Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/450 |
Resumo: | Purpose: To investigate the effect of mycophenolate mofetil on Walker’s carcinosarcoma, without versus with the growth and regression of cyclosporine. Methods and Results. Wistar rats received water (control), MMF, and/or CsA-N 1 day before tumor inoculation. On day 10, tumor volume (TV) was lower among MMF (10.3 ± 2.8 cmᶾ) than control rats (14.9 ± 4.2 cmᶾ, P <.05), and similar to that in CsA-N (13.9 ± 3.0 cmᶾ). However, tumor weight (TW) was significantly lower in MMF (5.2 ± 2.0 g) than CsA-N (8.8 ± 2.1g) or control hosts (7.3 ± 2.0 g, P ≤ .01). Growth was inhibited by MMF (-28.2%). In experiment II, CsA-N, MMF + CsA-N, or water were introduced 1 day before tumor inoculation. On day 10, TV and TW were similar for MMF + CsA-N as compared to CsA-N and control animals. In experiment III, water or MMF was introduced on the day 4 after tumor inoculation. On day 10, tumor growth are TW in the MMF group was similar to, that in the controls. Conclusions: MMF produces an anti-tumoral effect against Walker’s carcinosarcoma. However, this inhibitory effect was lost when MMF was used in combination with CsA-N or administered in the presence of a well- established tumor. |
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Silva, Sônia Leite daSilva, S. F. RCavalcante, R. OMota, R. SCarvalho, Reinaldo de AmorimMoraes, M. OCampos, H. HMoraes, M. E. A2016-01-26T11:28:08Z2016-01-26T11:28:08Z2004SILVA, Sônia Leite da et al. Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine. Transplantation Proceedings, v. 36, n. 4, p. 1004-1006, 2004.0041-1345https://patua.iec.gov.br/handle/iec/450Purpose: To investigate the effect of mycophenolate mofetil on Walker’s carcinosarcoma, without versus with the growth and regression of cyclosporine. Methods and Results. Wistar rats received water (control), MMF, and/or CsA-N 1 day before tumor inoculation. On day 10, tumor volume (TV) was lower among MMF (10.3 ± 2.8 cmᶾ) than control rats (14.9 ± 4.2 cmᶾ, P <.05), and similar to that in CsA-N (13.9 ± 3.0 cmᶾ). However, tumor weight (TW) was significantly lower in MMF (5.2 ± 2.0 g) than CsA-N (8.8 ± 2.1g) or control hosts (7.3 ± 2.0 g, P ≤ .01). Growth was inhibited by MMF (-28.2%). In experiment II, CsA-N, MMF + CsA-N, or water were introduced 1 day before tumor inoculation. On day 10, TV and TW were similar for MMF + CsA-N as compared to CsA-N and control animals. In experiment III, water or MMF was introduced on the day 4 after tumor inoculation. On day 10, tumor growth are TW in the MMF group was similar to, that in the controls. Conclusions: MMF produces an anti-tumoral effect against Walker’s carcinosarcoma. However, this inhibitory effect was lost when MMF was used in combination with CsA-N or administered in the presence of a well- established tumor.Ceará Federal University. Medical School. Renal Transplant Unit. Fortaleza, CE, Brasil.Ceará Federal University. Medical School. Renal Transplant Unit. Fortaleza, CE, Brasil.Ceará Federal University. Medical School. Renal Transplant Unit. Fortaleza, CE, Brasil.Ceará Federal University. Medical School. Renal Transplant Unit. Fortaleza, CE, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ceará Federal University. Medical School. Renal Transplant Unit. Fortaleza, CE, Brasil.Ceará Federal University. Medical School. Renal Transplant Unit. Fortaleza, CE, Brasil.Ceará Federal University. Medical School. Renal Transplant Unit. Fortaleza, CE, Brasil.application/pdfengElsevierMycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCiclosporina / farmacocinéticaCarcinoma 256 de Walker / induzido quimicamenteRatos Wistarinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALMycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine .pdfapplication/pdf75491https://patua.iec.gov.br/bitstreams/f084bcc0-110c-49ac-b897-608323b31b80/download60cab33250164540377efa6407756954MD51TEXTfile_1.pdf.txtfile_1.pdf.txtExtracted texttext/plain11014https://patua.iec.gov.br/bitstreams/58deed50-b212-4d5e-9bec-6a9c8424e9bc/download8f0a2cb89985fb032027a16663d37d98MD52Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine .pdf.txtMycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine .pdf.txtExtracted texttext/plain11657https://patua.iec.gov.br/bitstreams/0d869f0b-b363-40b9-8d0e-0a633ba56468/download9f0ddcab457bd128c32a02902f950e54MD57THUMBNAILfile_1.pdf.jpgfile_1.pdf.jpgIM Thumbnailimage/jpeg5040https://patua.iec.gov.br/bitstreams/cd263693-2185-4041-9a4c-5cf232e788b1/download8dc150149fdb3b35f638ff2f62d33caaMD53Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine .pdf.jpgMycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine .pdf.jpgGenerated Thumbnailimage/jpeg5849https://patua.iec.gov.br/bitstreams/23727270-1037-47bb-b1bf-606bf5e544d1/download0e79a6660a2119405e39a75a2e8b159aMD58LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine |
title |
Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine |
spellingShingle |
Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine Silva, Sônia Leite da Ciclosporina / farmacocinética Carcinoma 256 de Walker / induzido quimicamente Ratos Wistar |
title_short |
Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine |
title_full |
Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine |
title_fullStr |
Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine |
title_full_unstemmed |
Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine |
title_sort |
Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine |
author |
Silva, Sônia Leite da |
author_facet |
Silva, Sônia Leite da Silva, S. F. R Cavalcante, R. O Mota, R. S Carvalho, Reinaldo de Amorim Moraes, M. O Campos, H. H Moraes, M. E. A |
author_role |
author |
author2 |
Silva, S. F. R Cavalcante, R. O Mota, R. S Carvalho, Reinaldo de Amorim Moraes, M. O Campos, H. H Moraes, M. E. A |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Sônia Leite da Silva, S. F. R Cavalcante, R. O Mota, R. S Carvalho, Reinaldo de Amorim Moraes, M. O Campos, H. H Moraes, M. E. A |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Ciclosporina / farmacocinética Carcinoma 256 de Walker / induzido quimicamente Ratos Wistar |
topic |
Ciclosporina / farmacocinética Carcinoma 256 de Walker / induzido quimicamente Ratos Wistar |
description |
Purpose: To investigate the effect of mycophenolate mofetil on Walker’s carcinosarcoma, without versus with the growth and regression of cyclosporine. Methods and Results. Wistar rats received water (control), MMF, and/or CsA-N 1 day before tumor inoculation. On day 10, tumor volume (TV) was lower among MMF (10.3 ± 2.8 cmᶾ) than control rats (14.9 ± 4.2 cmᶾ, P <.05), and similar to that in CsA-N (13.9 ± 3.0 cmᶾ). However, tumor weight (TW) was significantly lower in MMF (5.2 ± 2.0 g) than CsA-N (8.8 ± 2.1g) or control hosts (7.3 ± 2.0 g, P ≤ .01). Growth was inhibited by MMF (-28.2%). In experiment II, CsA-N, MMF + CsA-N, or water were introduced 1 day before tumor inoculation. On day 10, TV and TW were similar for MMF + CsA-N as compared to CsA-N and control animals. In experiment III, water or MMF was introduced on the day 4 after tumor inoculation. On day 10, tumor growth are TW in the MMF group was similar to, that in the controls. Conclusions: MMF produces an anti-tumoral effect against Walker’s carcinosarcoma. However, this inhibitory effect was lost when MMF was used in combination with CsA-N or administered in the presence of a well- established tumor. |
publishDate |
2004 |
dc.date.issued.fl_str_mv |
2004 |
dc.date.accessioned.fl_str_mv |
2016-01-26T11:28:08Z |
dc.date.available.fl_str_mv |
2016-01-26T11:28:08Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVA, Sônia Leite da et al. Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine. Transplantation Proceedings, v. 36, n. 4, p. 1004-1006, 2004. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/450 |
dc.identifier.issn.-.fl_str_mv |
0041-1345 |
identifier_str_mv |
SILVA, Sônia Leite da et al. Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine. Transplantation Proceedings, v. 36, n. 4, p. 1004-1006, 2004. 0041-1345 |
url |
https://patua.iec.gov.br/handle/iec/450 |
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eng |
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eng |
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openAccess |
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Elsevier |
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Elsevier |
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