High incidence of respiratory syncytial virus in children with community-acquired pneumonia from a city in the Brazilian Pre-Amazon Region

• Autor(a) principal: Fontes, Valéria
• Data de Publicação: 2023
• Outros Autores: Ferreira, Hivylla, Ribeiro, Marilene, Pinheiro, Aruanã, Maramaldo, Carlos, Pereira, Eduardo, Batista, Luís, Júnior, Antonio, Lobato, Luis, Silva, Fabiano, Sousa, Luis, Lima, Washington, Lima, Claudia, Soczek, Suzany, Carvalho, Rafael, Santos, Mirleide Cordeiro dos, Fernandes, Elizabeth, Sousa, Eduardo, Neto, Lidio
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/6848
• topic: Infecções Respiratórias / virologia; Infecções por Vírus Respiratório Sincicial; Vírus Sincicial Respiratório Humano

Introduction: Although fewer children have been affected by the severe form of the coronavirus disease 2019 (COVID-19), community-acquired pneumonia (CAP) continues to be the leading global cause of child hospitalizations and deaths. Aim: This study investigated the incidence of respiratory syncytial virus (RSV) as well its subtypes (RSV A and B), adenovirus (ADV), rhinovirus (HRV), metapneumovirus (HMPV), coronavirus (NL63, OC43, 229E and HKU1), parainfluenza virus subtypes (PI1, PI2 and PI3), bocavirus and influenza A and B viruses (FluA and FluB) in children diagnosed with CAP during the COVID-19 pandemic. Methods: A total of 200 children with clinically confirmed CAP were initially recruited, of whom 107 had negative qPCR results for SARS-CoV-2 and were included in this study. Viral subtypes were identified using a real-time polymerase chain reaction in the nasopharyngeal swab samples. Results: Viruses were identified in 69.2% of the patients. RSV infections were the most frequently identified (65.4%), with type RSV B being the most prevalent (63.5%). In addition, HCoV 229E and HRV were detected in 6.5% and 3.7% of the patients, respectively. RSV type B was associated with severe acute respiratory infection (ARI) and a younger age (less than 24 months). Conclusions: New strategies for preventing and treating viral respiratory infections, particularly RSV infections, are necessary.