Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis

Detalhes bibliográficos
Autor(a) principal: Araújo, Thessika Hialla Almeida
Data de Publicação: 2020
Outros Autores: Barreto, Fernanda Khouri, Menezes, Aline Dórea Luz, Lima, Clayton Pereira Silva de, Oliveira, Rodrigo Santos de, Lemos, Poliana da Silva, Galvão-Castro, Bernardo, Kashima, Simone, Farre, Lourdes, Bittencourt, Achilea Lisboa, Carvalho, Edgar Marcelino de, Santos, Luciane Amorim, Rego, Filipe Ferreira de Almeida, Mota-Miranda, Aline Cristina Andrade, Nunes, Márcio Roberto Teixeira, Alcantara, Luiz Carlos Júnior
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/4051
Resumo: The HTLV-1 is the first human retrovirus and is associated with several clinical syndromes, however, the pathogenesis of these clinical manifestations is still not fully understood. Furthermore, there are few complete genomes publicly available, about 0.12 complete genomes per 10,000 infected individuals and the databases have a major deficiency of sequences information. This study generated and characterized 31 HTLV-1 complete genomes sequences derived from individuals with Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM), Adult T-cell leukemia/lymphoma (ATL), infective dermatitis associated to HTLV-1 (IDH) and asymptomatic patients. These sequences are associated to clinical and epidemiological information about the patients. The sequencing data generated on Ion Torrent PGM platform were assembled and mapped against the reference HTLV-1 genome. These sequences were genotyped as Cosmopolitan subtype, Transcontinental subgroup. We identified the variants in the coding regions of the genome of the different clinical profiles, however, no statistical relation was detected. This study contributed to increase of HTLV-1 complete genomes in the world. Furthermore, to better investigate the contribution of HTLV-1 mutations for the disease outcome it is necessary to evaluate the interaction of the viral genome and characteristics of the human host.
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spelling Araújo, Thessika Hialla AlmeidaBarreto, Fernanda KhouriMenezes, Aline Dórea LuzLima, Clayton Pereira Silva deOliveira, Rodrigo Santos deLemos, Poliana da SilvaGalvão-Castro, BernardoKashima, SimoneFarre, LourdesBittencourt, Achilea LisboaCarvalho, Edgar Marcelino deSantos, Luciane AmorimRego, Filipe Ferreira de AlmeidaMota-Miranda, Aline Cristina AndradeNunes, Márcio Roberto TeixeiraAlcantara, Luiz Carlos Júnior2020-02-19T18:01:24Z2020-02-19T18:01:24Z2020ARAÚJO, Thessika Hialla Almeida et al. Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis. Infection, Genetics and Evolution, v. 79, n. 104166, p. xx, Apr. 2020. DOI: https://doi.org/10.1016/j.meegid.2019.104166.1567-7257https://patua.iec.gov.br/handle/iec/405110.1016/j.meegid.2019.104166The HTLV-1 is the first human retrovirus and is associated with several clinical syndromes, however, the pathogenesis of these clinical manifestations is still not fully understood. Furthermore, there are few complete genomes publicly available, about 0.12 complete genomes per 10,000 infected individuals and the databases have a major deficiency of sequences information. This study generated and characterized 31 HTLV-1 complete genomes sequences derived from individuals with Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM), Adult T-cell leukemia/lymphoma (ATL), infective dermatitis associated to HTLV-1 (IDH) and asymptomatic patients. These sequences are associated to clinical and epidemiological information about the patients. The sequencing data generated on Ion Torrent PGM platform were assembled and mapped against the reference HTLV-1 genome. These sequences were genotyped as Cosmopolitan subtype, Transcontinental subgroup. We identified the variants in the coding regions of the genome of the different clinical profiles, however, no statistical relation was detected. This study contributed to increase of HTLV-1 complete genomes in the world. Furthermore, to better investigate the contribution of HTLV-1 mutations for the disease outcome it is necessary to evaluate the interaction of the viral genome and characteristics of the human host.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil / Universidade Federal da Bahia, Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brazil.Fundação Hemocentro de Ribeirão Preto. São Paulo, SP, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil / Bellvitge Biomedical Research Institute. Catalan Institute of Oncology. Barcelona, Spain.Universidade Federal da Bahia. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil / Universidade Federal da Bahia. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brazil.Universidade Católica do Salvador. Salvador, BA, Brazil.Universidade Federal da Bahia. Salvador, BA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil.engElsevierComplete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleVírus Linfotrópico T Tipo 1 Humano / isolamento & purificaçãoVírus Linfotrópico T Tipo 1 Humano / patogenicidadeGenoma ViralGenoma / genéticaNucleotídeos / genéticaInterações Hospedeiro-Patógenoinfo:eu-repo/semantics/embargoedAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALAcesso Embargado.pdfAcesso Embargado.pdfapplication/pdf551083https://patua.iec.gov.br/bitstreams/f47a57f1-09c8-4c66-8256-d36130158260/downloadc9a9c128e29cac82a5d7fdf3f4e6da73MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/0854b35e-0108-40cb-b526-50532477ba2e/download11832eea31b16df8613079d742d61793MD52TEXTComplete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis.pdf.txtComplete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis.pdf.txtExtracted texttext/plain1https://patua.iec.gov.br/bitstreams/ab4eec52-809b-4224-ad25-e4a6e5c57b78/download68b329da9893e34099c7d8ad5cb9c940MD53Acesso Embargado.pdf.txtAcesso Embargado.pdf.txtExtracted texttext/plain2https://patua.iec.gov.br/bitstreams/a823a50c-bcc4-483c-bbbe-661b90075a4a/downloade1c06d85ae7b8b032bef47e42e4c08f9MD57THUMBNAILComplete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis.pdf.jpgComplete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis.pdf.jpgGenerated Thumbnailimage/jpeg1401https://patua.iec.gov.br/bitstreams/b9044bb2-e800-4c4f-a2a5-cdb5d142c4cf/download2294bfc411bc4060290a7b5b1213088bMD54Acesso Embargado.pdf.jpgAcesso Embargado.pdf.jpgGenerated Thumbnailimage/jpeg3095https://patua.iec.gov.br/bitstreams/db57e93e-a649-4d1c-b036-ff591b65f4d8/download71859d578212107f7f8c49a4ce09d9eeMD58iec/40512022-10-21 00:47:13.02oai:patua.iec.gov.br:iec/4051https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-21T00:47:13Repositório Digital do Instituto Evandro Chagas (Patuá) - 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dc.title.pt_BR.fl_str_mv Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis
title Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis
spellingShingle Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis
Araújo, Thessika Hialla Almeida
Vírus Linfotrópico T Tipo 1 Humano / isolamento & purificação
Vírus Linfotrópico T Tipo 1 Humano / patogenicidade
Genoma Viral
Genoma / genética
Nucleotídeos / genética
Interações Hospedeiro-Patógeno
title_short Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis
title_full Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis
title_fullStr Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis
title_full_unstemmed Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis
title_sort Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis
author Araújo, Thessika Hialla Almeida
author_facet Araújo, Thessika Hialla Almeida
Barreto, Fernanda Khouri
Menezes, Aline Dórea Luz
Lima, Clayton Pereira Silva de
Oliveira, Rodrigo Santos de
Lemos, Poliana da Silva
Galvão-Castro, Bernardo
Kashima, Simone
Farre, Lourdes
Bittencourt, Achilea Lisboa
Carvalho, Edgar Marcelino de
Santos, Luciane Amorim
Rego, Filipe Ferreira de Almeida
Mota-Miranda, Aline Cristina Andrade
Nunes, Márcio Roberto Teixeira
Alcantara, Luiz Carlos Júnior
author_role author
author2 Barreto, Fernanda Khouri
Menezes, Aline Dórea Luz
Lima, Clayton Pereira Silva de
Oliveira, Rodrigo Santos de
Lemos, Poliana da Silva
Galvão-Castro, Bernardo
Kashima, Simone
Farre, Lourdes
Bittencourt, Achilea Lisboa
Carvalho, Edgar Marcelino de
Santos, Luciane Amorim
Rego, Filipe Ferreira de Almeida
Mota-Miranda, Aline Cristina Andrade
Nunes, Márcio Roberto Teixeira
Alcantara, Luiz Carlos Júnior
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Araújo, Thessika Hialla Almeida
Barreto, Fernanda Khouri
Menezes, Aline Dórea Luz
Lima, Clayton Pereira Silva de
Oliveira, Rodrigo Santos de
Lemos, Poliana da Silva
Galvão-Castro, Bernardo
Kashima, Simone
Farre, Lourdes
Bittencourt, Achilea Lisboa
Carvalho, Edgar Marcelino de
Santos, Luciane Amorim
Rego, Filipe Ferreira de Almeida
Mota-Miranda, Aline Cristina Andrade
Nunes, Márcio Roberto Teixeira
Alcantara, Luiz Carlos Júnior
dc.subject.decsPrimary.pt_BR.fl_str_mv Vírus Linfotrópico T Tipo 1 Humano / isolamento & purificação
Vírus Linfotrópico T Tipo 1 Humano / patogenicidade
Genoma Viral
Genoma / genética
Nucleotídeos / genética
Interações Hospedeiro-Patógeno
topic Vírus Linfotrópico T Tipo 1 Humano / isolamento & purificação
Vírus Linfotrópico T Tipo 1 Humano / patogenicidade
Genoma Viral
Genoma / genética
Nucleotídeos / genética
Interações Hospedeiro-Patógeno
description The HTLV-1 is the first human retrovirus and is associated with several clinical syndromes, however, the pathogenesis of these clinical manifestations is still not fully understood. Furthermore, there are few complete genomes publicly available, about 0.12 complete genomes per 10,000 infected individuals and the databases have a major deficiency of sequences information. This study generated and characterized 31 HTLV-1 complete genomes sequences derived from individuals with Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM), Adult T-cell leukemia/lymphoma (ATL), infective dermatitis associated to HTLV-1 (IDH) and asymptomatic patients. These sequences are associated to clinical and epidemiological information about the patients. The sequencing data generated on Ion Torrent PGM platform were assembled and mapped against the reference HTLV-1 genome. These sequences were genotyped as Cosmopolitan subtype, Transcontinental subgroup. We identified the variants in the coding regions of the genome of the different clinical profiles, however, no statistical relation was detected. This study contributed to increase of HTLV-1 complete genomes in the world. Furthermore, to better investigate the contribution of HTLV-1 mutations for the disease outcome it is necessary to evaluate the interaction of the viral genome and characteristics of the human host.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-02-19T18:01:24Z
dc.date.available.fl_str_mv 2020-02-19T18:01:24Z
dc.date.issued.fl_str_mv 2020
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dc.identifier.citation.fl_str_mv ARAÚJO, Thessika Hialla Almeida et al. Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis. Infection, Genetics and Evolution, v. 79, n. 104166, p. xx, Apr. 2020. DOI: https://doi.org/10.1016/j.meegid.2019.104166.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/4051
dc.identifier.issn.-.fl_str_mv 1567-7257
dc.identifier.doi.pt_BR.fl_str_mv 10.1016/j.meegid.2019.104166
identifier_str_mv ARAÚJO, Thessika Hialla Almeida et al. Complete genome sequence of human T-cell lymphotropic type 1 from patients with different clinical profiles, including infective dermatitis. Infection, Genetics and Evolution, v. 79, n. 104166, p. xx, Apr. 2020. DOI: https://doi.org/10.1016/j.meegid.2019.104166.
1567-7257
10.1016/j.meegid.2019.104166
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