Human herpesvirus 8 in brazilian amerindians: a hyperendemic population with a new subtype
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/927 |
Resumo: | Human herpesvirus 8 (HHV-8) epidemiology in Brazilian Amerindians was studied. Use of an immunofluorescence (IFA) test for latent antibody demonstrated that the prevalence of HHV-8 in 781 Amerindians of diverse tribes (overall, 53% prevalence) was not related to language group or sex but rather increased gradually from 41% in children !10 years of age to 65% in adults >30 years of age. In IFA-positive subjects, HHV-8 DNA was detected in 3 (16%) of 19 mononuclear cell samples from peripheral blood and in 1 of 16 saliva samples. The sequences of conserved ORF22 and K6 genes were typical of HHV-8, but the variable K1 gene sequences were only 70%–75% identical to other known HHV-8 strains. Thus, a new HHV-8 subtype, E, is hyperendemic in Brazilian Amerindians, although Kaposi’s sarcoma has not been reported. Transmission is probably oral rather than sexual. The limited genetic pool in isolated groups may permit more frequent transmission of a virus with a low prevalence in heterogeneous populations. |
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Biggar, Robert JWhitby, DeniseMarshall, VickieLinhares, Alexandre da CostaBlack, Francis2016-01-26T11:39:48Z2016-01-26T11:39:48Z2000BIGGAR, Robert J. et al. Human herpesvirus 8 in brazilian amerindians: a hyperendemic population with a new subtype. Journal of Infectious Diseases, v. 181, n. 5, p. 1562-1568, May 2000.1553-6203https://patua.iec.gov.br/handle/iec/927Human herpesvirus 8 (HHV-8) epidemiology in Brazilian Amerindians was studied. Use of an immunofluorescence (IFA) test for latent antibody demonstrated that the prevalence of HHV-8 in 781 Amerindians of diverse tribes (overall, 53% prevalence) was not related to language group or sex but rather increased gradually from 41% in children !10 years of age to 65% in adults >30 years of age. In IFA-positive subjects, HHV-8 DNA was detected in 3 (16%) of 19 mononuclear cell samples from peripheral blood and in 1 of 16 saliva samples. The sequences of conserved ORF22 and K6 genes were typical of HHV-8, but the variable K1 gene sequences were only 70%–75% identical to other known HHV-8 strains. Thus, a new HHV-8 subtype, E, is hyperendemic in Brazilian Amerindians, although Kaposi’s sarcoma has not been reported. Transmission is probably oral rather than sexual. The limited genetic pool in isolated groups may permit more frequent transmission of a virus with a low prevalence in heterogeneous populations.National Cancer Institute. National Institutes of Health. Viral Epidemiology Branch. Frederick, Maryland.National Cancer Institute. Frederick Cancer Research and Development Center. Viral Epidemiology Section. AIDS Vaccine Program. Frederick, Maryland.National Cancer Institute. Frederick Cancer Research and Development Center. Viral Epidemiology Section. AIDS Vaccine Program. Frederick, Maryland.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Yale University. School of Public Health. Department of Epidemiology. New Haven, Connecticut.application/pdfengOxford University PressHuman herpesvirus 8 in brazilian amerindians: a hyperendemic population with a new subtypeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHerpesvirus Humano 8 / isolamento & purificaçãoHerpesvirus Humano 8 / patogenicidadeInfecções por Herpesviridae / epidemiologiaSarcoma de Kaposi / imunologiaÍndios Sul-AmericanosPopulação Indígenainfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALHuman herpesvirus 8 in Brazilian Amerindians: a hyperendemic population with a new subtype .pdfapplication/pdf234794https://patua.iec.gov.br/bitstreams/46d99174-2ba5-45bd-b3cd-358c523c92b0/download47a3ccf6250d1cf4eb366b8f5ff0597dMD51TEXTfile_1.pdf.txtfile_1.pdf.txtExtracted texttext/plain30021https://patua.iec.gov.br/bitstreams/23a20484-153d-4e8f-930a-6e3505fc3638/download9dee3c023813bfb14f0354454507d4eeMD52Human herpesvirus 8 in Brazilian Amerindians: a hyperendemic population with a new subtype .pdf.txtHuman herpesvirus 8 in Brazilian Amerindians: a hyperendemic population with a new subtype .pdf.txtExtracted texttext/plain30255https://patua.iec.gov.br/bitstreams/60d5f61b-2cf7-40fe-bc08-54e5fdc1d4b4/download32cab91318986b6692fee327e08c907aMD56THUMBNAILHuman herpesvirus 8 in Brazilian Amerindians: a hyperendemic population with a new subtype .pdf.jpgHuman herpesvirus 8 in Brazilian Amerindians: a hyperendemic population with a new subtype .pdf.jpgGenerated Thumbnailimage/jpeg5939https://patua.iec.gov.br/bitstreams/45b53939-f9f4-4b6b-9347-35b63aa8f57e/download8f3218e9315f960b1a21af46a3f8b0ffMD57LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Human herpesvirus 8 in brazilian amerindians: a hyperendemic population with a new subtype |
title |
Human herpesvirus 8 in brazilian amerindians: a hyperendemic population with a new subtype |
spellingShingle |
Human herpesvirus 8 in brazilian amerindians: a hyperendemic population with a new subtype Biggar, Robert J Herpesvirus Humano 8 / isolamento & purificação Herpesvirus Humano 8 / patogenicidade Infecções por Herpesviridae / epidemiologia Sarcoma de Kaposi / imunologia Índios Sul-Americanos População Indígena |
title_short |
Human herpesvirus 8 in brazilian amerindians: a hyperendemic population with a new subtype |
title_full |
Human herpesvirus 8 in brazilian amerindians: a hyperendemic population with a new subtype |
title_fullStr |
Human herpesvirus 8 in brazilian amerindians: a hyperendemic population with a new subtype |
title_full_unstemmed |
Human herpesvirus 8 in brazilian amerindians: a hyperendemic population with a new subtype |
title_sort |
Human herpesvirus 8 in brazilian amerindians: a hyperendemic population with a new subtype |
author |
Biggar, Robert J |
author_facet |
Biggar, Robert J Whitby, Denise Marshall, Vickie Linhares, Alexandre da Costa Black, Francis |
author_role |
author |
author2 |
Whitby, Denise Marshall, Vickie Linhares, Alexandre da Costa Black, Francis |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Biggar, Robert J Whitby, Denise Marshall, Vickie Linhares, Alexandre da Costa Black, Francis |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Herpesvirus Humano 8 / isolamento & purificação Herpesvirus Humano 8 / patogenicidade Infecções por Herpesviridae / epidemiologia Sarcoma de Kaposi / imunologia Índios Sul-Americanos População Indígena |
topic |
Herpesvirus Humano 8 / isolamento & purificação Herpesvirus Humano 8 / patogenicidade Infecções por Herpesviridae / epidemiologia Sarcoma de Kaposi / imunologia Índios Sul-Americanos População Indígena |
description |
Human herpesvirus 8 (HHV-8) epidemiology in Brazilian Amerindians was studied. Use of an immunofluorescence (IFA) test for latent antibody demonstrated that the prevalence of HHV-8 in 781 Amerindians of diverse tribes (overall, 53% prevalence) was not related to language group or sex but rather increased gradually from 41% in children !10 years of age to 65% in adults >30 years of age. In IFA-positive subjects, HHV-8 DNA was detected in 3 (16%) of 19 mononuclear cell samples from peripheral blood and in 1 of 16 saliva samples. The sequences of conserved ORF22 and K6 genes were typical of HHV-8, but the variable K1 gene sequences were only 70%–75% identical to other known HHV-8 strains. Thus, a new HHV-8 subtype, E, is hyperendemic in Brazilian Amerindians, although Kaposi’s sarcoma has not been reported. Transmission is probably oral rather than sexual. The limited genetic pool in isolated groups may permit more frequent transmission of a virus with a low prevalence in heterogeneous populations. |
publishDate |
2000 |
dc.date.issued.fl_str_mv |
2000 |
dc.date.accessioned.fl_str_mv |
2016-01-26T11:39:48Z |
dc.date.available.fl_str_mv |
2016-01-26T11:39:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BIGGAR, Robert J. et al. Human herpesvirus 8 in brazilian amerindians: a hyperendemic population with a new subtype. Journal of Infectious Diseases, v. 181, n. 5, p. 1562-1568, May 2000. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/927 |
dc.identifier.issn.-.fl_str_mv |
1553-6203 |
identifier_str_mv |
BIGGAR, Robert J. et al. Human herpesvirus 8 in brazilian amerindians: a hyperendemic population with a new subtype. Journal of Infectious Diseases, v. 181, n. 5, p. 1562-1568, May 2000. 1553-6203 |
url |
https://patua.iec.gov.br/handle/iec/927 |
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eng |
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info:eu-repo/semantics/openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Oxford University Press |
publisher.none.fl_str_mv |
Oxford University Press |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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