Despite great advances in our knowledge of the consequences of Zika virus to human health, many questions remain unanswered, and results are often inconsistent. The small sample size of individual studies has limited inference about the spectrum of congenital Zika manifestations and the prognosis of affected children. The Brazilian Zika Cohorts Consortium addresses these limitations by bringing together and harmonizing epidemiological data from a series of prospective cohort studies of pregnant women with rash and of children with microcephaly and/or other manifestations of congenital Zika. The objective is to estimate the absolute risk of congenital Zika manifestations and to characterize the full spectrum and natural history of the manifestations of congenital Zika in children with and without microcephaly. This protocol describes the assembly of the Consortium and protocol for the Individual Participant Data Meta-analyses (IPD Meta-analyses). The findings will address knowledge gaps and inform public policies related to Zika virus. The large harmonized dataset and joint analyses will facilitate more precise estimates of the absolute risk of congenital Zika manifestations among Zika virus-infected pregnancies and more complete descriptions of its full spectrum, including rare manifestations. It will enable sensitivity analyses using different definitions of exposure and outcomes, and the investigation of the sources of heterogeneity between studies and regions.application/pdfengViruses. Basel. Vol. 13, no. 4 (2021), e687, 13 p.Zika virusExposição maternaMicrocefaliaAnomalias congênitasIPD meta-analysisZika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001153914.pdf.txt001153914.pdf.txtExtracted Texttext/plain54822http://www.lume.ufrgs.br/bitstream/10183/267016/2/001153914.pdf.txt1992f6456c86e22662a5170e2515bfe3MD52ORIGINAL001153914.pdfTexto completo (inglês)application/pdf499764http://www.lume.ufrgs.br/bitstream/10183/267016/1/001153914.pdf0c2aaa1f8138dc6ddca211e8e57665e1MD5110183/2670162023-11-12 04:24:07.434443oai:www.lume.ufrgs.br:10183/267016Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-11-12T06:24:07Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy |
title |
Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy |
spellingShingle |
Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy Alecrim, Maria das Graças Costa Zika virus Exposição materna Microcefalia Anomalias congênitas IPD meta-analysis |
title_short |
Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy |
title_full |
Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy |
title_fullStr |
Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy |
title_full_unstemmed |
Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy |
title_sort |
Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy |
author |
Alecrim, Maria das Graças Costa |
author_facet |
Alecrim, Maria das Graças Costa Ximenes, Ricardo Arraes de Alencar Faccini, Lavinia Schuler Zara, Ana Laura de Sene Amâncio |
author_role |
author |
author2 |
Ximenes, Ricardo Arraes de Alencar Faccini, Lavinia Schuler Zara, Ana Laura de Sene Amâncio |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Alecrim, Maria das Graças Costa Ximenes, Ricardo Arraes de Alencar Faccini, Lavinia Schuler Zara, Ana Laura de Sene Amâncio |
dc.subject.por.fl_str_mv |
Zika virus Exposição materna Microcefalia Anomalias congênitas |
topic |
Zika virus Exposição materna Microcefalia Anomalias congênitas IPD meta-analysis |
dc.subject.eng.fl_str_mv |
IPD meta-analysis |
description |
Despite great advances in our knowledge of the consequences of Zika virus to human health, many questions remain unanswered, and results are often inconsistent. The small sample size of individual studies has limited inference about the spectrum of congenital Zika manifestations and the prognosis of affected children. The Brazilian Zika Cohorts Consortium addresses these limitations by bringing together and harmonizing epidemiological data from a series of prospective cohort studies of pregnant women with rash and of children with microcephaly and/or other manifestations of congenital Zika. The objective is to estimate the absolute risk of congenital Zika manifestations and to characterize the full spectrum and natural history of the manifestations of congenital Zika in children with and without microcephaly. This protocol describes the assembly of the Consortium and protocol for the Individual Participant Data Meta-analyses (IPD Meta-analyses). The findings will address knowledge gaps and inform public policies related to Zika virus. The large harmonized dataset and joint analyses will facilitate more precise estimates of the absolute risk of congenital Zika manifestations among Zika virus-infected pregnancies and more complete descriptions of its full spectrum, including rare manifestations. It will enable sensitivity analyses using different definitions of exposure and outcomes, and the investigation of the sources of heterogeneity between studies and regions. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2023-11-11T03:25:04Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/267016 |
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1999-4915 |
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001153914 |
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1999-4915 001153914 |
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http://hdl.handle.net/10183/267016 |
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eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Viruses. Basel. Vol. 13, no. 4 (2021), e687, 13 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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