Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | http://patua.iec.gov.br//handle/iec/4300 |
Resumo: | Currently, the Milwaukee protocol presents healing results in human beings affected by the rabies virus. However, there are many points to clarify on the action of drugs and the immune mechanism involved in the evolution of the disease. One of the drugs used is biopterin, which is an important cofactor for nitric oxide, important for preventing vasospasm. Thus, we describe the effect of biopterin on some inflammatory factors in a rabies virus infection developed in an animal model. The immunological mediators studied in animals infected with rabies virus submitted to doses of sapropterin were Anti-RABV, IL-6, IL-2, IL-17a, INF-gamma and Anti-iNOS. It is suggested that the medication in the context of a RABV infection already installed, had the effect of modulating the inflammatory mechanisms mainly linked to the permeability of the blood-brain barrier and the migration of cytotoxic cells. |
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Brito, Caio Vinicius BotelhoRodrigues, Érika Dayane LealMartins, Fernanda Monik SilvaTavares, Lavínia DiasLima, André Luis de Sousa NogueiraFerreira, Lucas CarvalhoSantana, Carlos Junior LopesBrito, João Augusto Gomes de Souza Monteiro deCasseb, Lívia Medeiros NevesDiniz Junior, José Antônio Picanço2021-05-03T16:25:16Z2021-05-03T16:25:16Z2021BRITO, Caio Vinicius Botelho et al. Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection. Revista do Instituto de Medicina Tropical de Sao Paulo, v. 63, n. e28, p. 1-7, Apr. 2021.1678-9946http://patua.iec.gov.br//handle/iec/430010.1590/s1678-9946202163028Currently, the Milwaukee protocol presents healing results in human beings affected by the rabies virus. However, there are many points to clarify on the action of drugs and the immune mechanism involved in the evolution of the disease. One of the drugs used is biopterin, which is an important cofactor for nitric oxide, important for preventing vasospasm. Thus, we describe the effect of biopterin on some inflammatory factors in a rabies virus infection developed in an animal model. The immunological mediators studied in animals infected with rabies virus submitted to doses of sapropterin were Anti-RABV, IL-6, IL-2, IL-17a, INF-gamma and Anti-iNOS. It is suggested that the medication in the context of a RABV infection already installed, had the effect of modulating the inflammatory mechanisms mainly linked to the permeability of the blood-brain barrier and the migration of cytotoxic cells.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Programa de Pós-Graduação em Virologia. Ananindeua, PA, Brasil.Universidade Federal do Pará. Programa de Biologia e Agente Infeciosos e Parasitários. Ananindeua, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Programa de Iniciação Científica. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Programa de Iniciação Científica. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Programa de Iniciação Científica. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Programa de Iniciação Científica. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Programa de Iniciação Científica. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Programa de Iniciação Científica. Ananindeua, PA, Brasil.Universidade do Estado do Pará. Faculdade de Medicina. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.engInstituto de Medicina TropicalImmunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleRaiva / patologiaVírus da Raiva / patogenicidadeSistema Nervoso Central / efeitos dos fármacosBarreira HematoencefálicaInterleucina-6Biopterinainfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALImmunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection.pdfImmunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection.pdfapplication/pdf392450https://patua.iec.gov.br/bitstreams/25090a97-79c7-457a-a245-8fd844d60ef4/download8f4d9cb35be8609db70592c91b03effcMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/f026575c-cfc0-4b2c-935b-972510beed79/download11832eea31b16df8613079d742d61793MD52TEXTImmunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection.pdf.txtImmunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection.pdf.txtExtracted texttext/plain31999https://patua.iec.gov.br/bitstreams/f7e1863c-b74e-4e62-a0a6-d20e04f965ec/download868fcdc48625824c03a5e421c30fc21eMD55THUMBNAILImmunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection.pdf.jpgImmunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection.pdf.jpgGenerated Thumbnailimage/jpeg5944https://patua.iec.gov.br/bitstreams/74e71fe8-9128-4418-8b57-f64d8aaf6876/download582d6ce000235c5a99a43326e2b40799MD56iec/43002022-10-20 21:23:52.727oai:patua.iec.gov.br:iec/4300https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T21:23:52Repositório Digital do Instituto Evandro Chagas (Patuá) - 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dc.title.pt_BR.fl_str_mv |
Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection |
title |
Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection |
spellingShingle |
Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection Brito, Caio Vinicius Botelho Raiva / patologia Vírus da Raiva / patogenicidade Sistema Nervoso Central / efeitos dos fármacos Barreira Hematoencefálica Interleucina-6 Biopterina |
title_short |
Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection |
title_full |
Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection |
title_fullStr |
Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection |
title_full_unstemmed |
Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection |
title_sort |
Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection |
author |
Brito, Caio Vinicius Botelho |
author_facet |
Brito, Caio Vinicius Botelho Rodrigues, Érika Dayane Leal Martins, Fernanda Monik Silva Tavares, Lavínia Dias Lima, André Luis de Sousa Nogueira Ferreira, Lucas Carvalho Santana, Carlos Junior Lopes Brito, João Augusto Gomes de Souza Monteiro de Casseb, Lívia Medeiros Neves Diniz Junior, José Antônio Picanço |
author_role |
author |
author2 |
Rodrigues, Érika Dayane Leal Martins, Fernanda Monik Silva Tavares, Lavínia Dias Lima, André Luis de Sousa Nogueira Ferreira, Lucas Carvalho Santana, Carlos Junior Lopes Brito, João Augusto Gomes de Souza Monteiro de Casseb, Lívia Medeiros Neves Diniz Junior, José Antônio Picanço |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Brito, Caio Vinicius Botelho Rodrigues, Érika Dayane Leal Martins, Fernanda Monik Silva Tavares, Lavínia Dias Lima, André Luis de Sousa Nogueira Ferreira, Lucas Carvalho Santana, Carlos Junior Lopes Brito, João Augusto Gomes de Souza Monteiro de Casseb, Lívia Medeiros Neves Diniz Junior, José Antônio Picanço |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Raiva / patologia Vírus da Raiva / patogenicidade Sistema Nervoso Central / efeitos dos fármacos Barreira Hematoencefálica Interleucina-6 |
topic |
Raiva / patologia Vírus da Raiva / patogenicidade Sistema Nervoso Central / efeitos dos fármacos Barreira Hematoencefálica Interleucina-6 Biopterina |
dc.subject.decsPrimary.pt_B.fl_str_mv |
Biopterina |
description |
Currently, the Milwaukee protocol presents healing results in human beings affected by the rabies virus. However, there are many points to clarify on the action of drugs and the immune mechanism involved in the evolution of the disease. One of the drugs used is biopterin, which is an important cofactor for nitric oxide, important for preventing vasospasm. Thus, we describe the effect of biopterin on some inflammatory factors in a rabies virus infection developed in an animal model. The immunological mediators studied in animals infected with rabies virus submitted to doses of sapropterin were Anti-RABV, IL-6, IL-2, IL-17a, INF-gamma and Anti-iNOS. It is suggested that the medication in the context of a RABV infection already installed, had the effect of modulating the inflammatory mechanisms mainly linked to the permeability of the blood-brain barrier and the migration of cytotoxic cells. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-05-03T16:25:16Z |
dc.date.available.fl_str_mv |
2021-05-03T16:25:16Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BRITO, Caio Vinicius Botelho et al. Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection. Revista do Instituto de Medicina Tropical de Sao Paulo, v. 63, n. e28, p. 1-7, Apr. 2021. |
dc.identifier.uri.fl_str_mv |
http://patua.iec.gov.br//handle/iec/4300 |
dc.identifier.issn.-.fl_str_mv |
1678-9946 |
dc.identifier.doi.-.fl_str_mv |
10.1590/s1678-9946202163028 |
identifier_str_mv |
BRITO, Caio Vinicius Botelho et al. Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection. Revista do Instituto de Medicina Tropical de Sao Paulo, v. 63, n. e28, p. 1-7, Apr. 2021. 1678-9946 10.1590/s1678-9946202163028 |
url |
http://patua.iec.gov.br//handle/iec/4300 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Instituto de Medicina Tropical |
publisher.none.fl_str_mv |
Instituto de Medicina Tropical |
dc.source.none.fl_str_mv |
reponame:Repositório Digital do Instituto Evandro Chagas (Patuá) instname:Instituto Evandro Chagas (IEC) instacron:IEC |
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Instituto Evandro Chagas (IEC) |
instacron_str |
IEC |
institution |
IEC |
reponame_str |
Repositório Digital do Instituto Evandro Chagas (Patuá) |
collection |
Repositório Digital do Instituto Evandro Chagas (Patuá) |
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clariceneta@iec.gov.br || Biblioteca@iec.gov.br |
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