Sinu Virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia.
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/3856 |
Resumo: | The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus. |
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Contreras-Gutiérrez, María AngélicaNunes, Márcio Roberto TeixeiraGuzman, HildaUribe, SandraGómez, Juan Carlos GallegoVasco, Juan David SuazaCardoso, Jedson FerreiraPopov, Vsevolod LeonidovichWiden, Steven GWood, Thomas GVasilakis, NikosTesh, Robert B2019-08-27T18:07:56Z2019-08-27T18:07:56Z2017CONTRERAS-GUTIÉRREZ, María Angélica et al. Sinu Virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. Virology, v. 501, p. 166-175, 2017.0042-6822https://patua.iec.gov.br/handle/iec/385610.1016/j.virol.2016.11.014The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.Universidad de Antioquia. SIUSde de Investigación Universitaria. Programa de Estudio y Control de Enfermedades Tropicales. Medellín, Colombia / Universidad Nacional de Colombia. Facultad de Ciencias. Grupo de Investigación en Sistemática Molecular. Medellín, Colombia.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.University of Texas Medical Branch. Institute for Human Infections and Immunity. Department of Pathology. Galveston, TX, USA.Universidad Nacional de Colombia. Facultad de Ciencias. Grupo de Investigación en Sistemática Molecular. Medellín, Colombia.Universidad de Antioquia. Grupo de Investigación en Medicina Molecular y Traslacional. Medellín, Colombia.Universidad de Antioquia. SIUSde de Investigación Universitaria. Programa de Estudio y Control de Enfermedades Tropicales. Medellín, ColombiaMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.University of Texas Medical Branch. Institute for Human Infections and Immunity. Department of Pathology. Galveston, TX, USA.University of Texas Medical Branch. Institute for Human Infections and Immunity. Department of Pathology. Galveston, TX, USA.University of Texas Medical Branch. Institute for Human Infections and Immunity. Department of Pathology. Galveston, TX, USA.University of Texas Medical Branch. Institute for Human Infections and Immunity. Department of Pathology. Galveston, TX, USA.University of Texas Medical Branch. Institute for Human Infections and Immunity. Department of Pathology. Galveston, TX, USA.engElsevierSinu Virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCulicidae / virologiaOrthomyxoviridae / classificaçãoOrthomyxoviridae / químicaOrthomyxoviridae / genéticaOrthomyxoviridae / isolamento & purificaçãoOrthomyxoviridae / ultraestruturaThogotovirus / classificaçãoThogotovirus / químicaThogotovirus / genéticaThogotovirus / isolamento & purificaçãoThogotovirus / ultraestruturaProteínas Virais / genéticaProteínas Virais / químicaProteínas Virais / metabolismoEvolução MolecularModelos MolecularesGenoma ViralSequência de AminoácidosDados de Sequência MolecularTécnica Indireta de Fluorescência para Anticorpo / MétodosReação em Cadeia da Polimerase Via Transcriptase Reversa / métodosinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Sinu Virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. |
title |
Sinu Virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. |
spellingShingle |
Sinu Virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. Contreras-Gutiérrez, María Angélica Culicidae / virologia Orthomyxoviridae / classificação Orthomyxoviridae / química Orthomyxoviridae / genética Orthomyxoviridae / isolamento & purificação Orthomyxoviridae / ultraestrutura Thogotovirus / classificação Thogotovirus / química Thogotovirus / genética Thogotovirus / isolamento & purificação Thogotovirus / ultraestrutura Proteínas Virais / genética Proteínas Virais / química Proteínas Virais / metabolismo Evolução Molecular Modelos Moleculares Genoma Viral Sequência de Aminoácidos Dados de Sequência Molecular Técnica Indireta de Fluorescência para Anticorpo / Métodos Reação em Cadeia da Polimerase Via Transcriptase Reversa / métodos |
title_short |
Sinu Virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. |
title_full |
Sinu Virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. |
title_fullStr |
Sinu Virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. |
title_full_unstemmed |
Sinu Virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. |
title_sort |
Sinu Virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. |
author |
Contreras-Gutiérrez, María Angélica |
author_facet |
Contreras-Gutiérrez, María Angélica Nunes, Márcio Roberto Teixeira Guzman, Hilda Uribe, Sandra Gómez, Juan Carlos Gallego Vasco, Juan David Suaza Cardoso, Jedson Ferreira Popov, Vsevolod Leonidovich Widen, Steven G Wood, Thomas G Vasilakis, Nikos Tesh, Robert B |
author_role |
author |
author2 |
Nunes, Márcio Roberto Teixeira Guzman, Hilda Uribe, Sandra Gómez, Juan Carlos Gallego Vasco, Juan David Suaza Cardoso, Jedson Ferreira Popov, Vsevolod Leonidovich Widen, Steven G Wood, Thomas G Vasilakis, Nikos Tesh, Robert B |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Contreras-Gutiérrez, María Angélica Nunes, Márcio Roberto Teixeira Guzman, Hilda Uribe, Sandra Gómez, Juan Carlos Gallego Vasco, Juan David Suaza Cardoso, Jedson Ferreira Popov, Vsevolod Leonidovich Widen, Steven G Wood, Thomas G Vasilakis, Nikos Tesh, Robert B |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Culicidae / virologia Orthomyxoviridae / classificação Orthomyxoviridae / química Orthomyxoviridae / genética Orthomyxoviridae / isolamento & purificação Orthomyxoviridae / ultraestrutura Thogotovirus / classificação Thogotovirus / química Thogotovirus / genética Thogotovirus / isolamento & purificação Thogotovirus / ultraestrutura Proteínas Virais / genética Proteínas Virais / química Proteínas Virais / metabolismo Evolução Molecular Modelos Moleculares Genoma Viral Sequência de Aminoácidos Dados de Sequência Molecular Técnica Indireta de Fluorescência para Anticorpo / Métodos |
topic |
Culicidae / virologia Orthomyxoviridae / classificação Orthomyxoviridae / química Orthomyxoviridae / genética Orthomyxoviridae / isolamento & purificação Orthomyxoviridae / ultraestrutura Thogotovirus / classificação Thogotovirus / química Thogotovirus / genética Thogotovirus / isolamento & purificação Thogotovirus / ultraestrutura Proteínas Virais / genética Proteínas Virais / química Proteínas Virais / metabolismo Evolução Molecular Modelos Moleculares Genoma Viral Sequência de Aminoácidos Dados de Sequência Molecular Técnica Indireta de Fluorescência para Anticorpo / Métodos Reação em Cadeia da Polimerase Via Transcriptase Reversa / métodos |
dc.subject.decsPrimary.none.fl_str_mv |
Reação em Cadeia da Polimerase Via Transcriptase Reversa / métodos |
description |
The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2019-08-27T18:07:56Z |
dc.date.available.fl_str_mv |
2019-08-27T18:07:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CONTRERAS-GUTIÉRREZ, María Angélica et al. Sinu Virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. Virology, v. 501, p. 166-175, 2017. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/3856 |
dc.identifier.issn.-.fl_str_mv |
0042-6822 |
dc.identifier.doi.-.fl_str_mv |
10.1016/j.virol.2016.11.014 |
identifier_str_mv |
CONTRERAS-GUTIÉRREZ, María Angélica et al. Sinu Virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. Virology, v. 501, p. 166-175, 2017. 0042-6822 10.1016/j.virol.2016.11.014 |
url |
https://patua.iec.gov.br/handle/iec/3856 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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