Association of cerebral malaria and TNF-alpha levels: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/4121 |
Resumo: | Background: Cerebral malaria is the most severe form of infection with Plasmodium falciparum characterized by a highly inflammatory response. This systematic review aimed to investigate the association between TNF-α levels and cerebral malaria. Methods: This review followed the Preferred Reporting of Systematic Review and Meta-analyses (PRISMA) guidelines. The search was performed at PubMed, LILACS, Scopus, Web of Science, The Cochrane Library, OpenGrey and Google Scholar. We have included studies of P. falciparum-infected humans with or without cerebral malaria and TNF-α dosage level. All studies were evaluated using a risk of bias tool and the GRADE approach. Results: Our results have identified 2338 studies, and 8 articles were eligible according to this systematic review inclusion criteria. Among the eight articles, five have evaluated TNF- α plasma dosage, while two have evaluated at the blood and one at the brain (post-Morten). Among them, only five studies showed higher TNF-α levels in the cerebral malaria group compared to the severe malaria group. Methodological problems were identified regarding sample size, randomization and blindness, but no risk of bias was detected. Conclusion: Although the results suggested that that TNF-α level is associated with cerebral malaria, the evidence is inconsistent and imprecise. More observational studies evaluating the average TNF-alpha are needed. |
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Leão, LuanaPuty, BrunaDolabela, Maria FâniPovoa, Marinete MarinsNé, Yago Gecy de SousaEiró, Luciana GuimarãesFagundes, Nathália Carolina FernandesMaia, Lucianne CopleLima, Rafael Rodrigues2020-07-20T18:06:14Z2020-07-20T18:06:14Z2020LEÃO, Luana et al. Association of cerebral malaria and TNF-alpha levels: a systematic review. BMC Infectious Diseases, v. 20, n. 422, 2020.1471-2334https://patua.iec.gov.br/handle/iec/412110.1186/s12879-020-05107-2Background: Cerebral malaria is the most severe form of infection with Plasmodium falciparum characterized by a highly inflammatory response. This systematic review aimed to investigate the association between TNF-α levels and cerebral malaria. Methods: This review followed the Preferred Reporting of Systematic Review and Meta-analyses (PRISMA) guidelines. The search was performed at PubMed, LILACS, Scopus, Web of Science, The Cochrane Library, OpenGrey and Google Scholar. We have included studies of P. falciparum-infected humans with or without cerebral malaria and TNF-α dosage level. All studies were evaluated using a risk of bias tool and the GRADE approach. Results: Our results have identified 2338 studies, and 8 articles were eligible according to this systematic review inclusion criteria. Among the eight articles, five have evaluated TNF- α plasma dosage, while two have evaluated at the blood and one at the brain (post-Morten). Among them, only five studies showed higher TNF-α levels in the cerebral malaria group compared to the severe malaria group. Methodological problems were identified regarding sample size, randomization and blindness, but no risk of bias was detected. Conclusion: Although the results suggested that that TNF-α level is associated with cerebral malaria, the evidence is inconsistent and imprecise. More observational studies evaluating the average TNF-alpha are needed.This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Código de Financiamento 001.Federal University of Pará. Institute of Biological Sciences. Laboratory of Functional and Structural Biology. Belém, PA, Brazil.Federal University of Pará. Institute of Health Sciences. Postgraduate Program in Pharmaceutical Sciences. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Functional and Structural Biology. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Functional and Structural Biology. Belém, PA, Brazil.University of Alberta. Faculty of Medicine and Dentistry. School of Dentistry. Edmonton, Canada.Federal University of Rio de Janeiro. School of Dentistry. Department of Pediatric Dentistry and Orthodontics. Rio de Janeiro, RJ, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Functional and Structural Biology. Belém, PA, Brazil.engBMCAssociation of cerebral malaria and TNF-alpha levels: a systematic reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMalária Cerebral / patologiaPlasmodium falciparum / patogenicidadeFator de Necrose Tumoral alfaRevisão Sistemáticainfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALAssociation of cerebral malaria and TNF-alpha levels: a systematic review.pdfAssociation of cerebral malaria and TNF-alpha levels: a systematic review.pdfapplication/pdf903409https://patua.iec.gov.br/bitstreams/4017eb25-3b22-4d80-8e8b-61b6a2fe0d55/downloaddd575fb964abfc1119f847ffbb04e4eeMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/7611795d-ee3e-420c-9a4b-71fce4b65424/download11832eea31b16df8613079d742d61793MD52TEXTAssociation of cerebral malaria and TNF-alpha levels: a systematic review.pdf.txtAssociation of cerebral malaria and TNF-alpha levels: a systematic review.pdf.txtExtracted texttext/plain71703https://patua.iec.gov.br/bitstreams/7a0bd9ea-6821-4af4-8e5f-648a29f2b296/downloadb047a7983b33a8fd1e840cbf48196747MD55THUMBNAILAssociation of cerebral malaria and TNF-alpha levels: a systematic review.pdf.jpgAssociation of cerebral malaria and TNF-alpha levels: a systematic review.pdf.jpgGenerated Thumbnailimage/jpeg5768https://patua.iec.gov.br/bitstreams/d62a8994-0e30-43f4-bf89-2796f82ae89c/download271d6506a5411d440ee41f1ec4089316MD56iec/41212022-10-20 21:31:26.906oai:patua.iec.gov.br:iec/4121https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T21:31:26Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)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 |
dc.title.pt_BR.fl_str_mv |
Association of cerebral malaria and TNF-alpha levels: a systematic review |
title |
Association of cerebral malaria and TNF-alpha levels: a systematic review |
spellingShingle |
Association of cerebral malaria and TNF-alpha levels: a systematic review Leão, Luana Malária Cerebral / patologia Plasmodium falciparum / patogenicidade Fator de Necrose Tumoral alfa Revisão Sistemática |
title_short |
Association of cerebral malaria and TNF-alpha levels: a systematic review |
title_full |
Association of cerebral malaria and TNF-alpha levels: a systematic review |
title_fullStr |
Association of cerebral malaria and TNF-alpha levels: a systematic review |
title_full_unstemmed |
Association of cerebral malaria and TNF-alpha levels: a systematic review |
title_sort |
Association of cerebral malaria and TNF-alpha levels: a systematic review |
author |
Leão, Luana |
author_facet |
Leão, Luana Puty, Bruna Dolabela, Maria Fâni Povoa, Marinete Marins Né, Yago Gecy de Sousa Eiró, Luciana Guimarães Fagundes, Nathália Carolina Fernandes Maia, Lucianne Cople Lima, Rafael Rodrigues |
author_role |
author |
author2 |
Puty, Bruna Dolabela, Maria Fâni Povoa, Marinete Marins Né, Yago Gecy de Sousa Eiró, Luciana Guimarães Fagundes, Nathália Carolina Fernandes Maia, Lucianne Cople Lima, Rafael Rodrigues |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Leão, Luana Puty, Bruna Dolabela, Maria Fâni Povoa, Marinete Marins Né, Yago Gecy de Sousa Eiró, Luciana Guimarães Fagundes, Nathália Carolina Fernandes Maia, Lucianne Cople Lima, Rafael Rodrigues |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Malária Cerebral / patologia Plasmodium falciparum / patogenicidade Fator de Necrose Tumoral alfa Revisão Sistemática |
topic |
Malária Cerebral / patologia Plasmodium falciparum / patogenicidade Fator de Necrose Tumoral alfa Revisão Sistemática |
description |
Background: Cerebral malaria is the most severe form of infection with Plasmodium falciparum characterized by a highly inflammatory response. This systematic review aimed to investigate the association between TNF-α levels and cerebral malaria. Methods: This review followed the Preferred Reporting of Systematic Review and Meta-analyses (PRISMA) guidelines. The search was performed at PubMed, LILACS, Scopus, Web of Science, The Cochrane Library, OpenGrey and Google Scholar. We have included studies of P. falciparum-infected humans with or without cerebral malaria and TNF-α dosage level. All studies were evaluated using a risk of bias tool and the GRADE approach. Results: Our results have identified 2338 studies, and 8 articles were eligible according to this systematic review inclusion criteria. Among the eight articles, five have evaluated TNF- α plasma dosage, while two have evaluated at the blood and one at the brain (post-Morten). Among them, only five studies showed higher TNF-α levels in the cerebral malaria group compared to the severe malaria group. Methodological problems were identified regarding sample size, randomization and blindness, but no risk of bias was detected. Conclusion: Although the results suggested that that TNF-α level is associated with cerebral malaria, the evidence is inconsistent and imprecise. More observational studies evaluating the average TNF-alpha are needed. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-07-20T18:06:14Z |
dc.date.available.fl_str_mv |
2020-07-20T18:06:14Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
LEÃO, Luana et al. Association of cerebral malaria and TNF-alpha levels: a systematic review. BMC Infectious Diseases, v. 20, n. 422, 2020. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/4121 |
dc.identifier.issn.-.fl_str_mv |
1471-2334 |
dc.identifier.doi.-.fl_str_mv |
10.1186/s12879-020-05107-2 |
identifier_str_mv |
LEÃO, Luana et al. Association of cerebral malaria and TNF-alpha levels: a systematic review. BMC Infectious Diseases, v. 20, n. 422, 2020. 1471-2334 10.1186/s12879-020-05107-2 |
url |
https://patua.iec.gov.br/handle/iec/4121 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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BMC |
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BMC |
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Instituto Evandro Chagas (IEC) |
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IEC |
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IEC |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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