Nutritional status in relation to the eficacy of the Rhesus-Human Reassortant, Tetravalent Rotavirus Vaccine (RRV-TV) in infants from Belém, Pará State, Brazil

• Autor(a) principal: Linhares, Alexandre da Costa
• Data de Publicação: 2002
• Outros Autores: Carmo, Kênea B. do, Oliveira, Krynnssya Kleinlein, Oliveira, Consuelo Silva de, Freitas, Ronaldo Barros de, Bellesi, Newton, Monteiro, Talita Antônia Furtado, Gabbay, Yvone Benchimol, Mascarenhas, Joana D'Arc Pereira
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/3286
• topic: Vacinas contra Rotavirus / uso terapêutico; Transtornos da Nutrição Infantil / complicações; Estado Nutricional / efeitos de drogas

The rhesus-human reassortant, tetravalent rotavirus vaccine (RRV-TV) was licensed for routine use in the United States of America but it was recently withdrawn from the market because of its possible association with intussusception as an adverse event. The protective efficacy of 3 doses of RRV-TV, in its lower-titer (4 x 104 pfu/dose) formulation, was evaluated according to the nutritional status of infants who participated in a phase III trial in Belém, Northern Brazil. A moderate protection conferred by RRVTV was related to weight-for-age Z-scores (WAZ) greater than -1 only, with rates of 38% (p = 0.04) and 40% (p = 0.04) for all- andpure rotavirus diarrhoeal cases, respectively. In addition, there was a trend for greater efficacy (43%, p = 0.05) among infants reaching an height-for-age Z-score (HAZ) of > -1. Taking WAZ, HAZ and weight-for-height Z-score (WHZ) indices -1 together, there was no significant protection (p > 0.05) if both placebo and vaccine groups are compared. There was no significant difference if rates of mixed and pure rotavirus diarrhoeal cases are compared in relation to HAZ, WAZ and weight-for-height Z-score (WHZ) indices. Although a low number of malnourished infants could be identified in the present study, our data show some evidence that malnutrition may interfere with the efficacy of rotavirus vaccines in developing countries.