Virus infections on prion diseased mice exacerbate inflammatory microglial response
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/2514 |
Resumo: | We investigated possible interaction between an arbovirus infection and the ME7 induced mice prion disease. C57BL/6, females, 6- week-old, were submitted to a bilateral intrahippocampal injection of ME7 prion strain (ME7) or normal brain homogenate (NBH). After injections, animals were organized into two groups: NBH (n = 26) and ME7 (n = 29). At 15th week after injections (wpi), animals were challenged intranasally with a suspension of Piry arbovirus 0.001% or with NBH. Behavioral changes in ME7 animals appeared in burrowing activity at 14 wpi. Hyperactivity on open field test, errors on rod bridge, and time reduction in inverted screen were detected at 15th, 19th, and 20th wpi respectively. Burrowing was more sensitive to earlier hippocampus dysfunction. However, Piry-infection did not significantly affect the already ongoing burrowing decline in the ME7-treated mice. After behavioral tests, brains were processed for IBA1, protease-resistant form of PrP, and Piry virus antigens. Although virus infection in isolation did not change the number of microglia in CA1, virus infection in prion diseased mice (at 17th wpi) induced changes in number and morphology of microglia in a laminar-dependent way. We suggest that virus infection exacerbates microglial inflammatory response to a greater degree in prion-infected mice, and this is not necessarily correlated with hippocampal-dependent behavioral deficits. |
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Lins, NaraMourão, LuizTrévia, NonataPassos, AlineFarias, José AugustoAssunção, JarilaQuintairos, AmandaTorres Neto, João BentoSosthenes, Marcia Consentino KronkaDiniz Junior, José Antonio PicançoVasconcelos, Pedro Fernando da CostaDiniz, Cristovam Wanderley Picanço2017-02-14T11:35:46Z2017-02-14T11:35:46Z2016LINS, Nara et al. Virus infections on prion diseased mice exacerbate inflammatory microglial response. Oxidative Medicine and Cellular Longevity, v. 2016, p. 1-12, 2016.1942-0994https://patua.iec.gov.br/handle/iec/251410.1155/2016/3974648We investigated possible interaction between an arbovirus infection and the ME7 induced mice prion disease. C57BL/6, females, 6- week-old, were submitted to a bilateral intrahippocampal injection of ME7 prion strain (ME7) or normal brain homogenate (NBH). After injections, animals were organized into two groups: NBH (n = 26) and ME7 (n = 29). At 15th week after injections (wpi), animals were challenged intranasally with a suspension of Piry arbovirus 0.001% or with NBH. Behavioral changes in ME7 animals appeared in burrowing activity at 14 wpi. Hyperactivity on open field test, errors on rod bridge, and time reduction in inverted screen were detected at 15th, 19th, and 20th wpi respectively. Burrowing was more sensitive to earlier hippocampus dysfunction. However, Piry-infection did not significantly affect the already ongoing burrowing decline in the ME7-treated mice. After behavioral tests, brains were processed for IBA1, protease-resistant form of PrP, and Piry virus antigens. Although virus infection in isolation did not change the number of microglia in CA1, virus infection in prion diseased mice (at 17th wpi) induced changes in number and morphology of microglia in a laminar-dependent way. We suggest that virus infection exacerbates microglial inflammatory response to a greater degree in prion-infected mice, and this is not necessarily correlated with hippocampal-dependent behavioral deficits.Universidade Federal do Pará. Instituto de Ciências Biológicas. Hospital Universitário João de Barros Barreto. Laboratório de Investigações em Neurodegeneração e Infecção. Belém, PA, Brasil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Hospital Universitário João de Barros Barreto. Laboratório de Investigações em Neurodegeneração e Infecção. Belém, PA, Brasil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Hospital Universitário João de Barros Barreto. Laboratório de Investigações em Neurodegeneração e Infecção. Belém, PA, Brasil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Hospital Universitário João de Barros Barreto. Laboratório de Investigações em Neurodegeneração e Infecção. Belém, PA, Brasil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Hospital Universitário João de Barros Barreto. Laboratório de Investigações em Neurodegeneração e Infecção. Belém, PA, Brasil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Hospital Universitário João de Barros Barreto. Laboratório de Investigações em Neurodegeneração e Infecção. Belém, PA, Brasil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Hospital Universitário João de Barros Barreto. Laboratório de Investigações em Neurodegeneração e Infecção. Belém, PA, Brasil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Hospital Universitário João de Barros Barreto. Laboratório de Investigações em Neurodegeneração e Infecção. Belém, PA, Brasil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Hospital Universitário João de Barros Barreto. Laboratório de Investigações em Neurodegeneração e Infecção. Belém, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Universidade Federal do Pará. Instituto de Ciências Biológicas. Hospital Universitário João de Barros Barreto. Laboratório de Investigações em Neurodegeneração e Infecção. Belém, PA, Brasil.engHindawi Publishing CorporationVirus infections on prion diseased mice exacerbate inflammatory microglial responseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDoenças NeurodegenerativasArbovirusDoenças de PríonMicrogliaRatosinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALVirus infections on prion diseased mice exacerbate inflammatory microglial response.pdfVirus infections on prion diseased mice exacerbate inflammatory microglial response.pdfapplication/pdf5751431https://patua.iec.gov.br/bitstreams/b5d4f72c-7be7-4a94-b61d-d533673ff468/download2a99af8e61b7800c3f58fbbd936fb2e2MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/c3d1591b-d6ef-41cd-9444-a4fe1b17cb33/download52f1732ea66fbd1123abe39f5373b797MD52TEXTvirus infection3974648 (1).pdf.txtvirus infection3974648 (1).pdf.txtExtracted texttext/plain58906https://patua.iec.gov.br/bitstreams/51993fab-2941-4063-9308-ccc1f2a40a33/download9c2ae8602f5db83ec234588e2519c2f2MD53Virus infections on prion diseased mice exacerbate inflammatory microglial response.pdf.txtVirus infections on prion diseased mice exacerbate inflammatory microglial response.pdf.txtExtracted texttext/plain59274https://patua.iec.gov.br/bitstreams/ba9eea40-a107-4caa-a09d-71eb93fb7dc0/downloada8502f44db5359562b0fd2590c74881cMD56THUMBNAILVirus infections on prion diseased mice exacerbate inflammatory microglial response.pdf.jpgVirus infections on prion diseased mice exacerbate inflammatory microglial response.pdf.jpgGenerated Thumbnailimage/jpeg5474https://patua.iec.gov.br/bitstreams/9da9b34c-5b43-4c97-8e0e-6b2d716d2dc5/downloadc3b32449e3d3d5301228e0055721bee0MD57iec/25142022-10-21 00:03:12.654oai:patua.iec.gov.br:iec/2514https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-21T00:03:12Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4= |
dc.title.pt_BR.fl_str_mv |
Virus infections on prion diseased mice exacerbate inflammatory microglial response |
title |
Virus infections on prion diseased mice exacerbate inflammatory microglial response |
spellingShingle |
Virus infections on prion diseased mice exacerbate inflammatory microglial response Lins, Nara Doenças Neurodegenerativas Arbovirus Doenças de Príon Microglia Ratos |
title_short |
Virus infections on prion diseased mice exacerbate inflammatory microglial response |
title_full |
Virus infections on prion diseased mice exacerbate inflammatory microglial response |
title_fullStr |
Virus infections on prion diseased mice exacerbate inflammatory microglial response |
title_full_unstemmed |
Virus infections on prion diseased mice exacerbate inflammatory microglial response |
title_sort |
Virus infections on prion diseased mice exacerbate inflammatory microglial response |
author |
Lins, Nara |
author_facet |
Lins, Nara Mourão, Luiz Trévia, Nonata Passos, Aline Farias, José Augusto Assunção, Jarila Quintairos, Amanda Torres Neto, João Bento Sosthenes, Marcia Consentino Kronka Diniz Junior, José Antonio Picanço Vasconcelos, Pedro Fernando da Costa Diniz, Cristovam Wanderley Picanço |
author_role |
author |
author2 |
Mourão, Luiz Trévia, Nonata Passos, Aline Farias, José Augusto Assunção, Jarila Quintairos, Amanda Torres Neto, João Bento Sosthenes, Marcia Consentino Kronka Diniz Junior, José Antonio Picanço Vasconcelos, Pedro Fernando da Costa Diniz, Cristovam Wanderley Picanço |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lins, Nara Mourão, Luiz Trévia, Nonata Passos, Aline Farias, José Augusto Assunção, Jarila Quintairos, Amanda Torres Neto, João Bento Sosthenes, Marcia Consentino Kronka Diniz Junior, José Antonio Picanço Vasconcelos, Pedro Fernando da Costa Diniz, Cristovam Wanderley Picanço |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Doenças Neurodegenerativas Arbovirus Doenças de Príon Microglia Ratos |
topic |
Doenças Neurodegenerativas Arbovirus Doenças de Príon Microglia Ratos |
description |
We investigated possible interaction between an arbovirus infection and the ME7 induced mice prion disease. C57BL/6, females, 6- week-old, were submitted to a bilateral intrahippocampal injection of ME7 prion strain (ME7) or normal brain homogenate (NBH). After injections, animals were organized into two groups: NBH (n = 26) and ME7 (n = 29). At 15th week after injections (wpi), animals were challenged intranasally with a suspension of Piry arbovirus 0.001% or with NBH. Behavioral changes in ME7 animals appeared in burrowing activity at 14 wpi. Hyperactivity on open field test, errors on rod bridge, and time reduction in inverted screen were detected at 15th, 19th, and 20th wpi respectively. Burrowing was more sensitive to earlier hippocampus dysfunction. However, Piry-infection did not significantly affect the already ongoing burrowing decline in the ME7-treated mice. After behavioral tests, brains were processed for IBA1, protease-resistant form of PrP, and Piry virus antigens. Although virus infection in isolation did not change the number of microglia in CA1, virus infection in prion diseased mice (at 17th wpi) induced changes in number and morphology of microglia in a laminar-dependent way. We suggest that virus infection exacerbates microglial inflammatory response to a greater degree in prion-infected mice, and this is not necessarily correlated with hippocampal-dependent behavioral deficits. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-02-14T11:35:46Z |
dc.date.available.fl_str_mv |
2017-02-14T11:35:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
LINS, Nara et al. Virus infections on prion diseased mice exacerbate inflammatory microglial response. Oxidative Medicine and Cellular Longevity, v. 2016, p. 1-12, 2016. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/2514 |
dc.identifier.issn.-.fl_str_mv |
1942-0994 |
dc.identifier.doi.-.fl_str_mv |
10.1155/2016/3974648 |
identifier_str_mv |
LINS, Nara et al. Virus infections on prion diseased mice exacerbate inflammatory microglial response. Oxidative Medicine and Cellular Longevity, v. 2016, p. 1-12, 2016. 1942-0994 10.1155/2016/3974648 |
url |
https://patua.iec.gov.br/handle/iec/2514 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Hindawi Publishing Corporation |
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Hindawi Publishing Corporation |
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