The protective effect of Canova homeopathic medicine in cyclophosphamide-treated non-human primates

• Autor(a) principal: Leal, Mariana Ferreira
• Data de Publicação: 2012
• Outros Autores: Antunes, Lusânia Maria Greggi, Lamarão, Maria Fernanda Vita, Silva, Carla Elvira Araújo da, Silva, Ismael Dale Cotrim Guerreiro da, Assumpção, Paulo Pimentel, Andrade, Edilson Ferreira, Rezende, Alexandre Pingarilho, Imbeloni, Aline Amaral, Muniz, José Augusto Pereira Carneiro, Pinto, Giovanny Rebouças, Smith, Marília de Arruda Cardoso, Burbano, Rommel Mário Rodríguez
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/4642
• topic: Primatas / anatomia & histologia; Medicamento Homeopático / uso terapêutico; Macrofagos; Sistema Imunitário

Background: Canova activates macrophages and indirectly induces lymphocyte proliferation. Here we evaluated the effects of Canova in cyclophosphamide-treated non-human primates. Methods: Twelve Cebus apella were evaluated. Four animals were treated with Canova only. Eight animals were treated with two doses of cyclophosphamide (50 mg/kg) and four of these animals received Canova. Body weight, biochemistry and hematologic analyses were performed for 40 days. Micronucleus and comet assays were performed for the evaluation of DNA damage. Results: We observed that cyclophosphamide induced abnormal WBC count in all animals. However, the group treated with cyclophosphamide plus Canova presented a higher leukocyte count than that which received only cyclophosphamide. Cyclophosphamide induced micronucleus and DNA damage in all animals. The frequency of these alterations was significantly lower in the Canova group than in the group without this medicine. Conclusions: Our results demonstrated that Canova treatment minimizes cyclophosphamide myelotoxicity in C. apella.