Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine

Detalhes bibliográficos
Autor(a) principal: Silva, Sônia Leite da
Data de Publicação: 2004
Outros Autores: Silva, S. F. R, Cavalcante, R. O, Mota, R. S, Carvalho, Reinaldo de Amorim, Moraes, M. O, Campos, H. H, Moraes, M. E. A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/450
Resumo: Purpose: To investigate the effect of mycophenolate mofetil on Walker’s carcinosarcoma, without versus with the growth and regression of cyclosporine. Methods and Results. Wistar rats received water (control), MMF, and/or CsA-N 1 day before tumor inoculation. On day 10, tumor volume (TV) was lower among MMF (10.3 ± 2.8 cmᶾ) than control rats (14.9 ± 4.2 cmᶾ, P <.05), and similar to that in CsA-N (13.9 ± 3.0 cmᶾ). However, tumor weight (TW) was significantly lower in MMF (5.2 ± 2.0 g) than CsA-N (8.8 ± 2.1g) or control hosts (7.3 ± 2.0 g, P ≤ .01). Growth was inhibited by MMF (-28.2%). In experiment II, CsA-N, MMF + CsA-N, or water were introduced 1 day before tumor inoculation. On day 10, TV and TW were similar for MMF + CsA-N as compared to CsA-N and control animals. In experiment III, water or MMF was introduced on the day 4 after tumor inoculation. On day 10, tumor growth are TW in the MMF group was similar to, that in the controls. Conclusions: MMF produces an anti-tumoral effect against Walker’s carcinosarcoma. However, this inhibitory effect was lost when MMF was used in combination with CsA-N or administered in the presence of a well- established tumor.
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spelling Silva, Sônia Leite daSilva, S. F. RCavalcante, R. OMota, R. SCarvalho, Reinaldo de AmorimMoraes, M. OCampos, H. HMoraes, M. E. A2016-01-26T11:28:08Z2016-01-26T11:28:08Z2004SILVA, Sônia Leite da et al. Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine. Transplantation Proceedings, v. 36, n. 4, p. 1004-1006, 2004.0041-1345https://patua.iec.gov.br/handle/iec/450Purpose: To investigate the effect of mycophenolate mofetil on Walker’s carcinosarcoma, without versus with the growth and regression of cyclosporine. Methods and Results. Wistar rats received water (control), MMF, and/or CsA-N 1 day before tumor inoculation. On day 10, tumor volume (TV) was lower among MMF (10.3 ± 2.8 cmᶾ) than control rats (14.9 ± 4.2 cmᶾ, P <.05), and similar to that in CsA-N (13.9 ± 3.0 cmᶾ). However, tumor weight (TW) was significantly lower in MMF (5.2 ± 2.0 g) than CsA-N (8.8 ± 2.1g) or control hosts (7.3 ± 2.0 g, P ≤ .01). Growth was inhibited by MMF (-28.2%). In experiment II, CsA-N, MMF + CsA-N, or water were introduced 1 day before tumor inoculation. On day 10, TV and TW were similar for MMF + CsA-N as compared to CsA-N and control animals. In experiment III, water or MMF was introduced on the day 4 after tumor inoculation. On day 10, tumor growth are TW in the MMF group was similar to, that in the controls. Conclusions: MMF produces an anti-tumoral effect against Walker’s carcinosarcoma. However, this inhibitory effect was lost when MMF was used in combination with CsA-N or administered in the presence of a well- established tumor.Ceará Federal University. Medical School. Renal Transplant Unit. Fortaleza, CE, Brasil.Ceará Federal University. Medical School. Renal Transplant Unit. Fortaleza, CE, Brasil.Ceará Federal University. Medical School. Renal Transplant Unit. Fortaleza, CE, Brasil.Ceará Federal University. Medical School. Renal Transplant Unit. Fortaleza, CE, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.Ceará Federal University. Medical School. Renal Transplant Unit. Fortaleza, CE, Brasil.Ceará Federal University. Medical School. Renal Transplant Unit. Fortaleza, CE, Brasil.Ceará Federal University. Medical School. Renal Transplant Unit. 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dc.title.pt_BR.fl_str_mv Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine
title Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine
spellingShingle Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine
Silva, Sônia Leite da
Ciclosporina / farmacocinética
Carcinoma 256 de Walker / induzido quimicamente
Ratos Wistar
title_short Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine
title_full Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine
title_fullStr Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine
title_full_unstemmed Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine
title_sort Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine
author Silva, Sônia Leite da
author_facet Silva, Sônia Leite da
Silva, S. F. R
Cavalcante, R. O
Mota, R. S
Carvalho, Reinaldo de Amorim
Moraes, M. O
Campos, H. H
Moraes, M. E. A
author_role author
author2 Silva, S. F. R
Cavalcante, R. O
Mota, R. S
Carvalho, Reinaldo de Amorim
Moraes, M. O
Campos, H. H
Moraes, M. E. A
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Sônia Leite da
Silva, S. F. R
Cavalcante, R. O
Mota, R. S
Carvalho, Reinaldo de Amorim
Moraes, M. O
Campos, H. H
Moraes, M. E. A
dc.subject.decsPrimary.pt_BR.fl_str_mv Ciclosporina / farmacocinética
Carcinoma 256 de Walker / induzido quimicamente
Ratos Wistar
topic Ciclosporina / farmacocinética
Carcinoma 256 de Walker / induzido quimicamente
Ratos Wistar
description Purpose: To investigate the effect of mycophenolate mofetil on Walker’s carcinosarcoma, without versus with the growth and regression of cyclosporine. Methods and Results. Wistar rats received water (control), MMF, and/or CsA-N 1 day before tumor inoculation. On day 10, tumor volume (TV) was lower among MMF (10.3 ± 2.8 cmᶾ) than control rats (14.9 ± 4.2 cmᶾ, P <.05), and similar to that in CsA-N (13.9 ± 3.0 cmᶾ). However, tumor weight (TW) was significantly lower in MMF (5.2 ± 2.0 g) than CsA-N (8.8 ± 2.1g) or control hosts (7.3 ± 2.0 g, P ≤ .01). Growth was inhibited by MMF (-28.2%). In experiment II, CsA-N, MMF + CsA-N, or water were introduced 1 day before tumor inoculation. On day 10, TV and TW were similar for MMF + CsA-N as compared to CsA-N and control animals. In experiment III, water or MMF was introduced on the day 4 after tumor inoculation. On day 10, tumor growth are TW in the MMF group was similar to, that in the controls. Conclusions: MMF produces an anti-tumoral effect against Walker’s carcinosarcoma. However, this inhibitory effect was lost when MMF was used in combination with CsA-N or administered in the presence of a well- established tumor.
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2016-01-26T11:28:08Z
dc.date.available.fl_str_mv 2016-01-26T11:28:08Z
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dc.identifier.citation.fl_str_mv SILVA, Sônia Leite da et al. Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine. Transplantation Proceedings, v. 36, n. 4, p. 1004-1006, 2004.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/450
dc.identifier.issn.-.fl_str_mv 0041-1345
identifier_str_mv SILVA, Sônia Leite da et al. Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine. Transplantation Proceedings, v. 36, n. 4, p. 1004-1006, 2004.
0041-1345
url https://patua.iec.gov.br/handle/iec/450
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