Nutritional status in relation to the eficacy of the Rhesus-Human Reassortant, Tetravalent Rotavirus Vaccine (RRV-TV) in infants from Belém, Pará State, Brazil
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Publication Date: | 2002 |
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Format: | Article |
Language: | eng |
Source: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Download full: | https://patua.iec.gov.br/handle/iec/3286 |
Summary: | The rhesus-human reassortant, tetravalent rotavirus vaccine (RRV-TV) was licensed for routine use in the United States of America but it was recently withdrawn from the market because of its possible association with intussusception as an adverse event. The protective efficacy of 3 doses of RRV-TV, in its lower-titer (4 x 104 pfu/dose) formulation, was evaluated according to the nutritional status of infants who participated in a phase III trial in Belém, Northern Brazil. A moderate protection conferred by RRVTV was related to weight-for-age Z-scores (WAZ) greater than -1 only, with rates of 38% (p = 0.04) and 40% (p = 0.04) for all- andpure rotavirus diarrhoeal cases, respectively. In addition, there was a trend for greater efficacy (43%, p = 0.05) among infants reaching an height-for-age Z-score (HAZ) of > -1. Taking WAZ, HAZ and weight-for-height Z-score (WHZ) indices -1 together, there was no significant protection (p > 0.05) if both placebo and vaccine groups are compared. There was no significant difference if rates of mixed and pure rotavirus diarrhoeal cases are compared in relation to HAZ, WAZ and weight-for-height Z-score (WHZ) indices. Although a low number of malnourished infants could be identified in the present study, our data show some evidence that malnutrition may interfere with the efficacy of rotavirus vaccines in developing countries. |
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Linhares, Alexandre da CostaCarmo, Kênea B. doOliveira, Krynnssya KleinleinOliveira, Consuelo Silva deFreitas, Ronaldo Barros deBellesi, NewtonMonteiro, Talita Antônia FurtadoGabbay, Yvone BenchimolMascarenhas, Joana D'Arc Pereira2018-08-21T17:30:05Z2018-08-21T17:30:05Z2002LINHARES, Alexandre da Costa et al. Nutritional status in relation to the eficacy of the Rhesus-Human Reassortant, Tetravalent Rotavirus Vaccine (RRV-TV) in infants from Belém, Pará State, Brazil. Revista do Instituto de Medicina Tropical de São Paulo, v. 44, n. 1, p. 13-16, Jan.-Feb. 2002.0036-4665https://patua.iec.gov.br/handle/iec/3286The rhesus-human reassortant, tetravalent rotavirus vaccine (RRV-TV) was licensed for routine use in the United States of America but it was recently withdrawn from the market because of its possible association with intussusception as an adverse event. The protective efficacy of 3 doses of RRV-TV, in its lower-titer (4 x 104 pfu/dose) formulation, was evaluated according to the nutritional status of infants who participated in a phase III trial in Belém, Northern Brazil. A moderate protection conferred by RRVTV was related to weight-for-age Z-scores (WAZ) greater than -1 only, with rates of 38% (p = 0.04) and 40% (p = 0.04) for all- andpure rotavirus diarrhoeal cases, respectively. In addition, there was a trend for greater efficacy (43%, p = 0.05) among infants reaching an height-for-age Z-score (HAZ) of > -1. Taking WAZ, HAZ and weight-for-height Z-score (WHZ) indices -1 together, there was no significant protection (p > 0.05) if both placebo and vaccine groups are compared. There was no significant difference if rates of mixed and pure rotavirus diarrhoeal cases are compared in relation to HAZ, WAZ and weight-for-height Z-score (WHZ) indices. Although a low number of malnourished infants could be identified in the present study, our data show some evidence that malnutrition may interfere with the efficacy of rotavirus vaccines in developing countries.A vacina tetravalente contra rotavírus de origem símio-humana, geneticamente rearranjada (RRV-TV), foi licenciada para uso rotineiro nos Estados Unidos da América do Norte; entretanto, tal imunizante foi removido do mercado, uma vez que a intussuscepção emergiu como possível evento adverso vacinal. A eficácia da RRV-TV - em sua formulação menos concentrada (10 x 104 pfu/dose) û foi avaliada no tocante ao estado nutricional das crianças que integraram estudo caracterizado como de fase III, levado a efeito em Belém, região norte do Brasil. Observou-se proteção (moderada) apenas entre os indivíduos com escore ôZö (peso-por-idade, WAZ) superior a û1, com eficácias de 38 por cento (p = 0,04) e 40 por cento (p = 0,04) para todos os episódios de diarréia por rotavírus e os caracterizados como ôpurosö (sem outro enteropatógeno identificado no espécime clínico), respectivamente. A par disso, denotou-se tendência a mais elevados níveis protetores (43 por cento, p = 0.05) entre crianças que apresentavam escore ôZö (estatura-por-idade, HAZ) -1. Considerando-se conjuntamente os escores ôZö [WAZ, HAZ e peso-por estatura (WHZ)] menores ou iguais a û1, não se registrou proteção significativa (p 0,05), uma vez comparadas as crianças que receberam placebo àquelas vacinadas. Também não resultaram expressivas as diferenças, se as infecções ôpurasö e ômistasö por rotavírus são comparadas relativamente às variáveis antropométricas HAZ, WAZ e WHZ. Não obstante o reduzido número de infantes desnutridos no presente estudo, os resultados disponíveis oferecem evidências de que o estado nutricional pode interferir na eficácia das vacinas contra rotavirus nos países em desenvolvimento.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Clínica de Medicina Preventiva do Pará. Belém, PA, Brasil.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ministério da Saúde. Fundação Nacional de Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.engUniversidade de São PauloNutritional status in relation to the eficacy of the Rhesus-Human Reassortant, Tetravalent Rotavirus Vaccine (RRV-TV) in infants from Belém, Pará State, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleVacinas contra Rotavirus / uso terapêuticoTranstornos da Nutrição Infantil / complicaçõesEstado Nutricional / efeitos de drogasinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALNutritional status in relation to the eficacy of the Rhesus-Human Reassortant, Tetravalent Rotavirus Vaccine (RRV-TV) in infants from Belém, Pará State, Brazil.pdfNutritional status in relation to the eficacy of the Rhesus-Human Reassortant, Tetravalent Rotavirus Vaccine (RRV-TV) in infants from Belém, Pará State, Brazil.pdfapplication/pdf59157https://patua.iec.gov.br/bitstreams/64f2f3fb-589f-411b-bc7f-b76ff7007e39/download48e04ec0609c26d5681f228d0aec92ccMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/70d534c2-a522-4ad6-a3de-be9184c59b05/download52f1732ea66fbd1123abe39f5373b797MD52TEXTNutritional status in relation to the eficacy of the Rhesus-Human Reassortant, Tetravalent Rotavirus Vaccine (RRV-TV) in infants from Belém, Pará State, Brazil.pdf.txtNutritional status in relation to the eficacy of the Rhesus-Human Reassortant, Tetravalent Rotavirus Vaccine (RRV-TV) in infants from Belém, Pará State, Brazil.pdf.txtExtracted texttext/plain23878https://patua.iec.gov.br/bitstreams/c34685e6-c21e-42cc-b611-f6dd4feaf3d8/downloadbc41b6c9d81f564a3d9ea6de5d4c7482MD55THUMBNAILNutritional status in relation to the eficacy of the Rhesus-Human Reassortant, Tetravalent Rotavirus Vaccine (RRV-TV) in infants from Belém, Pará State, Brazil.pdf.jpgNutritional status in relation to the eficacy of the Rhesus-Human Reassortant, Tetravalent Rotavirus Vaccine (RRV-TV) in infants from Belém, Pará State, Brazil.pdf.jpgGenerated Thumbnailimage/jpeg6048https://patua.iec.gov.br/bitstreams/a7572089-73a8-4b39-8bc5-2851dcdd4459/download7dc4b0f2e5f0e274e8ffafeb0807fdb8MD56iec/32862022-10-20 21:51:23.011oai:patua.iec.gov.br:iec/3286https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T21:51:23Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4= |
dc.title.pt_BR.fl_str_mv |
Nutritional status in relation to the eficacy of the Rhesus-Human Reassortant, Tetravalent Rotavirus Vaccine (RRV-TV) in infants from Belém, Pará State, Brazil |
title |
Nutritional status in relation to the eficacy of the Rhesus-Human Reassortant, Tetravalent Rotavirus Vaccine (RRV-TV) in infants from Belém, Pará State, Brazil |
spellingShingle |
Nutritional status in relation to the eficacy of the Rhesus-Human Reassortant, Tetravalent Rotavirus Vaccine (RRV-TV) in infants from Belém, Pará State, Brazil Linhares, Alexandre da Costa Vacinas contra Rotavirus / uso terapêutico Transtornos da Nutrição Infantil / complicações Estado Nutricional / efeitos de drogas |
title_short |
Nutritional status in relation to the eficacy of the Rhesus-Human Reassortant, Tetravalent Rotavirus Vaccine (RRV-TV) in infants from Belém, Pará State, Brazil |
title_full |
Nutritional status in relation to the eficacy of the Rhesus-Human Reassortant, Tetravalent Rotavirus Vaccine (RRV-TV) in infants from Belém, Pará State, Brazil |
title_fullStr |
Nutritional status in relation to the eficacy of the Rhesus-Human Reassortant, Tetravalent Rotavirus Vaccine (RRV-TV) in infants from Belém, Pará State, Brazil |
title_full_unstemmed |
Nutritional status in relation to the eficacy of the Rhesus-Human Reassortant, Tetravalent Rotavirus Vaccine (RRV-TV) in infants from Belém, Pará State, Brazil |
title_sort |
Nutritional status in relation to the eficacy of the Rhesus-Human Reassortant, Tetravalent Rotavirus Vaccine (RRV-TV) in infants from Belém, Pará State, Brazil |
author |
Linhares, Alexandre da Costa |
author_facet |
Linhares, Alexandre da Costa Carmo, Kênea B. do Oliveira, Krynnssya Kleinlein Oliveira, Consuelo Silva de Freitas, Ronaldo Barros de Bellesi, Newton Monteiro, Talita Antônia Furtado Gabbay, Yvone Benchimol Mascarenhas, Joana D'Arc Pereira |
author_role |
author |
author2 |
Carmo, Kênea B. do Oliveira, Krynnssya Kleinlein Oliveira, Consuelo Silva de Freitas, Ronaldo Barros de Bellesi, Newton Monteiro, Talita Antônia Furtado Gabbay, Yvone Benchimol Mascarenhas, Joana D'Arc Pereira |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Linhares, Alexandre da Costa Carmo, Kênea B. do Oliveira, Krynnssya Kleinlein Oliveira, Consuelo Silva de Freitas, Ronaldo Barros de Bellesi, Newton Monteiro, Talita Antônia Furtado Gabbay, Yvone Benchimol Mascarenhas, Joana D'Arc Pereira |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Vacinas contra Rotavirus / uso terapêutico Transtornos da Nutrição Infantil / complicações Estado Nutricional / efeitos de drogas |
topic |
Vacinas contra Rotavirus / uso terapêutico Transtornos da Nutrição Infantil / complicações Estado Nutricional / efeitos de drogas |
description |
The rhesus-human reassortant, tetravalent rotavirus vaccine (RRV-TV) was licensed for routine use in the United States of America but it was recently withdrawn from the market because of its possible association with intussusception as an adverse event. The protective efficacy of 3 doses of RRV-TV, in its lower-titer (4 x 104 pfu/dose) formulation, was evaluated according to the nutritional status of infants who participated in a phase III trial in Belém, Northern Brazil. A moderate protection conferred by RRVTV was related to weight-for-age Z-scores (WAZ) greater than -1 only, with rates of 38% (p = 0.04) and 40% (p = 0.04) for all- andpure rotavirus diarrhoeal cases, respectively. In addition, there was a trend for greater efficacy (43%, p = 0.05) among infants reaching an height-for-age Z-score (HAZ) of > -1. Taking WAZ, HAZ and weight-for-height Z-score (WHZ) indices -1 together, there was no significant protection (p > 0.05) if both placebo and vaccine groups are compared. There was no significant difference if rates of mixed and pure rotavirus diarrhoeal cases are compared in relation to HAZ, WAZ and weight-for-height Z-score (WHZ) indices. Although a low number of malnourished infants could be identified in the present study, our data show some evidence that malnutrition may interfere with the efficacy of rotavirus vaccines in developing countries. |
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2002 |
dc.date.issued.fl_str_mv |
2002 |
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2018-08-21T17:30:05Z |
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2018-08-21T17:30:05Z |
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dc.identifier.citation.fl_str_mv |
LINHARES, Alexandre da Costa et al. Nutritional status in relation to the eficacy of the Rhesus-Human Reassortant, Tetravalent Rotavirus Vaccine (RRV-TV) in infants from Belém, Pará State, Brazil. Revista do Instituto de Medicina Tropical de São Paulo, v. 44, n. 1, p. 13-16, Jan.-Feb. 2002. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/3286 |
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0036-4665 |
identifier_str_mv |
LINHARES, Alexandre da Costa et al. Nutritional status in relation to the eficacy of the Rhesus-Human Reassortant, Tetravalent Rotavirus Vaccine (RRV-TV) in infants from Belém, Pará State, Brazil. Revista do Instituto de Medicina Tropical de São Paulo, v. 44, n. 1, p. 13-16, Jan.-Feb. 2002. 0036-4665 |
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Universidade de São Paulo |
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Universidade de São Paulo |
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