Prevalence of arbovirus antibodies in young healthy adult population in Brazil

Detalhes bibliográficos
Autor(a) principal: Salgado, Bárbara Batista
Data de Publicação: 2021
Outros Autores: Maués, Fábio Carmona de Jesus, Pereira, Renato Lemos, Chiang, Jannifer Oliveira, Freitas, Maria Nazaré de Oliveira, Ferreira, Milene Silveira, Martins, Lívia Caricio, Vasconcelos, Pedro Fernando da Costa, Ganoza, Christian, Lalwani, Pritesh
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/4425
Resumo: Background: The emergence and re-emergence of infectious diseases are a cause for worldwide concern. The introduction of Zika and Chikungunya diseases in the Americas has exposed unforeseen medical and logistical challenges for public health systems. Moreover, the lack of preventive measures and vaccination against known and emerging mosquito-transmitted pathogens, and the occurrence of unanticipated clinical complications, has had an enormous social and economic impact on the affected populations. In this study, we aimed to measure the seroprevalence of endemic and emerging viral pathogens in military personnel stationed in Manaus, Amazonas state. Methods: We measured the seropositivity of antibodies against 19 endemic and emerging viruses in a healthy military personnel group using a hemagglutination inhibition assay (HIA). Results: Overall, DENV positivity was 60.4%, and 30.9% of the individuals reacted against ZIKV. Also, 46.6%, 54.7%, 51.3% and 48.7% individuals reacted against West Nile virus (WNV), Saint Louis encephalitis virus (SLEV), Ilheus virus (ILHV) and Rocio virus (ROCV), respectively. Individuals with high DENV HIA titer reacted more frequently with ZIKV or WNV compared to those with low HIA titers. Observed cross-reactivity between Flaviviruses varied depending on the virus serogroup. Additionally, 0.6% and 0.3% individuals were seropositive for Oropouche virus (OROV) and Catu virus (CATUV) from the family Peribunyaviridae, respectively. All samples were negative for Eastern Equine Encephalitis virus (EEEV), Western Equine Encephalomyelitis virus (WEEV), Mayaro virus (MAYV), Mucambo virus (MUCV) and CHIKV from the family Togaviridae. Conclusions: A high proportion of individuals in our high-risk population (~ 60%) lacked antibodies against major endemic and emerging viruses, which makes them susceptible for further infections. Military personnel serving in the Amazon region could serve as sentinels to strengthen global infectious disease surveillance, particularly in remote areas.
id IEC-2_abf26fd432aa4875fcc3c13a26a62bb9
oai_identifier_str oai:patua.iec.gov.br:iec/4425
network_acronym_str IEC-2
network_name_str Repositório Digital do Instituto Evandro Chagas (Patuá)
repository_id_str
spelling Salgado, Bárbara BatistaMaués, Fábio Carmona de JesusPereira, Renato LemosChiang, Jannifer OliveiraFreitas, Maria Nazaré de OliveiraFerreira, Milene SilveiraMartins, Lívia CaricioVasconcelos, Pedro Fernando da CostaGanoza, ChristianLalwani, Pritesh2021-08-23T13:38:08Z2021-08-23T13:38:08Z2021SALGADO, Bárbara Batista et al. Prevalence of arbovirus antibodies in young healthy adult population in Brazil. Parasites and Vectors, v. 14, n. 1, p. 1-11, Dec. 2021.1756-3305https://patua.iec.gov.br/handle/iec/442510.1186/s13071-021-04901-4Background: The emergence and re-emergence of infectious diseases are a cause for worldwide concern. The introduction of Zika and Chikungunya diseases in the Americas has exposed unforeseen medical and logistical challenges for public health systems. Moreover, the lack of preventive measures and vaccination against known and emerging mosquito-transmitted pathogens, and the occurrence of unanticipated clinical complications, has had an enormous social and economic impact on the affected populations. In this study, we aimed to measure the seroprevalence of endemic and emerging viral pathogens in military personnel stationed in Manaus, Amazonas state. Methods: We measured the seropositivity of antibodies against 19 endemic and emerging viruses in a healthy military personnel group using a hemagglutination inhibition assay (HIA). Results: Overall, DENV positivity was 60.4%, and 30.9% of the individuals reacted against ZIKV. Also, 46.6%, 54.7%, 51.3% and 48.7% individuals reacted against West Nile virus (WNV), Saint Louis encephalitis virus (SLEV), Ilheus virus (ILHV) and Rocio virus (ROCV), respectively. Individuals with high DENV HIA titer reacted more frequently with ZIKV or WNV compared to those with low HIA titers. Observed cross-reactivity between Flaviviruses varied depending on the virus serogroup. Additionally, 0.6% and 0.3% individuals were seropositive for Oropouche virus (OROV) and Catu virus (CATUV) from the family Peribunyaviridae, respectively. All samples were negative for Eastern Equine Encephalitis virus (EEEV), Western Equine Encephalomyelitis virus (WEEV), Mayaro virus (MAYV), Mucambo virus (MUCV) and CHIKV from the family Togaviridae. Conclusions: A high proportion of individuals in our high-risk population (~ 60%) lacked antibodies against major endemic and emerging viruses, which makes them susceptible for further infections. Military personnel serving in the Amazon region could serve as sentinels to strengthen global infectious disease surveillance, particularly in remote areas.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil / Centro de Instrução de Guerra na Selva. Manaus, AM, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Universidad Peruana Cayetano Heredia. Instituto de Medicina Tropical Alexander von Humboldt. Lima, Peru.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil.engBMCPrevalence of arbovirus antibodies in young healthy adult population in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInfecções por Arbovirus / sangueInfecção por Zika virus / sangueFebre de Chikungunya / sangueEstudos SoroepidemiológicosAnticorpos / análiseSaúde MilitarMilitaresinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALPrevalence of arbovirus antibodies in young healthy adult population in Brazil.pdfPrevalence of arbovirus antibodies in young healthy adult population in Brazil.pdfapplication/pdf7093994https://patua.iec.gov.br/bitstreams/b8a459c5-e6d7-496c-8a0c-d1f61e4f2f34/download116c097813c4ae49f12bb16b70c70702MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/d68361bd-ef98-45ad-b854-4933fd8dd58f/download11832eea31b16df8613079d742d61793MD52TEXTPrevalence of arbovirus antibodies in young healthy adult population in Brazil.pdf.txtPrevalence of arbovirus antibodies in young healthy adult population in Brazil.pdf.txtExtracted texttext/plain45639https://patua.iec.gov.br/bitstreams/d917f95c-b7c4-4a43-a36e-432520331ad1/downloade393b9b39bb5b2b362b82fce23f28828MD55THUMBNAILPrevalence of arbovirus antibodies in young healthy adult population in Brazil.pdf.jpgPrevalence of arbovirus antibodies in young healthy adult population in Brazil.pdf.jpgGenerated Thumbnailimage/jpeg5746https://patua.iec.gov.br/bitstreams/6b73ea0f-ed37-4e65-90f0-abe07e25a39a/download9f7300e6e23078d160162b1ab40c06a4MD56iec/44252022-10-20 22:18:49.612oai:patua.iec.gov.br:iec/4425https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T22:18:49Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)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
dc.title.pt_BR.fl_str_mv Prevalence of arbovirus antibodies in young healthy adult population in Brazil
title Prevalence of arbovirus antibodies in young healthy adult population in Brazil
spellingShingle Prevalence of arbovirus antibodies in young healthy adult population in Brazil
Salgado, Bárbara Batista
Infecções por Arbovirus / sangue
Infecção por Zika virus / sangue
Febre de Chikungunya / sangue
Estudos Soroepidemiológicos
Anticorpos / análise
Saúde Militar
Militares
title_short Prevalence of arbovirus antibodies in young healthy adult population in Brazil
title_full Prevalence of arbovirus antibodies in young healthy adult population in Brazil
title_fullStr Prevalence of arbovirus antibodies in young healthy adult population in Brazil
title_full_unstemmed Prevalence of arbovirus antibodies in young healthy adult population in Brazil
title_sort Prevalence of arbovirus antibodies in young healthy adult population in Brazil
author Salgado, Bárbara Batista
author_facet Salgado, Bárbara Batista
Maués, Fábio Carmona de Jesus
Pereira, Renato Lemos
Chiang, Jannifer Oliveira
Freitas, Maria Nazaré de Oliveira
Ferreira, Milene Silveira
Martins, Lívia Caricio
Vasconcelos, Pedro Fernando da Costa
Ganoza, Christian
Lalwani, Pritesh
author_role author
author2 Maués, Fábio Carmona de Jesus
Pereira, Renato Lemos
Chiang, Jannifer Oliveira
Freitas, Maria Nazaré de Oliveira
Ferreira, Milene Silveira
Martins, Lívia Caricio
Vasconcelos, Pedro Fernando da Costa
Ganoza, Christian
Lalwani, Pritesh
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Salgado, Bárbara Batista
Maués, Fábio Carmona de Jesus
Pereira, Renato Lemos
Chiang, Jannifer Oliveira
Freitas, Maria Nazaré de Oliveira
Ferreira, Milene Silveira
Martins, Lívia Caricio
Vasconcelos, Pedro Fernando da Costa
Ganoza, Christian
Lalwani, Pritesh
dc.subject.decsPrimary.pt_BR.fl_str_mv Infecções por Arbovirus / sangue
Infecção por Zika virus / sangue
Febre de Chikungunya / sangue
Estudos Soroepidemiológicos
Anticorpos / análise
Saúde Militar
topic Infecções por Arbovirus / sangue
Infecção por Zika virus / sangue
Febre de Chikungunya / sangue
Estudos Soroepidemiológicos
Anticorpos / análise
Saúde Militar
Militares
dc.subject.decsPrimary.pt-BR.fl_str_mv Militares
description Background: The emergence and re-emergence of infectious diseases are a cause for worldwide concern. The introduction of Zika and Chikungunya diseases in the Americas has exposed unforeseen medical and logistical challenges for public health systems. Moreover, the lack of preventive measures and vaccination against known and emerging mosquito-transmitted pathogens, and the occurrence of unanticipated clinical complications, has had an enormous social and economic impact on the affected populations. In this study, we aimed to measure the seroprevalence of endemic and emerging viral pathogens in military personnel stationed in Manaus, Amazonas state. Methods: We measured the seropositivity of antibodies against 19 endemic and emerging viruses in a healthy military personnel group using a hemagglutination inhibition assay (HIA). Results: Overall, DENV positivity was 60.4%, and 30.9% of the individuals reacted against ZIKV. Also, 46.6%, 54.7%, 51.3% and 48.7% individuals reacted against West Nile virus (WNV), Saint Louis encephalitis virus (SLEV), Ilheus virus (ILHV) and Rocio virus (ROCV), respectively. Individuals with high DENV HIA titer reacted more frequently with ZIKV or WNV compared to those with low HIA titers. Observed cross-reactivity between Flaviviruses varied depending on the virus serogroup. Additionally, 0.6% and 0.3% individuals were seropositive for Oropouche virus (OROV) and Catu virus (CATUV) from the family Peribunyaviridae, respectively. All samples were negative for Eastern Equine Encephalitis virus (EEEV), Western Equine Encephalomyelitis virus (WEEV), Mayaro virus (MAYV), Mucambo virus (MUCV) and CHIKV from the family Togaviridae. Conclusions: A high proportion of individuals in our high-risk population (~ 60%) lacked antibodies against major endemic and emerging viruses, which makes them susceptible for further infections. Military personnel serving in the Amazon region could serve as sentinels to strengthen global infectious disease surveillance, particularly in remote areas.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-08-23T13:38:08Z
dc.date.available.fl_str_mv 2021-08-23T13:38:08Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SALGADO, Bárbara Batista et al. Prevalence of arbovirus antibodies in young healthy adult population in Brazil. Parasites and Vectors, v. 14, n. 1, p. 1-11, Dec. 2021.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/4425
dc.identifier.issn.-.fl_str_mv 1756-3305
dc.identifier.doi.-.fl_str_mv 10.1186/s13071-021-04901-4
identifier_str_mv SALGADO, Bárbara Batista et al. Prevalence of arbovirus antibodies in young healthy adult population in Brazil. Parasites and Vectors, v. 14, n. 1, p. 1-11, Dec. 2021.
1756-3305
10.1186/s13071-021-04901-4
url https://patua.iec.gov.br/handle/iec/4425
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Digital do Instituto Evandro Chagas (Patuá)
instname:Instituto Evandro Chagas (IEC)
instacron:IEC
instname_str Instituto Evandro Chagas (IEC)
instacron_str IEC
institution IEC
reponame_str Repositório Digital do Instituto Evandro Chagas (Patuá)
collection Repositório Digital do Instituto Evandro Chagas (Patuá)
bitstream.url.fl_str_mv https://patua.iec.gov.br/bitstreams/b8a459c5-e6d7-496c-8a0c-d1f61e4f2f34/download
https://patua.iec.gov.br/bitstreams/d68361bd-ef98-45ad-b854-4933fd8dd58f/download
https://patua.iec.gov.br/bitstreams/d917f95c-b7c4-4a43-a36e-432520331ad1/download
https://patua.iec.gov.br/bitstreams/6b73ea0f-ed37-4e65-90f0-abe07e25a39a/download
bitstream.checksum.fl_str_mv 116c097813c4ae49f12bb16b70c70702
11832eea31b16df8613079d742d61793
e393b9b39bb5b2b362b82fce23f28828
9f7300e6e23078d160162b1ab40c06a4
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)
repository.mail.fl_str_mv clariceneta@iec.gov.br || Biblioteca@iec.gov.br
_version_ 1809190046604984320