Nerve growth factor and pathogenesis of Leprosy: review and update
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/3164 |
Resumo: | Neurotrophins are a family of proteins that regulate different aspects of biological development and neural function and are of great importance in neuroplasticity. This group of proteins has multiple functions in neuronal cells, as well as in other cellular populations. Nerve growth factor (NGF) is a neurotrophin that is endogenously produced during development and maturation by multiple cell types, including neurons, Schwann cells, oligodendrocytes, lymphocytes, mast cells, macrophages, keratinocytes, and fibroblasts. These cells produce proNGF, which is transformed by proteolytic cleavage into the biologically active NGF in the endoplasmic reticulum. The present review describes the role of NGF in the pathogenesis of leprosy and its correlations with different clinical forms of the disease and with the phenomena of regeneration and neural injury observed during infection. We discuss the involvement of NGF in the induction of neural damage and the pathophysiology of pain associated with peripheral neuropathy in leprosy. We also discuss the roles of immune factors in the evolution of this pathological process. Finally, we highlight avenues of investigation for future research to broaden our understanding of the role of NGF in the pathogenesis of leprosy. Our analysis of the literature indicates that NGF plays an important role in the evolution and outcome of Mycobacterium leprae infection. The findings described here highlight an important area of investigation, as leprosy is one of the main causes of infection in the peripheral nervous system. |
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Aarão, Tinara Leila de SouzaSousa, Jorge Rodrigues deFalcão, Aline Semblano CarreiraFalcão, Luiz Fábio MagnoQuaresma, Juarez Antônio Simões2018-06-13T17:40:23Z2018-06-13T17:40:23Z2018AARÃO, Tinara Leila de Souza et al. Nerve growth factor and pathogenesis of Leprosy: review and update. Frontiers in Immunology, v. 9, art. 939, p. 1-8, May 2018. DOI: https://doi.org/ 10.3389/fimmu.2018.00939. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949531/pdf/fimmu-09-00939.pdf1664-3224https://patua.iec.gov.br/handle/iec/316410.3389/fimmu.2018.00939Neurotrophins are a family of proteins that regulate different aspects of biological development and neural function and are of great importance in neuroplasticity. This group of proteins has multiple functions in neuronal cells, as well as in other cellular populations. Nerve growth factor (NGF) is a neurotrophin that is endogenously produced during development and maturation by multiple cell types, including neurons, Schwann cells, oligodendrocytes, lymphocytes, mast cells, macrophages, keratinocytes, and fibroblasts. These cells produce proNGF, which is transformed by proteolytic cleavage into the biologically active NGF in the endoplasmic reticulum. The present review describes the role of NGF in the pathogenesis of leprosy and its correlations with different clinical forms of the disease and with the phenomena of regeneration and neural injury observed during infection. We discuss the involvement of NGF in the induction of neural damage and the pathophysiology of pain associated with peripheral neuropathy in leprosy. We also discuss the roles of immune factors in the evolution of this pathological process. Finally, we highlight avenues of investigation for future research to broaden our understanding of the role of NGF in the pathogenesis of leprosy. Our analysis of the literature indicates that NGF plays an important role in the evolution and outcome of Mycobacterium leprae infection. The findings described here highlight an important area of investigation, as leprosy is one of the main causes of infection in the peripheral nervous system.JQ is a Research Productivity Fellow and Senior Postdoctoral Fellow at the Brazilian National Council for Scientific and Technological Development—CNPq/Brazil (Grants number 302553/2015-0 and 116427/2016-7). Program of support for qualified production—PAPQ/UFPA.State University of Para. Center of Health and Biological Sciences. Belem, PA, Brazil.Federal University of Para. Tropical Medicine Center. Belem, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.State University of Para. Center of Health and Biological Sciences. Belem, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.engFrontiers MediaNerve growth factor and pathogenesis of Leprosy: review and updateinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHanseníase / imunologiaFatores de Crescimento Neural / fisiologiaMycobacterium leprae / patogenicidadeinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALNerve growth factor and pathogenesis of Leprosy: review and update.pdfNerve growth factor and pathogenesis of Leprosy: review and update.pdfapplication/pdf749536https://patua.iec.gov.br/bitstreams/49e5b527-a650-4b50-ad96-d120034b5dbc/download710a3ee511aa8f22fee399832ea0839eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-871https://patua.iec.gov.br/bitstreams/6d13ad89-0fab-4c13-865f-f2d5fe3c6ca3/download52f1732ea66fbd1123abe39f5373b797MD52TEXTNerve growth factor and pathogenesis of Leprosy: review and update.pdf.txtNerve growth factor and pathogenesis of Leprosy: review and update.pdf.txtExtracted texttext/plain50662https://patua.iec.gov.br/bitstreams/c6677d1c-ff80-40da-8ca8-1c9a0d6f62e4/download35dcedd503a6fd67ccd2c0fbeb27e845MD55THUMBNAILNerve growth factor and pathogenesis of Leprosy: review and update.pdf.jpgNerve growth factor and pathogenesis of Leprosy: review and update.pdf.jpgGenerated Thumbnailimage/jpeg5472https://patua.iec.gov.br/bitstreams/25ce4528-1728-4cff-af9d-92eda45bdb55/downloadfbead6422042f6818575aba808aa22aeMD56iec/31642022-10-20 22:54:23.17oai:patua.iec.gov.br:iec/3164https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T22:54:23Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)falseVG9kb3Mgb3MgZG9jdW1lbnRvcyBkZXNzYSBjb2xlw6fDo28gc2VndWVtIGEgTGljZW7Dp2EgQ3JlYXRpdmUgY29tbW9ucy4= |
dc.title.pt_BR.fl_str_mv |
Nerve growth factor and pathogenesis of Leprosy: review and update |
title |
Nerve growth factor and pathogenesis of Leprosy: review and update |
spellingShingle |
Nerve growth factor and pathogenesis of Leprosy: review and update Aarão, Tinara Leila de Souza Hanseníase / imunologia Fatores de Crescimento Neural / fisiologia Mycobacterium leprae / patogenicidade |
title_short |
Nerve growth factor and pathogenesis of Leprosy: review and update |
title_full |
Nerve growth factor and pathogenesis of Leprosy: review and update |
title_fullStr |
Nerve growth factor and pathogenesis of Leprosy: review and update |
title_full_unstemmed |
Nerve growth factor and pathogenesis of Leprosy: review and update |
title_sort |
Nerve growth factor and pathogenesis of Leprosy: review and update |
author |
Aarão, Tinara Leila de Souza |
author_facet |
Aarão, Tinara Leila de Souza Sousa, Jorge Rodrigues de Falcão, Aline Semblano Carreira Falcão, Luiz Fábio Magno Quaresma, Juarez Antônio Simões |
author_role |
author |
author2 |
Sousa, Jorge Rodrigues de Falcão, Aline Semblano Carreira Falcão, Luiz Fábio Magno Quaresma, Juarez Antônio Simões |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Aarão, Tinara Leila de Souza Sousa, Jorge Rodrigues de Falcão, Aline Semblano Carreira Falcão, Luiz Fábio Magno Quaresma, Juarez Antônio Simões |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Hanseníase / imunologia Fatores de Crescimento Neural / fisiologia Mycobacterium leprae / patogenicidade |
topic |
Hanseníase / imunologia Fatores de Crescimento Neural / fisiologia Mycobacterium leprae / patogenicidade |
description |
Neurotrophins are a family of proteins that regulate different aspects of biological development and neural function and are of great importance in neuroplasticity. This group of proteins has multiple functions in neuronal cells, as well as in other cellular populations. Nerve growth factor (NGF) is a neurotrophin that is endogenously produced during development and maturation by multiple cell types, including neurons, Schwann cells, oligodendrocytes, lymphocytes, mast cells, macrophages, keratinocytes, and fibroblasts. These cells produce proNGF, which is transformed by proteolytic cleavage into the biologically active NGF in the endoplasmic reticulum. The present review describes the role of NGF in the pathogenesis of leprosy and its correlations with different clinical forms of the disease and with the phenomena of regeneration and neural injury observed during infection. We discuss the involvement of NGF in the induction of neural damage and the pathophysiology of pain associated with peripheral neuropathy in leprosy. We also discuss the roles of immune factors in the evolution of this pathological process. Finally, we highlight avenues of investigation for future research to broaden our understanding of the role of NGF in the pathogenesis of leprosy. Our analysis of the literature indicates that NGF plays an important role in the evolution and outcome of Mycobacterium leprae infection. The findings described here highlight an important area of investigation, as leprosy is one of the main causes of infection in the peripheral nervous system. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-06-13T17:40:23Z |
dc.date.available.fl_str_mv |
2018-06-13T17:40:23Z |
dc.date.issued.fl_str_mv |
2018 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
AARÃO, Tinara Leila de Souza et al. Nerve growth factor and pathogenesis of Leprosy: review and update. Frontiers in Immunology, v. 9, art. 939, p. 1-8, May 2018. DOI: https://doi.org/ 10.3389/fimmu.2018.00939. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949531/pdf/fimmu-09-00939.pdf |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/3164 |
dc.identifier.issn.-.fl_str_mv |
1664-3224 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.3389/fimmu.2018.00939 |
identifier_str_mv |
AARÃO, Tinara Leila de Souza et al. Nerve growth factor and pathogenesis of Leprosy: review and update. Frontiers in Immunology, v. 9, art. 939, p. 1-8, May 2018. DOI: https://doi.org/ 10.3389/fimmu.2018.00939. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949531/pdf/fimmu-09-00939.pdf 1664-3224 10.3389/fimmu.2018.00939 |
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https://patua.iec.gov.br/handle/iec/3164 |
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eng |
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eng |
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Frontiers Media |
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Frontiers Media |
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