The pressure pan evolution of human erythrovirus B19 in the Amazon

• Autor(a) principal: Freitas, Ronaldo Barros de
• Data de Publicação: 2007
• Outros Autores: Durigon, Edison Luiz, Oliveira, Darleise de Souza, Romano, Camila Malta, Freitas, Maria Rute Castro, Linhares, Alexandre da Costa, Melo, Fernando Lucas, Walshkeller, Lílian, Barbosa, Maria Luiza, Huatuco, Egma M. Mayta, Holmes, Edward C, Zanotto, Paolo Marinho de A
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/3260
• topic: Parvovirus B19 Humano; Filogenia

To understand the evolutionary dynamics of human parvovirus B19, we analyzed VP1 and VP2 gene sequences of B19 sampled from Belém (Amazon), the city of São Paulo, Brazil and globally. Our analysis revealed a strikingly different pattern of evolutionary change for those viral lineages introduced into Belém, which exhibited a higher rate of nonsynonymous substitutions compared to those viruses sampled from other locations. We propose that difference this is due to the high prevalence of B19 in Belem (up to 85 per cent) compared to other locations (prevalenceÆs of approximately 50 per cent), which imposes a more intense selection pressure. Hence, those B19 lineages introduced into Belem experienced an elevated rate of amino acid change, driven by positive selection, in order to generate serial re-infections in a small web of transmission, which can be thought of as an evolutionary "pressure pan"