High incidence of respiratory syncytial virus in children with community-acquired pneumonia from a city in the Brazilian Pre-Amazon Region

Detalhes bibliográficos
Autor(a) principal: Fontes, Valéria
Data de Publicação: 2023
Outros Autores: Ferreira, Hivylla, Ribeiro, Marilene, Pinheiro, Aruanã, Maramaldo, Carlos, Pereira, Eduardo, Batista, Luís, Júnior, Antonio, Lobato, Luis, Silva, Fabiano, Sousa, Luis, Lima, Washington, Lima, Claudia, Soczek, Suzany, Carvalho, Rafael, Santos, Mirleide Cordeiro dos, Fernandes, Elizabeth, Sousa, Eduardo, Neto, Lidio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/6848
Resumo: Introduction: Although fewer children have been affected by the severe form of the coronavirus disease 2019 (COVID-19), community-acquired pneumonia (CAP) continues to be the leading global cause of child hospitalizations and deaths. Aim: This study investigated the incidence of respiratory syncytial virus (RSV) as well its subtypes (RSV A and B), adenovirus (ADV), rhinovirus (HRV), metapneumovirus (HMPV), coronavirus (NL63, OC43, 229E and HKU1), parainfluenza virus subtypes (PI1, PI2 and PI3), bocavirus and influenza A and B viruses (FluA and FluB) in children diagnosed with CAP during the COVID-19 pandemic. Methods: A total of 200 children with clinically confirmed CAP were initially recruited, of whom 107 had negative qPCR results for SARS-CoV-2 and were included in this study. Viral subtypes were identified using a real-time polymerase chain reaction in the nasopharyngeal swab samples. Results: Viruses were identified in 69.2% of the patients. RSV infections were the most frequently identified (65.4%), with type RSV B being the most prevalent (63.5%). In addition, HCoV 229E and HRV were detected in 6.5% and 3.7% of the patients, respectively. RSV type B was associated with severe acute respiratory infection (ARI) and a younger age (less than 24 months). Conclusions: New strategies for preventing and treating viral respiratory infections, particularly RSV infections, are necessary.
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spelling Fontes, ValériaFerreira, HivyllaRibeiro, MarilenePinheiro, AruanãMaramaldo, CarlosPereira, EduardoBatista, LuísJúnior, AntonioLobato, LuisSilva, FabianoSousa, LuisLima, WashingtonLima, ClaudiaSoczek, SuzanyCarvalho, RafaelSantos, Mirleide Cordeiro dosFernandes, ElizabethSousa, EduardoNeto, Lidio2023-07-17T17:59:30Z2023-07-17T17:59:30Z2023FONTES, Valéria et al. High incidence of respiratory syncytial virus in children with community-acquired pneumonia from a city in the Brazilian Pre-Amazon Region. Viruses, v. 15, n. 6, 2023. DOI: https://doi.org/10.3390/v15061306. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305439/pdf/viruses-15-01306.pdf.1999-4915https://patua.iec.gov.br/handle/iec/684810.3390/v15061306Introduction: Although fewer children have been affected by the severe form of the coronavirus disease 2019 (COVID-19), community-acquired pneumonia (CAP) continues to be the leading global cause of child hospitalizations and deaths. Aim: This study investigated the incidence of respiratory syncytial virus (RSV) as well its subtypes (RSV A and B), adenovirus (ADV), rhinovirus (HRV), metapneumovirus (HMPV), coronavirus (NL63, OC43, 229E and HKU1), parainfluenza virus subtypes (PI1, PI2 and PI3), bocavirus and influenza A and B viruses (FluA and FluB) in children diagnosed with CAP during the COVID-19 pandemic. Methods: A total of 200 children with clinically confirmed CAP were initially recruited, of whom 107 had negative qPCR results for SARS-CoV-2 and were included in this study. Viral subtypes were identified using a real-time polymerase chain reaction in the nasopharyngeal swab samples. Results: Viruses were identified in 69.2% of the patients. RSV infections were the most frequently identified (65.4%), with type RSV B being the most prevalent (63.5%). In addition, HCoV 229E and HRV were detected in 6.5% and 3.7% of the patients, respectively. RSV type B was associated with severe acute respiratory infection (ARI) and a younger age (less than 24 months). Conclusions: New strategies for preventing and treating viral respiratory infections, particularly RSV infections, are necessary.CEUMA University. Post-Graduate Programme in Microbial Biology. Laboratory of Virology. São Luís, MA, Brazil.Osvaldo Cruz Institute. Central Public Health Laboratory of Maranhão. São Luís, MA, Brazil.Hospital of Federal University of Maranhão. São Luís, MA, Brazil.CEUMA University. Postdoctoral Program in Microbial Biology. São Luís, MA, Brazil.Osvaldo Cruz Institute. Central Public Health Laboratory of Maranhão. São Luís, MA, Brazil.CEUMA University. Post-Graduate Programme in Microbial Biology. Laboratory of Virology. São Luís, MA, Brazil.Federal University of Maranhão. Postgraduate Program in Adult Health. São Luís, MA, Brazil.Federal University of Maranhão. Postgraduate Program in Adult Health. São Luís, MA, Brazil.Osvaldo Cruz Institute. Central Public Health Laboratory of Maranhão. São Luís, MA, Brazil / Oswaldo Cruz Foundation. Post-Graduate Programme in Tropical Medicine. Rio de Janeiro, RJ, Brazil.Osvaldo Cruz Institute. Central Public Health Laboratory of Maranhão. São Luís, MA, Brazil / Oswaldo Cruz Foundation. Post-Graduate Programme in Tropical Medicine. Rio de Janeiro, RJ, Brazil.CEUMA University. Post-Graduate Programme in Microbial Biology. Laboratory of Virology. São Luís, MA, Brazil / Osvaldo Cruz Institute. Central Public Health Laboratory of Maranhão. São Luís, MA, Brazil.CEUMA University. Post-Graduate Programme in Biodiversity and Biotechnology. São Luís, MA, Brazil.CEUMA University. Post-Graduate Programme in Microbial Biology. Laboratory of Virology. São Luís, MA, Brazil.Pelé Pequeno Príncipe Research Institute. Post-Graduate Programme in Biotechnology Applied to Child and Adolescent Health. Curitiba, PR, Brazil.Federal University of Maranhão. Postgraduate Program in Adult Health. São Luís, MA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Pelé Pequeno Príncipe Research Institute. Post-Graduate Programme in Biotechnology Applied to Child and Adolescent Health. Curitiba, PR, Brazil.CEUMA University. Post-Graduate Programme in Microbial Biology. Laboratory of Virology. São Luís, MA, Brazil / Federal University of Maranhão. Postgraduate Program in Adult Health. São Luís, MA, Brazil.CEUMA University. Post-Graduate Programme in Microbial Biology. Laboratory of Virology. São Luís, MA, Brazil / Osvaldo Cruz Institute. Central Public Health Laboratory of Maranhão. São Luís, MA, Brazil / CEUMA University. Post-Graduate Programme in Biodiversity and Biotechnology. 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dc.title.pt_BR.fl_str_mv High incidence of respiratory syncytial virus in children with community-acquired pneumonia from a city in the Brazilian Pre-Amazon Region
title High incidence of respiratory syncytial virus in children with community-acquired pneumonia from a city in the Brazilian Pre-Amazon Region
spellingShingle High incidence of respiratory syncytial virus in children with community-acquired pneumonia from a city in the Brazilian Pre-Amazon Region
Fontes, Valéria
Infecções Respiratórias / virologia
Infecções por Vírus Respiratório Sincicial
Vírus Sincicial Respiratório Humano
title_short High incidence of respiratory syncytial virus in children with community-acquired pneumonia from a city in the Brazilian Pre-Amazon Region
title_full High incidence of respiratory syncytial virus in children with community-acquired pneumonia from a city in the Brazilian Pre-Amazon Region
title_fullStr High incidence of respiratory syncytial virus in children with community-acquired pneumonia from a city in the Brazilian Pre-Amazon Region
title_full_unstemmed High incidence of respiratory syncytial virus in children with community-acquired pneumonia from a city in the Brazilian Pre-Amazon Region
title_sort High incidence of respiratory syncytial virus in children with community-acquired pneumonia from a city in the Brazilian Pre-Amazon Region
author Fontes, Valéria
author_facet Fontes, Valéria
Ferreira, Hivylla
Ribeiro, Marilene
Pinheiro, Aruanã
Maramaldo, Carlos
Pereira, Eduardo
Batista, Luís
Júnior, Antonio
Lobato, Luis
Silva, Fabiano
Sousa, Luis
Lima, Washington
Lima, Claudia
Soczek, Suzany
Carvalho, Rafael
Santos, Mirleide Cordeiro dos
Fernandes, Elizabeth
Sousa, Eduardo
Neto, Lidio
author_role author
author2 Ferreira, Hivylla
Ribeiro, Marilene
Pinheiro, Aruanã
Maramaldo, Carlos
Pereira, Eduardo
Batista, Luís
Júnior, Antonio
Lobato, Luis
Silva, Fabiano
Sousa, Luis
Lima, Washington
Lima, Claudia
Soczek, Suzany
Carvalho, Rafael
Santos, Mirleide Cordeiro dos
Fernandes, Elizabeth
Sousa, Eduardo
Neto, Lidio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fontes, Valéria
Ferreira, Hivylla
Ribeiro, Marilene
Pinheiro, Aruanã
Maramaldo, Carlos
Pereira, Eduardo
Batista, Luís
Júnior, Antonio
Lobato, Luis
Silva, Fabiano
Sousa, Luis
Lima, Washington
Lima, Claudia
Soczek, Suzany
Carvalho, Rafael
Santos, Mirleide Cordeiro dos
Fernandes, Elizabeth
Sousa, Eduardo
Neto, Lidio
dc.subject.decsPrimary.pt_BR.fl_str_mv Infecções Respiratórias / virologia
Infecções por Vírus Respiratório Sincicial
Vírus Sincicial Respiratório Humano
topic Infecções Respiratórias / virologia
Infecções por Vírus Respiratório Sincicial
Vírus Sincicial Respiratório Humano
description Introduction: Although fewer children have been affected by the severe form of the coronavirus disease 2019 (COVID-19), community-acquired pneumonia (CAP) continues to be the leading global cause of child hospitalizations and deaths. Aim: This study investigated the incidence of respiratory syncytial virus (RSV) as well its subtypes (RSV A and B), adenovirus (ADV), rhinovirus (HRV), metapneumovirus (HMPV), coronavirus (NL63, OC43, 229E and HKU1), parainfluenza virus subtypes (PI1, PI2 and PI3), bocavirus and influenza A and B viruses (FluA and FluB) in children diagnosed with CAP during the COVID-19 pandemic. Methods: A total of 200 children with clinically confirmed CAP were initially recruited, of whom 107 had negative qPCR results for SARS-CoV-2 and were included in this study. Viral subtypes were identified using a real-time polymerase chain reaction in the nasopharyngeal swab samples. Results: Viruses were identified in 69.2% of the patients. RSV infections were the most frequently identified (65.4%), with type RSV B being the most prevalent (63.5%). In addition, HCoV 229E and HRV were detected in 6.5% and 3.7% of the patients, respectively. RSV type B was associated with severe acute respiratory infection (ARI) and a younger age (less than 24 months). Conclusions: New strategies for preventing and treating viral respiratory infections, particularly RSV infections, are necessary.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-07-17T17:59:30Z
dc.date.available.fl_str_mv 2023-07-17T17:59:30Z
dc.date.issued.fl_str_mv 2023
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dc.identifier.citation.fl_str_mv FONTES, Valéria et al. High incidence of respiratory syncytial virus in children with community-acquired pneumonia from a city in the Brazilian Pre-Amazon Region. Viruses, v. 15, n. 6, 2023. DOI: https://doi.org/10.3390/v15061306. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305439/pdf/viruses-15-01306.pdf.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/6848
dc.identifier.issn.-.fl_str_mv 1999-4915
dc.identifier.doi.pt_BR.fl_str_mv 10.3390/v15061306
identifier_str_mv FONTES, Valéria et al. High incidence of respiratory syncytial virus in children with community-acquired pneumonia from a city in the Brazilian Pre-Amazon Region. Viruses, v. 15, n. 6, 2023. DOI: https://doi.org/10.3390/v15061306. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10305439/pdf/viruses-15-01306.pdf.
1999-4915
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